Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database. Cousin Family Names Seeds Members Fumarate reductase flavoprotein subunit Inhibitor Thiabendazol... 3 20 Aurora kinase B and Aurora kinase C Inhibitor SNS-314 Family 2 75 Aurora kinase B and Aurora kinase A Inhibitor CYC116 Family 16 135 Cytochrome P450 26A1 Inhibitor Rambazole Family 7 77 Serine/threonine-protein kinase B-raf Inhibitor GSK2118436 Family 5 19 Cyclin-dependent kinase 2 Inhibitor 4-(2,4-dimethyl-thiazol-5-... 2 14 Steroid 17-alpha-hydroxylase/17,20 lyase Inhibitor 1-(1-(4-thi... 3 36 Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 4 22 Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 1 9 Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-(4-e... 2 5 Cyclin-dependent kinase 5 Inhibitor 1-phenyl-3-(2-(pyridin-4-y... 3 53 5-hydroxytryptamine receptor 2B and 5-hydroxytryptamine recept... 7 15 Glycogen synthase kinase-3 beta and Mitogen-activated protein ... 4 23 Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-chlo... 3 20 Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-ethy... 2 2 Histamine H3 receptor Ligand 2-(1,4'-bipiperidin-1'-yl)thiazol... 2 23 D(2) dopamine receptor and D(3) dopamine receptor Ligand D-264... 6 32 D(2) dopamine receptor Ligand PD-135146 Family 5 11 Peptide deformylase, mitochondrial Inhibitor 6-phenylsulfanylm... 2 3 Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 55 Reverse transcriptase Inhibitor 1-benzothiazol-2-yl-3-phenethy... 2 19 NADH-ubiquinone oxidoreductase chain 3 Inhibitor 6-thiophen-3-... 2 0 Aurora kinase B and Aurora kinase A inhibitor AGN-PC-07ZBLC fa... 3 8 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 8 6 Potassium voltage-gated channel subfamily H member 2 and Neuro... 2 3 Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 2-[3-(4-acet... 4 12 Tyrosine-protein kinase JAK2 and Potassium voltage-gated chann... 1 0 5-hydroxytryptamine receptor 6 ligand AGN-PC-03P3TZ family 6 88 5-hydroxytryptamine receptor 6 ligand AGN-PC-031XQS family 1 1 Neuropeptide Y receptor type 5 ligand N-[[(1S,5R)-3-(1-phenyle... 5 1 5-hydroxytryptamine receptor 6 ligand 6-chloro-5-[1-(1-methylp... 9 0 Mitogen-activated protein kinase 14 and LIM domain kinase 1 in... 4 19 Neuropeptide S receptor and Niemann-Pick C1 protein ligand CHE... 1 1 DNA-(apurinic or apyrimidinic site) lyase and Neuropeptide S r... 1 4 Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 3 10 Cell division cycle 7-related protein kinase inhibitor AGN-PC-... 6 6 Platelet-activating factor receptor ligand Foropafant family 2 0 Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 5 27 Fatty-acid amide hydrolase 1 inhibitor 3-[(3S)-1-[4-(5-chlorot... 2 1 Fatty-acid amide hydrolase 1 inhibitor AGN-PC-0A9RCZ family 7 7 Calcitonin gene-related peptide type 1 receptor ligand SureCN1... 2 0 Fatty-acid amide hydrolase 1 inhibitor 5-[5-(4-chlorophenyl)su... 2 4 Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 7 21 Neuropeptide Y receptor type 5 ligand 2-fluoro-N-[5-[(4-pyridi... 2 2 TGF-beta receptor type-1 ligand 6-[(5E)-5-(4-methyl-3H-1,3-thi... 22 9 Adenosine receptor A2b and Adenosine receptor A3 ligand 3-[5-(... 4 2 Serine/threonine-protein kinase Chk1 inhibitor 5-[5-(1-methylp... 3 2 Ketohexokinase inhibitor 4-N-(2-methylsulfanylphenyl)-2-pipera... 6 23 Microtubule-associated protein tau inhibitor 4-[(6-iodo-1,3-be... 1 1 5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 0 TGF-beta receptor type-1 and Mitogen-activated protein kinase ... 6 4 Cyclin-dependent kinase 6 and Cyclin-dependent kinase 4 inhibi... 1 0 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 1 G1/S-specific cyclin-E1 and G1/S-specific cyclin-E2 inhibitor ... 5 1 Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor CDK Inhibito... 8 3 Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 2-[3-(1,4-di... 3 3 Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 5-[5-chloro-... 2 18 Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 2 7 Methionine aminopeptidase 2 inhibitor SureCN5376630 family 1 0 Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 3 6 Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 2 1 Adenosine receptor A2a and Adenosine receptor A1 ligand [(2S)-... 2 0 5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 1 0 Adenosine receptor A2a and Adenosine receptor A2b ligand SureC... 4 5 Alpha-1A adrenergic receptor and Alpha-2A adrenergic receptor ... 1 0 Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 4 1 Transient receptor potential cation channel subfamily V member... 1 0 5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 2 4 Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor AGN-P... 1 0 Angiopoietin-1 receptor and Tyrosine-protein kinase Lck ligand... 1 0 D(4) dopamine receptor and D(2) dopamine receptor ligand 3-(1-... 1 0 Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 0 Prostaglandin G/H synthase 2 inhibitor AGN-PC-00GDEY family 1 4 Vascular endothelial growth factor receptor 2 and Insulin rece... 2 0 Cytochrome P450 11B1, mitochondrial and Cytochrome P450 11B2, ... 1 1 cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 5 1 Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 3 1 5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 1
CFAM Mol ID
External ID
Functional Category
Molecule Name
CFAM Mol ID
External ID
Functional Category
Molecule Name
CFAMM00270223 CHEMBL260718 Bioactive
[(2S)-1-[4-(1,3-thiazol-2-yl)thieno[3,2-d]pyrimidin-2-yl]pyrrolidin-2-yl]methanol CFAMM00270245 CHEMBL406048 Bioactive
[(2R)-1-[4-(1,3-thiazol-2-yl)thieno[3,2-d]pyrimidin-2-yl]pyrrolidin-2-yl]methanol CFAMM00270231 CHEMBL398511 Bioactive
imidazothienopyrazine, 13c CFAMM00270230 CHEMBL398512 Bioactive
CHEMBL398512 CFAMM00270253 CHEMBL407652 Bioactive
2-ethyl-4-(triazol-2-yl)thieno[3,2-d]pyrimidine CFAMM00270235 CHEMBL326639 Bioactive
SureCN5594402 CFAMM00270260 CHEMBL1173062 Bioactive
AGN-PC-0886X1 CFAMM00270226 CHEMBL249073 Bioactive
imidazothienopyrazine, 21b CFAMM00270225 CHEMBL2375675 Bioactive
CHEMBL2375675 CFAMM00270224 CHEMBL406314 Bioactive
N,N-dimethyl-4-(1-methylimidazol-2-yl)thieno[3,2-d]pyrimidin-2-amine CFAMM00270257 CHEMBL447370 Bioactive
2-(4-prop-2-enylpiperazin-1-yl)-1,3-benzothiazole CFAMM00270229 CHEMBL2377084 Bioactive
AGN-PC-07C7LQ CFAMM00270239 CHEMBL407638 Bioactive
2-[[4-(1,3-thiazol-2-yl)thieno[3,2-d]pyrimidin-2-yl]amino]ethanol CFAMM00270228 CHEMBL2377235 Bioactive
AGN-PC-07C8OZ CFAMM00270227 CHEMBL2377230 Bioactive
SureCN3300401 CFAMM00270249 CHEMBL1912083 Bioactive
N-[5-[(4-pyridin-2-yl-1,3-thiazol-2-yl)amino]pentyl]thiophene-2-sulfonamide CFAMM00270234 CHEMBL583417 Bioactive
2-N-(4-aminocyclohexyl)-6-N-[[5-(4-methyl-1,3-thiazol-2-yl)thiophen-2-yl]methyl]-9-propan-2-ylpurine-2,6-diamine;hydrochloride CFAMM00270246 CHEMBL354070 Bioactive
imidazopyridine 10f CFAMM00270232 CHEMBL354895 Bioactive
imidazopyridine 10e CFAMM00270242 18365074 Patent Compound
SureCN7960123
Statistics of CFAM Database
490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
How to cite our database
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering.
Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
Last update by
2014.08.29
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Chen Yuzong Deputy
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