CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2663
Family Name Delta-type opioid receptor and Kappa-type opioid receptor Ligand 4-(spiro[chromene-2,4'-piperidine]-4-yl)phenol Family
No. of Seeds 5 No. of Other Members 11
Family Centroid CFAMM00273487 Functional Category Investigative Drug
Superfamily Delta-type opioid receptor and Kappa-type opioid receptor Ligand 4-(spiro[chromene-2,4'-piperidine]-4-yl)phenol Superfamily
Class Class 2524

Cousin Family NamesSeedsMembers
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 5 209
Noradrenergic re-uptake and Serotonin re-uptake inhibitor bicy... 6 375
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 61 433
Beta adrenergic receptor ligand naphthol derivative Propranolo... 11 218
Oestrogen receptor Ligand triphenyl ethylene stilbene derivati... 22 420
Histamine H1 receptor Ligand Doxepin Family 8 89
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Alpha-1 adrenergic receptor ligand Dextroamphetamine derivativ... 5 29
Beta-2 adrenergic receptor ligand catecholamine Salbutamol Family 10 90
Beta-1 adrenergic receptor Ligand Esmolol Family 5 39
Beta-1 adrenergic receptor Ligand Metoprolol Family 29 90
Muscarinic acetylcholine receptor M3 Ligand Tolterodine Family 8 171
Alpha adrenergic receptor Ligand Phenoxybenzamine Family 4 63
Beta adrenergic receptor Ligand Metipranolol Family 5 1
Beta-1 adrenergic receptor Ligand Oxprenolol Family 3 27
Noradrenergic re-uptake and Serotonin re-uptake Inhibitor Dulo... 8 6
Sodium channel protein type 5 subunit alpha Ligand Mexiletine ... 7 74
Sodium channel protein type 5 subunit alpha Ligand Dyclonine F... 6 174
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Alpha-1B adrenergic receptor ligand Phenylephrine analog Metho... 9 56
Muscarinic acetylcholine receptor M1 Ligand Trihexyphenidyl Fa... 14 199
Alpha adrenergic receptor Ligand Bevantolol Family 4 48
Beta-1 adrenergic receptor Ligand Nebivolol Family 5 22
Muscarinic acetylcholine receptor Ligand Methantheline Family 6 8
Muscarinic acetylcholine receptor Ligand Flavoxate Family 9 350
5-hydroxytryptamine receptor 2A Ligand Sarpogrelate Family 2 15
Oestrogen receptor Ligand Lasofoxifene Family 19 152
Nicotinic acetylcholine receptor Ligand Benztropine Mesylate F... 10 20
Noradrenergic re-uptake Inhibitor Desvenalfaxine Succinate Family 2 4
Eptazocine Hbr family 6 8
Noradrenergic re-uptake and Opioid receptor Ligand Tapentadol ... 21 79
Gadoxetate family 1 3
Serine/threonine-protein kinase PLK1 Inhibitor On 019190.na Fa... 16 138
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 6 33
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 4 35
Substance-P receptor Ligand Ezlopitant Family 10 207
5-hydroxytryptamine receptor 1A Ligand MN-305 Family 12 26
D(3) dopamine receptor Ligand U-99194A Family 7 33
Acolbifene family 10 115
Dapoxetine family 3 40
5-hydroxytryptamine receptor 2A and Sodium-dependent serotonin... 2 5
Squalene synthase Inhibitor (z)-3-[2-(9h-fluoren-2-yloxy)ethyl... 12 92
Arachidonate 5-lipoxygenase Inhibitor Bw A360C Family 12 8
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
M-phase inducer phosphatase 1 Inhibitor Naphthoquinone Analogs... 11 56
Extracellular calcium-sensing receptor Ligand Nps 568 Family 5 54
Sodium- and chloride-dependent GABA transporter 3 Inhibitor SN... 1 4
Fibroblast growth factor receptor Ligand SU5403 Family 8 8
Tumor necrosis factor Inhibitor Y-39041 Family 9 51
Histamine H3 receptor Ligand A-331440 Family 6 7
Histamine H3 receptor Ligand UCL-2138 Family 23 172
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 11
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 25 50
Adenosine receptor A3 and Mu-type opioid receptor Ligand GBR-1... 80 110
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 7 22
Extracellular calcium-sensing receptor and Potassium voltage-g... 3 11
Adenosine receptor A3 and Muscarinic acetylcholine receptor M2... 4 31
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
Dipeptidyl peptidase 4 Inhibitor (2-chloro-6-phenoxyphenyl)met... 17 24
Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 2 214
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 41
Histamine H3 receptor and Sodium-dependent serotonin transport... 25 28
Histamine H3 receptor Ligand (r)-1-(2-methoxyphenethyl)-2-meth... 10 27
Histamine H3 receptor Ligand 4-isopropyl-2-(phenoxymethyl)morp... 4 10
5-hydroxytryptamine receptor 2A Ligand 3-methoxy-9-aminomethyl... 7 14
Fatty-acid amide hydrolase 1 Inhibitor N-butylcarbamic Acid Bi... 9 31
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 2
Histamine H3 receptor Ligand 1-(3-(2-(3-methoxyphenoxy)ethoxy)... 3 9
Sodium-dependent dopamine transporter and Sodium-dependent nor... 2 6
Sodium-dependent serotonin transporter Inhibitor 4-(2-((dimeth... 3 1
Sodium-dependent noradrenaline transporter Inhibitor WAY-25680... 4 6
5-hydroxytryptamine receptor 2A and D(1A) dopamine receptor Li... 8 33
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 9 79
Leukotriene A-4 hydrolase Inhibitor (r/s)-2-((4-phenoxyphenoxy... 7 18
Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 13
5-hydroxytryptamine receptor 7 Ligand (r)-8-phenyl-n,n-dipropy... 9 14
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 10 15
Renin Inhibitor Ro-65-7219 Family 10 8
5-hydroxytryptamine receptor 1A Ligand 9-methoxy-1,2,3,4-tetra... 7 10
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 44 3
5-hydroxytryptamine receptor 2A Ligand C-(9h-xanthen-9-yl)-met... 3 5
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 2 3
Tyrosinase Inhibitor 1-(3-phenoxypropyl)-4-(piperidin-1-yl)pip... 2 13
5-hydroxytryptamine receptor 2A Ligand 1-(2,6-dimethoxy-4-meth... 14 3
Fatty-acid amide hydrolase 1 Inhibitor 8-phenyloctylcarbamic A... 12 1
Sodium-dependent dopamine transporter Inhibitor Secocularidine... 3 9
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 24 73
Glutamate receptor ionotropic, NMDA 3A and Glutamate receptor ... 2 1
5-hydroxytryptamine receptor 1A and Alpha-1D adrenergic recept... 2 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 6 5
Sodium-dependent serotonin transporter and Sodium-dependent no... 1 0
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 8 4
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 1 2
Mu-type opioid receptor and Sigma non-opioid intracellular rec... 10 20
Leukotriene A-4 hydrolase inhibitor 3-[3-(4-benzylphenoxy)prop... 2 0
Sodium-dependent serotonin transporter and Transporter inhibit... 1 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 2 8
Sigma non-opioid intracellular receptor 1 ligand 1-[4-(4-metho... 1 0
D(4) dopamine receptor and D(3) dopamine receptor ligand N-[2-... 6 15
Squalene synthase inhibitor 3-[4-[[(E)-ethylideneamino]oxymeth... 1 0
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 7 0
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 1
Sodium-dependent serotonin transporter and Sodium-dependent no... 1 0
Substance-P receptor ligand AGN-PC-02K8FR family 1 3
Sodium-dependent dopamine transporter and Sodium-dependent ser... 6 0
5-hydroxytryptamine receptor 2A and Potassium voltage-gated ch... 2 8
Sodium-dependent dopamine transporter and Sodium-dependent ser... 1 0
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 7 4
5-hydroxytryptamine receptor 1A ligand [(1S,2R)-8-methoxy-2-(p... 4 0
D(2) dopamine receptor and D(1A) dopamine receptor ligand ISOM... 2 5
5-hydroxytryptamine receptor 1A and Sodium-dependent noradrena... 2 0
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 11 2
Sodium-dependent serotonin transporter and Sodium-dependent no... 6 21
Nitric oxide synthase, inducible and Cytochrome P450 2D6 inhib... 2 1
Sigma non-opioid intracellular receptor 1 ligand methyl (1R,2S... 4 0
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 1 0
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 12 0
Estrogen receptor and Estrogen receptor beta ligand (2R,3R,4S)... 3 0
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 4
Histamine H3 receptor ligand cyclohexyl-[4-(3-piperidin-1-ylpr... 4 1
Histamine H3 receptor and Sodium-dependent serotonin transport... 15 1
Histamine H3 receptor ligand SureCN5093910 family 3 16
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 28
Histamine H3 receptor ligand 1-[[4-[4-[(1R)-4-(4-methoxyphenox... 2 1
Transporter and 5-hydroxytryptamine receptor 2C ligand CHEMBL1... 5 5
Histamine H3 receptor ligand 1'-cyclobutyl-6-(1-ethylsulfonylp... 7 10
D(4) dopamine receptor and D(2) dopamine receptor ligand 4-(4-... 2 6
5-hydroxytryptamine receptor 1A ligand oxalic acid;(1R,5S)-5-[... 2 0
Histamine H3 receptor ligand 1-[4-(1'-cyclobutylspiro[3,4-dihy... 4 0
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 1 0
Muscarinic acetylcholine receptor M3 ligand AGN-PC-005QPZ family 1 0
Histamine H3 receptor ligand SureCN6071181 family 2 1
Histamine H3 receptor ligand AGN-PC-0765YW family 1 4
Histamine H3 receptor and Sodium-dependent serotonin transport... 6 1
5-hydroxytryptamine receptor 7 and Alpha-2C adrenergic recepto... 3 0
Sodium-dependent noradrenaline transporter and Sodium-dependen... 14 1
Sodium-dependent serotonin transporter and Histamine H3 recept... 7 0
Sodium-dependent serotonin transporter and Histamine H3 recept... 7 0
Sigma non-opioid intracellular receptor 1 ligand (1S,4R,5R)-7-... 2 7
Histamine H3 receptor and Sodium-dependent serotonin transport... 4 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 3 6
Histamine H3 receptor and Sodium-dependent serotonin transport... 6 1
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 1 7
Sigma non-opioid intracellular receptor 1 ligand 4-[[1-[(2-bro... 2 0
Substance-P receptor ligand (5S,10S)-5-(4-fluorophenyl)-10-(2-... 3 2
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 6
Histamine H3 receptor and Sodium-dependent serotonin transport... 1 0
Scytalone dehydratase inhibitor 2-cyano-N-[(1S,2R)-1-(2-cyanop... 5 0
Sodium-dependent noradrenaline transporter and Sodium-dependen... 2 0
Sodium-dependent noradrenaline transporter and Cytochrome P450... 11 2
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 0
Vesicular acetylcholine transporter inhibitor (2R,3R)-5-(3-flu... 2 0
Sigma non-opioid intracellular receptor 1 ligand SureCN7450653... 1 0
Bifunctional epoxide hydrolase 2 and Cytochrome P450 2C9 inhib... 2 1
Histamine H3 receptor and Histamine H1 receptor ligand AGN-PC-... 1 0
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 2 2
Muscleblind-like protein 1 and Ferritin light chain inhibitor ... 1 1
Sodium-dependent noradrenaline transporter and Sodium-dependen... 4 2
Sodium-dependent noradrenaline transporter and Sodium-dependen... 1 1
Trace amine-associated receptor 1 ligand SureCN13886619 family 1 1
Trace amine-associated receptor 1 ligand 4-[4-(2-AMINO-ETHYL)-... 1 0
Mu-type opioid receptor ligand 2-[[2-[(2R)-2-ethyl-4-(4-fluoro... 1 3
Histamine H3 receptor and Histamine H1 receptor ligand (NE)-N-... 1 1
Metabotropic glutamate receptor 2 ligand (5R)-3-[[4-(4-ethoxyp... 3 9
Putative NP ZINC04061066 Family 18 0
Putative NP ZINC04029215 Family 6 0
Putative NP ZINC04029538 Family 3 0
NP 1-(7-hydroxyspiro[chroman-2,4'-piperidin]-1'-yl)ethanone Fa... 2 0
Putative NP ZINC04026929 Family 4 0
Putative NP ZINC38201335 Family 8 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00273489 CHEMBL1923521 Bioactive 4-(2-benzylphenoxy)piperidine
CFAMM00273482 CHEMBL2375598 Bioactive 1-[4-(3-piperidin-1-ylpropoxy)phenyl]cyclohexan-1-ol
CFAMM00273491 CHEMBL2375584 Bioactive 2-methyl-4-[4-(3-piperidin-1-ylpropoxy)phenyl]butan-2-ol
CFAMM00273487 DNC008940 Investigative Drug 4-(Spiro[chromene-2,4'-piperidine]-4-yl)phenol

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

22060 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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