CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2532
Family Name Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-chloro-4-(thiazol-2-yl)thieno[3,2-d]pyrimidine Family
No. of Seeds 11 No. of Other Members 20
Family Centroid CFAMM00270258 Functional Category Investigative Drug
Superfamily Adenosine receptor A1 and Adenosine receptor A2a Binder Superfamily 8
Class Class 1151

Cousin Family NamesSeedsMembers
Fumarate reductase flavoprotein subunit Inhibitor Thiabendazol... 3 20
Aurora kinase B and Aurora kinase C Inhibitor SNS-314 Family 2 75
Aurora kinase B and Aurora kinase A Inhibitor CYC116 Family 16 135
Cytochrome P450 26A1 Inhibitor Rambazole Family 7 77
Serine/threonine-protein kinase B-raf Inhibitor GSK2118436 Family 5 19
Cyclin-dependent kinase 2 Inhibitor 4-(2,4-dimethyl-thiazol-5-... 2 14
Steroid 17-alpha-hydroxylase/17,20 lyase Inhibitor 1-(1-(4-thi... 3 36
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 4 22
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 1 9
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-(4-e... 2 5
Cyclin-dependent kinase 5 Inhibitor 1-phenyl-3-(2-(pyridin-4-y... 3 53
5-hydroxytryptamine receptor 2B and 5-hydroxytryptamine recept... 7 15
Glycogen synthase kinase-3 beta and Mitogen-activated protein ... 4 23
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-chlo... 3 20
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-ethy... 2 2
Histamine H3 receptor Ligand 2-(1,4'-bipiperidin-1'-yl)thiazol... 2 23
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-264... 6 32
D(2) dopamine receptor Ligand PD-135146 Family 5 11
Peptide deformylase, mitochondrial Inhibitor 6-phenylsulfanylm... 2 3
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 55
Reverse transcriptase Inhibitor 1-benzothiazol-2-yl-3-phenethy... 2 19
NADH-ubiquinone oxidoreductase chain 3 Inhibitor 6-thiophen-3-... 2 0
Aurora kinase B and Aurora kinase A inhibitor AGN-PC-07ZBLC fa... 3 8
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 8 6
Potassium voltage-gated channel subfamily H member 2 and Neuro... 2 3
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 2-[3-(4-acet... 4 12
Tyrosine-protein kinase JAK2 and Potassium voltage-gated chann... 1 0
5-hydroxytryptamine receptor 6 ligand AGN-PC-03P3TZ family 6 88
5-hydroxytryptamine receptor 6 ligand AGN-PC-031XQS family 1 1
Neuropeptide Y receptor type 5 ligand N-[[(1S,5R)-3-(1-phenyle... 5 1
5-hydroxytryptamine receptor 6 ligand 6-chloro-5-[1-(1-methylp... 9 0
Mitogen-activated protein kinase 14 and LIM domain kinase 1 in... 4 19
Neuropeptide S receptor and Niemann-Pick C1 protein ligand CHE... 1 1
DNA-(apurinic or apyrimidinic site) lyase and Neuropeptide S r... 1 4
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 3 10
Cell division cycle 7-related protein kinase inhibitor AGN-PC-... 6 6
Platelet-activating factor receptor ligand Foropafant family 2 0
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 5 27
Fatty-acid amide hydrolase 1 inhibitor 3-[(3S)-1-[4-(5-chlorot... 2 1
Fatty-acid amide hydrolase 1 inhibitor AGN-PC-0A9RCZ family 7 7
Calcitonin gene-related peptide type 1 receptor ligand SureCN1... 2 0
Fatty-acid amide hydrolase 1 inhibitor 5-[5-(4-chlorophenyl)su... 2 4
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 7 21
Neuropeptide Y receptor type 5 ligand 2-fluoro-N-[5-[(4-pyridi... 2 2
TGF-beta receptor type-1 ligand 6-[(5E)-5-(4-methyl-3H-1,3-thi... 22 9
Adenosine receptor A2b and Adenosine receptor A3 ligand 3-[5-(... 4 2
Serine/threonine-protein kinase Chk1 inhibitor 5-[5-(1-methylp... 3 2
Ketohexokinase inhibitor 4-N-(2-methylsulfanylphenyl)-2-pipera... 6 23
Microtubule-associated protein tau inhibitor 4-[(6-iodo-1,3-be... 1 1
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 0
TGF-beta receptor type-1 and Mitogen-activated protein kinase ... 6 4
Cyclin-dependent kinase 6 and Cyclin-dependent kinase 4 inhibi... 1 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 1
G1/S-specific cyclin-E1 and G1/S-specific cyclin-E2 inhibitor ... 5 1
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor CDK Inhibito... 8 3
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 2-[3-(1,4-di... 3 3
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 5-[5-chloro-... 2 18
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 2 7
Methionine aminopeptidase 2 inhibitor SureCN5376630 family 1 0
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 3 6
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 2 1
Adenosine receptor A2a and Adenosine receptor A1 ligand [(2S)-... 2 0
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 1 0
Adenosine receptor A2a and Adenosine receptor A2b ligand SureC... 4 5
Alpha-1A adrenergic receptor and Alpha-2A adrenergic receptor ... 1 0
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 4 1
Transient receptor potential cation channel subfamily V member... 1 0
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 2 4
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor AGN-P... 1 0
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck ligand... 1 0
D(4) dopamine receptor and D(2) dopamine receptor ligand 3-(1-... 1 0
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 0
Prostaglandin G/H synthase 2 inhibitor AGN-PC-00GDEY family 1 4
Vascular endothelial growth factor receptor 2 and Insulin rece... 2 0
Cytochrome P450 11B1, mitochondrial and Cytochrome P450 11B2, ... 1 1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 5 1
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 3 1
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00270222 CHEMBL260719 Bioactive 2-cyclopropyl-4-(1,3-thiazol-2-yl)thieno[3,2-d]pyrimidine
CFAMM00270262 CHEMBL407307 Bioactive SureCN1754983
CFAMM00270244 CHEMBL406049 Bioactive 2-tert-butyl-4-(1,3-thiazol-2-yl)thieno[3,2-d]pyrimidine
CFAMM00270259 DNC008469 Investigative Drug 4-(thiazol-2-yl)thieno[3,2-d]pyrimidin-2-amine
CFAMM00270258 DNC008468 Investigative Drug 2-chloro-4-(thiazol-2-yl)thieno[3,2-d]pyrimidine
CFAMM00270255 DNC008472 Investigative Drug 2-ethyl-4-(thiazol-2-yl)thieno[3,2-d]pyrimidine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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