CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2562
Family Name Leukotriene A-4 hydrolase Inhibitor N5-[4-(2-oxo-3-phenylpropoxy)phenyl]-l-glutamine Family
No. of Seeds 1 No. of Other Members 61
Family Centroid CFAMM00271007 Functional Category Investigative Drug with Natural Product
Superfamily Leukotriene A-4 hydrolase Binder Superfamily
Class Class 1884

Cousin Family NamesSeedsMembers
Sodium channel protein type 5 subunit alpha Ligand Proparacain... 2 26
Sodium channel protein type 5 subunit alpha Ligand Encainide F... 4 248
Beta-2 adrenergic receptor Ligand Olodaterol Family 16 27
Dihydroorotate dehydrogenase and Interleukin-17A Inhibitor Vid... 4 74
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Muscarinic acetylcholine receptor M1 Ligand AC-260584 Family 4 36
Alpha-2C adrenergic receptor Ligand ARC239 Family 15 23
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
5-hydroxytryptamine receptor 1A Ligand NAN-190 Family 14 28
Amine oxidase [flavin-containing] A Inhibitor Ethyl 4-(2-oxo-2... 4 117
Sodium channel protein type 10 subunit alpha Ligand A-803467 F... 2 81
Histamine H3 receptor Ligand A-317920 Family 9 240
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 7 49
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 4-(2... 4 31
Oxytocin receptor and Vasopressin V1a receptor Ligand L-371257... 8 92
MO15-related protein kinase Pfmrk Inhibitor 3-[3-(2-hydroxy-et... 1 6
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 6 23
Substance-K receptor Ligand MEN-14933 Family 13 154
Alpha-1A adrenergic receptor Ligand Upidosin Family 8 46
Amyloid beta A4 protein Inhibitor 5-hydroxy-2-(4-methylaminoph... 6 71
Alpha-1A adrenergic receptor and D(2) dopamine receptor Ligand... 5 49
Granulocyte colony-stimulating factor receptor Ligand N-(2-mor... 1 24
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 11 13
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Macrophage migration inhibitory factor Inhibitor Benzofuran-2-... 5 67
Sodium channel protein type 10 subunit alpha and Sodium channe... 2 13
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 8 41
Proto-oncogene tyrosine-protein kinase receptor Ret Ligand (z)... 1 60
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
Histone deacetylase 2 Inhibitor N-(2-amino-5-(furan-2-yl)pheny... 3 7
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 8 39
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 2 17
D(2) dopamine receptor ligand 7-[4-[4-(2-ethoxyphenyl)piperazi... 12 14
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 5
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 11 4
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 49 8
Sodium channel protein type 10 subunit alpha ligand AGN-PC-09M... 1 7
Coagulation factor X and Trypsin-1 inhibitor AGN-PC-01ZLS4 family 2 8
Survival motor neuron protein and Nuclear receptor ROR-gamma l... 1 3
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 35
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 4 4
D(4) dopamine receptor and D(2) dopamine receptor ligand SureC... 4 3
D(4) dopamine receptor and D(3) dopamine receptor ligand SureC... 5 0
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 6
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 2 4
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[3-... 4 2
Histone deacetylase 6 and Histone deacetylase 1 inhibitor AGN-... 6 11
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 2
Androgen receptor ligand (2R)-2-ethyl-1-(2,2,2-trifluoroethyl)... 32 6
Prostaglandin D2 receptor and Prostacyclin receptor ligand 2-[... 15 5
Prostaglandin D2 receptor 2 and Prostaglandin D2 receptor liga... 18 2
Prostaglandin D2 receptor 2 ligand 2-[4-methoxy-3-[2-[[(1S)-1-... 5 28
MAP kinase-activated protein kinase 2 inhibitor 5-(4-cyanophen... 3 8
Cathepsin K and Cathepsin L1 inhibitor 4-ethyl-N-[(2S)-1-[2-(4... 7 10
Cathepsin S and Cathepsin K inhibitor arylaminoethyl amide, 7 ... 2 0
Neuronal acetylcholine receptor subunit alpha-7 and 5-hydroxyt... 4 6
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 9 3
Potassium voltage-gated channel subfamily H member 2 and Melan... 5 4
Mitogen-activated protein kinase 14 inhibitor N-[2-fluoro-5-[(... 4 5
Bifunctional epoxide hydrolase 2 inhibitor 3-[4-[[4-(trifluoro... 5 22
Integrin alpha-4 inhibitor SureCN14558473 family 7 4
G-protein coupled receptor 35 ligand 6-chloro-8-[(2-fluoro-4-m... 3 9
G-protein coupled receptor 35 ligand 6-bromo-8-[(2-fluoro-4-me... 6 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 11 8
Poly [ADP-ribose] polymerase 1 inhibitor 3-chloro-N-cyclopropy... 1 2
Poly [ADP-ribose] polymerase 1 inhibitor N-ethyl-4-[4-[(8-meth... 1 0
Poly [ADP-ribose] polymerase 1 inhibitor 6-[[4-(4-chlorophenyl... 1 0
Glutamate receptor ionotropic, NMDA 2B and Potassium voltage-g... 2 1
Macrophage colony-stimulating factor 1 receptor ligand 5-cyano... 5 6
5-hydroxytryptamine receptor 1A ligand SureCN10513645 family 9 1
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 2
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 1 0
Mu-type opioid receptor ligand AGN-PC-00NCMO family 3 1
Glucagon receptor and Adenylate cyclase type 1 ligand AGN-PC-0... 3 1
Smoothened homolog inhibitor SureCN13591524 family 1 2
Mitogen-activated protein kinase 14 inhibitor SureCN4822166 fa... 1 4
Mitogen-activated protein kinase 14 and Heat shock protein bet... 2 1
Leukotriene A-4 hydrolase inhibitor SureCN5313952 family 4 1
ATP-sensitive inward rectifier potassium channel 11 ligand N-[... 1 0
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 1 0
Sphingosine 1-phosphate receptor 4 ligand AGN-PC-079GSR family 11 7
Leukotriene B4 receptor 1 ligand 4-methoxy-3-[[(E)-3-(4-phenyl... 2 10
Huntingtin and Ras-related protein Rab-9A inhibitor CHEMBL1971... 1 1
Mineralocorticoid receptor and Glucocorticoid receptor ligand ... 2 0
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 2 0
Arachidonate 5-lipoxygenase inhibitor ethyl (E)-3-(10H-phenoxa... 1 1
Mitogen-activated protein kinase 14 inhibitor SureCN1600485 fa... 1 1
Acyl-CoA:cholesterol acyltransferase inhibitor SureCN8808982 f... 1 2
Ras-related protein Rab-9A and Niemann-Pick C1 protein inhibit... 1 4
Luciferin 4-monooxygenase and Nuclear receptor ROR-gamma ligan... 1 1
G-protein coupled receptor 35 and G-protein coupled receptor 5... 1 1
methoxybenzoate NP (2-hydroxy-6-methoxyquinolin-3-yl)methyl 4-... 2 1
3-[(3-amino-4-methoxybenzoyl)amino]propanoate NP Agn-pc-09e1h5... 1 1
3,5-bis[[2-(4-methoxyphenoxy)acetyl]amino]benzoate NP Agn-pc-0... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00271007 DNC008542 Investigative Drug N5-[4-(2-Oxo-3-phenylpropoxy)phenyl]-L-glutamine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26830 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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