CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2660
Family Name Oestrogen receptor Ligand 4-benzyl-2,6-diisobutylamino-pyrimidine Family
No. of Seeds 5 No. of Other Members 37
Family Centroid CFAMM00273358 Functional Category Investigative Drug
Superfamily Adenosine receptor A1 and Adenosine receptor A2a Binder Superfamily 5
Class Class 1373

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 2C ligand Tetracyclic antidepress... 14 498
Alpha-2 adrenergic receptor Ligand Dexmedetomidine Family 32 639
Omega 1 Benzodiazepine receptor Ligand Zaleplon Family 6 589
Toll-like receptor 7 Ligand Imiquimod Family 3 237
Amiloride-sensitive sodium channel subunit alpha Ligand Triamt... 8 98
Peptide deformylase, mitochondrial Inhibitor Pyrimethamine Family 10 145
Histamine H1 receptor Ligand Mizolastine Family 14 603
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Transient receptor potential cation channel subfamily V member... 16 295
Neuropeptide Y receptor type 5 Ligand CGP71683A Family 5 74
Transient receptor potential cation channel subfamily V member... 15 457
Cyclin-dependent kinase 2 Inhibitor Seliciclib Family 29 292
Fibroblast growth factor receptor 2 and Fibroblast growth fact... 11 86
Cyclin-dependent kinase 4 Inhibitor PD-332991 Family 13 155
Reverse transcriptase Inhibitor Dapivirine Family 5 72
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
GDC-0349 family 44 77
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 8 55
Corticotropin-releasing factor receptor 1 Ligand CP-154526 Family 9 29
Tryptase Inhibitor Babim Family 12 90
B1 bradykinin receptor Ligand Des-arg(9)-[leu(8)]-bk Family 6 9
D(4) dopamine receptor Ligand L-745,870 Family 30 205
5-hydroxytryptamine receptor 2B Ligand MT-500 Family 8 39
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Epidermal growth factor receptor and Receptor tyrosine-protein... 11 138
Peptide deformylase, mitochondrial Inhibitor 5-chloryl-2,4,6-q... 2 6
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2,6-di... 13 14
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 32
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Vascular endothelial growth factor receptor 1 and Vascular end... 6 23
Peptide deformylase, mitochondrial Inhibitor 5-phenethyl-quina... 5 14
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Epidermal growth factor receptor Ligand N*4*-(3-bromo-phenyl)-... 7 11
Cyclin-dependent kinase 4 Inhibitor 1-pyridin-2-yl-3-quinolin-... 2 5
Scytalone dehydratase Inhibitor Isoquinolin-1-yl-(3-phenyl-pro... 4 9
Epidermal growth factor receptor Ligand Benzo[g]quinazolin-4-y... 5 3
Epidermal growth factor receptor Ligand (3-bromo-phenyl)-quina... 7 5
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
Adenosine receptor A1 Ligand Phenyl-(9-phenyl-9h-purin-6-yl)-a... 7 12
Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... 8 5
Histamine H3 receptor Ligand 2-(4-isopropyl-piperazin-1-yl)-qu... 17 29
Epidermal growth factor receptor Ligand N4-(3-chlorophenyl)qui... 7 39
RAC-gamma serine/threonine-protein kinase and Rho-associated p... 16 46
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 4 30
Metabotropic glutamate receptor 5 Ligand 2-m-tolyl-1,8-naphthy... 7 11
Adenosine receptor A1 and Adenosine receptor A2a Ligand 3-benz... 1 6
DNA-dependent protein kinase catalytic subunit Inhibitor 2-mor... 2 6
D(2) dopamine receptor and D(3) dopamine receptor Ligand A-706... 4 20
Cyclin-dependent kinase 2 and Mitogen-activated protein kinase... 7 30
Adenosine receptor A3 Ligand 1-(2-(diethylamino)quinazolin-4-y... 2 9
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 3 9
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-amin... 2 30
Cathepsin K Inhibitor 2-cyclohexylamino-pyridine-2-carbonitril... 1 2
Adenosine receptor A1 Ligand N-(4,6-diphenylpyrimidin-2-yl)ben... 4 8
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2,6... 22 18
Cathepsin K Inhibitor 4-phenyl-6-propylpyrimidine-2-carbonitri... 6 10
Adenosine receptor A1 and Adenosine receptor A2a Ligand 4-amin... 4 11
Fatty-acid amide hydrolase 1 Inhibitor JNJ-1661010 Family 3 14
Macrophage migration inhibitory factor Inhibitor 4-iodo-6-phen... 5 4
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 9 24
Histamine H4 receptor Ligand A-943931 Family 14 11
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Prostaglandin G/H synthase 2 Inhibitor GW-637185X Family 27 48
Protein kinase C theta type Inhibitor 4-(3h-indol-4-ylamino)-5... 2 2
Urotensin-2 receptor Ligand Palosuran Family 4 4
Sodium-dependent serotonin transporter Inhibitor 6-nitroquipaz... 18 21
Proto-oncogene tyrosine-protein kinase Src Inhibitor CGP-62464... 3 10
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 4 22
Peptide deformylase, mitochondrial Inhibitor 7h-pyrrolo[3,2-f]... 2 10
Sodium-dependent serotonin transporter Inhibitor 6-chloro-2-pi... 5 35
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Metabotropic glutamate receptor 5 Ligand 2-methyl-7-m-tolyl-1,... 5 2
Amine oxidase [flavin-containing] A Inhibitor 3-benzyl-n-(2-mo... 2 3
Amine oxidase [flavin-containing] A Inhibitor 1-(3-(4-chlorobe... 3 12
Metabotropic glutamate receptor 5 Ligand 5-(2-m-tolylethynyl)p... 7 49
Metabotropic glutamate receptor 5 Ligand 5-(2-(3-chlorophenyl)... 2 13
Acetylcholinesterase Inhibitor N-benzyl-2-morpholinopyrimidin-... 6 16
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 10 7
Corticotropin-releasing factor receptor 1 ligand 4-N-(2-bromo-... 9 48
Corticotropin-releasing factor receptor 1 ligand N-(2-bromo-4-... 5 0
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 8
Corticotropin-releasing factor receptor 1 ligand 3-(2-bromo-4-... 13 34
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 6
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-07ZB89 family 6 13
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 9
Adenosine kinase inhibitor 5-(4-chlorophenyl)-6-[2-(6-morpholi... 8 8
Neuronal acetylcholine receptor subunit alpha-7 ligand 2-(4-cy... 1 0
Polycystin-2 and Serine/threonine-protein kinase D1 inhibitor ... 4 12
Cathepsin K and Potassium voltage-gated channel subfamily H me... 4 7
Bloom syndrome protein inhibitor SR 57227A family 2 12
Cathepsin K and Potassium voltage-gated channel subfamily H me... 3 1
Cathepsin K and Potassium voltage-gated channel subfamily H me... 5 1
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 3 11
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 8
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 2
Histamine H4 receptor ligand 2-[[6-iodo-2-(4-methylpiperazin-1... 4 2
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 5 0
Dihydrofolate reductase inhibitor AC1LAKQL family 3 1
D(4) dopamine receptor and D(2) dopamine receptor ligand N-(1-... 2 6
Survival motor neuron protein inhibitor CHEMBL1581561 family 1 3
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 5 0
Prostaglandin D2 receptor ligand N-[2-(2,4-dichlorophenyl)ethy... 1 0
Corticotropin-releasing factor receptor 1 ligand 2-[butyl-[4-[... 9 9
Corticotropin-releasing factor receptor 1 ligand 9-(2-bromo-4-... 15 3
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 3 3
Corticotropin-releasing factor receptor 1 ligand 9-(2-bromo-4-... 5 2
Toll-like receptor 7 ligand 6-amino-2-(butylamino)-9-[[4-(dime... 5 4
Histamine H4 receptor ligand 4-[(3R)-3-(methylamino)pyrrolidin... 7 6
Corticotropin-releasing factor receptor 1 ligand SureCN8181501... 4 2
Neuropeptide Y receptor type 5 ligand SureCN8898853 family 2 3
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 3 0
Corticotropin-releasing factor receptor 1 ligand AGN-PC-008HTV... 2 1
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A ... 1 1
Dipeptidyl peptidase 4 inhibitor Aminomethylpyrimidine 1ck family 6 3
Mitogen-activated protein kinase 14 inhibitor 4-(2-chloropheny... 4 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family 10 11
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 2 2
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 10 6
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 3 0
Transient receptor potential cation channel subfamily V member... 4 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 1
Growth hormone secretagogue receptor type 1 ligand AGN-PC-0760... 4 0
Translocator protein inhibitor N-butan-2-yl-4-(2-chlorophenyl)... 14 12
Acetylcholinesterase and Cholinesterase inhibitor 2-amino-6-[3... 1 4
Beta-secretase 1 and Potassium voltage-gated channel subfamily... 3 4
Dipeptidyl peptidase 4 inhibitor (4R,5R)-5-amino-1-[6-(3-methy... 2 5
Adenosine kinase inhibitor 5-(4-bromophenyl)-6-[2-[4-(dimethyl... 1 0
Adenosine kinase inhibitor 4-[2-[5-(4-chlorophenyl)-6-piperazi... 3 1
Cholinesterase inhibitor 4-[4,5-diphenyl-1-[7-(1,2,3,4-tetrahy... 2 1
Histamine H4 receptor and Histamine H3 receptor ligand 7-cyclo... 2 0
Bifunctional epoxide hydrolase 2 and Cytochrome P450 2C9 inhib... 8 6
Bifunctional epoxide hydrolase 2 and Cytochrome P450 2C9 inhib... 3 0
Nitric oxide synthase, inducible inhibitor SureCN2258300 family 2 24
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor AG... 3 1
Cathepsin K and Cathepsin S inhibitor SureCN4138353 family 3 0
Cathepsin K inhibitor 4-[2,2-dimethylpropyl-[[4-(1,2,4-triazol... 2 1
LIM domain kinase 2 inhibitor (2S)-N-cyano-N'-(3-cyanophenyl)-... 4 0
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 7 2
Cathepsin K and Cathepsin L1 inhibitor 5-[3-(3,4-dihydro-1H-is... 2 0
Cathepsin K inhibitor 4-[2,2-dimethylpropyl-[[4-[3-(4-piperidi... 2 0
Dihydrofolate reductase inhibitor 5-[4-[(3,4-dichlorophenyl)me... 1 0
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 3 0
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 1 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 7 0
Metabotropic glutamate receptor 1 ligand AGN-PC-00FV3S family 2 0
Nitric oxide synthase, brain and Nitric oxide synthase, induci... 2 0
Nitric oxide synthase, brain and Nitric oxide synthase, endoth... 1 0
Ribosomal protein S6 kinase beta-1 and Aurora kinase B inhibit... 1 5
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 1 0
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor AGN-P... 1 0
Dipeptidyl peptidase 4 and Potassium voltage-gated channel sub... 1 0
Histamine H4 receptor ligand 2-[[6-chloro-2-(4-methylpiperazin... 7 2
Dihydrofolate reductase inhibitor N-(2,4-diamino-5-methylquina... 2 0
D(4) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 2
Adenosine receptor A1 and Adenosine receptor A2a ligand 2-(2-c... 2 0
P2Y purinoceptor 14 inhibitor AGN-PC-0A9S8H family 3 2
Cytochrome P450 1A2 inhibitor AGN-PC-0BTGP4 family 1 0
Corticotropin-releasing factor receptor 1 ligand 5-N,5-N-bis(c... 2 0
Epidermal growth factor receptor and Receptor tyrosine-protein... 1 0
Coagulation factor X and Prothrombin inhibitor SureCN6578740 f... 1 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand 4-N-[... 16 21
ATP-binding cassette sub-family G member 2 and cGMP-specific 3... 2 0
Induced myeloid leukemia cell differentiation protein Mcl-1 an... 1 0
Sigma non-opioid intracellular receptor 1 and Alpha-1B adrener... 1 4


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00273354 DNC014574 Investigative Drug N*4*-Benzyl-6-chloro-pyrimidine-2,4-diamine
CFAMM00273347 DNC010259 Investigative Drug GNF-PF-2094
CFAMM00273358 DNC008932 Investigative Drug 4-benzyl-2,6-diisobutylamino-pyrimidine
CFAMM00273357 DNC008935 Investigative Drug 2,4-Dibenzylamino-6-isopentylpyrimidine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26197 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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