CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2482
Family Name Histamine H3 receptor Ligand (r)-1-(4-nitrophenethyl)-2-methylpyrrolidine Family
No. of Seeds 16 No. of Other Members 38
Family Centroid CFAMM00269291 Functional Category Investigative Drug
Superfamily Histamine H3 receptor and Amyloid beta A4 protein Binder Superfamily
Class Class 2177

Cousin Family NamesSeedsMembers
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Voltage-dependent T-type calcium channel subunit alpha-1H liga... 10 397
Noradrenergic re-uptake inhibitor Dibenzazepine Imipramine Family 8 178
D(2) dopamine receptor Ligand Nomifensine Family 6 100
Vasopressin-neurophysin 2-copeptin Inhibitor Niravoline Family 7 45
5-hydroxytryptamine receptor 6 Ligand 4-(1h-inden-1-ylmethyl)-... 5 99
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 1-methyl-5-(... 6 17
Progesterone receptor Ligand 2,2,4-trimethyl-6-phenyl-1,2-dihy... 5 82
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 67
Aromatase Inhibitor 3-(4-amino-phenyl)-1-methyl-pyrrolidine-2,... 4 8
Alpha-2A adrenergic receptor Ligand 7-nitro-1,2,3,4-tetrahydro... 6 31
5-hydroxytryptamine receptor 6 Ligand [2-(3h-indol-1-yl)-ethyl... 2 7
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 8 32
Aromatase Inhibitor 3-amino-4'-amino-trans-stilbene Family 5 47
Amyloid beta A4 protein Inhibitor 1,6-bis(4'-nitrophenyl)-hexa... 3 60
Dipeptidyl peptidase 4 Inhibitor (3s,4r)-3-butyl-1-phenylpiper... 2 40
Sodium-dependent dopamine transporter and Sodium-dependent nor... 28 71
Sodium-dependent dopamine transporter and Sodium-dependent nor... 2 7
5-hydroxytryptamine receptor 3A Ligand 1-(biphenyl-4-yl)-3-(4-... 20 67
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 5 47
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 42
Nitric oxide synthase, brain Inhibitor N*1*-(5-methyl-2-nitro-... 1 19
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 5 18
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 3 31
D(4) dopamine receptor ligand AGN-PC-074VC9 family 2 3
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 4
D(4) dopamine receptor and Alpha-1B adrenergic receptor ligand... 7 27
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 1
5-hydroxytryptamine receptor 2A ligand AGN-PC-075LXD family 4 4
Sigma non-opioid intracellular receptor 1 ligand 2-(2-nitrophe... 2 5
Sigma non-opioid intracellular receptor 1 ligand 1-[4-[1-adama... 4 23
Sigma non-opioid intracellular receptor 1 ligand 1-[(3-nitroph... 4 2
5-hydroxytryptamine receptor 7 ligand 1-[2-(4-nitrophenyl)phen... 1 0
Mu-type opioid receptor ligand CHEMBL2310836 family 4 4
Kappa-type opioid receptor ligand 1-[4-acetyl-2-[[(3S)-3-hydro... 1 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 0
Androgen receptor and Cathepsin B ligand 1-(4-nitronaphthalen-... 1 1
Kappa-type opioid receptor ligand N-[(2S)-1-(2,5-dihydropyrrol... 1 1
Nitric oxide synthase, brain and Nitric oxide synthase, induci... 1 2
Progesterone receptor and Androgen receptor ligand SureCN89245... 1 4
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 0
Phenylethanolamine N-methyltransferase and Alpha-2A adrenergic... 1 3
C-X-C chemokine receptor type 3 ligand [(1S,5R)-6,6-dimethyl-4... 1 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 3 4
Glutamate receptor 4 ligand SureCN4607627 family 1 0


External ID

Functional Category

Molecule Name

CFAMM00269320 CHEMBL324513 Bioactive N-methyl-2-(2-nitrophenyl)-N-(2-pyrrolidin-1-ylethyl)ethanamine
CFAMM00269299 CHEMBL536947 Bioactive (10bS)-6-(4-nitrophenyl)-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinoline;hydrobromide
CFAMM00269336 CHEMBL414138 Bioactive 1-[(4-nitrophenyl)methyl]-4-(3-phenylpropyl)piperazine
CFAMM00269313 CHEMBL1163765 Bioactive SureCN7940007
CFAMM00269343 CHEMBL2146866 Bioactive 1-[2-(4-nitrophenyl)ethyl]-4-[1-(4-nitrophenyl)propan-2-yl]piperazine
CFAMM00269327 CHEMBL1743812 Bioactive (6S,10bR)-6-(4-nitrophenyl)-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinoline;hydrobromide
CFAMM00269342 CHEMBL2146867 Bioactive 2-methyl-1,4-bis[2-(4-nitrophenyl)ethyl]piperazine
CFAMM00269324 CHEMBL1163919 Bioactive SureCN3120676
CFAMM00269332 CHEMBL118405 Bioactive N-methyl-2-(3-nitrophenyl)-N-(2-pyrrolidin-1-ylethyl)ethanamine
CFAMM00269290 CHEMBL182977 Bioactive LY97241
CFAMM00269322 CHEMBL118797 Bioactive N-methyl-2-(4-nitrophenyl)-N-(2-pyrrolidin-1-ylethyl)ethanamine
CFAMM00269331 CHEMBL148008 Bioactive 1-[2-(4-nitrophenyl)ethyl]-4-(3-phenylpropyl)piperazine
CFAMM00269292 DNC008259 Investigative Drug 1-(4-nitrophenethyl)pyrrolidine
CFAMM00269291 DNC008257 Investigative Drug (R)-1-(4-nitrophenethyl)-2-methylpyrrolidine
CFAMM00269293 DNC008258 Investigative Drug (S)-1-(4-nitrophenethyl)-2-methylpyrrolidine

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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