CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2512
Family Name 5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine receptor 2B Ligand 7,8,9,10-tetrahydro-6h-furo-[3,2-g][3]benzazepine Family
No. of Seeds 3 No. of Other Members 33
Family Centroid CFAMM00269851 Functional Category Investigative Drug with Natural Product
Superfamily Melatonin receptor type 1A and Melatonin receptor type 1B Binder Superfamily
Class Class 769

Cousin Family NamesSeedsMembers
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 61 433
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Acetylcholinesterase Inhibitor Donepezil Family 23 242
Muscarinic acetylcholine receptor M3 Ligand Darifenacin Family 3 17
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
Substance-P receptor Ligand DA-5018 Family 14 73
Microsomal triglyceride transfer protein large subunit Inhibit... 3 103
Dapoxetine family 3 40
Cytochrome P450 2D6 and Delta-type opioid receptor Ligand 4-(s... 17 381
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
Guanylate cyclase soluble subunit beta-1 Inhibitor Cinaciguat ... 7 50
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Histamine H3 receptor Ligand A-317920 Family 9 240
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 8 66
Histamine H3 receptor Ligand A-349821 Family 49 228
Mitogen-activated protein kinase 14 Inhibitor N-(4-(trifluorom... 8 39
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
Estradiol 17-beta-dehydrogenase 1 Inhibitor N(furan-2-ylmethyl... 2 1
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Melatonin receptor type 1A and Melatonin receptor type 1B Liga... 33 98
Fatty-acid amide hydrolase 1 Inhibitor 3'-carbamoylbiphenyl-3-... 8 50
5-hydroxytryptamine receptor 2A Ligand 3-methoxy-9-aminomethyl... 7 14
Fatty-acid amide hydrolase 1 Inhibitor N-butylcarbamic Acid Bi... 9 31
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 2
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
Fatty-acid amide hydrolase 1 Inhibitor Furan-2-ylmethylcarbami... 1 105
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 2
Glycine receptor subunit beta Ligand ORG-25543 Family 10 153
Peroxisome proliferator-activated receptor delta and Peroxisom... 20 8
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 2 0
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 8 36
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 55 36
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 6 19
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 1 4
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 1 0
D(4) dopamine receptor and D(3) dopamine receptor ligand N-[(3... 2 11
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 10 8
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 5 0
Melatonin receptor type 1A ligand [7-methoxy-1-[2-(propanoylam... 3 0
Lethal(3)malignant brain tumor-like protein 1 and Lysine-speci... 1 6
Hypoxia-inducible factor 1-alpha and Cytochrome P450 2D6 inhib... 1 2
Survival motor neuron protein and Retinal dehydrogenase 1 inhi... 2 9
Histamine H3 receptor ligand SureCN2785131 family 7 1
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 2 6
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 3
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 7 18
Mu-type opioid receptor ligand AGN-PC-075GAC family 16 8
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase and Sigma no... 2 4
Sodium-dependent serotonin transporter and Sodium-dependent do... 1 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 15 4
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 2 4
Neuronal acetylcholine receptor subunit alpha-7 and Neuronal a... 2 4
Gonadotropin-releasing hormone receptor ligand N-[[4-[(diamino... 6 4
Sodium-dependent dopamine transporter and Sodium-dependent nor... 1 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 1 0
Naphthofurans Metabolite Pyrocurzerenone Family 1 9


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00269870 CHEMBL11404 Bioactive AGN-PC-00OXUL
CFAMM00269852 DNC008397 Investigative Drug 7,8,9,10-tetrahydro-6H-furo-[2,3-g][3]benzazepine
CFAMM00269851 DNC008396 Investigative Drug 7,8,9,10-tetrahydro-6H-furo-[3,2-g][3]benzazepine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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