CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2592
Family Name Calcitonin gene-related peptide type 1 receptor and Cytochrome P450 2D6 Ligand BMS-694153 Family
No. of Seeds 19 No. of Other Members 12
Family Centroid CFAMM00271433 Functional Category Investigative Drug
Superfamily Calcitonin gene-related peptide type 1 receptor and Cytochrome P450 2D6 Ligand BMS-694153 Superfamily
Class Class 843

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 3A Ligand Granisetron Family 26 212
Transient receptor potential cation channel subfamily V member... 12 108
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Vascular endothelial growth factor receptor 1 and Angiopoietin... 29 127
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 5 10
Adenosine receptor A3 Ligand 2-benzyl-2h-pyrazolo[3,4-c]quinol... 3 11
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand N-(1h... 2 12
Cytochrome P450 3A4 Inhibitor 5-(2-phenethylpiperazin-1-yl)-1h... 12 35
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 17 28
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 2
5-hydroxytryptamine receptor 3A ligand SureCN8035577 family 5 4
Serine/threonine-protein kinase 17A and Myosin light chain kin... 3 7
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 5 11
Serine/threonine-protein kinase mTOR inhibitor AGN-PC-093LHN f... 3 2
Smoothened homolog inhibitor (8aS)-N-[2-(3-cyanophenyl)pyridin... 3 4
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 2 18
Ribosomal protein S6 kinase alpha-3 inhibitor 1-oxo-N-[1-(pyri... 5 11
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 4 3
Calcitonin gene-related peptide type 1 receptor ligand 2-[(7-m... 2 1
Calcitonin gene-related peptide type 1 receptor ligand 2-[(7-m... 3 0
Calcitonin gene-related peptide type 1 receptor ligand [2-(7-m... 14 0
Calcitonin gene-related peptide type 1 receptor ligand 3-[1-[4... 5 3
Calcitonin gene-related peptide type 1 receptor ligand N-[2-(7... 5 3
Calcitonin gene-related peptide type 1 receptor and Cytochrome... 2 0
Vascular endothelial growth factor receptor 2 and Angiopoietin... 14 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN14402832 ... 6 5
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 0
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 1 1
Serine/threonine-protein kinase PLK4 inhibitor (3E)-3-[[3-[(E)... 5 2
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 4 1
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 3 0
Glucocorticoid receptor ligand 3,3,3-trifluoro-N-[(3S)-3-[1-(4... 10 4
Calcitonin gene-related peptide type 1 receptor ligand N-[2-(7... 16 0
Serine/threonine-protein kinase Chk1 inhibitor 5-[(2S)-3-amino... 4 6
Pol polyprotein inhibitor AC1LAMOI family 12 0
Gonadotropin-releasing hormone receptor ligand 1-(7-azabicyclo... 2 0
Histone deacetylase 1 inhibitor N-hydroxy-N',N'-bis[2-(1H-inda... 1 0
Calcitonin gene-related peptide type 1 receptor ligand SureCN2... 11 0
Calcitonin gene-related peptide type 1 receptor ligand [(2R)-3... 2 0
Cell division cycle 7-related protein kinase and Dual specific... 3 0
Melanocyte-stimulating hormone receptor and Melanocortin recep... 3 7
Serine/threonine-protein kinase D1 inhibitor 3-[5-[3-bromo-4-(... 1 1
Rho-associated protein kinase 2 and Cytochrome P450 3A4 inhibi... 3 5


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00271459 CHEMBL2397415 Bioactive N-[(2R)-3-(7-methyl-1H-indazol-5-yl)-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]-1-oxopropan-2-yl]-4-(2-oxo-1H-quinolin-3-yl)piperidine-1-carboxamide
CFAMM00271439 CHEMBL2336418 Bioactive N-[(2R)-3-(4-chloro-7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-piperidin-1-ylpiperidin-1-yl)propan-2-yl]-4-(2-oxo-1,4-dihydroquinazolin-3-yl)piperidine-1-carboxamide
CFAMM00271458 CHEMBL2018511 Bioactive 2-[(7-methyl-1H-indazol-5-yl)methyl]-1-(4-methylpiperidin-1-yl)-4-[4-(2-oxo-1,4-dihydroquinazolin-3-yl)piperidin-1-yl]butane-1,4-dione
CFAMM00271438 CHEMBL2336419 Bioactive N-[3-(7-ethyl-3-methyl-2H-indazol-5-yl)-1-oxo-1-(4-piperidin-1-ylpiperidin-1-yl)propan-2-yl]-4-(2-oxo-1,4-dihydroquinazolin-3-yl)piperidine-1-carboxamide
CFAMM00271451 CHEMBL2024590 Bioactive 3-[1-[4-(7-methyl-1H-indazol-5-yl)-3-[5-(piperidin-1-ylmethyl)pyridin-2-yl]butanoyl]piperidin-4-yl]-1,4-dihydroquinazolin-2-one
CFAMM00271430 CHEMBL454751 Bioactive SureCN3757956
CFAMM00271444 CHEMBL2018520 Bioactive (2R)-4-[4-(8-fluoro-2-oxo-1,4-dihydroquinazolin-3-yl)piperidin-1-yl]-2-[(7-methyl-1H-indazol-5-yl)methyl]-1-(4-piperidin-1-ylpiperidin-1-yl)butane-1,4-dione
CFAMM00271457 CHEMBL454791 Bioactive SureCN13053544
CFAMM00271450 CHEMBL2336421 Bioactive N-[3-(7-ethyl-1H-indazol-5-yl)-1-oxo-1-(4-piperidin-1-ylpiperidin-1-yl)propan-2-yl]-4-(2-oxo-1,4-dihydroquinazolin-3-yl)piperidine-1-carboxamide
CFAMM00271456 CHEMBL2018513 Bioactive 2-[(7-methyl-1H-indazol-5-yl)methyl]-4-[4-(2-oxo-1,4-dihydroquinazolin-3-yl)piperidin-1-yl]-1-piperidin-1-ylbutane-1,4-dione
CFAMM00271449 CHEMBL2336420 Bioactive 4-(2-oxo-1,4-dihydroquinazolin-3-yl)-N-[1-oxo-1-(4-piperidin-1-ylpiperidin-1-yl)-3-(7-propan-2-yl-1H-indazol-5-yl)propan-2-yl]piperidine-1-carboxamide
CFAMM00271442 CHEMBL2018506 Bioactive 2-[(7-methyl-1H-indazol-5-yl)methyl]-4-(2-oxospiro[1,3-dihydroquinazoline-4,4'-piperidine]-1'-yl)-1-(4-piperidin-1-ylpiperidin-1-yl)butane-1,4-dione
CFAMM00271448 CHEMBL2336422 Bioactive N-[3-(7-chloro-1H-indazol-5-yl)-1-oxo-1-(4-piperidin-1-ylpiperidin-1-yl)propan-2-yl]-4-(2-oxo-1,4-dihydroquinazolin-3-yl)piperidine-1-carboxamide
CFAMM00271441 CHEMBL2018505 Bioactive 4-[4-(8-fluoro-2-oxo-1,4-dihydroquinazolin-3-yl)piperidin-1-yl]-2-[(7-methyl-1H-indazol-5-yl)methyl]-1-(4-piperidin-1-ylpiperidin-1-yl)butane-1,4-dione
CFAMM00271447 CHEMBL2336424 Bioactive SureCN3607829
CFAMM00271460 CHEMBL2018519 Bioactive (2S)-4-[4-(8-fluoro-2-oxo-1,4-dihydroquinazolin-3-yl)piperidin-1-yl]-2-[(7-methyl-1H-indazol-5-yl)methyl]-1-(4-piperidin-1-ylpiperidin-1-yl)butane-1,4-dione
CFAMM00271440 CHEMBL2018504 Bioactive AGN-PC-0BSQSM
CFAMM00271453 CHEMBL2018517 Bioactive (2S)-2-[(7-methyl-1H-indazol-5-yl)methyl]-4-[4-(2-oxo-1,4-dihydroquinazolin-3-yl)piperidin-1-yl]-1-(4-piperidin-1-ylpiperidin-1-yl)butane-1,4-dione
CFAMM00271433 DNC008664 Investigative Drug BMS-694153

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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