CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2609
Family Name Macrophage migration inhibitory factor Inhibitor 2-(4-hydroxystyryl)quinolin-8-ol Family
No. of Seeds 8 No. of Other Members 19
Family Centroid CFAMM00271932 Functional Category Investigative Drug with Human Metabolite & Natural Product
Superfamily Oestrogen receptor and Estrogen receptor beta Binder Superfamily 2
Class Class 1996

Cousin Family NamesSeedsMembers
Cyclooxygenase Inhibitor Acetaminophen Family 2 42
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 6 40
Oestrogen receptor and Estrogen receptor beta Ligand 2-(4-hydr... 10 17
D(2) dopamine receptor Ligand 2,3-dihydro-1h-indol-5-ol Family 1 4
High affinity nerve growth factor receptor and RAF proto-oncog... 3 29
Oestrogen receptor and Estrogen receptor beta Ligand 4-bromo-2... 3 0
Epidermal growth factor receptor Ligand 4-acrylamido-n-(3-brom... 2 20
Transient receptor potential cation channel subfamily V member... 2 29
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-(... 7 18
Indoleamine 2,3-dioxygenase 1 Inhibitor 4-(ethylamino)naphthal... 10 13
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 3
Glutamate receptor ionotropic, NMDA 2A and Glutamate receptor ... 3 8
Glutamate receptor ionotropic, NMDA 2A and Glutamate receptor ... 6 13
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 5 3
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 4 2
Carbonic anhydrase 12 and Carbonic anhydrase 2 inhibitor (E)-2... 5 6
Amyloid beta A4 protein inhibitor SureCN6372684 family 2 7
Carbonic anhydrase 1 and Carbonic anhydrase 2 inhibitor [4-[(4... 2 0
C-X-C chemokine receptor type 2 ligand 4-[(2-anilino-3,4-dioxo... 1 2
Vascular endothelial growth factor receptor 3 and Vascular end... 1 0
Carbonic anhydrase 9 and Carbonic anhydrase 12 inhibitor (E)-2... 2 1
Kinesin-like protein KIF11 inhibitor 3-benzyl-2-(3-hydroxyphen... 2 1
G-protein coupled receptor 55 and Cannabinoid receptor 1 ligan... 1 1
Glycogen synthase kinase-3 beta and Glycogen synthase kinase-3... 5 0
MAP kinase-activated protein kinase 2 and Lethal factor inhibi... 1 0
NS3 inhibitor AGN-PC-074L2C family 1 3
Amino Acids and Derivatives Metabolite 5-Hydroxy-N-formylkynur... 3 3
Phenols and Derivatives Metabolite Methyl 2,3-dihydro-3,5-dihy... 1 1


External ID

Functional Category

Molecule Name

CFAMM00271918 CHEMBL2336362 Bioactive (E)-3-(3-hydroxyphenyl)-N-phenylprop-2-enamide
CFAMM00271939 CHEMBL421295 Bioactive (E)-3-(3,4-dihydroxyphenyl)-N-(2-hydroxyphenyl)prop-2-enamide
CFAMM00271938 CHEMBL2336783 Bioactive (E)-3-(3-hydroxyphenyl)-N-(2-methylphenyl)prop-2-enamide
CFAMM00271937 CHEMBL2336785 Bioactive (E)-3-(3-hydroxyphenyl)-N-(4-methylphenyl)prop-2-enamide
CFAMM00271936 CHEMBL2336338 Bioactive (E)-N-(2-hydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-enamide
CFAMM00271928 CHEMBL2336353 Bioactive (E)-N-(2-hydroxyphenyl)-3-phenylprop-2-enamide
CFAMM00271919 CHEMBL2336365 Bioactive (E)-N-(2-hydroxyphenyl)-3-(3-hydroxyphenyl)prop-2-enamide
CFAMM00271932 DNC008703 Investigative Drug 2-(4-hydroxystyryl)quinolin-8-ol

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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