CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2695
Family Name Hepatocyte growth factor receptor Ligand BMS-777607 Family
No. of Seeds 10 No. of Other Members 1
Family Centroid CFAMM00273923 Functional Category Investigative Drug
Superfamily Nuclear factor NF-kappa-B p100 subunit Inhibitor GMX1777 Superfamily
Class Class 873

Cousin Family NamesSeedsMembers
Serine/threonine-protein kinase B-raf inhibitor diaryl urea an... 12 93
AP26113 family 16 90
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 11 10
E7050 family 2 13
Proto-oncogene tyrosine-protein kinase Src Inhibitor PD166285 ... 6 70
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
Integrin alpha-V and Integrin beta-1 Inhibitor SB-265123 Family 30 170
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
Platelet-derived growth factor receptor alpha and Fibroblast g... 3 47
C-X-C chemokine receptor type 3 Ligand AMG-487 Family 28 73
Potassium voltage-gated channel subfamily H member 2 Ligand Be... 22 56
Mitogen-activated protein kinase 14 Inhibitor Pamapimod Family 15 7
Reverse transcriptase/RNaseH inhibitor AC1LALKM family 2 19
Hepatocyte growth factor receptor and Receptor-type tyrosine-p... 12 26
Hepatocyte growth factor receptor ligand SureCN4492034 family 2 2
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Bifunctional epoxide hydrolase 2 inhibitor SureCN3216677 family 4 9
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 1 0
Inositol monophosphatase 1 inhibitor CHEMBL1588383 family 1 6
Glycogen synthase kinase-3 beta inhibitor 6-[(2S)-2-(2-methoxy... 1 0
Corticotropin-releasing factor receptor 1 ligand AGN-PC-009TSL... 3 3
Rho-associated protein kinase 1 and cAMP-dependent protein kin... 1 11
Epidermal growth factor receptor ligand N-[3-[7-[2-methoxy-4-(... 9 3
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Receptor-type tyrosine-protein kinase FLT3 and Vascular endoth... 2 0
Motilin receptor ligand SureCN2765637 family 1 1
Hepatocyte growth factor receptor ligand 4-pyridone analogue, ... 8 0
Hepatocyte growth factor receptor and Cytochrome P450 3A4 liga... 5 0
Tyrosine-protein kinase receptor Tie-1 and Receptor-type tyros... 1 0
Transient receptor potential cation channel subfamily V member... 1 3
Vascular endothelial growth factor receptor 2 ligand SureCN472... 1 0


External ID

Functional Category

Molecule Name

CFAMM00273922 CHEMBL460502 Bioactive SureCN1137714
CFAMM00273928 CHEMBL518656 Bioactive AGN-PC-050GTA
CFAMM00273927 CHEMBL461582 Bioactive AGN-PC-050GTF
CFAMM00273926 CHEMBL461583 Bioactive AGN-PC-050GTG
CFAMM00273931 CHEMBL462624 Bioactive AGN-PC-050GTE
CFAMM00273924 CHEMBL517293 Bioactive AGN-PC-050GTB
CFAMM00273930 CHEMBL462623 Bioactive AGN-PC-050GTD
CFAMM00273929 CHEMBL516790 Bioactive pyridone, 2
CFAMM00273923 DNC009048 Investigative Drug BMS-777607

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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