CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2541
Family Name Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor 5-hexyl-2-(pyridin-2-yloxy)phenol Family
No. of Seeds 4 No. of Other Members 5
Family Centroid CFAMM00270371 Functional Category Investigative Drug
Superfamily Hemoglobin subunit alpha and Enoyl-[acyl-carrier-protein] reductase [NADH] Binder Superfamily
Class Class 284

Cousin Family NamesSeedsMembers
DNA Binder Primaquine Family 3 245
Histamine H1 receptor Ligand Doxylamine Family 2 91
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Histamine H1 receptor Ligand Mepyramine Family 5 65
Na+-K+-ATPase transmembrane protein Inhibitor Sanguinarine Family 8 20
Amyloid beta A4 protein Inhibitor Florbetapir F-18 Family 8 265
Citric Acid family 2 58
Arachidonate 5-lipoxygenase-activating protein Inhibitor DG031... 3 206
Nicotinic acetylcholine receptor Ligand AZD0328 Family 11 97
Corticotropin-releasing factor receptor 1 Ligand Cp-316,311 Fa... 5 74
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
Apricoxib family 8 77
Nicotinic acetylcholine receptor Ligand Dianicline Family 6 13
Reverse transcriptase Inhibitor 3'thiacytidine Family 4 29
5-hydroxytryptamine receptor 1A Ligand Sun N4057 Family 2 86
Tissue-type plasminogen activator Inhibitor N-(7-benzyloxy-iso... 4 37
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Hemoglobin subunit alpha Inhibitor 4-[(5-methoxy-2-methylpheno... 3 12
Estradiol 17-beta-dehydrogenase 1 Inhibitor 4'-(6-methoxypyrid... 5 34
Integrin alpha-V and Integrin beta-1 Inhibitor SB-265123 Family 30 170
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
Platelet-derived growth factor receptor beta and Epidermal gro... 3 7
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 12 3
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 13 26
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 6
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 2 5
Macrophage migration inhibitory factor Inhibitor 4-((pyridin-4... 1 0
Oestrogen receptor and Estrogen receptor beta Ligand Estrogen ... 7 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
Cytochrome P450 11B1, mitochondrial Inhibitor 5-(6-methoxynaph... 7 4
Fatty-acid amide hydrolase 1 Inhibitor Pyridin-3-yl 4-butoxybe... 10 5
DNA topoisomerase 1 Inhibitor 3-(4-phenyl-2,4'-bipyridin-6-yl)... 4 13
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Metabotropic glutamate receptor 5 Ligand 7-(3,5-dimethoxypheny... 2 7
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Endothelin-1 receptor and Endothelin B receptor ligand (5S,6R,... 15 28
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 7 1
Endothelin-1 receptor and Endothelin B receptor ligand 3-(1,3-... 1 1
Histamine H1 receptor and Potassium voltage-gated channel subf... 3 1
Endothelin-1 receptor and Endothelin B receptor ligand SureCN1... 3 16
Leukotriene B4 receptor 1 ligand AGN-PC-04XM3V family 3 10
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 3 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 17
Acetylcholinesterase and Cholinesterase inhibitor (2Z)-5-metho... 4 23
Leukotriene B4 receptor 1 ligand SureCN8987047 family 4 3
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 8 8
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 11 4
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 4
cAMP-specific 3',5'-cyclic phosphodiesterase 4A inhibitor Sure... 14 8
Endothelin-1 receptor ligand SureCN8118632 family 4 5
Translocator protein inhibitor 2-fluoro-N-[(2-methoxyphenyl)me... 8 27
Proteinase-activated receptor 1 ligand (3R,3aR,4S,5R,6S,7aS)-5... 2 3
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 5 0
Beta-secretase 1 inhibitor N-[(2S,3R)-1-(1,3-benzodioxol-5-yl)... 3 5
Peroxisome proliferator-activated receptor delta and Peroxisom... 1 1
Histamine H3 receptor and D(3) dopamine receptor ligand BODILI... 1 0
Sodium-dependent serotonin transporter and Histamine H3 recept... 6 4
Peroxisome proliferator-activated receptor delta and Peroxisom... 2 2
Histamine H3 receptor and Sodium-dependent serotonin transport... 3 2
Potassium voltage-gated channel subfamily KQT member 2 ligand ... 3 4
Transient receptor potential cation channel subfamily V member... 6 1
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A inhibitor N-[4... 1 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A inhibitor AGN-... 1 3
Glucocorticoid receptor ligand SureCN3894124 family 3 0
Sodium-dependent serotonin transporter inhibitor SureCN5878703... 4 5
Renin inhibitor SureCN7300793 family 2 5
Lanosterol synthase inhibitor AGN-PC-07BZTX family 2 0
Bile acid receptor ligand pyridin-4-yl (1R,3aS,5aR,5bR,7aR,9S,... 1 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and Potassium ... 1 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 1 2
Sodium/hydrogen exchanger 1 inhibitor 2-[(E)-[7-(2-chloropheny... 2 0
Reverse transcriptase/RNaseH inhibitor 3-[4-cyclopropyl-1,1,1-... 1 0
Retinoic acid receptor RXR-alpha and Retinoic acid receptor RX... 1 0
Farnesyl pyrophosphate synthase inhibitor [phosphono-[[4-(4-pr... 6 0
Peroxisome proliferator-activated receptor delta and Peroxisom... 1 2
Enoyl-acyl-carrier protein reductase inhibitor Triclosan deriv... 3 0
Butyrylcholinesterase and Muscarinic acetylcholine receptor M2... 1 0
(4-methoxyphenyl)-[(2R)-2-pyridin-3-ylpiperidin-1-yl]phosphina... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00270379 CHEMBL35391 Bioactive SureCN6883651
CFAMM00270371 DNC008490 Investigative Drug 5-hexyl-2-(pyridin-2-yloxy)phenol
CFAMM00270370 DNC008493 Investigative Drug 5-hexyl-2-(pyridin-4-yloxy)phenol
CFAMM00270369 DNC008494 Investigative Drug 5-hexyl-2-(pyridin-3-yloxy)phenol

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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