CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2534
Family Name Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-ethyl-4-(pyridin-2-yl)thieno[3,2-d]pyrimidine Family
No. of Seeds 2 No. of Other Members 2
Family Centroid CFAMM00270280 Functional Category Investigative Drug
Superfamily Adenosine receptor A1 and Adenosine receptor A2a Binder Superfamily 8
Class Class 1151

Cousin Family NamesSeedsMembers
Aurora kinase B and Aurora kinase C Inhibitor SNS-314 Family 2 75
Aurora kinase B and Aurora kinase A Inhibitor CYC116 Family 16 135
Cyclin-dependent kinase 2 Inhibitor 4-(2,4-dimethyl-thiazol-5-... 2 14
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-(4-e... 2 5
Metabotropic glutamate receptor 5 Ligand 4-(4-chlorophenylthio... 4 17
Inhibitor of nuclear factor kappa-B kinase subunit beta Inhibi... 6 64
Cyclin-dependent kinase 5 Inhibitor 1-phenyl-3-(2-(pyridin-4-y... 3 53
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-chlo... 3 20
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-chlo... 11 20
Histamine H3 receptor Ligand 2-(1,4'-bipiperidin-1'-yl)thiazol... 2 23
D(2) dopamine receptor Ligand PD-135146 Family 5 11
Peptide deformylase, mitochondrial Inhibitor 6-phenylsulfanylm... 2 3
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 4 22
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 55
Aurora kinase B and Aurora kinase A inhibitor AGN-PC-07ZBLC fa... 3 8
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 8 6
Tyrosine-protein kinase JAK2 and Potassium voltage-gated chann... 1 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 1
Neuropeptide Y receptor type 5 ligand N-[[(1S,5R)-3-(1-phenyle... 5 1
Mitogen-activated protein kinase 14 and LIM domain kinase 1 in... 4 19
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 3 10
Adenosine kinase inhibitor SureCN8183719 family 2 3
Epidermal growth factor receptor ligand AGN-PC-07C2E2 family 7 6
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 5 27
Fatty-acid amide hydrolase 1 inhibitor AGN-PC-0A9RCZ family 7 7
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 7 21
Neuropeptide Y receptor type 5 ligand 2-fluoro-N-[5-[(4-pyridi... 2 2
Histamine H4 receptor ligand 8-chloro-4-[(3R)-3-(methylamino)p... 3 10
Histamine H4 receptor ligand 8-bromo-4-(4-methylpiperazin-1-yl... 2 1
Vascular endothelial growth factor receptor 2 and Platelet-der... 3 3
Ketohexokinase inhibitor 4-N-(2-methylsulfanylphenyl)-2-pipera... 6 23
Cyclin-dependent kinase 6 and Cyclin-dependent kinase 4 inhibi... 1 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 1
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor CDK Inhibito... 8 3
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 2-[3-(1,4-di... 3 3
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 3 6
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 2 1
Prostaglandin G/H synthase 2 inhibitor 4-N,4-N-diethyl-2-(4-me... 5 1
Epidermal growth factor receptor and Vascular endothelial grow... 7 0
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 1 0
Histamine H4 receptor and Histamine H1 receptor ligand 6-chlor... 1 0
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 4 1
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 2 4
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor AGN-P... 1 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 5 0
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 0
Lysophosphatidic acid receptor 2 ligand N-[(2S)-1-[4-(3,4-dich... 2 3
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 5 1
Nuclear receptor ROR-gamma and Lysine-specific demethylase 4E ... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00270282 DNC010252 Investigative Drug 4-(piperazin-1-yl)thieno[3,2-d]pyrimidine
CFAMM00270280 DNC008471 Investigative Drug 2-ethyl-4-(pyridin-2-yl)thieno[3,2-d]pyrimidine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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