CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2567
Family Name Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)phenyl]-l-glutamamide Family
No. of Seeds 7 No. of Other Members 71
Family Centroid CFAMM00271190 Functional Category Investigative Drug with Natural Product
Superfamily Histone deacetylase 2 and Leukotriene A-4 hydrolase Binder Superfamily
Class Class 2495

Cousin Family NamesSeedsMembers
SUR1-type K(ATP) channel and SUR2-type K(ATP) channel Ligand R... 1 16
Sodium channel protein type 5 subunit alpha Ligand Flecainide ... 2 162
Sodium channel protein type 5 subunit alpha Ligand Encainide F... 4 248
Histamine H1 receptor Ligand Tranilast Family 5 125
Zucapsacin family 7 177
Serine/threonine-protein kinase PLK1 Inhibitor On 019190.na Fa... 16 138
Growth hormone secretagogue receptor type 1 Ligand TZP-101 Family 28 263
C-C chemokine receptor type 5 Ligand GW873140 Family 6 78
D(4) dopamine receptor Ligand PD-165167 Family 2 96
Cinitapride family 4 22
Dihydroorotate dehydrogenase and Interleukin-17A Inhibitor Vid... 4 74
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Alpha-2C adrenergic receptor Ligand ARC239 Family 15 23
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
Glucose-6-phosphate 1-dehydrogenase Inhibitor Metazamide Family 9 69
5-hydroxytryptamine receptor 1A Ligand NAN-190 Family 14 28
Amine oxidase [flavin-containing] A Inhibitor Ethyl 4-(2-oxo-2... 4 117
Sodium channel protein type 10 subunit alpha Ligand A-803467 F... 2 81
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Histamine H3 receptor Ligand A-317920 Family 9 240
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 3 89
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 7 49
Leukotriene A-4 hydrolase Inhibitor N-benzyl-4-[(2r)-pyrrolidi... 6 40
Plasmepsin-2 Inhibitor PS-662477 Family 7 55
Disintegrin and metalloproteinase domain-containing protein 17... 25 36
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Potassium ... 1 15
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
Oxytocin receptor and Vasopressin V1a receptor Ligand L-371257... 8 92
Cytochrome P450 1B1 Inhibitor N-(2,4-dimethoxy-phenyl)-3,5-dim... 1 110
Histamine H3 receptor Ligand A-349821 Family 49 228
Substance-K receptor Ligand MEN-14933 Family 13 154
Alpha-1A adrenergic receptor Ligand Upidosin Family 8 46
Cannabinoid receptor 1 Ligand N-(4-methoxyphenyl)oleamide Family 4 23
Interstitial collagenase Inhibitor N-hydroxycarbamoylmethyl-4-... 5 24
Mitogen-activated protein kinase 14 Inhibitor N-(4-(trifluorom... 8 39
Oxysterols receptor LXR-alpha Ligand N-{4-[2-(4-methoxyphenyl)... 3 16
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 9 12
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 12 46
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Liver carboxylesterase 1 Inhibitor 5-(trifluoromethoxy)-1h-ind... 3 12
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Alpha-1A adrenergic receptor and D(2) dopamine receptor Ligand... 5 49
Histone deacetylase 2 Inhibitor N-(4-amino-3'-methoxybiphenyl-... 3 49
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 11 13
Leukotriene A-4 hydrolase Inhibitor N5-[4-(2-oxo-3-phenylpropo... 1 61
Macrophage migration inhibitory factor Inhibitor Benzofuran-2-... 5 67
Urotensin-2 receptor Ligand SB-436811 Family 6 71
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 9 79
Renin Inhibitor Ro-66-1168 Family 10 30
Coagulation factor X Inhibitor BMS-269223 Family 15 58
Leukotriene A-4 hydrolase Inhibitor 1-[4-(4-iodophenoxy)phenyl... 5 18
Urotensin-2 receptor Ligand JNJ-28318706 Family 4 227
Proto-oncogene tyrosine-protein kinase receptor Ret Ligand (z)... 1 60
Fatty-acid amide hydrolase 1 Inhibitor Benzaldehyde O-4-ethoxy... 21 4
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
Histone deacetylase 2 Inhibitor N-(2-amino-5-(furan-2-yl)pheny... 3 7
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
Arachidonate 5-lipoxygenase Inhibitor 2-(4-butoxy-phenyl)-n-hy... 3 9
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
D(2) dopamine receptor Ligand Epidepride Family 31 66
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 5 17
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 8 39
Tyrosinase Inhibitor 1-(4-(benzyloxy)phenyl)-3-hydroxyurea Family 9 23
Acetylcholinesterase Inhibitor 6-methyl-4-(4-benzoylpiperazin-... 2 6
Liver carboxylesterase 1 Inhibitor SCH-48375 Family 2 28
Tubulin beta chain Inhibitor Gnf-pf-117 Family 2 16
Glycine receptor subunit beta Ligand ORG-25543 Family 10 153
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 1 7
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 2 17
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 1
Substance-P receptor ligand N-[1-[acetyl-[(2-methoxyphenyl)met... 3 9
Cathepsin K inhibitor N-[(2S)-1-(4-methoxyanilino)propan-2-yl]... 11 10
Vasopressin V1a receptor and Vasopressin V2 receptor ligand N-... 1 2
D(2) dopamine receptor ligand 7-[4-[4-(2-ethoxyphenyl)piperazi... 12 14
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04UEH3 family 3 16
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 10 9
Matrilysin and 72 kDa type IV collagenase inhibitor (3S,6R,7S)... 2 2
Stromelysin-1 and 72 kDa type IV collagenase inhibitor [(2S)-2... 2 2
Neutrophil elastase inhibitor (2S)-N-[(3S)-6-benzamido-5,5-dif... 6 10
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 5
Cathepsin S and Cathepsin L1 inhibitor arylaminoethyl amide, 8... 4 15
Integrin beta-3 and Integrin alpha-IIb inhibitor (2R)-2-(benze... 4 13
C-C chemokine receptor type 3 ligand SureCN6705515 family 2 16
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 49 8
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 4
Microsomal triglyceride transfer protein large subunit inhibit... 4 5
Lethal factor inhibitor (2R)-2-(4-fluoro-3,5-dimethylanilino)-... 1 0
Renin inhibitor 6-[[(2R)-1-[4-[3-[(2-methoxyphenyl)methoxy]pro... 3 1
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2C lig... 2 2
Progesterone receptor and Androgen receptor ligand SureCN38761... 2 5
Nuclear receptor ROR-gamma and Menin ligand CHEMBL1432265 family 1 18
Disintegrin and metalloproteinase domain-containing protein 17... 3 2
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 7 4
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[4-... 7 9
Substance-P receptor ligand (2S,4S)-1-N-(3-chlorophenyl)-2-N-[... 5 2
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 11 9
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[4-... 6 16
Prelamin-A/C and Survival motor neuron protein inhibitor CHEMB... 1 7
Matrix metalloproteinase-9 and Interstitial collagenase inhibi... 2 13
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[3-... 4 2
Gastrin/cholecystokinin type B receptor ligand 1-[3-[[2-(3-met... 2 12
C5a anaphylatoxin chemotactic receptor 1 ligand N-[(4-dimethyl... 1 4
Prostaglandin D2 receptor 2 ligand SureCN136287 family 1 9
Trace amine-associated receptor 1 ligand EPPTB family 4 9
3-oxo-5-alpha-steroid 4-dehydrogenase 1 inhibitor N-[(1S,5aR,9... 2 2
Vasopressin V1b receptor ligand AGN-PC-09QGT9 family 4 123
Angiotensin-converting enzyme and Angiotensin-converting enzym... 3 13
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 2
Leukotriene A-4 hydrolase inhibitor AGN-PC-0A9QDC family 2 5
Growth hormone secretagogue receptor type 1 ligand 2-(2-acetyl... 2 0
Androgen receptor ligand (2R)-2-ethyl-1-(2,2,2-trifluoroethyl)... 32 6
Prostaglandin D2 receptor and Prostacyclin receptor ligand 2-[... 15 5
Mu-type opioid receptor ligand AGN-PC-075GG7 family 4 2
Cystic fibrosis transmembrane conductance regulator inhibitor ... 2 3
Renin and Cytochrome P450 3A4 inhibitor SureCN6719989 family 2 0
MAP kinase-activated protein kinase 2 inhibitor 5-(4-cyanophen... 3 8
Histamine H3 receptor ligand N-[[2-[2-[(2R)-2-methylpyrrolidin... 4 1
Melanin-concentrating hormone receptor 1 and Potassium voltage... 3 6
Cathepsin K and Cathepsin L1 inhibitor 4-ethyl-N-[(2S)-1-[2-(4... 7 10
Cathepsin L1 and Cathepsin S inhibitor arylaminoethyl amide, 5... 4 5
Cathepsin S and Cathepsin K inhibitor arylaminoethyl amide, 7 ... 2 0
Growth hormone secretagogue receptor type 1 ligand (2R)-N-(1-b... 11 4
Sphingosine 1-phosphate receptor 1 ligand 2-methoxy-N-[(4-phen... 2 23
Bifunctional epoxide hydrolase 2 inhibitor 1-(1-adamantyl)-3-[... 2 0
Histamine H3 receptor and Cytochrome P450 2D6 ligand ethyl 4-[... 5 5
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial ... 3 3
Furin inhibitor phenyl 2-[[(2S)-1-[[(2S)-1-[[(2S)-1-(4-carbami... 2 5
Microsomal triglyceride transfer protein large subunit inhibit... 3 0
Neuronal acetylcholine receptor subunit alpha-7 and 5-hydroxyt... 4 6
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 9 3
Cathepsin S and Cathepsin K inhibitor SureCN3018173 family 2 4
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand CHEMB... 6 3
Cathepsin K inhibitor (1R,2R)-N-(cyanomethyl)-2-[4-(3-methoxyp... 2 1
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 2 1
Integrin beta-3 and Integrin alpha-2 inhibitor 3-(4-methoxyphe... 4 6
Bifunctional epoxide hydrolase 2 inhibitor 3-[4-[[4-(trifluoro... 5 22
5-hydroxytryptamine receptor 1B ligand SureCN5352760 family 2 5
Glucagon receptor and Gastric inhibitory polypeptide receptor ... 3 11
Sodium-dependent serotonin transporter and D(2) dopamine recep... 8 6
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltra... 2 1
E3 ubiquitin-protein ligase XIAP and Cytochrome P450 3A4 inhib... 4 11
E3 ubiquitin-protein ligase XIAP and Cytochrome P450 3A4 inhib... 1 2
Bifunctional epoxide hydrolase 2 inhibitor 8-(2,6-difluorobenz... 4 1
Bifunctional epoxide hydrolase 2 inhibitor 8-(2-fluoro-5-hydro... 2 0
Bifunctional epoxide hydrolase 2 inhibitor 8-(2-methylfuran-3-... 2 1
2-acylglycerol O-acyltransferase 2 inhibitor N-(4-methoxypheny... 1 0
Oxytocin receptor ligand SureCN8092936 family 2 0
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 20 23
Progesterone receptor ligand CHEMBL252850 family 2 0
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(3... 2 2
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 2 11
Delta-type opioid receptor and Kappa-type opioid receptor liga... 5 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 7
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 11 4
C-C chemokine receptor type 5 ligand dimethyl-[[4-[[7-(4-methy... 7 8
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 2
Neprilysin and Angiotensin-converting enzyme inhibitor 2-[(3S)... 5 6
Pol polyprotein inhibitor (3S)-N-tert-butyl-2-[(2R)-2-[(3S,6S,... 3 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2,6-... 4 1
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 2 2
Leukotriene A-4 hydrolase inhibitor 4-[[(1S,5R)-3-[4-(2-fluoro... 2 2
Mitogen-activated protein kinase 14 inhibitor SureCN4822166 fa... 1 4
Mitogen-activated protein kinase 14 and Heat shock protein bet... 2 1
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 5 5
Leukotriene A-4 hydrolase inhibitor SureCN5313952 family 4 1
Growth hormone secretagogue receptor type 1 ligand N-[4-[(2S)-... 1 0
5-hydroxytryptamine receptor 7 and 5-hydroxytryptamine recepto... 1 0
Cathepsin E and Cathepsin D inhibitor SureCN2529506 family 2 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 1
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 1 0
Neuropeptide Y receptor type 5 ligand 3-dibenzofuran-2-yl-1-[(... 1 2
fMet-Leu-Phe receptor ligand 2-[[(2S)-2-[[(2S)-2-[(4-methoxyph... 1 0
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 0
Coagulation factor VII and Prothrombin inhibitor AGN-PC-0752MU... 2 1
D(4) dopamine receptor and Alpha-1B adrenergic receptor ligand... 1 1
Histone deacetylase 8 and Histone deacetylase 6 inhibitor (3S)... 4 16
Amine oxidase [flavin-containing] B and Adenosine receptor A2b... 2 2
Glucose-dependent insulinotropic receptor ligand tert-butyl 4-... 1 0
Inosine-5'-monophosphate dehydrogenase 2 inhibitor SureCN32423... 1 0
Transient receptor potential M8 protein ligand 2-(2,3-dihydro-... 1 0
Sodium channel protein type 9 subunit alpha ligand SureCN12900... 9 8
Cathepsin K inhibitor benzyl N-[(2S)-4-methyl-1-oxo-1-[2-[[(4-... 2 0
Cathepsin K inhibitor N-[2-(4-methoxyanilino)ethyl]-4-methyl-2... 1 1
Histone deacetylase 1 and Histone deacetylase 2 inhibitor Sure... 2 0
Thyrotropin receptor and Cruzipain ligand ethyl 5-cyano-4-(fur... 1 0
Matrix metalloproteinase-9 and Metalloproteinase inhibitor 3 i... 1 3
Major prion protein and Microtubule-associated protein tau inh... 2 10
Glycogen synthase kinase-3 beta and Glycogen synthase kinase-3... 2 0
Acyl-CoA:cholesterol acyltransferase inhibitor SureCN8797527 f... 1 0
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 1 1
Beta-lactamase and Microtubule-associated protein tau inhibito... 1 1
NP (s)-3-(2,5-dioxo-2,3,4,5-tetrahydro-1h-benzo[e][1,4]diazepi... 3 0
methoxybenzoate NP (2-hydroxy-6-methoxyquinolin-3-yl)methyl 4-... 2 1
N-(4-acetamidophenyl)-2-(2,2-dimethyl-3,4-dihydrochromen-6-yl)... 1 0
4-(4-methoxyphenyl)-2,4,5,10-tetrahydro-1H-pyrrolo[3,4-c][1,5]... 4 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00271172 CHEMBL215402 Bioactive arylaminoethyl amide deriv. 18
CFAMM00271129 CHEMBL77665 Bioactive N-[(2S)-1-[2-(4-methoxyanilino)ethylamino]-4-methyl-1-oxopentan-2-yl]-4-phenylmethoxybenzamide
CFAMM00271184 CHEMBL59817 Bioactive 4-ethyl-N-[(2S)-4-methyl-1-oxo-1-[2-(4-phenylmethoxyanilino)ethylamino]pentan-2-yl]benzamide
CFAMM00271190 DNC008551 Investigative Drug N5-[4-(4-(3-Furyl)phenoxy)phenyl]-L-glutamamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27523 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543