CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2620
Family Name 5-hydroxytryptamine receptor 2A Ligand 3-methoxy-9-aminomethyl-9,10-dihydroanthracene Family
No. of Seeds 7 No. of Other Members 14
Family Centroid CFAMM00272089 Functional Category Investigative Drug
Superfamily Melatonin receptor type 1A Ligand Agomelatine Superfamily
Class Class 966

Cousin Family NamesSeedsMembers
D(2) dopamine receptor ligand catecholamine Dopamine family 9 170
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 5 209
Noradrenergic re-uptake and Serotonin re-uptake inhibitor bicy... 6 375
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 61 433
Beta adrenergic receptor ligand naphthol derivative Propranolo... 11 218
Oestrogen receptor Ligand triphenyl ethylene stilbene derivati... 22 420
Histamine H1 receptor Ligand Doxepin Family 8 89
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Opioid receptor ligand opiate Levorphanol Family 18 537
Alpha-1 adrenergic receptor ligand Dextroamphetamine derivativ... 5 29
Sigma non-opioid intracellular receptor 1 ligand opiate Dextro... 9 33
Muscarinic acetylcholine receptor M3 Ligand Tolterodine Family 8 171
Alpha adrenergic receptor Ligand Phenoxybenzamine Family 4 63
Sodium channel protein type 5 subunit alpha Ligand Mexiletine ... 7 74
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Prostaglandin G/H synthase 2 Inhibitor Nabumetone Family 4 267
Synaptic vesicular amine transporter Inhibitor Tetrabenazine F... 13 425
Alpha-1B adrenergic receptor ligand Phenylephrine analog Metho... 9 56
Oestrogen receptor Ligand Chlorotrianisene Family 2 102
Oestrogen receptor Ligand Mestranol Family 2 29
Kappa-type opioid receptor Ligand Dezocine Family 36 46
Oestrogen receptor Ligand Lasofoxifene Family 19 152
Eptazocine Hbr family 6 8
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
Substance-P receptor Ligand DA-5018 Family 14 73
Translocator protein Inhibitor Dextofisopam Family 3 250
Substance-P receptor Ligand Ezlopitant Family 10 207
D(3) dopamine receptor Ligand U-99194A Family 7 33
Dapoxetine family 3 40
5-hydroxytryptamine receptor 2A and Sodium-dependent serotonin... 2 5
5-hydroxytryptamine receptor 1A Ligand (s)-uh-301 Family 35 20
Squalene synthase Inhibitor (z)-3-[2-(9h-fluoren-2-yloxy)ethyl... 12 92
D(2) dopamine receptor and D(1A) dopamine receptor Ligand A-70... 16 27
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
M-phase inducer phosphatase 1 Inhibitor Naphthoquinone Analogs... 11 56
Extracellular calcium-sensing receptor Ligand Nps 568 Family 5 54
Neuropeptide Y receptor type 5 Ligand NPY-5 Receptor Antagonis... 1 1
Tumor necrosis factor Inhibitor Y-39041 Family 9 51
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Histamine H3 receptor Ligand A-331440 Family 6 7
Histamine H3 receptor Ligand UCL-2138 Family 23 172
5-hydroxytryptamine receptor 2A Ligand Phenethylamine Family 3 25
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 11
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 24
Glucocorticoid receptor Ligand 1-methoxy-6-phenyl-6h-benzo[c]c... 2 22
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 131
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 7 22
Oestrogen receptor and Estrogen receptor beta Ligand 6-(4-hydr... 30 63
Abelson tyrosine-protein kinase 2 Inhibitor 3'',5''-dimethoxy-... 3 9
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 5 13
Adenosine receptor A3 and Muscarinic acetylcholine receptor M2... 4 31
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 2 214
NAD(P)H dehydrogenase [quinone] 1 Inhibitor NSC-106547 Family 3 65
Histamine H3 receptor and Sodium-dependent serotonin transport... 25 28
Histamine H3 receptor Ligand (r)-1-(2-methoxyphenethyl)-2-meth... 10 27
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 33
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 4 37
Fatty-acid amide hydrolase 1 Inhibitor 3'-carbamoylbiphenyl-3-... 8 50
Androgen receptor Ligand 4-(m-tolyloxy)-2-(trifluoromethyl)ben... 7 65
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 11
Fatty-acid amide hydrolase 1 Inhibitor N-butylcarbamic Acid Bi... 9 31
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 2
Sodium-dependent noradrenaline transporter Inhibitor WAY-25680... 4 6
5-hydroxytryptamine receptor 2A and D(1A) dopamine receptor Li... 8 33
Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 13
5-hydroxytryptamine receptor 7 Ligand (r)-8-phenyl-n,n-dipropy... 9 14
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 10 15
Renin Inhibitor Ro-65-7219 Family 10 8
5-hydroxytryptamine receptor 1A Ligand 9-methoxy-1,2,3,4-tetra... 7 10
5-hydroxytryptamine receptor 2A Ligand C-(9h-xanthen-9-yl)-met... 3 5
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 2 3
D(1A) dopamine receptor Ligand SCH-12679 Family 1 0
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 1 2
5-hydroxytryptamine receptor 2A Ligand (s)-(-)-(4,5,6-trimetho... 3 1
Prostaglandin G/H synthase 1 Inhibitor 2-(2-methoxyphenyl)-1h-... 1 11
5-hydroxytryptamine receptor 2A Ligand 1-(2,6-dimethoxy-4-meth... 14 3
Fatty-acid amide hydrolase 1 Inhibitor 8-phenyloctylcarbamic A... 12 1
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 7 0
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 2 1
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 2 1
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 6 19
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 1 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 6 5
Sodium-dependent serotonin transporter and Transporter inhibit... 1 0
Sigma non-opioid intracellular receptor 1 ligand 1-[4-(4-metho... 1 0
Melatonin receptor type 1A ligand [7-methoxy-1-[2-(propanoylam... 3 0
D(2) dopamine receptor and D(1A) dopamine receptor ligand (2R,... 3 2
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 1
Sodium-dependent serotonin transporter and Sodium-dependent no... 1 0
D(3) dopamine receptor ligand S 14297 family 1 2
Substance-P receptor ligand AGN-PC-02K8FR family 1 3
5-hydroxytryptamine receptor 1A ligand [(1S,2R)-8-methoxy-2-(p... 4 0
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 11 2
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 4 2
Histamine H3 receptor and Sodium-dependent serotonin transport... 15 1
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 28
Histamine H3 receptor ligand SureCN6071181 family 2 1
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 2 0
Kinesin-like protein KIF11 inhibitor 2-amino-5-(4-methoxypheny... 1 4
Histamine H3 receptor and Sodium-dependent serotonin transport... 6 1
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 2 4
Sodium-dependent serotonin transporter and Histamine H3 recept... 7 0
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 2 11
Transporter and Sodium-dependent serotonin transporter inhibit... 1 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 6
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 5 5
Motilin receptor and Growth hormone secretagogue receptor type... 1 2
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 2 2
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 1 0
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 4 3
Steroidogenic factor 1 and Nuclear receptor subfamily 5 group ... 1 1
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-006SR... 1 2
Trace amine-associated receptor 1 ligand SureCN13886619 family 1 1
Trace amine-associated receptor 1 ligand 4-[4-(2-AMINO-ETHYL)-... 1 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 0
Putative NP ZINC01322649 Family 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00272088 DNC008732 Investigative Drug 2-methoxy-9-aminomethyl-9,10-dihydroanthracene
CFAMM00272102 DNC014043 Investigative Drug (6-Benzyloxy-2-naphthyl)-2-aminopropane
CFAMM00272087 DNC008734 Investigative Drug 4-methoxy-9-aminomethyl-9,10-dihydroanthracene
CFAMM00272101 DNC014041 Investigative Drug (6-Propoxy-2-naphthyl)-2-aminopropane
CFAMM00272090 DNC008731 Investigative Drug 1-methoxy-9-aminomethyl-9,10-dihydroanthracene
CFAMM00272089 DNC008733 Investigative Drug 3-methoxy-9-aminomethyl-9,10-dihydroanthracene
CFAMM00272103 DNC014042 Investigative Drug (6-Butoxy-2-naphthyl)-2-aminopropane

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27043 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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