CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2553
Family Name DNA topoisomerase 2-beta Inhibitor Lupeol Family
No. of Seeds 2 No. of Other Members 23
Family Centroid CFAMM00270622 Functional Category Investigative Drug with Human Metabolite & Natural Product
Superfamily Lanosterol synthase and DNA topoisomerase 2-beta Binder Superfamily
Class Class 1870

Cousin Family NamesSeedsMembers
Vitamin D3 receptor ligand Vitamin D analog Cholecalciferol Fa... 7 270
Biliverdin reductase A and Solute carrier Family 23 member 2 i... 9 112
Progesterone receptor Ligand Desogestrel Family 2 5
Trimegestone family 7 25
HE3286 family 5 34
Aminopeptidase N Inhibitor [(125)i] RB129 Family 11 204
DNA polymerase catalytic subunit Inhibitor Aphidicolin Family 2 38
Lanosterol synthase Inhibitor Lanosterol Family 2 62
Nuclear receptor ROR-alpha Ligand Cholesterol-sulfate Family 1 0
Tyrosine-protein phosphatase non-receptor type 1 Ligand Uvaol ... 3 24
DNA polymerase and Glycogen phosphorylase, muscle form Inhibit... 32 22
Prostaglandin G/H synthase 2 Inhibitor 8alpha,19-dihydroxylabd... 2 10
Acetylcholinesterase and Cholinesterase Inhibitor 24-ethylchol... 1 2
Prelamin-A/C and Ferritin light chain inhibitor CHEMBL1524039 ... 3 61
Sex hormone-binding globulin inhibitor (3R,5S,7R,8S,9R,10S,13S... 1 0
Estrogen receptor beta and Androgen receptor ligand (8R,9S,10S... 1 5
Bile acid receptor ligand aminomethyl (1R,3aS,5aR,5bR,7aR,9S,1... 2 0
Bile acid receptor ligand (1'R,3'aS,5'aR,5'bR,7'aR,11'aR,11'bR... 1 4
Bile acid receptor and G-protein coupled bile acid receptor 1 ... 4 15
Bile acid receptor ligand SureCN554372 family 1 0
7-dehydrocholesterol reductase inhibitor [(3R)-3-[(3S,10R,13R)... 1 5
Potassium-transporting ATPase alpha chain 2 and Sodium/potassi... 1 0
Botulinum neurotoxin type A inhibitor 28-Hemisuccinylbetulin f... 1 9
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor CALON... 2 24
Steroids and Steroid Derivatives Metabolite Cholesteryl acetat... 4 55
Prenol Lipids Metabolite gamma-Taraxastane-3,20-diol Family 1 11
Prenol Lipids Metabolite Fasciculol C Family 1 8


External ID

Functional Category

Molecule Name

CFAMM00270612 DNC013813 Investigative Drug BETULIN
CFAMM00270622 DNC008522 Investigative Drug LUPEOL

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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