CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2640
Family Name Nitric oxide synthase, inducible and Nitric oxide synthase, brain Inhibitor 4-methyl-6-propylpyridin-2-amine Family
No. of Seeds 9 No. of Other Members 24
Family Centroid CFAMM00272560 Functional Category Investigative Drug
Superfamily Adenosine receptor A1 and Adenosine receptor A2a Binder Superfamily 5
Class Class 1373

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 2C ligand Tetracyclic antidepress... 14 498
Nicotinic acetylcholine receptor Ligand Nicotine Family 14 686
Acetylcholinesterase Inhibitor Tacrine Family 12 515
Amiloride-sensitive sodium channel subunit alpha Ligand Triamt... 8 98
Peptide deformylase, mitochondrial Inhibitor Pyrimethamine Family 10 145
Histamine H1 receptor Ligand Triprolidine Family 19 316
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor Ethion... 5 68
Mitogen-activated protein kinase 12 Inhibitor VX-702 Family 3 49
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Carbonic anhydrase 2 Inhibitor Cyanamide Family 2 32
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 32
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
cGMP-inhibited 3',5'-cyclic phosphodiesterase A Inhibitor 1,3-... 7 2
Scytalone dehydratase Inhibitor Isoquinolin-1-yl-(3-phenyl-pro... 4 9
Histamine H3 receptor Ligand 2-(4-isopropyl-piperazin-1-yl)-qu... 17 29
Adenosine receptor A1 and Adenosine receptor A2a Ligand 3-benz... 1 6
Metabotropic glutamate receptor 5 Ligand 2-methyl-6-(4-phenylb... 6 32
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 13 26
Cyclin-dependent kinase 2 and Mitogen-activated protein kinase... 7 30
Metabotropic glutamate receptor 5 Ligand 3-cyano-n-(6-methylpy... 4 3
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-amin... 2 30
Cathepsin K Inhibitor 2-cyclohexylamino-pyridine-2-carbonitril... 1 2
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2,6... 22 18
Cathepsin K Inhibitor 4-phenyl-6-propylpyrimidine-2-carbonitri... 6 10
Adenosine receptor A1 and Adenosine receptor A2a Ligand 4-amin... 4 11
Oestrogen receptor Ligand 4-benzyl-2,6-diisobutylamino-pyrimid... 5 37
Histamine H4 receptor Ligand A-943931 Family 14 11
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Cathepsin S Inhibitor 6-(3-(trifluoromethyl)phenyl)picolinonit... 7 2
Sodium-dependent serotonin transporter Inhibitor 6-nitroquipaz... 18 21
Sodium-dependent serotonin transporter Inhibitor 6-chloro-2-pi... 5 35
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Reverse transcriptase Inhibitor PT-109 Family 6 7
Metabotropic glutamate receptor 5 Ligand 2-methyl-7-m-tolyl-1,... 5 2
Amine oxidase [flavin-containing] A Inhibitor 3-benzyl-n-(2-mo... 2 3
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 1 0
Metabotropic glutamate receptor 5 Ligand 5-((6-methylpyridin-2... 14 22
Acetylcholinesterase Inhibitor N-benzyl-2-morpholinopyrimidin-... 6 16
S-adenosylmethionine decarboxylase proenzyme inhibitor 6-[(E)-... 2 6
Bloom syndrome protein inhibitor SR 57227A family 2 12
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 3 3
Histamine H4 receptor ligand 4-[(3R)-3-(methylamino)pyrrolidin... 7 6
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 1
Acetylcholinesterase and Cholinesterase inhibitor 2-amino-6-[3... 1 4
Histamine H4 receptor and Histamine H3 receptor ligand 7-cyclo... 2 0
Bifunctional epoxide hydrolase 2 and Cytochrome P450 2C9 inhib... 3 0
Nitric oxide synthase, inducible inhibitor SureCN2258300 family 2 24
Androgen receptor ligand AGN-PC-009ZOP family 3 3
Nitric oxide synthase, brain and Nitric oxide synthase, induci... 2 0
Nitric oxide synthase, brain and Nitric oxide synthase, endoth... 1 0
Microtubule-associated protein tau and Thyrotropin receptor li... 1 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00272551 CHEMBL110888 Bioactive 6-N,6-N-dipropyl-5,6,7,8-tetrahydroquinoline-2,6-diamine
CFAMM00272544 DNC009149 Investigative Drug 4-Methyl-6-(2-methylprop-1-enyl)pyridin-2-amine
CFAMM00272543 DNC009148 Investigative Drug 6-(2-Fluoropropyl)-4-methylpyridin-2-amine
CFAMM00272550 DNC009152 Investigative Drug 6-(3-Fluoropropyl)-4-methylpyridin-2-amine
CFAMM00272534 DNC009153 Investigative Drug 6-(4-Fluorobutyl)-4-methylpyridin-2-amine
CFAMM00272533 DNC009150 Investigative Drug (E)-4-Methyl-6-(prop-1-enyl)pyridin-2-amine
CFAMM00272548 DNC008850 Investigative Drug 2-amino-4,6-dimethylpyridine
CFAMM00272560 DNC011161 Investigative Drug 4-methyl-6-propylpyridin-2-amine
CFAMM00272539 DNC009147 Investigative Drug 6-isobutyl-4-methylpyridin-2-amine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

25240 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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