CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID254
Family Name Corticotropin-releasing factor receptor 1 Ligand CRA1000 Family
No. of Seeds 4 No. of Other Members 39
Family Centroid CFAMM00185920 Functional Category Investigative Drug
Superfamily Corticotropin-releasing factor receptor 1 Ligand CRA1000 Superfamily
Class Class 1493

Cousin Family NamesSeedsMembers
Neuropeptide Y receptor type 5 Ligand CGP71683A Family 5 74
5-hydroxytryptamine receptor 2B Ligand MT-500 Family 8 39
Interleukin-1 receptor type 1 and Mitogen-activated protein ki... 7 151
Peptide deformylase, mitochondrial Inhibitor 5-phenylsulfanyl-... 5 23
Peptide deformylase, mitochondrial Inhibitor 5-phenethyl-quina... 5 14
Hepatocyte growth factor receptor Ligand 3-(phenylsulfonyl)-1h... 17 59
Prostaglandin G/H synthase 2 Inhibitor GW-637185X Family 27 48
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 4 22
Corticotropin-releasing factor receptor 1 Ligand N-mesityl-6-m... 3 2
Corticotropin-releasing factor receptor 1 ligand 4-N-(2-bromo-... 9 48
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 8
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-07ZB89 family 6 13
Histamine H4 receptor ligand 2-[[6-iodo-2-(4-methylpiperazin-1... 4 2
Growth hormone secretagogue receptor type 1 and Dihydrofolate ... 3 6
Corticotropin-releasing factor receptor 1 ligand N-butyl-N-eth... 2 1
Corticotropin-releasing factor receptor 1 ligand SureCN8181501... 4 2
Fatty-acid amide hydrolase 1 inhibitor 5-[5-(4-chlorophenyl)su... 2 4
Neuropeptide Y receptor type 5 ligand SureCN8898853 family 2 3
Growth hormone secretagogue receptor type 1 ligand AGN-PC-0760... 4 0
Growth hormone secretagogue receptor type 1 ligand SureCN63605... 5 7
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 2-[4... 5 5
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor AG... 3 1
Prostaglandin G/H synthase 2 inhibitor 4-N,4-N-diethyl-2-(4-me... 5 1
Dihydrofolate reductase inhibitor WR 158122 family 1 0
Prostaglandin G/H synthase 2 inhibitor 6-ethoxy-2-(4-methylsul... 5 1
Prostaglandin G/H synthase 2 inhibitor 2-(4-methylsulfonylphen... 1 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 1 0
Focal adhesion kinase 1 and Protein-tyrosine kinase 2-beta inh... 1 1
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 3 0
Prostaglandin G/H synthase 2 inhibitor AGN-PC-073UDQ family 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00185929 CHEMBL206446 Bioactive SureCN6360247
CFAMM00185913 CHEMBL296044 Bioactive N-ethyl-4-methyl-6-[5-(2-methylphenyl)-3,6-dihydro-2H-pyridin-1-yl]-N-(2-methylsulfanyl-4-propan-2-ylphenyl)pyrimidin-2-amine
CFAMM00185918 CHEMBL383454 Bioactive 6-[(4-fluoro-N-methylanilino)methyl]-5-[4-[(4-methylsulfonylphenyl)methylamino]phenyl]pyrimidine-2,4-diamine
CFAMM00185920 DNC000481 Investigative Drug CRA1000

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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