CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2499
Family Name Mineralocorticoid receptor and Androgen receptor Ligand WAY-255348 Family
No. of Seeds 10 No. of Other Members 26
Family Centroid CFAMM00269510 Functional Category Investigative Drug
Superfamily Mineralocorticoid receptor and Androgen receptor Ligand WAY-255348 Superfamily
Class Class 173

Cousin Family NamesSeedsMembers
Receptor-type tyrosine-protein kinase FLT3 inhibitor indoline ... 4 151
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
D(1A) dopamine receptor ligand ergot alkaloid Methylergonovine... 22 170
Hepatocyte growth factor receptor Ligand Arq 197 Family 10 400
Glycogen synthase kinase-3 beta and Protein kinase C beta type... 5 53
Cholecystokinin receptor type A Ligand Tarazepide Family 6 323
Receptor-type tyrosine-protein kinase FLT3 Inhibitor SU5614 Fa... 4 36
Fibroblast growth factor receptor 1 and Aurora kinase B Inhibi... 4 51
Poly [ADP-ribose] polymerase 1 Inhibitor AG-14699 Family 13 179
Growth hormone receptor Ligand EP-51216 Family 34 390
D(1B) dopamine receptor Ligand LE-300 Family 65 452
Histone deacetylase 1 Inhibitor Panobinostat Family 5 93
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Setipiprant family 5 118
Neuropeptide Y receptor type 5 Ligand Npy5ra-972 Family 6 29
Lethal factor Inhibitor GM6001 Family 50 435
Cyclin-dependent kinase 5 Inhibitor 9-nitropaullone Family 2 13
Fibroblast growth factor receptor 2 Ligand Interferon Alfa (if... 14 162
Cannabinoid receptor 2 Ligand JWH-167 Family 25 168
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
5-hydroxytryptamine receptor 2B Ligand Sb 206553 Family 14 21
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(4... 4 21
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[n... 12 10
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 24 50
Transient receptor potential cation channel subfamily V member... 6 23
Microsomal triglyceride transfer protein large subunit Inhibit... 5 9
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 19 108
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 3 29
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 3 27
Endothelin B receptor Ligand IRL-2500 Family 34 87
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Metabotropic glutamate receptor 5 Ligand 1-(3-(2-methylquinoli... 2 12
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Histone deacetylase Inhibitor ST-5732 Family 8 6
Huntingtin and Glycogen synthase kinase-3 beta inhibitor SB 21... 2 4
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 6 2
Gonadotropin-releasing hormone receptor ligand 5-[2-[[(2S)-2-[... 7 58
Vascular endothelial growth factor receptor 2 and Receptor-typ... 7 4
Sodium-dependent serotonin transporter and Sodium-dependent do... 10 2
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 11 20
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 36
Melatonin receptor type 1A and Melatonin receptor type 1C liga... 2 5
Thyroid hormone receptor beta and Microtubule-associated prote... 1 8
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 5 8
Acetylcholinesterase inhibitor CHEMBL1651131 family 6 9
Translocator protein inhibitor AGN-PC-08WI0V family 1 0
Dipeptidyl peptidase 4 inhibitor AGN-PC-09QKOM family 5 8
Gonadotropin-releasing hormone receptor and Cytochrome P450 3A... 5 1
Substance-P receptor ligand N-[(2S)-5-[3,5-bis(trifluoromethyl... 4 6
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 18 3
Glycogen synthase kinase-3 beta inhibitor 3-(2-bromoacetyl)-4-... 1 0
Melanin-concentrating hormone receptor 2 ligand N-[(1R)-1'-(9H... 4 1
Translocator protein inhibitor N,N-diethyl-11-(2-fluoroethyl)-... 14 9
Cannabinoid receptor 1 ligand (2-cyclopentyl-5-prop-2-enyl-3,4... 3 8
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 14 1
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 3 1
Neuropeptide Y receptor type 5 ligand 2-indol-1-yl-N-[4-[(prop... 7 6
Histone deacetylase 6 and Histone deacetylase 1 inhibitor 4-[(... 3 5
Cannabinoid receptor 1 ligand N-[2-(cyclopropylamino)-2-oxoeth... 5 5
High affinity nerve growth factor receptor and BDNF/NT-3 growt... 4 3
Egl nine homolog 1 inhibitor 1'-[(3-methylpyridin-2-yl)methyl]... 6 4
Cathepsin K and Cathepsin S inhibitor (2S)-N-(cyanomethyl)-4-m... 1 0
Cathepsin K and Cathepsin B inhibitor (1R,2R)-N-(1-cyanocyclop... 10 7
Progesterone receptor ligand N-[4-(5-cyano-1-methylpyrrol-2-yl... 6 6
Serine/threonine-protein kinase Chk1 inhibitor SureCN5547533 f... 3 2
RAC-beta serine/threonine-protein kinase and 3-phosphoinositid... 11 4
Gonadotropin-releasing hormone receptor ligand 1-adamantyl-[2-... 3 1
Gonadotropin-releasing hormone receptor ligand SureCN7899418 f... 12 4
3-oxo-5-alpha-steroid 4-dehydrogenase 2 and 3-oxo-5-alpha-ster... 2 1
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor (2... 2 2
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 2 1
Substance-P receptor ligand AGN-PC-004REJ family 3 0
Tyrosine-protein kinase Yes and Proto-oncogene tyrosine-protei... 7 18
Substance-P receptor and Substance-K receptor ligand N-methyl-... 2 2
C-X-C chemokine receptor type 2 and Cytochrome P450 2C9 ligand... 1 7
Gonadotropin-releasing hormone receptor ligand 1-(7-azabicyclo... 2 0
Sodium-dependent serotonin transporter and D(2) dopamine recep... 1 0
5-hydroxytryptamine receptor 7 ligand AGN-PC-00PFK0 family 1 0
Kinesin-like protein KIF11 inhibitor 9-(trifluoromethyl)-1,2,4... 4 1
Phospholipase A2, membrane associated inhibitor SureCN8298630 ... 1 0
Voltage-dependent N-type calcium channel subunit alpha-1B liga... 2 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-(1-... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00269490 CHEMBL407847 Bioactive 5-(7-fluoro-2-oxospiro[1H-indole-3,1'-cyclopentane]-5-yl)-1-methylpyrrole-2-carbonitrile
CFAMM00269517 CHEMBL429572 Bioactive 5-(7-fluoro-3,3-dimethyl-2-oxo-1-prop-2-enylindol-5-yl)-1-methylpyrrole-2-carbonitrile
CFAMM00269482 CHEMBL270714 Bioactive 5-(4-fluoro-3,3-dimethyl-2-oxo-1H-indol-5-yl)-1-methylpyrrole-2-carbonitrile
CFAMM00269503 CHEMBL272663 Bioactive 5-(3,3-diethyl-2-oxo-1H-indol-5-yl)-1-methylpyrrole-2-carbonitrile
CFAMM00269495 CHEMBL270908 Bioactive 5-(3,3-dimethyl-2-oxo-1H-indol-5-yl)-1-methylpyrrole-2-carbonitrile
CFAMM00269515 CHEMBL407622 Bioactive 1-methyl-5-(2-oxospiro[1H-indole-3,1'-cyclopentane]-5-yl)pyrrole-2-carbonitrile
CFAMM00269501 CHEMBL408648 Bioactive 5-(7-fluoro-2-oxospiro[1H-indole-3,1'-cyclohexane]-5-yl)-1-methylpyrrole-2-carbonitrile
CFAMM00269493 CHEMBL429928 Bioactive 5-(3,3-diethyl-7-fluoro-2-oxo-1H-indol-5-yl)-1-methylpyrrole-2-carbonitrile
CFAMM00269519 CHEMBL305298 Bioactive SureCN91102
CFAMM00269510 DNC008336 Investigative Drug WAY-255348

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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