CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2712
Family Name Bifunctional epoxide hydrolase 2 Inhibitor 1-adamantan-1-yl-3-(4-methoxy-phenyl)-urea Family
No. of Seeds 12 No. of Other Members 44
Family Centroid CFAMM00274733 Functional Category Investigative Drug
Superfamily Bifunctional epoxide hydrolase 2 Binder Superfamily 4
Class Class 2540

Cousin Family NamesSeedsMembers
Acetylcholinesterase Inhibitor Neostigmine Family 4 76
Beta-1 adrenergic receptor Ligand Practolol Family 2 82
Acyl-CoA desaturase Inhibitor Isoxyl Family 5 62
D(2) dopamine receptor Ligand Pardoprunox Family 4 81
Tumor necrosis factor Inhibitor Tgaac-94 Family 6 107
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
Alpha-1 adrenergic receptor Ligand DC-015 Family 8 25
Glucose-6-phosphate 1-dehydrogenase Inhibitor Metazamide Family 9 69
Inosine-5'-monophosphate dehydrogenase Inhibitor VX-148 Family 2 3
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 11 20
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor Liga... 40 90
Substance-K receptor Ligand MEN-14933 Family 13 154
Cannabinoid receptor 1 Ligand N-(4-methoxyphenyl)oleamide Family 4 23
Alpha-1A adrenergic receptor and D(2) dopamine receptor Ligand... 5 49
Bifunctional epoxide hydrolase 2 Inhibitor 1-adamantan-1-yl-3-... 3 3
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 9 79
Bifunctional epoxide hydrolase 2 Inhibitor 1-(3-(3-morpholinop... 24 102
Fatty-acid amide hydrolase 1 Inhibitor 2-fluorophenyl 4-(octyl... 15 9
Fatty-acid amide hydrolase 1 Inhibitor Propan-2-one O-4-(hexyl... 12 4
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
Fatty-acid amide hydrolase 1 Inhibitor Phenmedipham Family 2 5
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 21 13
Tyrosinase Inhibitor 1-(4-(benzyloxy)phenyl)-3-hydroxyurea Family 9 23
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 5 13
D(3) dopamine receptor and D(2) dopamine receptor ligand 1-(3-... 4 6
C-C chemokine receptor type 3 ligand SureCN6705515 family 2 16
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 9 37
Transient receptor potential cation channel subfamily V member... 3 15
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 3 1
Gastrin/cholecystokinin type B receptor ligand 1-[3-[[2-(3-met... 2 12
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-088O2I family 3 3
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-088O2K family 2 0
Gonadotropin-releasing hormone receptor ligand SureCN5756131 f... 5 7
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 6 1
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 4 19
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 6 3
Bifunctional epoxide hydrolase 2 inhibitor 1-(1-adamantyl)-3-[... 2 1
Carbonic anhydrase 1 and Carbonic anhydrase 2 inhibitor [4-[(4... 10 0
Carbonic anhydrase 1 and Carbonic anhydrase 2 inhibitor [4-(2,... 2 11
Fatty-acid amide hydrolase 1 inhibitor 4-[[3-(4-chlorophenoxy)... 1 0
Bifunctional epoxide hydrolase 2 inhibitor SureCN3178516 family 3 1
Histamine H3 receptor and Histamine receptor H3 ligand 1-[4-[3... 2 0
C-X-C chemokine receptor type 3 ligand 1-[1-[(9-acetyl-9-azabi... 1 0
Neuropeptide Y receptor type 5 ligand 3-[4-(4-fluorophenoxy)ph... 4 0
Neuropeptide Y receptor type 5 ligand 1-[1-(4-fluorophenyl)pro... 2 8
Neuropeptide Y receptor type 5 ligand AGN-PC-01NRZ6 family 3 6
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-00RZQT family 3 4
Bifunctional epoxide hydrolase 2 inhibitor [3-(1-adamantylcarb... 1 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 3 12
5-hydroxytryptamine receptor 7 and 5-hydroxytryptamine recepto... 1 0
Sigma non-opioid intracellular receptor 1 ligand 2-(1-adamanty... 1 1
Prostacyclin receptor ligand CAY10441 family 1 0
Sterol O-acyltransferase 1 inhibitor SureCN6152927 family 7 3
C-C chemokine receptor type 3 ligand SureCN6700764 family 2 2
C-X-C chemokine receptor type 3 ligand 1-[1-[[(1S,5R)-6,6-dime... 2 3
Acyl-CoA:cholesterol acyltransferase inhibitor SureCN9818603 f... 2 2
Cholinesterase inhibitor (13-methyl-5,6,8,13a-tetrahydroisoqui... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00274726 CHEMBL2031816 Bioactive 1-(1-adamantyl)-3-(3-phenoxyphenyl)urea
CFAMM00274725 CHEMBL476058 Bioactive [4-(1-adamantylcarbamoylamino)phenyl] acetate
CFAMM00274737 CHEMBL438867 Bioactive AGN-PC-046IOC
CFAMM00274704 CHEMBL2031791 Bioactive 1-(1-adamantyl)-3-[3-(trifluoromethoxy)phenyl]urea
CFAMM00274754 CHEMBL396760 Bioactive AGN-PC-046ISE
CFAMM00274696 CHEMBL292668 Bioactive 2-(1-adamantyl)-1-(4-methoxyphenyl)guanidine
CFAMM00274751 CHEMBL388015 Bioactive 1-(1-adamantyl)-3-[4-(4-fluorophenoxy)phenyl]urea
CFAMM00274702 CHEMBL2031798 Bioactive 1-(1-adamantyl)-3-[3-(difluoromethoxy)phenyl]urea
CFAMM00274727 CHEMBL2031812 Bioactive 1-(1-adamantyl)-3-(4-phenoxyphenyl)urea
CFAMM00274732 DNC009111 Investigative Drug 1-Adamantan-1-yl-3-(2-methoxy-phenyl)-urea
CFAMM00274734 DNC009112 Investigative Drug 1-Adamantan-1-yl-3-(3-methoxy-phenyl)-urea
CFAMM00274733 DNC009113 Investigative Drug 1-Adamantan-1-yl-3-(4-methoxy-phenyl)-urea

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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