| Cousin Family Names | Seeds | Members |
|---|
| Voltage-dependent T-type calcium channel subunit alpha-1I liga... | 5 | 209 |
| Noradrenergic re-uptake and Serotonin re-uptake inhibitor bicy... | 6 | 375 |
| Melatonin receptor type 1A and Melatonin receptor type 1B liga... | 61 | 433 |
| Beta adrenergic receptor ligand naphthol derivative Propranolo... | 11 | 218 |
| Oestrogen receptor Ligand triphenyl ethylene stilbene derivati... | 22 | 420 |
| Histamine H1 receptor Ligand Doxepin Family | 8 | 89 |
| Serotonin re-uptake Inhibitor Fluoxetine Family | 18 | 682 |
| Alpha-1 adrenergic receptor ligand Dextroamphetamine derivativ... | 5 | 29 |
| Beta-2 adrenergic receptor ligand catecholamine Salbutamol Family | 10 | 90 |
| Beta-1 adrenergic receptor Ligand Esmolol Family | 5 | 39 |
| Beta-1 adrenergic receptor Ligand Metoprolol Family | 29 | 90 |
| Muscarinic acetylcholine receptor M3 Ligand Tolterodine Family | 8 | 171 |
| Alpha adrenergic receptor Ligand Phenoxybenzamine Family | 4 | 63 |
| Beta adrenergic receptor Ligand Metipranolol Family | 5 | 1 |
| Beta-1 adrenergic receptor Ligand Oxprenolol Family | 3 | 27 |
| Noradrenergic re-uptake and Serotonin re-uptake Inhibitor Dulo... | 8 | 6 |
| Sodium channel protein type 5 subunit alpha Ligand Mexiletine ... | 7 | 74 |
| Sodium channel protein type 5 subunit alpha Ligand Dyclonine F... | 6 | 174 |
| Noradrenergic re-uptake Inhibitor Reboxetine Family | 26 | 206 |
| Alpha-1B adrenergic receptor ligand Phenylephrine analog Metho... | 9 | 56 |
| Muscarinic acetylcholine receptor M1 Ligand Trihexyphenidyl Fa... | 14 | 199 |
| Alpha adrenergic receptor Ligand Bevantolol Family | 4 | 48 |
| Beta-1 adrenergic receptor Ligand Nebivolol Family | 5 | 22 |
| Muscarinic acetylcholine receptor Ligand Methantheline Family | 6 | 8 |
| Muscarinic acetylcholine receptor Ligand Flavoxate Family | 9 | 350 |
| 5-hydroxytryptamine receptor 2A Ligand Sarpogrelate Family | 2 | 15 |
| Oestrogen receptor Ligand Lasofoxifene Family | 19 | 152 |
| Nicotinic acetylcholine receptor Ligand Benztropine Mesylate F... | 10 | 20 |
| Noradrenergic re-uptake Inhibitor Desvenalfaxine Succinate Family | 2 | 4 |
| Eptazocine Hbr family | 6 | 8 |
| Noradrenergic re-uptake and Opioid receptor Ligand Tapentadol ... | 21 | 79 |
| Gadoxetate family | 1 | 3 |
| Serine/threonine-protein kinase PLK1 Inhibitor On 019190.na Fa... | 16 | 138 |
| Melatonin receptor type 1A Ligand Agomelatine Family | 12 | 164 |
| Sodium- and chloride-dependent glycine transporter 1 Inhibitor... | 6 | 33 |
| 5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... | 4 | 35 |
| Substance-P receptor Ligand Ezlopitant Family | 10 | 207 |
| 5-hydroxytryptamine receptor 1A Ligand MN-305 Family | 12 | 26 |
| D(3) dopamine receptor Ligand U-99194A Family | 7 | 33 |
| Acolbifene family | 10 | 115 |
| Dapoxetine family | 3 | 40 |
| 5-hydroxytryptamine receptor 2A and Sodium-dependent serotonin... | 2 | 5 |
| Squalene synthase Inhibitor (z)-3-[2-(9h-fluoren-2-yloxy)ethyl... | 12 | 92 |
| Arachidonate 5-lipoxygenase Inhibitor Bw A360C Family | 12 | 8 |
| Potassium voltage-gated channel subfamily H member 2 and Sodiu... | 33 | 83 |
| M-phase inducer phosphatase 1 Inhibitor Naphthoquinone Analogs... | 11 | 56 |
| Extracellular calcium-sensing receptor Ligand Nps 568 Family | 5 | 54 |
| Sodium- and chloride-dependent GABA transporter 3 Inhibitor SN... | 1 | 4 |
| Fibroblast growth factor receptor Ligand SU5403 Family | 8 | 8 |
| Tumor necrosis factor Inhibitor Y-39041 Family | 9 | 51 |
| Histamine H3 receptor Ligand A-331440 Family | 6 | 7 |
| Histamine H3 receptor Ligand UCL-2138 Family | 23 | 172 |
| Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... | 5 | 11 |
| 5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... | 25 | 50 |
| Adenosine receptor A3 and Mu-type opioid receptor Ligand GBR-1... | 80 | 110 |
| 5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... | 7 | 22 |
| Extracellular calcium-sensing receptor and Potassium voltage-g... | 3 | 11 |
| Adenosine receptor A3 and Muscarinic acetylcholine receptor M2... | 4 | 31 |
| Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... | 10 | 36 |
| Dipeptidyl peptidase 4 Inhibitor (2-chloro-6-phenoxyphenyl)met... | 17 | 24 |
| Sodium-dependent dopamine transporter and Sodium-dependent nor... | 9 | 16 |
| 5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... | 2 | 214 |
| Delta-type opioid receptor and Kappa-type opioid receptor Liga... | 5 | 41 |
| Histamine H3 receptor and Sodium-dependent serotonin transport... | 25 | 28 |
| Histamine H3 receptor Ligand (r)-1-(2-methoxyphenethyl)-2-meth... | 10 | 27 |
| Histamine H3 receptor Ligand 4-isopropyl-2-(phenoxymethyl)morp... | 4 | 10 |
| 5-hydroxytryptamine receptor 2A Ligand 3-methoxy-9-aminomethyl... | 7 | 14 |
| Fatty-acid amide hydrolase 1 Inhibitor N-butylcarbamic Acid Bi... | 9 | 31 |
| Sodium-dependent dopamine transporter and Sodium-dependent nor... | 6 | 2 |
| Histamine H3 receptor Ligand 1-(3-(2-(3-methoxyphenoxy)ethoxy)... | 3 | 9 |
| Sodium-dependent dopamine transporter and Sodium-dependent nor... | 2 | 6 |
| Sodium-dependent serotonin transporter Inhibitor 4-(2-((dimeth... | 3 | 1 |
| Sodium-dependent noradrenaline transporter Inhibitor WAY-25680... | 4 | 6 |
| 5-hydroxytryptamine receptor 2A and D(1A) dopamine receptor Li... | 8 | 33 |
| 5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... | 9 | 79 |
| Leukotriene A-4 hydrolase Inhibitor (r/s)-2-((4-phenoxyphenoxy... | 7 | 18 |
| Sodium-dependent dopamine transporter and Sodium-dependent nor... | 9 | 16 |
| Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... | 53 | 30 |
| Sodium-dependent dopamine transporter and Sodium-dependent nor... | 6 | 13 |
| 5-hydroxytryptamine receptor 7 Ligand (r)-8-phenyl-n,n-dipropy... | 9 | 14 |
| Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... | 10 | 15 |
| Renin Inhibitor Ro-65-7219 Family | 10 | 8 |
| 5-hydroxytryptamine receptor 1A Ligand 9-methoxy-1,2,3,4-tetra... | 7 | 10 |
| Delta-type opioid receptor and Kappa-type opioid receptor Liga... | 44 | 3 |
| 5-hydroxytryptamine receptor 2A Ligand C-(9h-xanthen-9-yl)-met... | 3 | 5 |
| Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... | 2 | 3 |
| Tyrosinase Inhibitor 1-(3-phenoxypropyl)-4-(piperidin-1-yl)pip... | 2 | 13 |
| 5-hydroxytryptamine receptor 2A Ligand 1-(2,6-dimethoxy-4-meth... | 14 | 3 |
| Fatty-acid amide hydrolase 1 Inhibitor 8-phenyloctylcarbamic A... | 12 | 1 |
| Sodium-dependent dopamine transporter Inhibitor Secocularidine... | 3 | 9 |
| Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... | 24 | 73 |
| Glutamate receptor ionotropic, NMDA 3A and Glutamate receptor ... | 2 | 1 |
| 5-hydroxytryptamine receptor 1A and Alpha-1D adrenergic recept... | 2 | 2 |
| 5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... | 6 | 5 |
| Sodium-dependent serotonin transporter and Sodium-dependent no... | 1 | 0 |
| Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... | 8 | 4 |
| Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... | 1 | 2 |
| Mu-type opioid receptor and Sigma non-opioid intracellular rec... | 10 | 20 |
| Leukotriene A-4 hydrolase inhibitor 3-[3-(4-benzylphenoxy)prop... | 2 | 0 |
| Sodium-dependent serotonin transporter and Transporter inhibit... | 1 | 0 |
| Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... | 2 | 8 |
| Sigma non-opioid intracellular receptor 1 ligand 1-[4-(4-metho... | 1 | 0 |
| D(4) dopamine receptor and D(3) dopamine receptor ligand N-[2-... | 6 | 15 |
| Squalene synthase inhibitor 3-[4-[[(E)-ethylideneamino]oxymeth... | 1 | 0 |
| Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... | 7 | 0 |
| Sodium-dependent serotonin transporter and Sodium-dependent no... | 2 | 1 |
| Sodium-dependent serotonin transporter and Sodium-dependent no... | 1 | 0 |
| Substance-P receptor ligand AGN-PC-02K8FR family | 1 | 3 |
| Sodium-dependent dopamine transporter and Sodium-dependent ser... | 6 | 0 |
| 5-hydroxytryptamine receptor 2A and Potassium voltage-gated ch... | 2 | 8 |
| Sodium-dependent dopamine transporter and Sodium-dependent ser... | 1 | 0 |
| 5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... | 7 | 4 |
| 5-hydroxytryptamine receptor 1A ligand [(1S,2R)-8-methoxy-2-(p... | 4 | 0 |
| D(2) dopamine receptor and D(1A) dopamine receptor ligand ISOM... | 2 | 5 |
| 5-hydroxytryptamine receptor 1A and Sodium-dependent noradrena... | 2 | 0 |
| Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... | 11 | 2 |
| Sodium-dependent serotonin transporter and Sodium-dependent no... | 6 | 21 |
| Nitric oxide synthase, inducible and Cytochrome P450 2D6 inhib... | 2 | 1 |
| Sigma non-opioid intracellular receptor 1 ligand methyl (1R,2S... | 4 | 0 |
| Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... | 1 | 0 |
| Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... | 12 | 0 |
| Estrogen receptor and Estrogen receptor beta ligand (2R,3R,4S)... | 3 | 0 |
| Histamine H3 receptor and Potassium voltage-gated channel subf... | 1 | 4 |
| Histamine H3 receptor ligand cyclohexyl-[4-(3-piperidin-1-ylpr... | 4 | 1 |
| Histamine H3 receptor and Sodium-dependent serotonin transport... | 15 | 1 |
| Histamine H3 receptor ligand SureCN5093910 family | 3 | 16 |
| Melatonin receptor type 1B and Melatonin receptor type 1A liga... | 1 | 28 |
| Histamine H3 receptor ligand 1-[[4-[4-[(1R)-4-(4-methoxyphenox... | 2 | 1 |
| Transporter and 5-hydroxytryptamine receptor 2C ligand CHEMBL1... | 5 | 5 |
| Histamine H3 receptor ligand 1'-cyclobutyl-6-(1-ethylsulfonylp... | 7 | 10 |
| D(4) dopamine receptor and D(2) dopamine receptor ligand 4-(4-... | 2 | 6 |
| 5-hydroxytryptamine receptor 1A ligand oxalic acid;(1R,5S)-5-[... | 2 | 0 |
| Histamine H3 receptor ligand 1-[4-(1'-cyclobutylspiro[3,4-dihy... | 4 | 0 |
| D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... | 1 | 0 |
| Muscarinic acetylcholine receptor M3 ligand AGN-PC-005QPZ family | 1 | 0 |
| Histamine H3 receptor ligand SureCN6071181 family | 2 | 1 |
| Histamine H3 receptor ligand AGN-PC-0765YW family | 1 | 4 |
| Histamine H3 receptor and Sodium-dependent serotonin transport... | 6 | 1 |
| 5-hydroxytryptamine receptor 7 and Alpha-2C adrenergic recepto... | 3 | 0 |
| Sodium-dependent noradrenaline transporter and Sodium-dependen... | 14 | 1 |
| Sodium-dependent serotonin transporter and Histamine H3 recept... | 7 | 0 |
| Sodium-dependent serotonin transporter and Histamine H3 recept... | 7 | 0 |
| Sigma non-opioid intracellular receptor 1 ligand (1S,4R,5R)-7-... | 2 | 7 |
| Histamine H3 receptor and Sodium-dependent serotonin transport... | 4 | 0 |
| Histamine H3 receptor and Sodium-dependent serotonin transport... | 3 | 6 |
| Histamine H3 receptor and Sodium-dependent serotonin transport... | 6 | 1 |
| D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... | 1 | 7 |
| Sigma non-opioid intracellular receptor 1 ligand 4-[[1-[(2-bro... | 2 | 0 |
| Substance-P receptor ligand (5S,10S)-5-(4-fluorophenyl)-10-(2-... | 3 | 2 |
| Sodium-dependent dopamine transporter and Sodium-dependent ser... | 2 | 6 |
| Histamine H3 receptor and Sodium-dependent serotonin transport... | 1 | 0 |
| Scytalone dehydratase inhibitor 2-cyano-N-[(1S,2R)-1-(2-cyanop... | 5 | 0 |
| Sodium-dependent noradrenaline transporter and Sodium-dependen... | 2 | 0 |
| Sodium-dependent noradrenaline transporter and Cytochrome P450... | 11 | 2 |
| Sodium-dependent serotonin transporter and 5-hydroxytryptamine... | 3 | 0 |
| Vesicular acetylcholine transporter inhibitor (2R,3R)-5-(3-flu... | 2 | 0 |
| Sigma non-opioid intracellular receptor 1 ligand SureCN7450653... | 1 | 0 |
| Bifunctional epoxide hydrolase 2 and Cytochrome P450 2C9 inhib... | 2 | 1 |
| Histamine H3 receptor and Histamine H1 receptor ligand AGN-PC-... | 1 | 0 |
| Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... | 2 | 2 |
| Muscleblind-like protein 1 and Ferritin light chain inhibitor ... | 1 | 1 |
| Sodium-dependent noradrenaline transporter and Sodium-dependen... | 4 | 2 |
| Sodium-dependent noradrenaline transporter and Sodium-dependen... | 1 | 1 |
| Trace amine-associated receptor 1 ligand SureCN13886619 family | 1 | 1 |
| Trace amine-associated receptor 1 ligand 4-[4-(2-AMINO-ETHYL)-... | 1 | 0 |
| Mu-type opioid receptor ligand 2-[[2-[(2R)-2-ethyl-4-(4-fluoro... | 1 | 3 |
| Histamine H3 receptor and Histamine H1 receptor ligand (NE)-N-... | 1 | 1 |
| Metabotropic glutamate receptor 2 ligand (5R)-3-[[4-(4-ethoxyp... | 3 | 9 |
| Putative NP ZINC04061066 Family | 18 | 0 |
| Putative NP ZINC04029215 Family | 6 | 0 |
| Putative NP ZINC04029538 Family | 3 | 0 |
| NP 1-(7-hydroxyspiro[chroman-2,4'-piperidin]-1'-yl)ethanone Fa... | 2 | 0 |
| Putative NP ZINC04026929 Family | 4 | 0 |
| Putative NP ZINC38201335 Family | 8 | 0 |
Statistics of CFAM Database |
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
|
How to cite our database |
|
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering.
Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
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Last update by |
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2014.08.29
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