CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2673
Family Name Histamine H4 receptor Ligand A-943931 Family
No. of Seeds 14 No. of Other Members 11
Family Centroid CFAMM00273570 Functional Category Investigative Drug
Superfamily Histamine H4 receptor Ligand A-943931 Superfamily
Class Class 824

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 2C ligand Tetracyclic antidepress... 14 498
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
5-hydroxytryptamine receptor 1D Ligand Rizatriptan Family 7 460
Alpha-2 adrenergic receptor Ligand Dexmedetomidine Family 32 639
Omega 1 Benzodiazepine receptor Ligand Zaleplon Family 6 589
Toll-like receptor 7 Ligand Imiquimod Family 3 237
Amiloride-sensitive sodium channel subunit alpha Ligand Triamt... 8 98
Peptide deformylase, mitochondrial Inhibitor Pyrimethamine Family 10 145
Type-1 angiotensin II receptor Ligand Tasosartan Family 10 29
Histamine H1 receptor Ligand Mizolastine Family 14 603
Metabotropic glutamate receptor 5 Ligand ADX-48621 Family 15 444
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Transient receptor potential cation channel subfamily V member... 16 295
Neuropeptide Y receptor type 5 Ligand CGP71683A Family 5 74
Transient receptor potential cation channel subfamily V member... 15 457
Vascular endothelial growth factor Inhibitor PTC299 Family 6 145
Cyclin-dependent kinase 2 Inhibitor Seliciclib Family 29 292
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Fibroblast growth factor receptor 2 and Fibroblast growth fact... 11 86
Cyclin-dependent kinase 4 Inhibitor PD-332991 Family 13 155
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
Tyrosine-protein kinase JAK2 Inhibitor INCB18424 Family 3 130
C-reactive protein Inhibitor ISIS-CRP Family 4 105
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242
Reverse transcriptase Inhibitor Dapivirine Family 5 72
Translocator protein Inhibitor Emapunil Family 7 89
D(1B) dopamine receptor Ligand LE-300 Family 65 452
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Adenosine receptor A1 Ligand SLV320 Family 6 79
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 9
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 13 55
Amg 423 family 7 47
SB989 family 17 91
GDC-0349 family 44 77
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
PF-4217903 family 14 65
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 8 55
Corticotropin-releasing factor receptor 1 Ligand CP-154526 Family 9 29
Tryptase Inhibitor Babim Family 12 90
D(4) dopamine receptor Ligand L-745,870 Family 30 205
5-hydroxytryptamine receptor 2B Ligand MT-500 Family 8 39
Glucan synthesis regulatory protein Inhibitor Pyridobenzimidaz... 2 12
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Interleukin-1 receptor type 1 and Mitogen-activated protein ki... 7 151
Epidermal growth factor receptor and Receptor tyrosine-protein... 11 138
Peptide deformylase, mitochondrial Inhibitor 5-phenylsulfanyl-... 5 23
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2,6-di... 13 14
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 32
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Vascular endothelial growth factor receptor 1 and Vascular end... 6 23
Peptide deformylase, mitochondrial Inhibitor 5-phenethyl-quina... 5 14
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 9
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Adenosine receptor A2a and Adenosine receptor A3 Ligand 5-buty... 3 18
Epidermal growth factor receptor Ligand N*4*-(3-bromo-phenyl)-... 7 11
Cyclin-dependent kinase 4 Inhibitor 1-pyridin-2-yl-3-quinolin-... 2 5
Arachidonate 5-lipoxygenase Inhibitor 2,4,5-triarylimidazole A... 3 16
Methionine aminopeptidase 2 Inhibitor 2-(pyridin-2-yl)-1h-benz... 6 19
Scytalone dehydratase Inhibitor Isoquinolin-1-yl-(3-phenyl-pro... 4 9
Epidermal growth factor receptor Ligand Benzo[g]quinazolin-4-y... 5 3
Epidermal growth factor receptor Ligand (3-bromo-phenyl)-quina... 7 5
Aromatase and Thromboxane-A synthase Inhibitor 6-(1h-imidazol-... 3 8
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
Adenosine receptor A1 Ligand Phenyl-(9-phenyl-9h-purin-6-yl)-a... 7 12
Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... 8 5
Histamine H3 receptor Ligand 2-(4-isopropyl-piperazin-1-yl)-qu... 17 29
Epidermal growth factor receptor Ligand N4-(3-chlorophenyl)qui... 7 39
Alpha-1A adrenergic receptor Ligand A-315456 Family 7 17
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
RAC-gamma serine/threonine-protein kinase and Rho-associated p... 16 46
Metabotropic glutamate receptor 5 Ligand 2-m-tolyl-1,8-naphthy... 7 11
Adenosine receptor A1 and Adenosine receptor A2a Ligand 3-benz... 1 6
Adenosine receptor A3 Ligand 2-(5-chloro-1h-benzo[d]imidazol-2... 7 51
DNA-dependent protein kinase catalytic subunit Inhibitor 2-mor... 2 6
D(2) dopamine receptor and D(3) dopamine receptor Ligand A-706... 4 20
Inhibitor of nuclear factor kappa-B kinase subunit beta Inhibi... 6 64
Cyclin-dependent kinase 2 and Mitogen-activated protein kinase... 7 30
Adenosine receptor A3 Ligand 1-(2-(diethylamino)quinazolin-4-y... 2 9
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 3 9
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-amin... 2 30
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2,6... 22 18
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-phen... 8 11
Dipeptidyl peptidase 4 Inhibitor (5-phenyl-3h-benzo[d]imidazol... 5 13
Cathepsin K Inhibitor 4-phenyl-6-propylpyrimidine-2-carbonitri... 6 10
Adenosine receptor A1 and Adenosine receptor A2a Ligand 4-amin... 4 11
Fatty-acid amide hydrolase 1 Inhibitor JNJ-1661010 Family 3 14
Indoleamine 2,3-dioxygenase 1 Inhibitor 3-(4h-imidazol-4-yl)be... 6 3
Aromatase Inhibitor NSC-356781 Family 3 10
Macrophage migration inhibitory factor Inhibitor 4-iodo-6-phen... 5 4
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 9 24
Oestrogen receptor Ligand 4-benzyl-2,6-diisobutylamino-pyrimid... 5 37
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Potassium voltage-gated channel subfamily H member 2 Ligand AZ... 21 42
Glycogen synthase kinase-3 beta Inhibitor CHIR-98023 Family 5 6
Glycogen synthase kinase-3 beta Inhibitor 4-(5-bromo-1h-indol-... 7 18
Protein kinase C theta type Inhibitor 4-(3h-indol-4-ylamino)-5... 2 2
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-bromobenzyl... 3 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
Urotensin-2 receptor Ligand Palosuran Family 4 4
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
Sodium-dependent serotonin transporter Inhibitor 6-nitroquipaz... 18 21
Type-2 angiotensin II receptor Ligand L-158809 Family 22 136
Proto-oncogene tyrosine-protein kinase Src Inhibitor CGP-62464... 3 10
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 4 22
Peptide deformylase, mitochondrial Inhibitor 7h-pyrrolo[3,2-f]... 2 10
Sodium-dependent serotonin transporter Inhibitor 6-chloro-2-pi... 5 35
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Metabotropic glutamate receptor 5 Ligand 2-methyl-7-m-tolyl-1,... 5 2
Corticotropin-releasing factor receptor 1 Ligand N-mesityl-6-m... 3 2
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 3 63
Amine oxidase [flavin-containing] A Inhibitor 3-benzyl-n-(2-mo... 2 3
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 2 2
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 1 0
Xanthine dehydrogenase/oxidase Inhibitor 3,5-di(pyridin-4-yl)-... 6 3
Acetylcholinesterase Inhibitor N-benzyl-2-morpholinopyrimidin-... 6 16
Protein kinase C alpha type Inhibitor Dequalinium Analogue Family 1 10
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 10 7
Adenosine receptor A3 and Adenosine receptor A2a ligand 5-buty... 3 13
Adenosine kinase inhibitor abt-702 family 14 1
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 8
Prothrombin inhibitor SureCN5856722 family 3 16
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-07ZB89 family 6 13
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 7 3
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 9
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 13 1
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 6 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 7 0
Platelet-activating factor receptor ligand AGN-PC-0750SP family 4 0
Adenosine kinase inhibitor 5-(4-chlorophenyl)-6-[2-(6-morpholi... 8 8
Neuronal acetylcholine receptor subunit alpha-7 ligand 2-(4-cy... 1 0
Serine/threonine-protein kinase D1 inhibitor SureCN1424142 family 13 8
Polycystin-2 and Serine/threonine-protein kinase D1 inhibitor ... 4 12
Cathepsin K and Potassium voltage-gated channel subfamily H me... 4 7
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 7 10
Cyclin-dependent kinase 5 and Cyclin-dependent kinase 1 inhibi... 2 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 27
DNA-dependent protein kinase catalytic subunit and Tyrosine-pr... 2 10
Bloom syndrome protein inhibitor SR 57227A family 2 12
Cathepsin K and Potassium voltage-gated channel subfamily H me... 3 1
Cathepsin K and Potassium voltage-gated channel subfamily H me... 5 1
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 3 11
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 19
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 6 27
Survival motor neuron protein and Menin inhibitor CHEMBL132797... 1 1
Type-1B angiotensin II receptor ligand SureCN683399 family 3 0
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 7 9
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 8
Mitogen-activated protein kinase 14 inhibitor AGN-PC-03XQYG fa... 7 1
Histamine H4 receptor ligand 2-[[6-iodo-2-(4-methylpiperazin-1... 4 2
D(4) dopamine receptor and D(2) dopamine receptor ligand 4-met... 13 8
Nociceptin receptor and Kappa-type opioid receptor ligand 1-[1... 4 4
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 5 0
Dihydrofolate reductase inhibitor AC1LAKQL family 3 1
Dihydrofolate reductase inhibitor 6-[[(4-chloronaphthalen-1-yl... 2 1
Adenosine kinase inhibitor SureCN8183719 family 2 3
D(4) dopamine receptor and D(2) dopamine receptor ligand N-(1-... 2 6
Growth hormone secretagogue receptor type 1 and Dihydrofolate ... 3 6
Survival motor neuron protein inhibitor CHEMBL1581561 family 1 3
Survival motor neuron protein inhibitor CHEMBL1583999 family 1 3
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 5 0
Adenosine receptor A3 and Adenosine receptor A1 ligand (8R)-8-... 4 0
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 5 27
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 3 7
Insulin-like growth factor 1 receptor ligand AGN-PC-09QIDN family 1 3
Corticotropin-releasing factor receptor 1 ligand 9-(2-bromo-4-... 15 3
Glycogen synthase kinase-3 beta and Dual specificity protein k... 4 5
Corticotropin-releasing factor receptor 1 ligand SureCN6301726... 4 1
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 3 3
Coagulation factor X and Cationic trypsin inhibitor AGN-PC-075... 5 13
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 0
Toll-like receptor 7 ligand 6-amino-2-(butylamino)-9-[[4-(dime... 5 4
Melanin-concentrating hormone receptor 1 ligand SureCN3334191 ... 4 7
Signal transducer and activator of transcription 6 inhibitor A... 3 0
Fatty-acid amide hydrolase 1 inhibitor AGN-PC-0A9RCZ family 7 7
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 5
Histamine H4 receptor ligand 4-[(3R)-3-(methylamino)pyrrolidin... 7 6
Corticotropin-releasing factor receptor 1 ligand Pyridopyrazin... 3 5
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 6 7
Fatty-acid amide hydrolase 1 inhibitor [5-(4-chlorophenyl)tria... 2 2
Neuropeptide Y receptor type 5 ligand SureCN8898853 family 2 3
Dihydrofolate reductase inhibitor 1-[3-(2,4-diaminoquinazolin-... 2 4
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 3 0
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A ... 1 1
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 4 ... 2 1
Mitogen-activated protein kinase 14 inhibitor 6-[5-(2,4-difluo... 9 3
Dipeptidyl peptidase 4 inhibitor Aminomethylpyrimidine 1ck family 6 3
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 18 5
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 9 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Mitogen-activated protein kinase 14 inhibitor 4-(2-chloropheny... 4 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family 10 11
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 2 2
Cell division cycle 7-related protein kinase and Protein DBF4 ... 15 7
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 10 6
Aurora kinase B and Vascular endothelial growth factor recepto... 1 2
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 3 0
Protein kinase C theta type and Leucine-rich repeat serine/thr... 1 1
Transient receptor potential cation channel subfamily V member... 4 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 1
Tyrosine-protein kinase Mer and Tyrosine-protein kinase recept... 5 3
TGF-beta receptor type-1 and TGF-beta receptor type-2 ligand S... 2 2
Cannabinoid receptor 2 ligand 8-(2-chlorophenyl)-9-cyclopropyl... 4 5
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 2-[8-... 2 5
Translocator protein inhibitor N-butan-2-yl-4-(2-chlorophenyl)... 14 12
Activated CDC42 kinase 1 inhibitor N,N-dimethyl-4-[4-[[(2S)-ox... 4 2
Acetylcholinesterase and Cholinesterase inhibitor 2-amino-6-[3... 1 4
Aurora kinase A and Cyclin-dependent kinase 4 inhibitor 7-cycl... 1 0
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 9 2
High affinity nerve growth factor receptor ligand N-[3-amino-5... 4 10
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2152398 family 16 1
Serine/threonine-protein kinase SMG1 and Cyclin-dependent kina... 3 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Beta-secretase 1 and Potassium voltage-gated channel subfamily... 3 4
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand N-[1-... 5 3
Adenosine receptor A1 and Adenosine receptor A2a ligand AGN-PC... 4 2
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206614 family 2 0
Mitogen-activated protein kinase 14 inhibitor 6-[2-(2,6-difluo... 3 0
Urokinase plasminogen activator surface receptor ligand 3-(1H-... 4 0
Dipeptidyl peptidase 4 inhibitor (4R,5R)-5-amino-1-[6-(3-methy... 2 5
Adenosine kinase inhibitor 5-(4-bromophenyl)-6-[2-[4-(dimethyl... 1 0
Adenosine kinase inhibitor 4-[2-[5-(4-chlorophenyl)-6-piperazi... 3 1
Adenosine receptor A1 ligand N-butyl-5-phenyl-3-[[2-(trifluoro... 7 2
Protein kinase C theta type and Protein kinase C delta type in... 9 0
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Cholinesterase inhibitor 4-[4,5-diphenyl-1-[7-(1,2,3,4-tetrahy... 2 1
Histamine H4 receptor and Histamine H3 receptor ligand 7-cyclo... 2 0
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 2 7
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 2 0
Bifunctional epoxide hydrolase 2 and Cytochrome P450 2C9 inhib... 3 0
Tyrosine-protein kinase JAK2 inhibitor N-(3-methylphenyl)-5-(3... 2 4
Serine/threonine-protein kinase mTOR inhibitor 1-ethyl-3-[4-[6... 4 1
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 8
Nitric oxide synthase, inducible inhibitor SureCN2258300 family 2 24
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor AG... 3 1
Cathepsin K inhibitor SureCN4141224 family 3 0
Cathepsin K and Cathepsin S inhibitor SureCN4138353 family 3 0
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 1 5
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 16 7
C-X-C chemokine receptor type 3 ligand 1-[3-[[(1R,5S)-3-[[7-(t... 3 1
Nociceptin receptor and Potassium voltage-gated channel subfam... 5 2
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor N-met... 2 1
Cathepsin K inhibitor 4-[2,2-dimethylpropyl-[[4-(1,2,4-triazol... 2 1
LIM domain kinase 2 inhibitor (2S)-N-cyano-N'-(3-cyanophenyl)-... 4 0
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 7 2
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 10 0
Cathepsin K and Cathepsin L1 inhibitor 5-[3-(3,4-dihydro-1H-is... 2 0
Cathepsin K inhibitor 4-[2,2-dimethylpropyl-[[4-[3-(4-piperidi... 2 0
D(4) dopamine receptor and D(3) dopamine receptor ligand SureC... 1 0
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 1 0
Vascular endothelial growth factor receptor 2 and Vascular end... 1 1
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 2
Corticotropin-releasing factor receptor 1 ligand SureCN7215846... 4 1
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 5 4
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 3 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 5 1
Corticotropin-releasing factor receptor 1 ligand 4-[7-(dipropy... 1 1
Type-1 angiotensin II receptor ligand SureCN7390271 family 2 1
Adenosine kinase inhibitor SureCN8248615 family 2 3
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 4-[6-... 3 3
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 4 0
Corticotropin-releasing factor receptor 1 ligand AGN-PC-00FF1P... 1 3
Adenosine receptor A1 ligand 3-[(2-chlorophenyl)methyl]-N-cycl... 1 1
Type-1B angiotensin II receptor ligand SureCN9309010 family 5 1
G2/mitotic-specific cyclin-B2 and Cyclin-dependent kinase 1 in... 2 1
Type-1 angiotensin II receptor ligand AGN-PC-04X8EF family 1 1
Proto-oncogene tyrosine-protein kinase Src and Tyrosine-protei... 3 0
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 0
Gonadotropin-releasing hormone receptor ligand 4-[[4-[2-(4-ter... 3 3
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 7 0
Metabotropic glutamate receptor 1 ligand AGN-PC-00FV3S family 2 0
Nitric oxide synthase, brain and Nitric oxide synthase, induci... 2 0
Nitric oxide synthase, brain and Nitric oxide synthase, endoth... 1 0
Cyclin-dependent kinase 2 inhibitor SureCN3549598 family 3 1
Nociceptin receptor and Mu-type opioid receptor ligand 2-(3-ch... 2 0
Ribosomal protein S6 kinase beta-1 and Aurora kinase B inhibit... 1 5
Neuropeptide Y receptor type 5 ligand 1-methylsulfonyl-N-(2-ph... 4 0
Gonadotropin-releasing hormone receptor ligand AGN-PC-00AWCA f... 1 0
5-hydroxytryptamine receptor 3A ligand AGN-PC-077D8K family 3 1
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 1 0
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor AGN-P... 1 0
Aurora kinase A inhibitor SureCN2205392 family 2 2
Dipeptidyl peptidase 4 and Potassium voltage-gated channel sub... 1 0
Tyrosine-protein kinase Lck inhibitor (3S)-3-[(1S)-1-[[4-(benz... 14 0
LIM domain kinase 1 and LIM domain kinase 2 inhibitor (2S)-N'-... 9 0
Rho-associated protein kinase 1 inhibitor AGN-PC-07COKD family 1 0
Dihydrofolate reductase type 1 and Dihydrofolate reductase inh... 1 0
Adenosine kinase inhibitor AGN-PC-074DKZ family 1 0
Dihydrofolate reductase inhibitor N-(2,4-diamino-5-methylquina... 2 0
D(4) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 2
Adenosine receptor A1 and Adenosine receptor A2a ligand 2-(2-c... 2 0
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 5
P2Y purinoceptor 14 inhibitor AGN-PC-0A9S8H family 3 2
Cytochrome P450 1A2 inhibitor AGN-PC-0BTGP4 family 1 0
Acetylcholinesterase and Butyrylcholinesterase inhibitor 5-ami... 2 0
Corticotropin-releasing factor receptor 1 ligand 5-N,5-N-bis(c... 2 0
Epidermal growth factor receptor and Receptor tyrosine-protein... 1 0
Dihydrofolate reductase inhibitor 5-[(4-amino-3,5-dibromopheny... 1 0
Coagulation factor X and Prothrombin inhibitor SureCN6578740 f... 1 0
Induced myeloid leukemia cell differentiation protein Mcl-1 an... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00273571 CHEMBL1077276 Bioactive 4-(1,2,3,4,4a,5,7,7a-octahydropyrrolo[3,4-b]pyridin-6-yl)-9-phenyl-6,7,8,9-tetrahydro-5H-cyclohepta[d]pyrimidin-2-amine
CFAMM00273584 CHEMBL521996 Bioactive SureCN603142
CFAMM00273582 CHEMBL82289 Bioactive 5,6-dimethyl-2-phenyl-7-[(1S)-1-phenylethyl]pyrrolo[2,3-d]pyrimidin-4-amine
CFAMM00273575 CHEMBL312150 Bioactive 5,6-dimethyl-2-phenyl-7-[(1R)-1-phenylethyl]pyrrolo[2,3-d]pyrimidin-4-amine
CFAMM00273566 CHEMBL523225 Bioactive AGN-PC-04WVDE
CFAMM00273574 CHEMBL135163 Bioactive 5,6-dimethyl-2-phenyl-7-[(2R)-1-phenylpropan-2-yl]pyrrolo[2,3-d]pyrimidin-4-amine
CFAMM00273570 DNC008971 Investigative Drug A-943931

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

48712 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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