CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2682
Family Name Fatty-acid amide hydrolase 1 Inhibitor N-butylcarbamic Acid Biphenyl-3-yl Ester Family
No. of Seeds 9 No. of Other Members 31
Family Centroid CFAMM00273695 Functional Category Investigative Drug with Human Metabolite & Natural Product
Superfamily Fatty-acid amide hydrolase 1 Binder Superfamily 4
Class Class 2531

Cousin Family NamesSeedsMembers
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 5 209
Noradrenergic re-uptake and Serotonin re-uptake inhibitor bicy... 6 375
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 61 433
Beta adrenergic receptor ligand naphthol derivative Propranolo... 11 218
Acetylcholinesterase Inhibitor Rivastigmine Family 2 59
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Alpha-1 adrenergic receptor ligand Dextroamphetamine derivativ... 5 29
Sigma non-opioid intracellular receptor 1 ligand opiate Dextro... 9 33
Alpha adrenergic receptor Ligand Phenoxybenzamine Family 4 63
Sodium channel protein type 5 subunit alpha Ligand Mexiletine ... 7 74
Beta adrenergic receptor Ligand Dipivefrin Family 3 55
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Alpha-1B adrenergic receptor ligand Phenylephrine analog Metho... 9 56
Alpha adrenergic receptor Ligand Bevantolol Family 4 48
Zucapsacin family 7 177
Serine/threonine-protein kinase PLK1 Inhibitor On 019190.na Fa... 16 138
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
Substance-P receptor Ligand DA-5018 Family 14 73
Substance-P receptor Ligand Ezlopitant Family 10 207
5-hydroxytryptamine receptor 2A Ligand Pimavanserin Family 4 23
D(3) dopamine receptor Ligand U-99194A Family 7 33
Dapoxetine family 3 40
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 6 40
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
M-phase inducer phosphatase 1 Inhibitor Naphthoquinone Analogs... 11 56
Extracellular calcium-sensing receptor Ligand Nps 568 Family 5 54
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 11
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 25 50
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
Adenosine receptor A3 and Muscarinic acetylcholine receptor M2... 4 31
Cannabinoid receptor 1 Ligand N-(3,5-dimethoxyphenethyl)oleami... 5 49
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
Angiopoietin-1 receptor and Cyclin-dependent kinase 1 Inhibito... 2 10
Histamine H3 receptor Ligand (r)-1-(2-methoxyphenethyl)-2-meth... 10 27
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 33
Fatty-acid amide hydrolase 1 Inhibitor 3'-carbamoylbiphenyl-3-... 8 50
5-hydroxytryptamine receptor 2A Ligand 3-methoxy-9-aminomethyl... 7 14
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 11
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 2
Sodium-dependent noradrenaline transporter Inhibitor WAY-25680... 4 6
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 13
Fatty-acid amide hydrolase 1 Inhibitor 3-(trifluoromethyl)phen... 3 0
Fatty-acid amide hydrolase 1 Inhibitor Phenylcarbamic Acid Bip... 3 7
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 10 15
Arachidonate 5-lipoxygenase Inhibitor 2-(4-butoxy-phenyl)-n-hy... 3 9
5-hydroxytryptamine receptor 1A Ligand 9-methoxy-1,2,3,4-tetra... 7 10
5-hydroxytryptamine receptor 2A Ligand C-(9h-xanthen-9-yl)-met... 3 5
5-hydroxytryptamine receptor 2A Ligand 1-(2,6-dimethoxy-4-meth... 14 3
Fatty-acid amide hydrolase 1 Inhibitor 8-phenyloctylcarbamic A... 12 1
Fatty-acid amide hydrolase 1 Inhibitor Adamant-1-ylcarbamic Ac... 1 0
Fatty-acid amide hydrolase 1 Inhibitor 3-(4,5-dihydrooxazol-2-... 6 11
Hormone-sensitive lipase Inhibitor Ethiofencarb Family 2 34
Acetylcholinesterase inhibitor [(3aR,8bS)-3,8b-dimethyl-1,2,3a... 1 27
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 6 19
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 1 0
Cathepsin K inhibitor [1-(3-methoxyphenyl)-2-methylpropan-2-yl... 2 10
Melatonin receptor type 1A ligand [7-methoxy-1-[2-(propanoylam... 3 0
Shiga toxin 1 variant B subunit and Shiga toxin 1 variant A su... 1 117
5-hydroxytryptamine receptor 1A ligand [(1S,2R)-8-methoxy-2-(p... 4 0
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 11 2
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 28
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 1 0
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 2 0
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 2 4
Fatty-acid amide hydrolase 1 inhibitor [4-hydroxy-3-(3-sulfamo... 2 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand (5Z,8... 4 2
Melatonin receptor type 1A and Melatonin receptor type 1C liga... 1 0
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 1 0
Scytalone dehydratase inhibitor 2-cyano-N-[(1S,2R)-1-(2-cyanop... 5 0
Lanosterol synthase and Cycloartenol synthase inhibitor 2-hydr... 1 1
Chymase inhibitor 1,3-bis[(3-methoxyphenyl)methyl]-1,3-diazeti... 3 1
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 5 5
Dehydrosqualene synthase inhibitor AGN-PC-077O7S family 1 0
Acyl-CoA:cholesterol acyltransferase inhibitor tridecyl N-[2,6... 2 3
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 1 0
Survival motor neuron protein and Thioredoxin glutathione redu... 1 0
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-006SR... 1 2
Neutral cholesterol ester hydrolase 1 inhibitor (1,6-dibromona... 1 4
Histone deacetylase 3 and Histone deacetylase 9 inhibitor (E)-... 1 0
Fatty-acid amide hydrolase 1 inhibitor AGN-PC-009L5C family 1 0
C-C chemokine receptor type 2 ligand (E)-N-[(1S,3R)-3-[[4-(4-m... 1 6
Dehydrosqualene synthase and Squalene synthase inhibitor dipot... 2 2
Fatty-acid amide hydrolase 1 and Monoglyceride lipase inhibito... 1 0
Neuronal acetylcholine receptor subunit alpha-7 and Neuronal a... 1 1
N-acylethanolamine-hydrolyzing acid amidase inhibitor (4-pheny... 1 0
Toluenes Metabolite Metaxalone Family 1 0
N-(2-hydroxyethyl)-1-benzoxepine-4-carboxamide NP N-(2-hydroxy... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00273675 DNC013800 Investigative Drug Cyclobutylcarbamic Acid Biphenyl-3-yl Ester
CFAMM00273701 DNC013799 Investigative Drug Cyclopentylcarbamic Acid Biphenyl-3-yl Ester
CFAMM00273694 DNC013802 Investigative Drug n-Hexylcarbamic Acid Biphenyl-3-yl Ester
CFAMM00273693 DNC013806 Investigative Drug Methylcarbamic Acid Biphenyl-3-yl Ester
CFAMM00273692 DNC013805 Investigative Drug Allylcarbamic Acid Biphenyl-3-yl Ester
CFAMM00273678 DNC009009 Investigative Drug cyclohexylcarbamic acidbiphenyl-3-yl ester
CFAMM00273691 DNC013804 Investigative Drug Isopropylcarbamic Acid Biphenyl-3-yl Ester
CFAMM00273676 DNC013801 Investigative Drug n-Octylcarbamic Acid Biphenyl-3-yl Ester
CFAMM00273695 DNC013803 Investigative Drug n-Butylcarbamic Acid Biphenyl-3-yl Ester

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

48712 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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