CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2735
Family Name Arachidonate 12-lipoxygenase, 12S-type and Arachidonate 15-lipoxygenase Inhibitor Jaspic Acid Family
No. of Seeds 3 No. of Other Members 7
Family Centroid CFAMM00275117 Functional Category Investigative Drug with Natural Product
Superfamily Tyrosinase and DNA polymerase Binder Superfamily
Class Class 2550

Cousin Family NamesSeedsMembers
Retinoic acid receptor Ligand naphthoic acid derivative Adapal... 2 264
Prostaglandin G/H synthase 2 Inhibitor Diflunisal Family 7 421
Retinoid X receptor Ligand Bexarotene Family 7 492
Prostaglandin G/H synthase 2 Inhibitor Ketoprofen Family 5 84
Fatty-acid amide hydrolase 1 Inhibitor Propofol Family 5 428
Prostaglandin G/H synthase 1 Inhibitor Salicyclic Acid Family 3 39
Prostaglandin G/H synthase 2 Inhibitor Nabumetone Family 4 267
Signal transducer and activator of transcription 3 Inhibitor A... 5 249
Vitamin K epoxide reductase complex subunit 1 Inhibitor Warfar... 9 508
Estrogen receptor beta Ligand Conjugated Estrogens Family 12 210
Oestrogen receptor ligand Dienestrol Family 35 440
Vitamin K-dependent gamma-carboxylase Inhibitor Anisindione Fa... 3 243
Ipriflavone family 62 2480
Danthron family 11 141
Agrimophol family 10 22
Leukotriene B4 receptor 1 Ligand LY293111 Family 24 79
Mitogen-activated protein kinase 12 Inhibitor SCIO-469 Family 1 7
Interleukin-1 beta Inhibitor Diacerein Family 3 77
Glucose-6-phosphate translocase Inhibitor Mumbaistatin Family 3 11
Bile acid receptor Ligand SR-45023A (apomine) Family 3 34
Macrophage migration inhibitory factor and Prothrombin Inhibit... 2 49
Phospholipase A2 Inhibitor P-anisic Acid Family 2 178
Arachidonate 5-lipoxygenase and Prostaglandin G/H synthase 1 I... 2 19
Steryl-sulfatase Inhibitor 3-{4-[(aminosulfonyl)oxy]benzoyl}ph... 5 3
Steryl-sulfatase Inhibitor Sulfamic Acid 3-(4-hydroxy-benzoyl)... 3 2
Epidermal growth factor receptor Ligand AG-538 Family 5 11
Estrogen receptor beta Ligand 3,6-dihydroxy-2-(4-hydroxy-pheny... 2 23
Oestrogen receptor and Estrogen receptor beta Ligand 6-(4-hydr... 30 63
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 2 56
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 9 81
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 2 3
4-aminobutyrate aminotransferase, mitochondrial and Succinate-... 4 22
Oestrogen receptor and Estrogen receptor beta Ligand 3,8-dihyd... 20 57
Glutamate carboxypeptidase 2 Inhibitor 2-(3-carboxybenzyl)succ... 2 7
Glutamate carboxypeptidase 2 Inhibitor 3-(2-carboxy-6-mercapto... 9 4
L-selectin and P-selectin Inhibitor 2,3,4-trihydroxybenzoic Ac... 2 10
Tyrosine-protein phosphatase non-receptor type 1 Ligand Licoag... 9 32
Cytosolic phospholipase A2 Inhibitor [6,3''']biflavone Family 5 5
Estradiol 17-beta-dehydrogenase 1 Inhibitor 3-(6-hydroxy-2-nap... 7 9
DNA topoisomerase 2-beta Inhibitor Demethylzeylasterone Family 1 2
Cannabinoid receptor 2 Ligand 2-(2-methoxybenzyl)-3h-benzo[f]c... 6 32
Indoleamine 2,3-dioxygenase 1 Inhibitor Garveatin E Family 2 0
NAD(P)H dehydrogenase [quinone] 1 Inhibitor 4-hydroxy-3-(2-nap... 12 1
Tyrosine-protein phosphatase non-receptor type 1 Ligand Kuwano... 3 3
DNA (cytosine-5)-methyltransferase 3B Inhibitor NSC-622444 Family 2 18
Epidermal growth factor receptor Ligand 3-(3-chloro-phenyl)-5,... 10 64
Protein farnesyltransferase subunit beta Inhibitor Cylindrol A... 3 43
Tyrosinase Inhibitor 3-(2,4-dihydroxyphenyl)-propionic Acid Et... 3 8
DNA polymerase Inhibitor 3alpha-o-trans-p-coumaroyl-7-labden-1... 1 13
Aromatase inhibitor (3R,4R)-4-benzyl-3-[(3-hydroxyphenyl)methy... 1 10
Estrogen receptor beta and Estrogen receptor ligand AGN-PC-007... 1 2
Estrogen receptor beta and Estrogen receptor ligand 4-bromo-9a... 3 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 14
Thromboxane A2 receptor ligand AGN-PC-003UTI family 1 0
Steryl-sulfatase inhibitor (8R,9S,13S,14S,17R)-17-benzyl-3,17-... 1 1
Tyrosine-protein kinase Lck inhibitor ZINC03370948 family 3 0
G2/mitotic-specific cyclin-B1 and Cyclin-dependent kinase 1 in... 2 8
Induced myeloid leukemia cell differentiation protein Mcl-1 an... 6 13
DNA-(apurinic or apyrimidinic site) lyase and Retinal dehydrog... 1 18
Nuclear receptor ROR-gamma and Huntingtin ligand CHEMBL1568747... 1 3
Peroxisome proliferator-activated receptor gamma and Peroxisom... 1 2
Vasopressin V2 receptor and C-C chemokine receptor type 4 liga... 1 1
Sterol O-acyltransferase 1 and Sterol O-acyltransferase 2 inhi... 1 5
Eukaryotic elongation factor 2 kinase and Proto-oncogene tyros... 1 1
Retinoic acid receptor beta ligand Adarotene family 1 0
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 1 3
Benzoic Acid and Derivatives Metabolite Methyl 3-(2,3-dihydrox... 1 3
Acenes Metabolite Lacinilene C Family 2 3
Acenes Metabolite 3-Hydroxy-9-(4-hydroxyphenyl)-1H,3H-naphtho[... 1 0
Putative NP ZINC49600254 Family 8 2
Putative NP ZINC31158464 Family 3 5
(1S)-1-hydroxy-1,4-dimethyl-2,3-dihydrocyclopenta[b]anthracene... 1 1
2,4-diacetyl-5-hydroxy-3-(4-hydroxyphenyl)-5-methylcyclohexen-... 4 0
carboxylate NP ZINC04026424 Family 3 7
[(E)-3-carboxy-2-(5-methyl-2-oxidophenyl)prop-2-enyl]-(2-pheny... 3 0
2,4-bis(4-hydroxyphenyl)cyclobutane-1,3-dicarboxylate NP ZINC0... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00275108 DNC010934 Investigative Drug isojaspic acid
CFAMM00275117 DNC009189 Investigative Drug jaspic acid
CFAMM00275116 DNC009188 Investigative Drug subersic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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