CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2523
Family Name Estradiol 17-beta-dehydrogenase 1 Inhibitor 3-(6-hydroxy-2-naphthyl)benzoic Acid Family
No. of Seeds 7 No. of Other Members 9
Family Centroid CFAMM00270069 Functional Category Investigative Drug with Human Metabolite
Superfamily Estradiol 17-beta-dehydrogenase 1 Inhibitor 3-(6-hydroxy-2-naphthyl)benzoic Acid Superfamily
Class Class 2480

Cousin Family NamesSeedsMembers
Retinoic acid receptor Ligand naphthoic acid derivative Adapal... 2 264
Prostaglandin G/H synthase 2 Inhibitor Diflunisal Family 7 421
Retinoid X receptor Ligand Bexarotene Family 7 492
Cyclooxygenase Inhibitor Fenoprofen Family 4 1077
Cyclooxygenase Inhibitor Flurbiprofen Family 18 294
Prostaglandin G/H synthase 2 Inhibitor Ketoprofen Family 5 84
Prostaglandin G/H synthase 1 Inhibitor Salicyclic Acid Family 3 39
Prostaglandin G/H synthase 2 Inhibitor Nabumetone Family 4 267
Signal transducer and activator of transcription 3 Inhibitor A... 5 249
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor Mycophenola... 4 353
Estrogen receptor beta Ligand Conjugated Estrogens Family 12 210
Oestrogen receptor ligand steroid Estradiol Family 18 147
Oestrogen receptor ligand Dienestrol Family 35 440
Vitamin K-dependent gamma-carboxylase Inhibitor Anisindione Fa... 3 243
Aldehyde oxidase Inhibitor Isovanillin Family 6 429
Ipriflavone family 62 2480
Danthron family 11 141
Agrimophol family 10 22
Leukotriene B4 receptor 1 Ligand LY293111 Family 24 79
Mitogen-activated protein kinase 12 Inhibitor SCIO-469 Family 1 7
NAD-dependent protein deacetylase sirtuin-1 Inhibitor SRT501 F... 19 88
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 9 123
Substance-P receptor Ligand CI-1021 Family 1 0
Interleukin-1 beta Inhibitor Diacerein Family 3 77
Apoptosis regulator Bcl-2 Inhibitor Gossypol Family 1 9
Glucose-6-phosphate translocase Inhibitor Mumbaistatin Family 3 11
Carbonic anhydrase 2 Inhibitor 4-(hydroxymercury)benzoic Acid ... 7 97
Macrophage migration inhibitory factor and Prothrombin Inhibit... 2 49
Estrogen receptor beta Ligand 2-(4-hydroxy-phenyl)benzofuran-5... 5 82
Estrogen receptor beta Ligand 1-chloro-6-(4-hydroxyphenyl)-2-n... 12 23
Phospholipase A2 Inhibitor P-anisic Acid Family 2 178
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 Ligand... 4 26
Arachidonate 5-lipoxygenase and Prostaglandin G/H synthase 1 I... 2 19
Steryl-sulfatase Inhibitor Sulfamic Acid 4-(3-methoxy-benzoyl)... 5 24
Steryl-sulfatase Inhibitor 3-{4-[(aminosulfonyl)oxy]benzoyl}ph... 5 3
Steryl-sulfatase Inhibitor Sulfamic Acid 3-(4-hydroxy-benzoyl)... 3 2
Epidermal growth factor receptor Ligand AG-538 Family 5 11
Aromatase and DNA-dependent protein kinase catalytic subunit I... 6 19
Estrogen receptor beta Ligand 3,6-dihydroxy-2-(4-hydroxy-pheny... 2 23
Liver carboxylesterase 1 Inhibitor 1,2-bis(2,5-difluorophenyl)... 12 10
Phospholipase A2 Inhibitor 3,9-dihydroxy-2,10-diprenylpterocap... 9 25
Oestrogen receptor and Estrogen receptor beta Ligand 6-(4-hydr... 30 63
Oestrogen receptor and Estrogen receptor beta Ligand 1-bromo-6... 3 4
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 2 56
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 9 81
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 2 3
4-aminobutyrate aminotransferase, mitochondrial and Succinate-... 4 22
Oestrogen receptor and Estrogen receptor beta Ligand 3,8-dihyd... 20 57
Glutamate carboxypeptidase 2 Inhibitor 2-(3-carboxybenzyl)succ... 2 7
Glutamate carboxypeptidase 2 Inhibitor 3-(2-carboxy-6-mercapto... 9 4
L-selectin and P-selectin Inhibitor 2,3,4-trihydroxybenzoic Ac... 2 10
Tyrosine-protein phosphatase non-receptor type 1 Ligand Licoag... 9 32
Cytosolic phospholipase A2 Inhibitor [6,3''']biflavone Family 5 5
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 4 37
DNA topoisomerase 2-beta Inhibitor Demethylzeylasterone Family 1 2
MO15-related protein kinase Pfmrk Inhibitor WR-289012 Family 2 17
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 3-ben... 4 74
Cannabinoid receptor 2 Ligand 2-(2-methoxybenzyl)-3h-benzo[f]c... 6 32
Arachidonate 12-lipoxygenase, 12S-type and Arachidonate 15-lip... 3 7
Indoleamine 2,3-dioxygenase 1 Inhibitor 2-hydroxygarvin A Family 2 2
Indoleamine 2,3-dioxygenase 1 Inhibitor Garveatin E Family 2 0
NAD(P)H dehydrogenase [quinone] 1 Inhibitor 4-hydroxy-3-(2-nap... 12 1
Indoleamine 2,3-dioxygenase 1 Inhibitor Naphthalene-1,4-diol F... 2 4
Tyrosine-protein phosphatase non-receptor type 1 Ligand Kuwano... 3 3
Histone deacetylase 1 Inhibitor Gymnochrome E Family 1 0
Cytochrome P450 3A4 Inhibitor Diethoxyflourescein Family 3 9
Arachidonate 5-lipoxygenase Inhibitor 4,5-dimethoxy-10h-anthra... 1 4
Epidermal growth factor receptor Ligand 3-(3-chloro-phenyl)-5,... 10 64
Protein farnesyltransferase subunit beta Inhibitor Cylindrol A... 3 43
Tyrosinase Inhibitor 3-(2,4-dihydroxyphenyl)-propionic Acid Et... 3 8
Tyrosinase Inhibitor 4-(6-hydroxynaphthalen-2-yl)benzene-1,3-d... 4 2
Prostaglandin G/H synthase 2 Inhibitor 3,4-dibenzyloxy-2'-hydr... 7 40
CGMP-dependent protein kinase Inhibitor Tenellone A Family 1 7
Isocitrate lyase Inhibitor Bis(3-bromo-4,5-dihydroxyphenyl)met... 1 2
Creatine kinase Inhibitor 5-(4'-benzoylbiphenyl-4-yl)-2-furoic... 2 66
DNA polymerase Inhibitor 3alpha-o-trans-p-coumaroyl-7-labden-1... 1 13
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 6 19
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 10 8
Estrogen receptor beta and Estrogen receptor ligand AGN-PC-007... 1 2
Estrogen receptor beta and Estrogen receptor ligand 4-bromo-9a... 3 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 14
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 7 13
Androgen receptor and Estrogen receptor ligand estradiol benzo... 1 29
Protein kinase C beta type and Protein kinase C eta type inhib... 1 0
Peroxisome proliferator-activated receptor delta and Peroxisom... 2 2
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 7
Thromboxane A2 receptor ligand AGN-PC-003UTI family 1 0
Glucocorticoid receptor ligand SureCN4024251 family 1 0
Steryl-sulfatase inhibitor (8R,9S,13S,14S,17R)-17-benzyl-3,17-... 1 1
Induced myeloid leukemia cell differentiation protein Mcl-1 an... 4 0
RAC-alpha serine/threonine-protein kinase inhibitor CHEMBL4933... 1 3
Tyrosine-protein kinase Lck inhibitor ZINC03370948 family 3 0
G2/mitotic-specific cyclin-B1 and Cyclin-dependent kinase 1 in... 2 8
Induced myeloid leukemia cell differentiation protein Mcl-1 an... 6 13
DNA-(apurinic or apyrimidinic site) lyase and Retinal dehydrog... 1 18
Peroxisome proliferator-activated receptor gamma and Peroxisom... 1 2
Vasopressin V2 receptor and C-C chemokine receptor type 4 liga... 1 1
Glutamate carboxypeptidase 2 inhibitor 2-[(3-hydroxyphenyl)met... 1 0
Sterol O-acyltransferase 1 and Sterol O-acyltransferase 2 inhi... 1 5
5-lipoxygenase inhibitor 6-(1,8-dihydroxy-9-oxo-10H-anthracen-... 6 0
Aldehyde dehydrogenase, cytosolic 1 and Aldehyde dehydrogenase... 2 0
Prenol Lipids Metabolite Scutigeral Family 1 0
Acenes Metabolite Lacinilene C Family 2 3
Acenes Metabolite 3-Hydroxy-9-(4-hydroxyphenyl)-1H,3H-naphtho[... 1 0
Acenes Metabolite Musanolone D Family 2 1
Putative NP ZINC49600254 Family 8 2
2,4-diacetyl-5-hydroxy-3-(4-hydroxyphenyl)-5-methylcyclohexen-... 4 0
carboxylate NP ZINC04026424 Family 3 7
Putative NP ZINC03197541 Family 1 0
2,4-bis(4-hydroxyphenyl)cyclobutane-1,3-dicarboxylate NP ZINC0... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00270087 CHEMBL365941 Bioactive AGN-PC-0093JI
CFAMM00270076 CHEMBL370403 Bioactive AGN-PC-075XAG
CFAMM00270075 CHEMBL192586 Bioactive SureCN3922937
CFAMM00270085 CHEMBL373095 Bioactive SureCN3929813
CFAMM00270081 CHEMBL177880 Bioactive PAMOIC ACID
CFAMM00270069 DNC008429 Investigative Drug 3-(6-hydroxy-2-naphthyl)benzoic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27408 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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