CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2594
Family Name Indoleamine 2,3-dioxygenase 1 Inhibitor 3-(4h-imidazol-4-yl)benzenethiol Family
No. of Seeds 6 No. of Other Members 3
Family Centroid CFAMM00271465 Functional Category Investigative Drug
Superfamily Alpha-2 adrenergic receptor Ligand Dexmedetomidine Superfamily
Class Class 177

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 4 171
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
Cytochrome P450 3A4 Inhibitor Clotrimazole Family 16 145
5-hydroxytryptamine receptor 1D Ligand Rizatriptan Family 7 460
Alpha-2 adrenergic receptor Ligand Dexmedetomidine Family 32 639
Benzodiazepine receptor Ligand Midazolam Family 5 160
Toll-like receptor 7 Ligand Imiquimod Family 3 237
Amiloride-sensitive sodium channel subunit alpha Ligand Triamt... 8 98
Tubulin beta chain Inhibitor Mebendazole Family 12 84
Histamine H1 receptor Ligand Mizolastine Family 14 603
Metabotropic glutamate receptor 5 Ligand ADX-48621 Family 15 444
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Farnesyltransferase beta subunit, putative Inhibitor BMS214662... 11 65
Telomerase protein component 1 Inhibitor GRN163L Family 5 29
Transient receptor potential cation channel subfamily V member... 15 457
Vascular endothelial growth factor Inhibitor PTC299 Family 6 145
Cyclin-dependent kinase 2 Inhibitor Seliciclib Family 29 292
Fibroblast growth factor receptor 2 and Fibroblast growth fact... 11 86
Tyrosine-protein kinase JAK2 Inhibitor INCB18424 Family 3 130
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242
Reverse transcriptase Inhibitor Dapivirine Family 5 72
D(1B) dopamine receptor Ligand LE-300 Family 65 452
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
HCV NS4B protein Inhibitor Clemizole Family 2 43
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 13 55
GDC-0349 family 44 77
Vascular endothelial growth factor receptor 2 Ligand XL999 Family 11 87
PF-4217903 family 14 65
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 8 55
Corticotropin-releasing factor receptor 1 Ligand CP-154526 Family 9 29
Tryptase Inhibitor Babim Family 12 90
Histamine H3 receptor and Histamine H4 receptor Ligand Clobenp... 31 38
D(4) dopamine receptor Ligand L-745,870 Family 30 205
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Olprin... 2 7
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Prostaglandin G/H synthase 2 Inhibitor RWJ-67657 Family 3 33
Interleukin-1 receptor type 1 and Mitogen-activated protein ki... 7 151
Histamine H3 receptor Ligand Proxyfan Family 12 32
Histamine H3 receptor Ligand SCH79687 Family 11 29
Steroid 17-alpha-hydroxylase/17,20 lyase Inhibitor 1-(1-(4-thi... 3 36
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2,6-di... 13 14
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 4 22
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-cyanobenzyl... 14 13
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Adenosine receptor A2a and Adenosine receptor A3 Ligand 5-buty... 3 18
Cyclin-dependent kinase 4 Inhibitor 1-pyridin-2-yl-3-quinolin-... 2 5
Arachidonate 5-lipoxygenase Inhibitor 2,4,5-triarylimidazole A... 3 16
Methionine aminopeptidase 2 Inhibitor 2-(pyridin-2-yl)-1h-benz... 6 19
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 1 0
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 5 7
Aromatase and Thromboxane-A synthase Inhibitor 6-(1h-imidazol-... 3 8
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 3 2
Adenosine receptor A1 Ligand Phenyl-(9-phenyl-9h-purin-6-yl)-a... 7 12
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 1 9
Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... 8 5
Alpha-1A adrenergic receptor Ligand A-315456 Family 7 17
RAC-gamma serine/threonine-protein kinase and Rho-associated p... 16 46
Adenosine receptor A3 and Dual specificity mitogen-activated p... 5 27
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-aminobenzyl... 3 6
Adenosine receptor A3 Ligand 2-(5-chloro-1h-benzo[d]imidazol-2... 7 51
Adenosine receptor A3 Ligand 2-(4-nitro-1h-benzo[d]imidazol-2-... 2 12
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 45
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 3 9
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-phen... 8 11
Cholinesterase Inhibitor 9-[9-(beta-carboline-9-yl)nonyl]-beta... 7 7
Dipeptidyl peptidase 4 Inhibitor (5-phenyl-3h-benzo[d]imidazol... 5 13
Fatty-acid amide hydrolase 1 Inhibitor JNJ-1661010 Family 3 14
Aromatase and Cytochrome P450 26A1 Inhibitor Liarozole Family 4 1
Histamine H4 receptor Ligand A-943931 Family 14 11
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Potassium voltage-gated channel subfamily H member 2 Ligand AZ... 21 42
Glycogen synthase kinase-3 beta Inhibitor CHIR-98023 Family 5 6
Glycogen synthase kinase-3 beta Inhibitor 4-(5-bromo-1h-indol-... 7 18
Hepatocyte growth factor receptor Ligand 3-(phenylsulfonyl)-1h... 17 59
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 6 6
Cytochrome P450 11B1, mitochondrial Inhibitor 3-(1-benzyl-1h-i... 3 5
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-bromobenzyl... 3 0
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-cyanobenzyl... 2 1
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 2 8
Histamine H3 receptor Ligand 4-(2-(phenylamino)ethyl)-1h-imida... 5 16
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand N-(9h-... 5 2
Histamine H3 receptor Ligand GT-2016 Family 4 6
Type-2 angiotensin II receptor Ligand L-158809 Family 22 136
Proto-oncogene tyrosine-protein kinase Src Inhibitor CGP-62464... 3 10
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 55
Peptide deformylase, mitochondrial Inhibitor 7h-pyrrolo[3,2-f]... 2 10
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 3-chlo... 3 2
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Xanthine dehydrogenase/oxidase Inhibitor 3,5-di(pyridin-4-yl)-... 6 3
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 1 4
Bombesin receptor subtype-3 and Gastrin-releasing peptide rece... 42 7
Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-(2-(4-... 25 10
Adenosine receptor A3 and Adenosine receptor A2a ligand 5-buty... 3 13
Prothrombin inhibitor SureCN5856722 family 3 16
Motilin receptor and Growth hormone secretagogue receptor type... 2 2
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 7 3
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 4 7
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Bombesin receptor subtype-3 ligand SureCN3515839 family 1 0
Bombesin receptor subtype-3 ligand (2R)-1-[4-[2-[5-(2,2-dimeth... 1 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 2
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 3 12
Macrophage colony-stimulating factor 1 receptor ligand SureCN1... 28 9
Macrophage colony-stimulating factor 1 receptor and Cytochrome... 13 3
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 4 3
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 7 4
Alpha-1D adrenergic receptor ligand 5-[(3-bromothiophen-2-yl)m... 8 0
Histamine H1 receptor and Alpha-1B adrenergic receptor ligand ... 1 6
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 7 10
Cyclin-dependent kinase 5 and Cyclin-dependent kinase 1 inhibi... 2 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 27
Adenosine receptor A1 and Adenosine receptor A2b ligand SureCN... 1 0
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 3 11
Neuropeptide Y receptor type 5 ligand 8-[6-(4-fluorophenyl)-1H... 2 1
Aromatase inhibitor AGN-PC-075MV1 family 1 3
Mitogen-activated protein kinase 14 inhibitor AGN-PC-03XQYG fa... 7 1
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL14574... 1 2
Gonadotropin-releasing hormone receptor ligand 1-(7-azabicyclo... 4 4
Histamine H3 receptor and Histamine H2 receptor ligand SureCN7... 3 20
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 1 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 5 0
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 3 7
Transient receptor potential M8 protein ligand 2-[(E)-2-(oxan-... 5 3
Histamine H3 receptor and Histamine H2 receptor ligand SureCN7... 2 2
Corticotropin-releasing factor receptor 1 ligand 9-(2-bromo-4-... 15 3
Glycogen synthase kinase-3 beta and Dual specificity protein k... 4 5
Corticotropin-releasing factor receptor 1 ligand SureCN6301726... 4 1
Alpha-1D adrenergic receptor ligand (E)-but-2-enedioic acid;5-... 8 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 5
Histone deacetylase 1 inhibitor (E)-N-hydroxy-3-[4-[[2-(1H-pyr... 2 8
Sphingosine 1-phosphate receptor 5 and Sphingosine 1-phosphate... 4 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family 10 11
Serine/threonine-protein kinase mTOR inhibitor 5-(2-amino-3H-b... 3 1
Cell division cycle 7-related protein kinase and Protein DBF4 ... 15 7
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 10 6
Prothrombin and Cationic trypsin inhibitor (2S)-1-[(2R)-3,3-di... 5 9
Protein kinase C theta type and Leucine-rich repeat serine/thr... 1 1
Histamine H3 receptor ligand 1-[4-(1H-imidazol-5-ylmethyl)pipe... 1 2
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 4 2
Somatostatin receptor type 3 and Potassium voltage-gated chann... 3 0
Somatostatin receptor type 3 ligand tert-butyl 4-[(3R)-3-(5-ph... 2 2
Transient receptor potential cation channel subfamily V member... 4 0
Melanin-concentrating hormone receptor 1 ligand AGN-PC-00BSP9 ... 6 12
Methionine--tRNA ligase inhibitor N-[(4R)-6,8-dibromo-1,2,3,4-... 1 1
Mitogen-activated protein kinase 14 inhibitor imidazole 81 family 2 1
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2152398 family 16 1
Melanin-concentrating hormone receptor 1 ligand 3-[(1R,3R,6S)-... 2 4
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 3 4
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Somatostatin receptor type 3 and Potassium voltage-gated chann... 3 3
Somatostatin receptor type 3 and Somatostatin receptor type 4 ... 5 1
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206614 family 2 0
Mitogen-activated protein kinase 14 inhibitor 6-[2-(2,6-difluo... 3 0
Tyrosine-protein kinase JAK1 and Aurora kinase A inhibitor CHE... 2 0
Protein kinase C theta type and Protein kinase C delta type in... 9 0
Dipeptidyl peptidase 4 and Seprase inhibitor (1S,5S)-5-[3-(tri... 1 0
Serine/threonine-protein kinase mTOR inhibitor 1-ethyl-3-[4-[6... 4 1
Methionine aminopeptidase 2 inhibitor SureCN5373581 family 6 0
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 8
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 3
Cyclin-dependent kinase 1 and Proto-oncogene tyrosine-protein ... 5 13
Cathepsin K and Cathepsin S inhibitor SureCN4138353 family 3 0
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 16 7
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 3 0
LIM domain kinase 2 inhibitor (2S)-N-cyano-N'-(3-cyanophenyl)-... 4 0
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 2
Alpha-2A adrenergic receptor and Alpha-2C adrenergic receptor ... 1 0
D(4) dopamine receptor and D(3) dopamine receptor ligand SureC... 1 0
Matrilysin and Stromelysin-1 inhibitor (2R)-N-[(1S)-1-(1H-benz... 3 0
Histamine H3 receptor ligand AGN-PC-074FK2 family 4 1
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 3 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
Gamma-aminobutyric acid receptor subunit pi and Gamma-aminobut... 4 0
Mitogen-activated protein kinase 14 inhibitor SureCN828349 family 1 0
Metabotropic glutamate receptor 1 ligand AGN-PC-00FV3S family 2 0
5-hydroxytryptamine receptor 2B ligand SureCN1299213 family 3 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Histidinol dehydrogenase inhibitor (3S)-3-amino-1-(2,4-difluor... 5 0
Histidinol dehydrogenase inhibitor (3S)-3-amino-1-(3,4-dichlor... 2 1
Serine/threonine-protein kinase B-raf inhibitor imidazole-base... 2 0
Nociceptin receptor and Mu-type opioid receptor ligand 2-(3-ch... 2 0
D(2) dopamine receptor ligand 4-bromo-6-[2-[4-[3-(trifluoromet... 1 2
Histamine H4 receptor and Histamine H3 receptor ligand AGN-PC-... 1 2
5-hydroxytryptamine receptor 3A ligand AGN-PC-077D8K family 3 1
Sodium/hydrogen exchanger 1 inhibitor SureCN14276439 family 1 1
Tyrosine-protein kinase Lck inhibitor (3S)-3-[(1S)-1-[[4-(benz... 14 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
Histamine H3 receptor ligand 5-(3-bromophenyl)-2-[2-(1H-imidaz... 2 2
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 5
Cytochrome P450 11B1, mitochondrial and Aromatase inhibitor (1... 1 0
Glucocorticoid receptor ligand SureCN13513652 family 1 0
Alpha-1A adrenergic receptor ligand 2-[4-[(3,3-difluoroazetidi... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00271471 CHEMBL2206400 Bioactive 5-(2-phenylethyl)-1H-imidazole
CFAMM00271470 CHEMBL298859 Bioactive N-[4-(1H-imidazol-5-yl)phenyl]-N'-(2-methylpropyl)methanimidamide;dihydrochloride
CFAMM00271469 CHEMBL99830 Bioactive 1-[3-(1H-imidazol-5-yl)propyl]-2-[(4-iodophenyl)methyl]guanidine
CFAMM00271472 CHEMBL299537 Bioactive N-[4-(1H-imidazol-5-yl)phenyl]-N'-(2-methylbutan-2-yl)methanimidamide;dihydrochloride
CFAMM00271464 DNC008668 Investigative Drug 3-(1H-Imidazol-4-yl)benzenethiol
CFAMM00271465 DNC008667 Investigative Drug 3-(4H-Imidazol-4-yl)benzenethiol

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

48712 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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