CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2607
Family Name Macrophage migration inhibitory factor Inhibitor Benzofuran-2-yl(indolin-1-yl)methanone Family
No. of Seeds 5 No. of Other Members 67
Family Centroid CFAMM00271850 Functional Category Investigative Drug with Natural Product
Superfamily Macrophage migration inhibitory factor Inhibitor Benzofuran-2-yl(indolin-1-yl)methanone Superfamily
Class Class 1685

Cousin Family NamesSeedsMembers
Sodium channel protein type 5 subunit alpha Ligand Encainide F... 4 248
Mucosal addressin cell adhesion molecule 1 Inhibitor PF-005476... 64 96
Histone deacetylase Inhibitor Abexinostat Family 1 20
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Alpha-2C adrenergic receptor Ligand ARC239 Family 15 23
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
5-hydroxytryptamine receptor 1A Ligand NAN-190 Family 14 28
Sodium channel protein type 10 subunit alpha Ligand A-803467 F... 2 81
Histamine H3 receptor Ligand A-317920 Family 9 240
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 4-(2... 4 31
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 6 23
Histamine H3 receptor Ligand A-349821 Family 49 228
Substance-K receptor Ligand MEN-14933 Family 13 154
Alpha-1A adrenergic receptor Ligand Upidosin Family 8 46
Amyloid beta A4 protein Inhibitor 5-hydroxy-2-(4-methylaminoph... 6 71
Granulocyte colony-stimulating factor receptor Ligand N-(2-mor... 1 24
Leukotriene A-4 hydrolase Inhibitor N5-[4-(2-oxo-3-phenylpropo... 1 61
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Sodium channel protein type 10 subunit alpha and Sodium channe... 2 13
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
Histone deacetylase 2 Inhibitor N-(2-amino-5-(furan-2-yl)pheny... 3 7
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 2 17
Substance-K receptor ligand 5-chloro-N-[1-[[(2S)-5-[4-(oxan-4-... 2 4
D(2) dopamine receptor ligand 7-[4-[4-(2-ethoxyphenyl)piperazi... 12 14
Beta-secretase 1 inhibitor SureCN3599637 family 1 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 2 0
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 20 9
Collagenase 3 inhibitor N-[[3-[5-[[(1R)-1-cyclohexyl-2-(methyl... 4 2
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 11 4
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 49 8
Sodium channel protein type 10 subunit alpha ligand AGN-PC-09M... 1 7
Survival motor neuron protein and Nuclear receptor ROR-gamma l... 1 3
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 35
Lethal(3)malignant brain tumor-like protein 1 and Lysine-speci... 1 6
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 4 4
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 6
Mu-type opioid receptor ligand SureCN9379472 family 1 1
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[3-... 4 2
DNA-dependent protein kinase catalytic subunit and Phosphatidy... 1 6
Prostaglandin E2 receptor EP4 subtype ligand SureCN5653729 family 3 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 2
Androgen receptor ligand (2R)-2-ethyl-1-(2,2,2-trifluoroethyl)... 32 6
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 2 4
Collagenase 3 and Matrilysin inhibitor N-({4'-[(1-BENZOFURAN-2... 24 45
MAP kinase-activated protein kinase 2 inhibitor 5-(4-cyanophen... 3 8
Histamine H3 receptor ligand N-[[2-[2-[(2R)-2-methylpyrrolidin... 4 1
Cathepsin S and Cathepsin K inhibitor arylaminoethyl amide, 7 ... 2 0
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 3 6
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 1
Translocator protein inhibitor N-[(2,5-dimethoxyphenyl)methyl]... 1 0
Histamine H3 receptor ligand SureCN5221194 family 1 8
Histamine H3 receptor ligand SureCN5218144 family 4 6
Neuronal acetylcholine receptor subunit alpha-7 and 5-hydroxyt... 4 6
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 9 3
Potassium voltage-gated channel subfamily H member 2 and Melan... 5 4
Bifunctional epoxide hydrolase 2 inhibitor 3-[4-[[4-(trifluoro... 5 22
Inosine-5'-monophosphate dehydrogenase inhibitor N-dibenzofura... 1 5
Alpha-2C adrenergic receptor and Alpha-2A adrenergic receptor ... 4 13
Macrophage colony-stimulating factor 1 receptor ligand SureCN1... 6 1
Macrophage colony-stimulating factor 1 receptor ligand 5-cyano... 5 6
Macrophage colony-stimulating factor 1 receptor ligand 5-cyano... 1 0
5-hydroxytryptamine receptor 1A ligand SureCN10513645 family 9 1
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 2
Oxytocin receptor and Vasopressin V1a receptor ligand N-[[5-[4... 1 0
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 1 0
Mu-type opioid receptor ligand AGN-PC-00NCMO family 3 1
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 1 1
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 1 0
Glucagon receptor and Adenylate cyclase type 1 ligand AGN-PC-0... 3 1
Smoothened homolog inhibitor SureCN13591524 family 1 2
Mitogen-activated protein kinase 14 inhibitor SureCN4822166 fa... 1 4
Mitogen-activated protein kinase 14 and Heat shock protein bet... 2 1
ATP-sensitive inward rectifier potassium channel 11 ligand N-[... 1 0
Gonadotropin-releasing hormone receptor ligand AG 045572 family 1 3
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 1
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 1 0
Gonadotropin-releasing hormone receptor ligand N-[[4-[(diamino... 6 4
Mitogen-activated protein kinase 14 inhibitor AGN-PC-00A4QT fa... 2 0
Sphingosine 1-phosphate receptor 4 ligand AGN-PC-079GSR family 11 7
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 2 1
Huntingtin and Ras-related protein Rab-9A inhibitor CHEMBL1971... 1 1
Mineralocorticoid receptor and Glucocorticoid receptor ligand ... 2 0
Sodium channel protein type 10 subunit alpha ligand 5-(4-chlor... 1 0
Acyl-CoA:cholesterol acyltransferase inhibitor SureCN8808982 f... 1 2
Ras-related protein Rab-9A and Niemann-Pick C1 protein inhibit... 1 4
Nuclear receptor ROR-gamma and Niemann-Pick C1 protein ligand ... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00271785 CHEMBL2205361 Bioactive 3-methyl-N-phenyl-N-(3-piperidin-1-ylpropyl)-1-benzofuran-2-carboxamide
CFAMM00271863 CHEMBL2386607 Bioactive N-[4-[4-(2-methoxyphenyl)-1,4-diazepan-1-yl]butyl]-1-benzofuran-2-carboxamide
CFAMM00271850 DNC008699 Investigative Drug benzofuran-2-yl(indolin-1-yl)methanone

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27526 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543