CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID270
Family Name Alpha-1 adrenergic receptor Ligand DC-015 Family
No. of Seeds 8 No. of Other Members 25
Family Centroid CFAMM00186183 Functional Category Investigative Drug
Superfamily Alpha-1 adrenergic receptor and Alpha-1A adrenergic receptor Binder Superfamily
Class Class 1503

Cousin Family NamesSeedsMembers
Tumor necrosis factor Inhibitor Tgaac-94 Family 6 107
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Muscarinic acetylcholine receptor M1 Ligand AC-260584 Family 4 36
Alpha-2C adrenergic receptor Ligand ARC239 Family 15 23
C-C chemokine receptor type 1 Ligand BX-471 Family 10 67
Glucose-6-phosphate 1-dehydrogenase Inhibitor Metazamide Family 9 69
5-hydroxytryptamine receptor 6 Ligand Sb 258585 Family 11 121
Leukotriene A-4 hydrolase Inhibitor N-benzyl-4-[(2r)-pyrrolidi... 6 40
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 7 23
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 18 12
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 6 23
Substance-K receptor Ligand MEN-14933 Family 13 154
Alpha-1A adrenergic receptor Ligand Upidosin Family 8 46
Alpha-1A adrenergic receptor Ligand Naftopidil Family 15 119
Bifunctional epoxide hydrolase 2 Inhibitor 1-adamantan-1-yl-3-... 12 44
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 9 79
Renin Inhibitor Ro-66-1168 Family 10 30
Bifunctional epoxide hydrolase 2 Inhibitor 1-(3-(3-morpholinop... 24 102
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 8 41
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 21 13
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
Tyrosinase Inhibitor 1-(4-(benzyloxy)phenyl)-3-hydroxyurea Family 9 23
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 28 91
Substance-P receptor ligand N-[1-[acetyl-[(2-methoxyphenyl)met... 3 9
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 14 12
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 5 13
D(3) dopamine receptor and D(2) dopamine receptor ligand 1-(3-... 4 6
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 6 2
C-C chemokine receptor type 3 ligand SureCN6705515 family 2 16
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-087THW family 1 0
D(3) dopamine receptor and D(2) dopamine receptor ligand (E)-N... 2 2
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 9 37
Transient receptor potential cation channel subfamily V member... 3 15
Nischarin inhibitor SureCN7818902 family 2 12
D(4) dopamine receptor and D(2) dopamine receptor ligand SureC... 4 3
D(4) dopamine receptor and D(3) dopamine receptor ligand SureC... 5 0
Prelamin-A/C and Survival motor neuron protein inhibitor CHEMB... 1 7
Survival motor neuron protein and Alpha-galactosidase A inhibi... 1 4
Gastrin/cholecystokinin type B receptor ligand 1-[3-[[2-(3-met... 2 12
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-088O2I family 3 3
Carbonic anhydrase 12 and Probable transmembrane carbonic anhy... 2 0
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 3 0
Gonadotropin-releasing hormone receptor ligand SureCN5756131 f... 5 7
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 6 1
Transient receptor potential cation channel subfamily V member... 1 0
D(2) dopamine receptor and Muscarinic acetylcholine receptor M... 1 0
Histamine H3 receptor and Histamine receptor H3 ligand 1-[4-[3... 2 0
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 10
Bifunctional epoxide hydrolase 2 inhibitor 8-(2-ethylbutanoyl)... 11 0
C-X-C chemokine receptor type 3 ligand 1-[1-[(9-acetyl-9-azabi... 1 0
Alpha-1D adrenergic receptor and D(2) dopamine receptor ligand... 3 0
Neuropeptide Y receptor type 5 ligand 1-[1-(4-fluorophenyl)pro... 2 8
Neuropeptide Y receptor type 5 ligand AGN-PC-01NRZ6 family 3 6
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 1 0
Transient receptor potential cation channel subfamily V member... 1 2
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 2 0
5-hydroxytryptamine receptor 7 and 5-hydroxytryptamine recepto... 1 0
Sterol O-acyltransferase 1 inhibitor SureCN6152927 family 7 3
Histamine H3 receptor ligand AGN-PC-07ZCFA family 1 0
C-C chemokine receptor type 3 ligand SureCN6700764 family 2 2
C-X-C chemokine receptor type 3 ligand 1-[1-[[(1S,5R)-6,6-dime... 2 3
Cholinesterase inhibitor (13-methyl-5,6,8,13a-tetrahydroisoqui... 1 0
D(3) dopamine receptor and D(2) dopamine receptor ligand 6-[2-... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00186180 CHEMBL1788222 Bioactive (3S)-3-[[4-(2-methoxyphenyl)piperazin-1-yl]methyl]-3,6-dihydro-2H-imidazo[1,2-c]quinazolin-5-one
CFAMM00186155 CHEMBL2114065 Bioactive SureCN8326693
CFAMM00186171 CHEMBL2114072 Bioactive SureCN8323168
CFAMM00186160 CHEMBL304165 Bioactive 2-MPMDQ
CFAMM00186175 CHEMBL309150 Bioactive AGN-PC-074GI4
CFAMM00186189 CHEMBL302021 Bioactive SureCN9414716
CFAMM00186183 DNC000522 Investigative Drug DC-015

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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