CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2623
Family Name Kappa-type opioid receptor and Mu-type opioid receptor Ligand Ketocyclazocine Family
No. of Seeds 18 No. of Other Members 13
Family Centroid CFAMM00272115 Functional Category Investigative Drug
Superfamily ALKS33 Superfamily
Class Class 30

Cousin Family NamesSeedsMembers
Opioid receptor ligand opiate Levorphanol Family 18 537
Sigma non-opioid intracellular receptor 1 ligand opiate Dextro... 9 33
D(1B) dopamine receptor Ligand Apomorphine Family 30 271
Muscarinic acetylcholine receptor M3 Ligand Tolterodine Family 8 171
Sodium channel protein type 5 subunit alpha Ligand Dyclonine F... 6 174
Acetylcholinesterase Inhibitor Donepezil Family 23 242
Kappa-type opioid receptor Ligand Dezocine Family 36 46
Mu-type opioid receptor Ligand Alvimopan Family 32 325
Eptazocine Hbr family 6 8
Noradrenergic re-uptake and Opioid receptor Ligand Tapentadol ... 21 79
5-hydroxytryptamine receptor 1A Ligand (s)-uh-301 Family 35 20
Delta-type opioid receptor Ligand Bw 373u86 Family 31 146
5-hydroxytryptamine receptor 1A Ligand Robalzotan Family 9 41
Delta-type opioid receptor Ligand Tonazocine Mesylate Family 1 0
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 8 66
Histamine H3 receptor Ligand A-349821 Family 49 228
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 18 25
Estradiol 17-beta-dehydrogenase 1 Inhibitor N-ethyl Estrone-16... 3 5
Caspase-3 Inhibitor 2-(4-methoxy-benzyl)isoquinoline-1,3,4-tri... 2 2
Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16
5-hydroxytryptamine receptor 2A and D(1A) dopamine receptor Li... 8 33
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-237... 21 56
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 44 3
Mu-type opioid receptor Ligand Cyprodime Family 12 8
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 5 11
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 24 73
Kappa-type opioid receptor Ligand Morphinan Cyclic Imine Analo... 3 1
Sigma non-opioid intracellular receptor 1 ligand AGN-PC-074TF5... 1 0
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 12
Sigma non-opioid intracellular receptor 1 ligand AGN-PC-074TFC... 2 7
Sigma non-opioid intracellular receptor 1 and Mu-type opioid r... 7 5
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 2 8
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 4 0
5-hydroxytryptamine receptor 1A ligand SureCN7763400 family 4 9
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 8 2
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 2 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 1 0
Neuronal acetylcholine receptor subunit alpha-7 ligand 2,7-bis... 3 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 4 0
Histamine H3 receptor and Cytochrome P450 2D6 ligand ethyl 4-[... 5 5
Histamine H3 receptor ligand 2-(3,3-difluoropyrrolidin-1-yl)-1... 2 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 6 2
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 1
Kappa-type opioid receptor ligand CHEMBL2367762 family 2 0
Sodium-dependent serotonin transporter and Sodium-dependent do... 1 1
Sodium-dependent dopamine transporter and Sodium-dependent ser... 3 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 3 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 1 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 0
Multidrug resistance protein 1 inhibitor 1-[4-[(2R)-2-hydroxy-... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00272120 CHEMBL48390 Bioactive SureCN5622604
CFAMM00272126 CHEMBL2338715 Bioactive CHEMBL2338715
CFAMM00272119 CHEMBL278086 Bioactive ETHYLKETAZOCINE
CFAMM00272125 CHEMBL71301 Bioactive AC1L28LJ
CFAMM00272118 CHEMBL279968 Bioactive ETHYLKETOCYCLAZOCINE
CFAMM00272130 CHEMBL295237 Bioactive SureCN5621345
CFAMM00272129 CHEMBL1202427 Bioactive CHEMBL1202427
CFAMM00272122 CHEMBL301804 Bioactive CHEMBL301804
CFAMM00272115 DNC008750 Investigative Drug KETOCYCLAZOCINE

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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