CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2722
Family Name Potassium voltage-gated channel subfamily H member 2 and Sodium-dependent dopamine transporter Ligand (s)-3-(naphthalen-2-ylmethoxy)pyrrolidine Family
No. of Seeds 5 No. of Other Members 14
Family Centroid CFAMM00274960 Functional Category Investigative Drug
Superfamily Sodium-dependent dopamine transporter and Sodium-dependent noradrenaline transporter Binder Superfamily 2
Class Class 2544

Cousin Family NamesSeedsMembers
Opioid receptor ligand synthetic opioid methadone analog Dextr... 2 108
Serotonin re-uptake Inhibitor Citalopram Family 6 4
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Histamine H1 receptor Ligand Clemastine Family 5 76
Histamine H1 receptor Ligand Diphenhydramine Family 5 75
Alpha-1B adrenergic receptor ligand Morpholine derivative Phen... 4 152
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Muscarinic acetylcholine receptor M1 Ligand Trihexyphenidyl Fa... 14 199
Histamine H1 receptor ligand diphenylpiperidine analog Dipheny... 13 224
Nicotinic acetylcholine receptor Ligand Benztropine Mesylate F... 10 20
Muscarinic acetylcholine receptor Ligand Umeclidinium Family 7 50
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor Sulfen... 5 13
Substance-P receptor Ligand L-733060 Family 19 71
Adenosine receptor A3 and Mu-type opioid receptor Ligand GBR-1... 80 110
Extracellular calcium-sensing receptor and Potassium voltage-g... 3 11
Cytochrome P450 2D6 Inhibitor Bs 7840 Family 4 9
Sodium-dependent dopamine transporter and Sodium-dependent nor... 2 2
Sodium-dependent dopamine transporter and Sodium-dependent nor... 3 0
Renin Inhibitor Ro-65-7219 Family 10 8
Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 1-(metho... 4 0
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 1 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 2 11
Sigma non-opioid intracellular receptor 1 ligand 2-[(3R)-1'-(c... 2 0
Sigma non-opioid intracellular receptor 1 ligand AGN-PC-076TWX... 8 5
Substance-P receptor ligand 1-[4-[[3,5-bis(trifluoromethyl)phe... 5 8
Substance-P receptor ligand SureCN8112982 family 1 0
Substance-P receptor ligand 4-[[3,5-bis(trifluoromethyl)phenyl... 2 1
Sigma non-opioid intracellular receptor 1 ligand N-benzyl-2-[(... 1 5
Substance-P receptor ligand 1-[[(1R,2R,3S)-3-[[3,5-bis(trifluo... 4 3
Substance-P receptor ligand 1-[3-[[(1R)-1-[3,5-bis(trifluorome... 2 0
Substance-P receptor and Neuromedin-K receptor ligand 3-[[(1R)... 1 2
Sodium-dependent serotonin transporter and Substance-P recepto... 2 2
Substance-P receptor and Sodium-dependent serotonin transporte... 6 1
Sodium-dependent dopamine transporter and Sodium-dependent ser... 3 0
Substance-P receptor ligand SureCN8415737 family 3 4
Sigma non-opioid intracellular receptor 1 ligand SureCN7425449... 2 0
Sodium-dependent dopamine transporter and Sigma non-opioid int... 2 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 0
Sigma non-opioid intracellular receptor 1 ligand AGN-PC-0793IB... 2 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 4
Histamine H1 receptor and 5-hydroxytryptamine receptor 2A liga... 1 0
Extracellular calcium-sensing receptor ligand SureCN4609584 fa... 7 8
Sodium-dependent noradrenaline transporter and Sodium-dependen... 1 0
Dibenzocycloheptenes Metabolite E-10-Hydroxynortriptyline Family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00274953 CHEMBL469811 Bioactive (3R)-3-[(6-fluoronaphthalen-2-yl)methoxy]pyrrolidine
CFAMM00274971 CHEMBL2171416 Bioactive 3-[naphthalen-2-yl(propoxy)methyl]azetidine;hydrochloride
CFAMM00274972 DNC009144 Investigative Drug LITOXETINE
CFAMM00274960 DNC009135 Investigative Drug (S)-3-(naphthalen-2-ylmethoxy)pyrrolidine
CFAMM00274959 DNC009136 Investigative Drug (R)-3-(naphthalen-2-ylmethoxy)pyrrolidine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

48716 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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