CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2697
Family Name Thyroid hormone receptor alpha and Thyroid hormone receptor beta Ligand MB-07344 Family
No. of Seeds 5 No. of Other Members 8
Family Centroid CFAMM00273964 Functional Category Investigative Drug
Superfamily Thyroid hormone receptor beta Ligand MB-07811 Superfamily
Class Class 470

Cousin Family NamesSeedsMembers
Fatty-acid amide hydrolase 1 Inhibitor Propofol Family 5 428
Prostaglandin G/H synthase 2 Inhibitor Nabumetone Family 4 267
Signal transducer and activator of transcription 3 Inhibitor A... 5 249
Tyrosinase Inhibitor Monobenzone Family 6 197
Oestrogen receptor ligand Dienestrol Family 35 440
Oestrogen receptor Ligand Chlorotrianisene Family 2 102
Sphingosine kinase 2 Inhibitor Phenoxodiol Family 24 682
NAD-dependent protein deacetylase sirtuin-1 Inhibitor SRT501 F... 19 88
Muscarinic acetylcholine receptor M1 Ligand GSK1034702 Family 7 148
Translocator protein Inhibitor Dextofisopam Family 3 250
Multidrug resistance protein Inhibitor Curcumin I Family 19 278
Thyroid hormone receptor beta Ligand MB-07811 Family 1 2
Oxi4503 family 4 27
TS-071 family 8 36
Platelet-activating factor receptor Ligand L-652731 Family 5 116
Glucocorticoid receptor Ligand 1-methoxy-6-phenyl-6h-benzo[c]c... 2 22
Oestrogen receptor and Estrogen receptor beta Ligand 6-(4-hydr... 30 63
Abelson tyrosine-protein kinase 2 Inhibitor 3'',5''-dimethoxy-... 3 9
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 5 13
Tubulin beta chain Inhibitor Combretastatin Family 3 5
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 2 214
NAD(P)H dehydrogenase [quinone] 1 Inhibitor NSC-106547 Family 3 65
Arachidonate 15-lipoxygenase and Arachidonate 5-lipoxygenase I... 3 18
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 4-(1,... 3 31
Thyroid hormone receptor beta Ligand 2-hexylphenyl Acrylate Fa... 4 83
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 4 37
Cannabinoid receptor 2 Ligand 2-(2-methoxybenzyl)-3h-benzo[f]c... 6 32
Androgen receptor Ligand 2'-hydroxy-3-methoxy-biphenyl-4-carbo... 2 13
NAD(P)H dehydrogenase [quinone] 1 Inhibitor 4-hydroxy-3-(2-nap... 12 1
Indoleamine 2,3-dioxygenase 1 Inhibitor Naphthalene-1,4-diol F... 2 4
Prostaglandin G/H synthase 1 Inhibitor 2-(2-methoxyphenyl)-1h-... 1 11
Androgen receptor Ligand Palodesangren E Family 12 43
Sodium/glucose cotransporter 2 and Sodium/glucose cotransporte... 3 19
Vitamin D3 receptor ligand (3E,5E)-6-[3-[[3,4-bis(hydroxymethy... 2 4
Estrogen receptor beta and Estrogen receptor ligand SureCN4017... 3 5
Thyroid hormone receptor beta ligand 2-[3,5-dibromo-4-(4-hydro... 1 1
Thyroid hormone receptor beta and Thyroid hormone receptor alp... 2 7
Trace amine-associated receptor 1 ligand 4-[4-(2-AMINO-ETHYL)-... 1 0
Geranylgeranyl pyrophosphate synthase inhibitor [1-Hydroxy-2-(... 1 2
NP (1r,2r,4s)-2-(2-methoxyphenyl)-1,3,3-trimethylbicyclo[2.2.1... 3 0
Putative NP ZINC00526277 Family 2 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00273956 CHEMBL448595 Bioactive SureCN282073
CFAMM00273960 CHEMBL457528 Bioactive SureCN282588
CFAMM00273966 CHEMBL512383 Bioactive SureCN282331
CFAMM00273964 DNC009051 Investigative Drug MB-07344

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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