CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2606
Family Name Macrophage migration inhibitory factor Inhibitor 3-benzyl-5-methylbenzo[d]oxazol-2(3h)-one Family
No. of Seeds 10 No. of Other Members 42
Family Centroid CFAMM00271738 Functional Category Investigative Drug with Natural Product
Superfamily D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A Binder Superfamily
Class Class 1069

Cousin Family NamesSeedsMembers
Acetylcholinesterase Inhibitor Neostigmine Family 4 76
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 3 27
D(2) dopamine receptor Ligand Pardoprunox Family 4 81
Tumor necrosis factor Inhibitor Tgaac-94 Family 6 107
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Muscarinic acetylcholine receptor M1 Ligand AC-260584 Family 4 36
Alpha-2C adrenergic receptor Ligand ARC239 Family 15 23
C-C chemokine receptor type 1 Ligand BX-471 Family 10 67
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
5-hydroxytryptamine receptor 1A Ligand NAN-190 Family 14 28
5-hydroxytryptamine receptor 6 Ligand Sb 258585 Family 11 121
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 7 49
Leukotriene A-4 hydrolase Inhibitor N-benzyl-4-[(2r)-pyrrolidi... 6 40
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor 5... 4 24
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 18 12
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 6 23
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 131
Substance-K receptor Ligand MEN-14933 Family 13 154
Alpha-1A adrenergic receptor Ligand RWJ-68141 Family 5 4
Alpha-1A adrenergic receptor Ligand Upidosin Family 8 46
Alpha-1A adrenergic receptor Ligand Naftopidil Family 15 119
Cannabinoid receptor 1 Ligand N-(4-methoxyphenyl)oleamide Family 4 23
Amyloid beta A4 protein Inhibitor SB-13 Family 1 2
Alpha-1A adrenergic receptor and D(2) dopamine receptor Ligand... 5 49
Cholesteryl ester transfer protein Inhibitor Tetrahydroquinoli... 3 8
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 9 79
Bifunctional epoxide hydrolase 2 Inhibitor 1-(3-(3-morpholinop... 24 102
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 8 41
Leukotriene A-4 hydrolase Inhibitor 1-[4-(4-iodophenoxy)phenyl... 5 18
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
Fatty-acid amide hydrolase 1 Inhibitor Phenmedipham Family 2 5
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 28
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 21 13
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
Liver carboxylesterase 1 Inhibitor SCH-48375 Family 2 28
D(4) dopamine receptor ligand AGN-PC-004XJQ family 2 1
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 1
Substance-P receptor ligand N-[1-[acetyl-[(2-methoxyphenyl)met... 3 9
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 10
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
Cathepsin K inhibitor N-[(2S)-1-(4-methoxyanilino)propan-2-yl]... 11 10
D(2) dopamine receptor ligand 7-[4-[4-(2-ethoxyphenyl)piperazi... 12 14
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 14 12
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 5 13
D(4) dopamine receptor and D(2) dopamine receptor ligand 1-(4-... 3 5
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 4 2
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 1 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 3 2
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 2 0
D(3) dopamine receptor and D(2) dopamine receptor ligand (E)-3... 2 3
D(3) dopamine receptor and D(2) dopamine receptor ligand (E)-N... 2 2
D(4) dopamine receptor and D(2) dopamine receptor ligand SureC... 4 3
D(4) dopamine receptor and D(3) dopamine receptor ligand SureC... 5 0
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 9 0
Survival motor neuron protein and ATP-dependent DNA helicase Q... 1 4
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[4-... 6 16
Potassium voltage-gated channel subfamily H member 2 and Melan... 9 4
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 4 1
Neuropeptide Y receptor type 5 ligand 2-(7-chloro-3-oxo-1,4-be... 3 3
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 1 0
Histamine H3 receptor ligand 5-[4-[3-[(2R)-2-methylpyrrolidin-... 2 3
C-C chemokine receptor type 1 ligand SureCN3164653 family 2 1
Translocator protein inhibitor [11C]DAA1106 family 15 2
Translocator protein inhibitor N-methyl-2-[2-oxo-5-[4-(trifluo... 9 3
Translocator protein inhibitor 2-(5-bromo-2-oxo-1,3-benzoxazol... 1 0
Translocator protein inhibitor 2-(5-chloro-2-oxo-1,3-benzoxazo... 1 2
Translocator protein inhibitor N-methyl-2-[5-(N-methylanilino)... 1 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 0
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2A lig... 1 0
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 6 11
Poly [ADP-ribose] polymerase 1 inhibitor 6-[[4-(4-chlorophenyl... 1 0
Glutamate receptor ionotropic, NMDA 2B and Potassium voltage-g... 2 1
Urotensin-2 receptor and Cytochrome P450 3A4 ligand 5-chloro-3... 2 1
D(2) dopamine receptor and Alpha-1B adrenergic receptor ligand... 2 2
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 2 0
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 7 10
Sigma non-opioid intracellular receptor 1 ligand (5S)-5-[[4-(1... 4 18
Sigma non-opioid intracellular receptor 1 ligand (5S)-5-[(4-hy... 1 5
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 3 12
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 1 0
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 4 0
Arachidonate 5-lipoxygenase inhibitor ethyl (E)-3-(10H-phenoxa... 1 1
Metabotropic glutamate receptor 2 ligand (5R)-3-[[4-(4-ethoxyp... 3 9
Neuronal acetylcholine receptor subunit alpha-7 ligand (5R)-3-... 1 0
Indolizidines Metabolite Aspidospermatine Family 1 1
Benzoxazoles Metabolite 4-Acetyl-2(3H)-benzoxazolone Family 1 0
2-methylpropyl 2-oxo-1,3-benzoxazole-3-carboxylate NP Isobutyl... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00271714 CHEMBL472979 Bioactive AGN-PC-04XRFF
CFAMM00271704 CHEMBL559292 Bioactive 3-[4-[benzyl(methyl)amino]butyl]-1,3-benzoxazol-2-one
CFAMM00271751 CHEMBL474565 Bioactive AGN-PC-04XRFJ
CFAMM00271743 CHEMBL515571 Bioactive AGN-PC-04XRFI
CFAMM00271720 CHEMBL551856 Bioactive AGN-PC-073ET5
CFAMM00271748 CHEMBL1255975 Bioactive SureCN2757836
CFAMM00271707 CHEMBL1256233 Bioactive SureCN2757837
CFAMM00271738 DNC008698 Investigative Drug 3-benzyl-5-methylbenzo[d]oxazol-2(3H)-one
CFAMM00271736 DNC011216 Investigative Drug 3-benzyl-6-methylbenzo[d]oxazol-2(3H)-one
CFAMM00271735 DNC011217 Investigative Drug 3-benzyl-5-fluorobenzo[d]oxazol-2(3H)-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

41155 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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