CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2561
Family Name Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)phenyl]-d-glutamine Family
No. of Seeds 11 No. of Other Members 13
Family Centroid CFAMM00270906 Functional Category Investigative Drug with Natural Product
Superfamily Leukotriene A-4 hydrolase Binder Superfamily
Class Class 1884

Cousin Family NamesSeedsMembers
Beta-1 adrenergic receptor Ligand Practolol Family 2 82
Acyl-CoA desaturase Inhibitor Isoxyl Family 5 62
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
Cyclophilin receptor and Cyclosporine receptor Ligand D-43787 ... 2 13
Glucose-6-phosphate 1-dehydrogenase Inhibitor Metazamide Family 9 69
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 7 49
Leukotriene A-4 hydrolase Inhibitor N-benzyl-4-[(2r)-pyrrolidi... 6 40
Substance-K receptor Ligand MEN-14933 Family 13 154
Cannabinoid receptor 1 Ligand N-(4-methoxyphenyl)oleamide Family 4 23
Histone deacetylase 1 Inhibitor 7-(4-(dimethylamino)phenoxy)-n... 2 1
Leukotriene A-4 hydrolase Inhibitor N5-[4-(2-oxo-3-phenylpropo... 1 61
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 9 79
Renin Inhibitor Ro-66-1168 Family 10 30
Bifunctional epoxide hydrolase 2 Inhibitor 1-(3-(3-morpholinop... 24 102
Leukotriene A-4 hydrolase Inhibitor 1-[4-(4-iodophenoxy)phenyl... 5 18
Fatty-acid amide hydrolase 1 Inhibitor 2-fluorophenyl 4-(octyl... 15 9
Fatty-acid amide hydrolase 1 Inhibitor Propan-2-one O-4-(hexyl... 12 4
Fatty-acid amide hydrolase 1 Inhibitor Benzaldehyde O-4-ethoxy... 21 4
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
Tyrosinase Inhibitor 1-(4-(benzyloxy)phenyl)-3-hydroxyurea Family 9 23
Substance-P receptor ligand N-[1-[acetyl-[(2-methoxyphenyl)met... 3 9
Cathepsin K inhibitor N-[(2S)-1-(4-methoxyanilino)propan-2-yl]... 11 10
Angiotensin-converting enzyme inhibitor (2R)-1-[4-carboxy-4-(p... 3 3
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 4
Renin inhibitor 6-[[(2R)-1-[4-[3-[(2-methoxyphenyl)methoxy]pro... 3 1
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 2 4
Dipeptidyl peptidase 4 inhibitor (2S)-1-[(2S,4S)-4-(4-methoxya... 1 26
Cathepsin K and Cathepsin L1 inhibitor 4-ethyl-N-[(2S)-1-[2-(4... 7 10
Cathepsin S and Cathepsin K inhibitor SureCN3018173 family 2 4
Bifunctional epoxide hydrolase 2 inhibitor 3-[4-[[4-(trifluoro... 5 22
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 20 23
Angiotensin-converting enzyme inhibitor 2-[[(2S)-6-amino-2-[hy... 2 1
Leukotriene A-4 hydrolase inhibitor SureCN5313952 family 4 1
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 1
Excitatory amino acid transporter 2 and Excitatory amino acid ... 1 0
Histone deacetylase 8 and Histone deacetylase 6 inhibitor (3S)... 4 16
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 1 7
Matrix metalloproteinase-9 and Metalloproteinase inhibitor 3 i... 1 3
Methionine aminopeptidase 2 and Methionine aminopeptidase 1 in... 1 1
1-(3-methoxyphenyl)-5-oxo-N-(2-oxochromen-6-yl)pyrrolidine-3-c... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00270907 DNC008536 Investigative Drug N5-[4-(Phenylmethoxy)phenyl]-L-glutamine
CFAMM00270913 DNC008543 Investigative Drug N5-[4-(3-Phenylpropoxy)phenyl]-L-glutamine
CFAMM00270906 DNC008535 Investigative Drug N5-[4-(Phenylmethoxy)phenyl]-D-glutamine
CFAMM00270912 DNC008547 Investigative Drug N5-(4-Phenoxyphenyl)-L-glutamine
CFAMM00270905 DNC008534 Investigative Drug N1-[4-(Phenylmethoxy)phenyl]-L-glutamine
CFAMM00270911 DNC008544 Investigative Drug N5-[4-(2-phenylethoxy)phenyl]-L-glutamine
CFAMM00270904 DNC008533 Investigative Drug N1-[4-(Phenylmethoxy)phenyl]-L-aspartamine
CFAMM00270903 DNC008539 Investigative Drug N1-[4-(Phenylmethoxy)phenyl]-D-glutamine
CFAMM00270902 DNC008538 Investigative Drug N1-[4-(Phenylmethoxy)phenyl]-D-aspartamine
CFAMM00270915 DNC008550 Investigative Drug N6-[4-(4-methylphenoxy)phenyl]-L-homoglutamine
CFAMM00270908 DNC008537 Investigative Drug N4-[4-(Phenylmethoxy)phenyl]-L-aspartamine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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