CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2480
Family Name Histamine H3 receptor Ligand (r)-1-(2-methoxyphenethyl)-2-methylpyrrolidine Family
No. of Seeds 10 No. of Other Members 27
Family Centroid CFAMM00269233 Functional Category Investigative Drug
Superfamily Histamine H3 receptor Ligand (r)-1-(2-methoxyphenethyl)-2-methylpyrrolidine Superfamily
Class Class 1211

Cousin Family NamesSeedsMembers
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 5 209
Noradrenergic re-uptake and Serotonin re-uptake inhibitor bicy... 6 375
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 61 433
Oestrogen receptor Ligand triphenyl ethylene stilbene derivati... 22 420
Acetylcholinesterase Inhibitor Rivastigmine Family 2 59
Histamine H1 receptor Ligand Doxepin Family 8 89
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Alpha-1 adrenergic receptor ligand Dextroamphetamine derivativ... 5 29
Sigma non-opioid intracellular receptor 1 ligand opiate Dextro... 9 33
Beta-1 adrenergic receptor Ligand Metoprolol Family 29 90
Muscarinic acetylcholine receptor M3 Ligand Tolterodine Family 8 171
Alpha adrenergic receptor Ligand Phenoxybenzamine Family 4 63
Sodium channel protein type 5 subunit alpha Ligand Mexiletine ... 7 74
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Synaptic vesicular amine transporter Inhibitor Tetrabenazine F... 13 425
Alpha-1B adrenergic receptor ligand Phenylephrine analog Metho... 9 56
Alpha adrenergic receptor Ligand Bevantolol Family 4 48
Beta-1 adrenergic receptor Ligand Nebivolol Family 5 22
5-hydroxytryptamine receptor 2A Ligand Sarpogrelate Family 2 15
Oestrogen receptor Ligand Lasofoxifene Family 19 152
Nicotinic acetylcholine receptor Ligand Benztropine Mesylate F... 10 20
Noradrenergic re-uptake Inhibitor Desvenalfaxine Succinate Family 2 4
Zucapsacin family 7 177
Eptazocine Hbr family 6 8
Noradrenergic re-uptake and Opioid receptor Ligand Tapentadol ... 21 79
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 6 33
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 4 35
Substance-P receptor Ligand Ezlopitant Family 10 207
D(3) dopamine receptor Ligand U-99194A Family 7 33
Dapoxetine family 3 40
5-hydroxytryptamine receptor 1A Ligand (s)-uh-301 Family 35 20
Squalene synthase Inhibitor (z)-3-[2-(9h-fluoren-2-yloxy)ethyl... 12 92
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
Arachidonate 5-lipoxygenase Inhibitor Bw A360C Family 12 8
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
M-phase inducer phosphatase 1 Inhibitor Naphthoquinone Analogs... 11 56
Tumor necrosis factor Inhibitor Y-39041 Family 9 51
Histamine H3 receptor Ligand A-331440 Family 6 7
Histamine H3 receptor Ligand UCL-2138 Family 23 172
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 11
Disintegrin and metalloproteinase domain-containing protein 17... 25 36
Adenosine receptor A3 and Mu-type opioid receptor Ligand GBR-1... 80 110
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 7 22
Histamine H3 receptor Ligand A-349821 Family 49 228
Adenosine receptor A3 and Muscarinic acetylcholine receptor M2... 4 31
Cannabinoid receptor 1 Ligand N-(3,5-dimethoxyphenethyl)oleami... 5 49
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
Angiopoietin-1 receptor and Cyclin-dependent kinase 1 Inhibito... 2 10
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 11 21
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 41
Histamine H3 receptor and Sodium-dependent serotonin transport... 25 28
5-hydroxytryptamine receptor 2A Ligand 3-methoxy-9-aminomethyl... 7 14
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 11
Fatty-acid amide hydrolase 1 Inhibitor N-butylcarbamic Acid Bi... 9 31
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 2
Sodium-dependent serotonin transporter Inhibitor 4-(2-((dimeth... 3 1
Sodium-dependent noradrenaline transporter Inhibitor WAY-25680... 4 6
5-hydroxytryptamine receptor 2A and D(1A) dopamine receptor Li... 8 33
Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 13
5-hydroxytryptamine receptor 7 Ligand (r)-8-phenyl-n,n-dipropy... 9 14
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 10 15
Arachidonate 5-lipoxygenase Inhibitor 2-(4-butoxy-phenyl)-n-hy... 3 9
5-hydroxytryptamine receptor 1A Ligand 9-methoxy-1,2,3,4-tetra... 7 10
5-hydroxytryptamine receptor 2A Ligand C-(9h-xanthen-9-yl)-met... 3 5
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 2 3
D(1A) dopamine receptor Ligand SCH-12679 Family 1 0
Tyrosinase Inhibitor 1-(3-phenoxypropyl)-4-(piperidin-1-yl)pip... 2 13
5-hydroxytryptamine receptor 2A Ligand 1-(2,6-dimethoxy-4-meth... 14 3
Sodium-dependent dopamine transporter Inhibitor Secocularidine... 3 9
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 7 0
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 2 1
Sodium-dependent serotonin transporter and Sodium-dependent no... 1 0
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 8 4
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 1 2
Histamine H3 receptor ligand 1-(4-pentan-3-ylpiperazin-1-yl)-2... 1 1
Sodium-dependent serotonin transporter and Transporter inhibit... 1 0
Sigma non-opioid intracellular receptor 1 ligand 1-[4-(4-metho... 1 0
Survival motor neuron protein and Lysine-specific demethylase ... 1 16
D(1A) dopamine receptor and D(3) dopamine receptor ligand N,N-... 3 1
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 7 0
D(3) dopamine receptor ligand S 14297 family 1 2
5-hydroxytryptamine receptor 2A and Potassium voltage-gated ch... 2 8
DNA-(apurinic or apyrimidinic site) lyase and Menin inhibitor ... 1 6
5-hydroxytryptamine receptor 1A ligand [(1S,2R)-8-methoxy-2-(p... 4 0
D(2) dopamine receptor and D(1A) dopamine receptor ligand ISOM... 2 5
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 11 2
Histamine H3 receptor ligand cyclohexyl-[4-(3-piperidin-1-ylpr... 4 1
Histamine H3 receptor and Sodium-dependent serotonin transport... 15 1
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 28
Carbonic anhydrase 14 and Carbonic anhydrase 9 inhibitor 1-(4-... 2 3
Histamine H3 receptor ligand 1-methyl-5-[4-[3-[(2R)-2-methylpy... 5 5
Histamine H3 receptor ligand SureCN6071181 family 2 1
Histamine H3 receptor and Sodium-dependent serotonin transport... 6 1
5-hydroxytryptamine receptor 7 and Alpha-2C adrenergic recepto... 3 0
Sodium-dependent serotonin transporter and Histamine H3 recept... 7 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 3 6
Sodium-dependent dopamine transporter and Sodium-dependent ser... 3 0
Melatonin receptor type 1A and Melatonin receptor type 1C liga... 1 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 6
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 2 2
Squalene monooxygenase inhibitor 2-[[3-[[[(E)-6,6-dimethylhept... 4 4
5-hydroxytryptamine receptor 1A ligand (Z)-1-diazonio-3-[[7-(d... 1 1
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-006SR... 1 2
Histamine H3 receptor ligand (E)-1-[(2S)-2-(pyrrolidin-1-ylmet... 1 1
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
Metabotropic glutamate receptor 2 ligand (5R)-3-[[4-(4-ethoxyp... 3 9
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 1 1
Sodium-dependent serotonin transporter and Transporter inhibit... 1 0
Arachidonate 5-lipoxygenase inhibitor AGN-PC-074BF6 family 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name
CFAMM00269250 CHEMBL1813480 Bioactive (3aS,6aR)-3a-(4-methoxyphenyl)-2-methyl-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrole
CFAMM00269233 DNC008244 Investigative Drug (R)-1-(2-methoxyphenethyl)-2-methylpyrrolidine
CFAMM00269232 DNC008246 Investigative Drug 1-(2-methoxyphenethyl)pyrrolidine
CFAMM00269231 DNC008241 Investigative Drug (R)-1-(3-methoxyphenethyl)-2-methylpyrrolidine
CFAMM00269230 DNC008240 Investigative Drug 1-(4-methoxyphenethyl)pyrrolidine
CFAMM00269236 DNC008238 Investigative Drug (R)-1-(4-methoxyphenethyl)-2-methylpyrrolidine
CFAMM00269229 DNC008243 Investigative Drug 1-(3-methoxyphenethyl)pyrrolidine
CFAMM00269228 DNC008242 Investigative Drug (S)-1-(3-methoxyphenethyl)-2-methylpyrrolidine
CFAMM00269255 DNC008239 Investigative Drug (S)-1-(4-methoxyphenethyl)-2-methylpyrrolidine
CFAMM00269234 DNC008245 Investigative Drug (S)-1-(2-methoxyphenethyl)-2-methylpyrrolidine

Statistics of CFAM Database
 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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