CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2481
Family Name Histamine H3 receptor Ligand 1-[2-(2,4,6-trimethyl-phenyl)-ethyl]-pyrrolidine Family
No. of Seeds 9 No. of Other Members 15
Family Centroid CFAMM00269278 Functional Category Investigative Drug
Superfamily Glutamate receptor AMPA subtype and Noradrenaline uptake Ligand Bicifadine Superfamily
Class Class 90

Cousin Family NamesSeedsMembers
Alpha-1B adrenergic receptor ligand phenethylamine derivative ... 12 283
5-hydroxytryptamine 2 receptor Ligand tricyclic antidepressant... 29 680
Adrenergic neuron Inhibitor guanidine isoquinoline analog Debr... 2 44
Voltage-dependent T-type calcium channel subunit alpha-1H liga... 10 397
Noradrenergic re-uptake and Serotonin re-uptake Inhibitor Sibu... 7 127
Extracellular calcium-sensing receptor ligand Cinacalcet Family 2 30
Histamine H1 receptor ligand piperazine derivative Cyclizine F... 16 140
Amine oxidase [flavin-containing] B Inhibitor Phenelzine Family 7 15
Amine oxidase [flavin-containing] B Inhibitor Selegiline Family 6 26
Noradrenergic re-uptake Inhibitor Phentermine Family 2 11
Squalene monooxygenase Inhibitor Naftifine Family 8 32
Noradrenergic re-uptake Inhibitor Protriptyline Family 3 25
Amine oxidase [flavin-containing] B Inhibitor Rasagiline Family 2 11
Muscarinic acetylcholine receptor M3 Ligand Diphemanil Methyls... 22 45
Noradrenergic re-uptake Inhibitor Maprotiline Family 6 33
Serotonin re-uptake Inhibitor Dexfenfluramine Family 6 31
Dermatan family 1 11
C-X-C chemokine receptor type 4 Ligand AMD-3100 Family 3 6
Glutamate receptor AMPA subtype and Noradrenaline uptake Ligan... 9 17
Zicronapine family 43 62
Sigma non-opioid intracellular receptor 1 Ligand Dimemorfan Fa... 5 15
Renin Inhibitor N-methyl-n-(methylbenzyl)formamide Family 2 17
Dipeptidyl peptidase 4 Inhibitor 1-biphenyl-2-ylmethanamine Fa... 2 23
Beta-secretase 1 Inhibitor 4-(4-fluorobenzyl)piperidine Family 2 4
D(2) dopamine receptor and D(3) dopamine receptor Ligand (-)-3... 15 19
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 5-(4-chloro-... 3 7
Adenosine receptor A3 and Glutamate receptor ionotropic, NMDA ... 4 30
Sodium-dependent noradrenaline transporter and Sodium-dependen... 3 10
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 7 19
Calcium-activated potassium channel subunit alpha-1 Ligand N-m... 2 10
Amine oxidase [flavin-containing] A Inhibitor 1-(2-naphthyl)-2... 4 4
Sodium-dependent serotonin transporter Inhibitor 1-(2-(naphtha... 5 2
Sodium-dependent dopamine transporter and Sodium-dependent nor... 28 71
Sodium-dependent serotonin transporter Inhibitor Tefludazine F... 8 9
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 1
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 3 6
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 17 9
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 4 1
Sodium-dependent dopamine transporter and Sodium-dependent ser... 8 2
Sodium-dependent serotonin transporter Inhibitor 2-n-ethylamin... 14 5
Squalene synthase Inhibitor Zwitterionic Sulfobetaine Derivati... 2 20
Sigma non-opioid intracellular receptor 1 ligand CHEMBL101300 ... 2 1
Sodium-dependent noradrenaline transporter and Sodium-dependen... 4 2
Sodium-dependent serotonin transporter and Sodium-dependent no... 12 0
Kappa-type opioid receptor ligand 1-[(2S)-2-(pyrrolidin-1-ylme... 4 0
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 1 2
5-hydroxytryptamine receptor 7 and Sodium-dependent serotonin ... 5 1
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 7 2
Sigma non-opioid intracellular receptor 1 ligand 2-(3-iodophen... 2 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 3 3
Transporter and Sodium-dependent serotonin transporter inhibit... 4 8
5-hydroxytryptamine receptor 7 ligand 5-methyl-6-(6-methyl-5,6... 2 0
Histamine H3 receptor ligand 1-[[4-[4-[(1R)-4-methoxy-1-[(2S)-... 2 0
Sigma non-opioid intracellular receptor 1 ligand 1-[2-[4-[1-ad... 1 0
Sodium-dependent noradrenaline transporter and Sodium-dependen... 2 12
Histamine H3 receptor ligand SureCN1641166 family 3 0
Histamine H3 receptor ligand 4-[6-(2-pyrrolidin-3-ylethyl)naph... 1 1
Sodium-dependent noradrenaline transporter and Sodium-dependen... 3 7
5-hydroxytryptamine receptor 1A ligand SureCN8901985 family 1 0
Histamine H3 receptor ligand 2-benzyl-4-[4-(2-pyrrolidin-1-yle... 8 4
Histamine H3 receptor ligand (3aR,6aR)-2-propan-2-yl-4-[4-(2-p... 6 5
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 6 7
Sodium-dependent serotonin transporter and Transporter inhibit... 7 2
Sodium-dependent serotonin transporter and Transporter inhibit... 7 2
D(1A) dopamine receptor and D(2) dopamine receptor ligand A314... 3 1
C-C chemokine receptor type 5 ligand 1-[[(3S,4S)-1-(cyclohexyl... 1 0
Sodium-dependent serotonin transporter and Sodium-dependent do... 2 0
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 2
Histamine H3 receptor ligand 1-[4-[4-(pyrrolidin-1-ylmethyl)ph... 4 2
Histamine H3 receptor ligand SureCN1640926 family 3 3
D(2) dopamine receptor ligand AGN-PC-041NNJ family 1 2
Sodium-dependent dopamine transporter and Sodium-dependent nor... 1 0
Sodium-dependent dopamine transporter and Sodium-dependent nor... 2 0
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 0
C-X-C chemokine receptor type 3 ligand [4-(2-bromophenyl)pheny... 1 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00269266 CHEMBL277462 Bioactive SureCN7366514
CFAMM00269272 CHEMBL441903 Bioactive (2R)-2-methyl-1-(2-naphthalen-2-ylethyl)pyrrolidine
CFAMM00269277 CHEMBL142353 Bioactive AGN-PC-003SR5
CFAMM00269270 CHEMBL2092872 Bioactive (3R)-3-(3,4-dimethylphenyl)-1-propylpiperidine;hydrochloride
CFAMM00269263 CHEMBL409984 Bioactive SureCN7332913
CFAMM00269278 DNC008253 Investigative Drug 1-[2-(2,4,6-trimethyl-phenyl)-ethyl]-pyrrolidine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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