CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2693
Family Name Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 Inhibitor 4,5-bis(4-methoxyphenyl)-3h-1,2-dithiol-3-one Family
No. of Seeds 2 No. of Other Members 12
Family Centroid CFAMM00273876 Functional Category Investigative Drug with Human Metabolite & Natural Product
Superfamily Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 Binder Superfamily 3
Class Class 426

Cousin Family NamesSeedsMembers
Oestrogen receptor Ligand triphenyl ethylene stilbene derivati... 22 420
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Sodium channel protein type 5 subunit alpha Ligand Mexiletine ... 7 74
Sodium channel protein type 5 subunit alpha Ligand Dyclonine F... 6 174
Cyclooxygenase Inhibitor Fenoprofen Family 4 1077
Prostaglandin G/H synthase 2 Inhibitor Nabumetone Family 4 267
Signal transducer and activator of transcription 3 Inhibitor A... 5 249
Vitamin K epoxide reductase complex subunit 1 Inhibitor Warfar... 9 508
Tyrosinase Inhibitor Monobenzone Family 6 197
Oestrogen receptor ligand Dienestrol Family 35 440
Oestrogen receptor Ligand Chlorotrianisene Family 2 102
Vitamin K-dependent gamma-carboxylase Inhibitor Anisindione Fa... 3 243
Aldehyde oxidase Inhibitor Isovanillin Family 6 429
Ipriflavone family 62 2480
Agrimophol family 10 22
Sphingosine kinase 2 Inhibitor Phenoxodiol Family 24 682
NAD-dependent protein deacetylase sirtuin-1 Inhibitor SRT501 F... 19 88
Translocator protein Inhibitor Dextofisopam Family 3 250
Proto-oncogene tyrosine-protein kinase Src Inhibitor Malonic A... 1 34
Phospholipase A2 Inhibitor P-anisic Acid Family 2 178
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 11
Peroxisome proliferator-activated receptor gamma Ligand (2s)-2... 10 126
Platelet-activating factor receptor Ligand L-652731 Family 5 116
Cytosolic phospholipase A2 Inhibitor 1,1,1-trifluoro-6-(4-hexy... 9 86
Steryl-sulfatase Inhibitor Sulfamic Acid 4-(3-methoxy-benzoyl)... 5 24
Steryl-sulfatase Inhibitor 3-{4-[(aminosulfonyl)oxy]benzoyl}ph... 5 3
Collagenase 3 and Interstitial collagenase Inhibitor 3-(4-meth... 12 76
Steryl-sulfatase Inhibitor Sulfamic Acid 2-nonyl-4-oxo-4h-chro... 4 68
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor 6-ph... 1 18
Abelson tyrosine-protein kinase 2 Inhibitor 3'',5''-dimethoxy-... 3 9
Interstitial collagenase Inhibitor N-hydroxy-4-(4-methoxy-phen... 6 4
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 2 56
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 9 81
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 2 3
4-aminobutyrate aminotransferase, mitochondrial and Succinate-... 4 22
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 2 214
Leukotriene A-4 hydrolase Inhibitor 1-butoxy-4-phenoxybenzene ... 3 85
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 4-(1,... 3 31
Thyroid hormone receptor beta Ligand 2-hexylphenyl Acrylate Fa... 4 83
Cytosolic phospholipase A2 Inhibitor [6,3''']biflavone Family 5 5
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 4 37
Androgen receptor Ligand 2-methoxy-4-(o-tolyloxy)benzonitrile ... 5 12
Androgen receptor Ligand 3-methoxy-4-(m-tolyloxy)benzonitrile ... 3 29
Androgen receptor Ligand 4-(m-tolyloxy)-2-(trifluoromethyl)ben... 7 65
Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16
Amine oxidase [flavin-containing] B Inhibitor (s)(+)-7-fluoro-... 11 11
Amine oxidase [flavin-containing] B Inhibitor 3-(4-methoxyphen... 3 29
Amine oxidase [flavin-containing] B Inhibitor 7-fluoro-2-p-tol... 4 11
Aromatase Inhibitor 3,4-bis(3,4-dimethoxyphenyl)furan-2(5h)-on... 4 86
Indoleamine 2,3-dioxygenase 1 Inhibitor 4-methoxybenzenemethan... 2 26
Arachidonate 5-lipoxygenase Inhibitor 4,5-dimethoxy-10h-anthra... 1 4
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 2-(3-c... 5 72
Epidermal growth factor receptor Ligand 3-(3-chloro-phenyl)-5,... 10 64
Prostaglandin G/H synthase 1 Inhibitor 2-(2-methoxyphenyl)-1h-... 1 11
Prelamin-A/C and Solute carrier organic anion transporter fami... 1 15
Carbonic anhydrase 2 and Carbonic anhydrase 5A, mitochondrial ... 4 5
Histone deacetylase 2 and Histone deacetylase 8 inhibitor 2-hy... 1 0
Steroidogenic factor 1 and Nuclear receptor subfamily 5 group ... 1 1
Steryl-sulfatase inhibitor [(8R,9S,13S,14S)-13-methyl-17-oxo-7... 1 9
Beta-lactamase inhibitor AGN-PC-0A9UJZ family 1 3
NS5B protein inhibitor SureCN3988565 family 2 4
Cannabinoid receptor 1 and Monoglyceride lipase ligand 4-(4-ph... 4 4
Benzyloxycarbonyls Metabolite 4-Methoxybenzyl formate Family 1 7
Phenylacetic Acid Derivatives Metabolite Guaicyl phenylacetate... 1 3
2-(4-methoxyphenyl)-10,10-dimethyl-1,3,9-trioxaspiro[5.5]undec... 4 19
5-(4-methoxyphenyl)-2,2-dimethyloxolan-3-one NP 5-(4-methoxyph... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00273876 DNC009038 Investigative Drug 4,5-Bis(4-methoxyphenyl)-3H-1,2-dithiol-3-one
CFAMM00273894 DNC013861 Investigative Drug 4,5-Bis(4-methoxyphenyl)-3H-1,2-dithiole-3-thione

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27276 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543