CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2723
Family Name Sodium-dependent serotonin transporter Inhibitor 1-(2-(naphthalen-2-yl)ethyl)piperazine Family
No. of Seeds 5 No. of Other Members 2
Family Centroid CFAMM00274977 Functional Category Investigative Drug
Superfamily 5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine receptor 2A Binder Superfamily
Class Class 2510

Cousin Family NamesSeedsMembers
Alpha-1B adrenergic receptor ligand phenethylamine derivative ... 12 283
5-hydroxytryptamine 2 receptor Ligand tricyclic antidepressant... 29 680
Adrenergic neuron Inhibitor guanidine isoquinoline analog Debr... 2 44
Voltage-dependent T-type calcium channel subunit alpha-1H liga... 10 397
Extracellular calcium-sensing receptor ligand Cinacalcet Family 2 30
Histamine H1 receptor ligand piperazine derivative Cyclizine F... 16 140
Amine oxidase [flavin-containing] B Inhibitor Selegiline Family 6 26
Noradrenergic re-uptake Inhibitor Phentermine Family 2 11
Squalene monooxygenase Inhibitor Naftifine Family 8 32
Noradrenergic re-uptake Inhibitor Protriptyline Family 3 25
Dopamine receptor ligand norcamphene derivative Fencamfamine F... 3 41
Amine oxidase [flavin-containing] B Inhibitor Rasagiline Family 2 11
Muscarinic acetylcholine receptor M3 Ligand Diphemanil Methyls... 22 45
Noradrenergic re-uptake Inhibitor Maprotiline Family 6 33
Serotonin re-uptake Inhibitor Dexfenfluramine Family 6 31
Glutamate receptor AMPA subtype and Noradrenaline uptake Ligan... 9 17
Substance-P receptor Ligand Vestipitant Family 14 137
Sigma non-opioid intracellular receptor 1 Ligand Dimemorfan Fa... 5 15
Dipeptidyl peptidase 4 Inhibitor 1-biphenyl-2-ylmethanamine Fa... 2 23
Beta-secretase 1 Inhibitor 4-(4-fluorobenzyl)piperidine Family 2 4
D(2) dopamine receptor and D(3) dopamine receptor Ligand (-)-3... 15 19
Sphingosine 1-phosphate receptor 1 Ligand [3-(4-nonyl-benzylam... 9 22
Adenosine receptor A3 and Glutamate receptor ionotropic, NMDA ... 4 30
Dipeptidyl peptidase 4 Inhibitor 2-(2-chlorophenyl)-2-morpholi... 2 34
Sodium-dependent noradrenaline transporter and Sodium-dependen... 3 10
D(2) dopamine receptor and D(3) dopamine receptor Ligand ST-19... 5 27
Histamine H3 receptor Ligand 1-[2-(2,4,6-trimethyl-phenyl)-eth... 9 15
Calcium-activated potassium channel subunit alpha-1 Ligand N-m... 2 10
Amine oxidase [flavin-containing] A Inhibitor 1-(2-naphthyl)-2... 4 4
Sodium-dependent dopamine transporter and Sodium-dependent nor... 28 71
Sodium-dependent serotonin transporter Inhibitor Tefludazine F... 8 9
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 1
Amine oxidase [flavin-containing] B Inhibitor Methyl-(1,2,3,4-... 2 0
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 3 6
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 17 9
Melatonin receptor type 1A Ligand N-(2,3-dihydro-1h-phenalen-2... 8 13
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 4 1
Sodium-dependent dopamine transporter and Sodium-dependent ser... 8 2
Sigma non-opioid intracellular receptor 1 ligand CHEMBL101300 ... 2 1
5-hydroxytryptamine receptor 7 and Sodium-dependent serotonin ... 5 1
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 7 2
D(1A) dopamine receptor and D(2) dopamine receptor ligand Sure... 2 0
5-hydroxytryptamine receptor 7 ligand 5-methyl-6-(6-methyl-5,6... 2 0
Sigma non-opioid intracellular receptor 1 ligand AGN-PC-003L8Y... 2 4
Sodium-dependent serotonin transporter and Sodium-dependent no... 9 0
Sodium-dependent noradrenaline transporter and Sodium-dependen... 2 12
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 5
Histamine H3 receptor ligand SureCN1641166 family 3 0
Histamine H3 receptor ligand 4-[6-(2-pyrrolidin-3-ylethyl)naph... 1 1
Sodium-dependent noradrenaline transporter and Sodium-dependen... 3 7
5-hydroxytryptamine receptor 1A ligand SureCN8901985 family 1 0
Sodium-dependent serotonin transporter and Transporter inhibit... 7 2
Sodium-dependent serotonin transporter and Transporter inhibit... 7 2
Sodium-dependent serotonin transporter and Sodium-dependent do... 2 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 6
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 2
Sodium-dependent dopamine transporter and Muscarinic acetylcho... 2 6
Histamine H3 receptor ligand SureCN1640926 family 3 3
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 0
Urease inhibitor 1-$l^{1}-selanyl-N,N-dimethyl-N'-[(1S)-1-naph... 1 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 1
1-[(E)-3-phenylprop-2-enyl]-4-[[(4S)-4-prop-1-en-2-ylcyclohexe... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00274983 CHEMBL19878 Bioactive (2R)-N-(3-naphthalen-2-ylpropyl)-1-phenylpropan-2-amine
CFAMM00274981 CHEMBL443090 Bioactive AGN-PC-077TKM
CFAMM00274980 CHEMBL19541 Bioactive AGN-PC-003L8T
CFAMM00274977 DNC009142 Investigative Drug 1-(2-(naphthalen-2-yl)ethyl)piperazine
CFAMM00274978 DNC009143 Investigative Drug 1-(2-(6-fluoronaphthalen-2-yl)ethyl)piperazine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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