CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2549
Family Name Corticosteroid 11-beta-dehydrogenase isozyme 1 Inhibitor 2-(4-tosylpiperazin-1-yl)nicotinonitrile Family
No. of Seeds 8 No. of Other Members 25
Family Centroid CFAMM00270485 Functional Category Investigative Drug
Superfamily Corticosteroid 11-beta-dehydrogenase isozyme 1 Binder Superfamily 3
Class Class 1174

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 2C ligand Tetracyclic antidepress... 14 498
Solute carrier family 12 member 1 Inhibitor Torasemide Family 13 75
Histamine H1 receptor Ligand Triprolidine Family 19 316
Dihydropterin pyrophosphokinase-dihydropteroate synthase inhib... 5 60
Transient receptor potential cation channel subfamily V member... 16 295
Reverse transcriptase Inhibitor Dapivirine Family 5 72
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Carbonic anhydrase 2 Inhibitor Cyanamide Family 2 32
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Scytalone dehydratase Inhibitor Isoquinolin-1-yl-(3-phenyl-pro... 4 9
Histamine H3 receptor Ligand 2-(4-isopropyl-piperazin-1-yl)-qu... 17 29
5-hydroxytryptamine receptor 6 Ligand 4-(1h-indol-1-ylsulfonyl... 7 79
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 13 26
Plasminogen and Urokinase-type plasminogen activator Inhibitor... 3 26
Transient receptor potential cation channel subfamily V member... 2 26
Corticosteroid 11-beta-dehydrogenase isozyme 1 Inhibitor 1-(3-... 2 29
Macrophage migration inhibitory factor Inhibitor 4-iodo-6-phen... 5 4
Prostaglandin G/H synthase 1 Inhibitor 1-(4-aminosulfonylpheny... 3 18
Macrophage migration inhibitory factor Inhibitor 1-(2-chloroph... 2 22
Reverse transcriptase Inhibitor PT-109 Family 6 7
Protein farnesyltransferase subunit beta Inhibitor BMS-316810 ... 11 18
Farnesyltransferase beta subunit, putative and Protein farnesy... 12 4
Corticosteroid 11-beta-dehydrogenase isozyme 1 Inhibitor PF-91... 8 14
Acetylcholinesterase Inhibitor N-benzyl-2-morpholinopyrimidin-... 6 16
Inhibitor of nuclear factor kappa-B kinase subunit beta inhibi... 1 7
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 4 14
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 27
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 3 1
Beta-3 adrenergic receptor and Beta-2 adrenergic receptor liga... 4 1
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (2R)-... 5 10
Nicotinamide phosphoribosyltransferase and Prelamin-A/C inhibi... 1 0
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor 4-[2-(... 2 6
Glucose-dependent insulinotropic receptor ligand AGN-PC-0A9QCI... 2 6
Aurora kinase A and Aurora kinase B inhibitor 2-[[5-chloro-2-[... 3 7
Protein farnesyltransferase alpha subunit and Protein farnesyl... 5 0
Serine/threonine-protein kinase SMG1 and Cyclin-dependent kina... 3 1
Bombesin receptor subtype-3 and Nuclear receptor subfamily 1 g... 12 11
Bombesin receptor subtype-3 and Nuclear receptor subfamily 1 g... 3 0
Urokinase-type plasminogen activator and Tissue-type plasminog... 3 15
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 5 2
Nicotinamide phosphoribosyltransferase inhibitor 1-[4-(8-oxa-3... 5 4
Nicotinamide phosphoribosyltransferase and Cytochrome P450 2C9... 4 5
Nicotinamide phosphoribosyltransferase inhibitor N-[[4-(3,5-di... 4 8
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 3
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 5
D(4) dopamine receptor and D(2) dopamine receptor ligand (E)-1... 1 2
Cyclin-dependent kinase 2 inhibitor Imidazo[1,2-a]pyridine der... 4 0
Suppressor of tumorigenicity 14 protein and Prothrombin inhibi... 1 3
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 1,1,1... 12 3
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor [1-[4... 2 0
Protein-glutamine gamma-glutamyltransferase 2 and Coagulation ... 1 0
Protein-glutamine gamma-glutamyltransferase 2 and Coagulation ... 1 2
C-X-C chemokine receptor type 3 ligand (1R,4S)-4-[[(3S)-4-[3-f... 5 16
C-X-C chemokine receptor type 3 and Cytochrome P450 1A2 ligand... 1 4
Coagulation factor X and Prothrombin inhibitor SureCN6578740 f... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00270493 CHEMBL257567 Bioactive arylsulfonylpiperazine, 39
CFAMM00270505 CHEMBL256760 Bioactive arylsulfonylpiperazine, 10
CFAMM00270492 CHEMBL257565 Bioactive arylsulfonylpiperazine, 40
CFAMM00270482 CHEMBL256927 Bioactive arylsulfonylpiperazine, 44
CFAMM00270489 CHEMBL429499 Bioactive arylsulfonylpiperazine, 43
CFAMM00270522 CHEMBL402575 Bioactive arylsulfonylpiperazine, 42
CFAMM00270485 DNC008514 Investigative Drug 2-(4-tosylpiperazin-1-yl)nicotinonitrile
CFAMM00270484 DNC008516 Investigative Drug 1-(3-chloropyridin-2-yl)-4-tosylpiperazine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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