CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2530
Family Name Histone deacetylase 1 and Histone deacetylase 4 Inhibitor Azumamide E Family
No. of Seeds 3 No. of Other Members 10
Family Centroid CFAMM00270183 Functional Category Investigative Drug with Natural Product
Superfamily Integrin alpha-V and Integrin beta-3 Binder Superfamily
Class Class 260

Cousin Family NamesSeedsMembers
Vasopressin V2 receptor ligand peptide analog Desmopressin family 111 1472
Sodium-dependent dopamine transporter inhibitor substituted ph... 22 416
Vasopressin V1a receptor Ligand Felypressin Family 12 820
Penicillin binding protein inhibitor β-lactam aminopenicillin ... 12 359
Sodium channel protein type 5 subunit alpha Ligand Indecainide... 2 41
Sodium channel protein type 5 subunit alpha Ligand Mephenytoin... 5 51
Glucan synthesis regulatory protein Inhibitor Caspofungin Family 17 71
Alpha-1B adrenergic receptor Ligand Lisdexamfetamine Family 14 443
Angiotensin-converting enzyme inhibitor Dicarboxylate-containi... 16 374
Angiotensin-converting enzyme Inhibitor Quinapril Family 3 105
Tyrosine 3-monooxygenase Inhibitor L-phenylalanine Family 19 144
Angiotensin-converting enzyme Inhibitor Spirapril Family 17 86
Angiotensin-converting enzyme inhibitor Dicarboxylate-containi... 7 54
ATP-sensitive inward rectifier potassium channel 10 Ligand Nat... 3 233
Growth hormone-releasing hormone receptor ligand polypeptide ... 14 34
Atrial natriuretic peptide receptor 1 Ligand Nesiritide Family 6 111
Bacterial outer membrane Inhibitor Polymyxin B Family 17 181
Thymopentin family 20 133
Puromycin-sensitive aminopeptidase Inhibitor CHR-2797 Family 1 2
Angiotensin-converting enzyme and Neprilysin Inhibitor M100,24... 18 60
Dopamine reuptake Inhibitor Amineptine Family 2 5
Thymosin Beta-4 family 8 30
Iofolastat I-124 family 6 33
Neuropeptide Y receptor type 1 Ligand BIBO3304 Family 4 69
Melanocortin receptor 4 Ligand Ro-27-3225 Family 6 52
Reverse transcriptase Inhibitor 3-benzylamino-5-ethyl-6-methyl... 2 24
Dipeptidyl peptidase 4 Inhibitor Denagliptin Family 24 151
72 kDa type IV collagenase Inhibitor Batimastat Family 6 52
Integrin alpha-V and Integrin beta-3 Inhibitor C[rgd-(s)-alpha... 19 95
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Renin Inhibitor CP-80794 Family 16 112
Prothrombin Inhibitor Efegatran Family 9 47
Neprilysin Inhibitor Thiorphan Family 41 68
Prothrombin Inhibitor Ppack Family 5 4
Vasopeptidase Inhibitor Sampatrilat Family 25 9
Neuromedin-K receptor Ligand Senktide Family 15 22
Prothrombin Inhibitor D-leucyl-n-(4-carbamimidoylbenzyl)-l-pro... 13 44
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Gamma-g... 2 1
Proto-oncogene tyrosine-protein kinase Src Inhibitor RU83876 F... 3 51
Cathepsin F and Cruzipain Inhibitor Benzoyl-arginine-alanine-m... 49 348
Cathepsin F and Cruzipain Inhibitor WRR-99 Family 13 131
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
Penicillin-binding protein 1B Inhibitor N-benzoyl-d-alanine Fa... 1 40
Beta-secretase 1 Inhibitor MMI-175 Family 30 137
Beta-secretase 1 Inhibitor N-(1-benzylpiperidin-4-yl)-4-sulfan... 7 62
Integrin alpha-V and Integrin beta-3 Inhibitor Cyclo-[-arg-gly... 5 38
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 40 87
Farnesyltransferase beta subunit, putative and Protein farnesy... 24 82
Disintegrin and metalloproteinase domain-containing protein 17... 8 7
Plasmepsin-2 Inhibitor PS-222036 Family 12 134
Integrin beta-3 Inhibitor RWJ-53419 Family 6 65
Integrin beta-3 Inhibitor DMP-728 Family 3 0
Plasmepsin-1 Inhibitor SC-5003 Family 93 173
Integrin beta-3 Inhibitor SKF-107260 Family 5 8
Neuromedin-K receptor Ligand PD-160946 Family 10 32
Nociceptin receptor Ligand Fggftgcrkscrk Family 10 0
Cathepsin B and Cathepsin L1 Inhibitor MDL-2170 Family 17 24
Neuromedin-K receptor Ligand PD-157672 Family 9 37
Beta-secretase 1 Inhibitor Glu-leu-asp-leu-(choh-ch2)-ala-ala-... 15 11
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Calcitonin gene-related peptide type 1 receptor Ligand Fvptdvg... 8 8
Caspase-1 Inhibitor Z-vad-cho Family 8 34
Cathepsin B and Cathepsin S Inhibitor Ac-hphe-leu-ala-leuvsme ... 17 51
Proto-oncogene tyrosine-protein kinase Src Inhibitor Ac-cys-il... 36 12
Melanocortin receptor 4 and Substance-K receptor Ligand Hoo-ph... 3 19
Beta-secretase 1 Inhibitor KMI-172 Family 3 0
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 6 24
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 14 110
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 3 21
Delta-type opioid receptor Ligand H-cxp-ala-gly-phe-leu-oh Family 1 8
Chymase Inhibitor Chymostatin Family 2 3
Disks large homolog 4 Inhibitor N-(3,4-difluorophenyl)propyl-e... 3 0
Substance-P receptor Ligand [sar9,met(o2)11]-sp Family 34 9
Cannabinoid receptor 1 Ligand N-(3,3-diphenyl)propyl-2-phenyla... 4 18
Cytosolic phospholipase A2 Inhibitor Methyl 2-(2-oxo-8-phenylo... 2 3
Integrin alpha-V Inhibitor C[rgdf-(3s)-carboxymorpholine] Family 10 2
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 20 55
Caspase-4 and Cathepsin D Inhibitor Grassystatin A Family 24 6
DNA (cytosine-5)-methyltransferase 3B Inhibitor NSC-154957 Family 2 3
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 44 28
Receptor-type tyrosine-protein phosphatase C Ligand Asp-brpmp-... 2 0
Aminopeptidase N Inhibitor N1,2-dibenzyl-n3-hydroxymalonamide ... 5 23
Endothelin-converting enzyme 1 Inhibitor PO3 2-leu-nal-o-3k Fa... 3 26
Sodium channel protein type 1 subunit alpha and Sodium channel... 4 31
Mu-type opioid receptor Ligand H-tyr-d-ala-aic-asp-val-val-gly... 48 8
Protein farnesyltransferase subunit beta Inhibitor L-739750 Fa... 4 0
Genome polyprotein Inhibitor Acasp-glu-dif-glu-cha-cys Family 13 17
Genome polyprotein Inhibitor Acasp-glu-met-glu-cha-cys Family 3 6
Genome polyprotein Inhibitor Acdif-ile-cha-cys Family 37 96
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 152 36
Aminopeptidase N Inhibitor 2-amino-n1-benzyl-n3-hydroxymalonam... 3 4
Aminopeptidase N Inhibitor 2-benzyl-n1-hydroxy-n3-(4-phenylbut... 5 3
Aminopeptidase N Inhibitor N1-(4-chlorobenzyl)-2-benzyl-n3-hyd... 9 86
Prolyl endopeptidase Inhibitor SUAM-1221 Family 42 47
Mu-type opioid receptor and Nociceptin receptor Ligand Nocicep... 35 5
Aminopeptidase N Inhibitor 2-cinnamamido-n4-hexyl-n1-hydroxysu... 24 8
Cholecystokinin receptor type A Ligand CR-1795 Family 19 41
Serine/threonine protein phosphatase PP1-alpha 1 catalytic sub... 10 0
Gamma-secretase subunit APH-1B and Presenilin-1 Inhibitor 3114... 8 9
Melanocortin receptor 4 and Melanocyte-stimulating hormone rec... 3 10
Renin inhibitor (2S,4S,5S)-N-butyl-6-cyclohexyl-4-hydroxy-5-[[... 12 1
Substance-K receptor ligand (4S)-4-amino-1-[4-(oxan-4-ylmethyl... 1 2
72 kDa type IV collagenase and Matrilysin inhibitor (2S,3R)-N-... 1 0
Tryptase alpha/beta-1 and Tryptase delta inhibitor (2S,3R)-3-[... 13 17
Renin and Cathepsin D inhibitor (2S)-N-[(2S,3R,4S)-1-cyclohexy... 13 2
Neprilysin and Aminopeptidase N inhibitor (2S)-2-[[(2S)-2-[[[a... 13 1
Carboxypeptidase B and Carboxypeptidase B2 inhibitor (2S)-7-am... 3 9
Renin inhibitor tert-butyl N-[1-[[(3S,6S,7R)-6-(cyclohexylmeth... 14 1
Glutamate receptor ionotropic, kainate 2 ligand (2S,3S,4S)-4-[... 14 2
NS3 and Non-structural protein 4A inhibitor (4S)-4-[[(2S)-3-ca... 1 1
Caspase-1 inhibitor (3S)-3-[[(2S)-4-(2-naphthalen-1-ylethylami... 1 0
Cathepsin K and Cathepsin S inhibitor (2S)-N-(cyanomethyl)-2-[... 14 4
Pol polyprotein inhibitor Lysine Sulfonamide 11c family 3 73
Endothelin-converting enzyme 1 and Neprilysin inhibitor (2S)-2... 1 8
Neprilysin inhibitor SureCN489232 family 3 9
Cathepsin S inhibitor SureCN7062841 family 7 7
Integrin beta-3 and Integrin alpha-IIb inhibitor (3R)-5-phenyl... 4 1
Peptide deformylase inhibitor (2R)-N-[(2S)-1-(4-fluorophenyl)-... 4 0
Cathepsin K inhibitor [(3R)-4,4-dimethyl-1-phenylpentan-3-yl] ... 7 7
Neprilysin inhibitor (2S)-2-methyl-3-oxo-3-[[(2S)-1-phenyl-3-s... 5 2
Cathepsin K and Cathepsin S inhibitor 1-benzyl-3-[(2S)-1-[[cya... 1 0
Neutrophil collagenase and Matrix metalloproteinase-9 inhibito... 6 1
Growth factor receptor-bound protein 2 ligand 2-[(9S,10S,11E,1... 5 14
Chymase and Chymotrypsinogen A inhibitor tert-butyl N-[(2S)-1-... 2 7
Renin and Cathepsin D inhibitor tert-butyl N-[(2S)-1-[[(2S)-1-... 3 4
Tryptase alpha/beta-1 inhibitor methyl 3-[3-(aminomethyl)pheny... 1 3
Melanocortin receptor 4 and Melanocortin receptor 5 ligand (2S... 16 24
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 3 0
Renin and Cathepsin D inhibitor (4S)-5-cyclohexyl-2,2-difluoro... 16 1
Pol polyprotein inhibitor AC1LADQG family 7 1
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 0
Endothelin-converting enzyme 1 and Cathepsin D inhibitor N-[(2... 6 2
C-C chemokine receptor type 5 ligand N-[(1S)-3-[4-[[2-(2,4-dic... 4 9
Oxytocin receptor and Vasopressin V2 receptor ligand (2R)-2-(2... 4 2
Kinesin-like protein KIF11 and Potassium voltage-gated channel... 4 1
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 4
Integrin beta-3 and Integrin alpha-V inhibitor 2-[(1R,5S,11S,1... 8 2
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 3 1
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 5 3
Renin inhibitor 2-hydroxy-3-[[(4S,7S)-5-hydroxy-2,8-dimethyl-7... 1 0
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2S,4R)... 5 8
Renin and Cathepsin D inhibitor (4S)-5-cyclohexyl-2,2-difluoro... 15 0
Renin and Cathepsin D inhibitor ethyl (4S)-5-cyclohexyl-2,2-di... 2 0
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-... 7 1
Integrin beta-3 and Integrin alpha-IIb inhibitor (3R,6S,12S)-6... 7 0
Type-2 angiotensin II receptor ligand SureCN3515167 family 2 0
Neprilysin inhibitor SureCN7437961 family 2 6
Follicle-stimulating hormone receptor ligand N-[[3-[4-[[(2S,5S... 7 0
Caspase-1 inhibitor (3S)-3-[[(4S,7S)-7-[(2-fluorobenzoyl)amino... 4 0
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-... 10 0
72 kDa type IV collagenase and Stromelysin-1 inhibitor methyl ... 6 2
Collagenase 3 and Interstitial collagenase inhibitor (4-benzyl... 2 0
Pol polyprotein inhibitor Diol-Based HIV-1 protease inhibitor ... 1 0
Pepsin A and Renin inhibitor N-[(3R)-1-[[(1S)-1-hydroxy-3-[[(2... 1 0
Chymase and Chymotrypsinogen B inhibitor AGN-PC-075LTI family 2 3
Sigma non-opioid intracellular receptor 1 ligand tert-butyl N-... 1 9
Histone deacetylase 1 and Histone deacetylase 8 inhibitor meth... 1 3
72 kDa type IV collagenase and Stromelysin-1 inhibitor (3R)-3-... 3 2
Angiotensin-converting enzyme inhibitor SureCN7263641 family 2 11
Calpain-1 catalytic subunit inhibitor Peptidyl alpha-Ketoacid,... 1 0
Growth hormone-releasing hormone receptor ligand (1S)-1'-[(2R)... 7 4
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 9 inhibitor N-... 9 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 6
Pol polyprotein and Pepsin A inhibitor cgp 53820 family 1 1
Ribonucleoside-diphosphate reductase large subunit and Ribonuc... 1 0
Glucose-dependent insulinotropic receptor ligand (1-methylcycl... 4 3
Gamma-secretase subunit PEN-2 inhibitor SureCN5966881 family 1 9
Papain and Cathepsin S inhibitor dipeptide-derived nitrile, 28... 1 2
Beta-secretase 1 inhibitor (2R)-4-amino-2-[[(2S)-2-[[(2S)-2-[[... 2 1
Peptide deformylase and Peptide deformylase 1A, chloroplastic/... 1 2
NS3 inhibitor 6-[[(2S)-1-[[(2S)-1-[(2S)-2-[[1-(cyclopropylamin... 2 0
Bifunctional epoxide hydrolase 2 inhibitor (2S)-3-(3a,7a-dihyd... 1 0
Bcl-2-like protein 1 inhibitor CHEMBL501005 family 2 2
Caspase-1 inhibitor (3S)-4-oxo-3-[[(2S)-4-oxo-4-[(3-oxo-3-phen... 1 1
4'-phosphopantetheinyl transferase ffp and Beta-lactamase inhi... 1 0
Integrin beta-1 and Integrin alpha-4 inhibitor 6-[4-[(2S)-2-ca... 1 0
Pol polyprotein inhibitor methyl (2S)-2-[[(2S)-2-[[(2S)-2-[5-[... 1 2
Tubulin beta-1 chain inhibitor SureCN6672529 family 1 0
Neuraminidase inhibitor AC1NQT84 family 2 0
Transcriptional activator protein LuxR inhibitor 3-(3-iodophen... 8 2
4-methyl-2-[[(E)-3-phenylprop-2-enyl]azaniumyl]pentanoate NP 2... 4 6
tanedioate NP ZINC08790785 Family 6 0
NP Tert-butyl ((s)-1-oxo-1-((1r,5s)-8-oxo-5,6-dihydro-1h-1,5-m... 1 0
NP (2s)-2-(2-((tert-butoxycarbonyl)amino)-3-phenylpropanamido)... 2 0
(2S)-2-[(3aR,6aS)-2,5-dioxo-3,3a,6,6a-tetrahydro-1H-imidazo[4,... 1 0
Putative NP ZINC08790318 Family 1 0
4-[[[1-[(2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-pheny... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00270185 CHEMBL49581 Bioactive (3S)-4-[[(2S)-1-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-[[(2S)-2-[[(2R)-2-aminopropanoyl]amino]-3-phenylpropanoyl]amino]-4-oxobutanoic acid
CFAMM00270187 DNC013537 Investigative Drug F(4-Fluoro)VAE
CFAMM00270183 DNC008463 Investigative Drug AZUMAMIDE E

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27518 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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