CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2630
Family Name Androgen receptor Ligand 4-(m-tolyloxy)-2-(trifluoromethyl)benzonitrile Family
No. of Seeds 7 No. of Other Members 65
Family Centroid CFAMM00272312 Functional Category Investigative Drug
Superfamily Androgen receptor Binder Superfamily
Class Class 2514

Cousin Family NamesSeedsMembers
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 5 209
Oestrogen receptor Ligand triphenyl ethylene stilbene derivati... 22 420
Histamine H1 receptor Ligand Doxepin Family 8 89
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Sodium channel protein type 5 subunit alpha Ligand Mexiletine ... 7 74
Prostaglandin G/H synthase 2 Inhibitor Nabumetone Family 4 267
Alpha-1B adrenergic receptor ligand Phenylephrine analog Metho... 9 56
Oestrogen receptor Ligand Chlorotrianisene Family 2 102
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
Translocator protein Inhibitor Dextofisopam Family 3 250
Multidrug resistance protein Inhibitor Curcumin I Family 19 278
Histamine H3 receptor Ligand A-331440 Family 6 7
Histamine H3 receptor Ligand UCL-2138 Family 23 172
Cytosolic phospholipase A2 Inhibitor 1,1,1-trifluoro-6-(4-hexy... 9 86
Oestrogen receptor and Estrogen receptor beta Ligand 6-(4-hydr... 30 63
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 2 214
NAD(P)H dehydrogenase [quinone] 1 Inhibitor NSC-106547 Family 3 65
Kinesin-like protein KIF11 Inhibitor 4'-(trifluoromethyl)-4-bi... 1 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 4-(1,... 3 31
Thyroid hormone receptor beta Ligand 2-hexylphenyl Acrylate Fa... 4 83
Prostaglandin D2 receptor 2 Ligand 2-(4-cyano-2-cyclohexylphen... 6 3
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 4 37
5-hydroxytryptamine receptor 2A Ligand 3-methoxy-9-aminomethyl... 7 14
Androgen receptor Ligand 2-methoxy-4-(o-tolyloxy)benzonitrile ... 5 12
Androgen receptor Ligand 3-chloro-4-(o-tolyloxy)benzonitrile F... 2 8
Androgen receptor Ligand 3-methoxy-4-(m-tolyloxy)benzonitrile ... 3 29
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 2 12
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 2
Androgen receptor Ligand 2'-hydroxy-3-methoxy-biphenyl-4-carbo... 2 13
Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
Amine oxidase [flavin-containing] B Inhibitor 7-fluoro-2-p-tol... 4 11
Prostaglandin G/H synthase 1 Inhibitor 2-(2-methoxyphenyl)-1h-... 1 11
Amine oxidase [flavin-containing] B inhibitor Phthalonitrile a... 1 6
Luciferin 4-monooxygenase inhibitor (5R)-5-benzyl-3-(4-methoxy... 5 9
Androgen receptor and Progesterone receptor ligand diarylpheno... 1 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand (6aR,... 1 3
Steroidogenic factor 1 and Nuclear receptor subfamily 5 group ... 1 1
Histamine H3 receptor ligand (NE)-N-[2-[2-(dimethylamino)ethox... 3 2
Androgen receptor ligand AGN-PC-00BPQ5 family 1 3
ahydropyrano[3,2-c]chromene NP ZINC04023039 Family 16 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00272263 CHEMBL235159 Bioactive AGN-PC-076BEN
CFAMM00272277 CHEMBL2204753 Bioactive 1,2-Benzenedicarbonitrile, 4-(phenylmethoxy)-
CFAMM00272293 CHEMBL471644 Bioactive AGN-PC-06P0XI
CFAMM00272312 DNC008776 Investigative Drug 4-(m-tolyloxy)-2-(trifluoromethyl)benzonitrile
CFAMM00272305 DNC009106 Investigative Drug 4-(mesityloxy)-2-(trifluoromethyl)benzonitrile
CFAMM00272316 DNC008779 Investigative Drug 4-(p-tolyloxy)-2-(trifluoromethyl)benzonitrile
CFAMM00272313 DNC008774 Investigative Drug 4-(o-tolyloxy)-2-(trifluoromethyl)benzonitrile

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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