CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2753
Family Name Urotensin-2 receptor Ligand SB-436811 Family
No. of Seeds 6 No. of Other Members 71
Family Centroid CFAMM00275672 Functional Category Investigative Drug with Natural Product
Superfamily Urotensin-2 receptor Ligand SB-436811 Superfamily
Class Class 1077

Cousin Family NamesSeedsMembers
Sodium channel protein type 5 subunit alpha Ligand Dyclonine F... 6 174
Sodium channel protein type 5 subunit alpha Ligand Flecainide ... 2 162
Sodium channel protein type 5 subunit alpha Ligand Encainide F... 4 248
Zucapsacin family 7 177
Serine/threonine-protein kinase PLK1 Inhibitor On 019190.na Fa... 16 138
Cytochrome P450 2D6 and Delta-type opioid receptor Ligand 4-(s... 17 381
Delta-type opioid receptor Ligand Bw 373u86 Family 31 146
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
C-C chemokine receptor type 5 Ligand E-913 Family 6 44
Sodium channel protein type 10 subunit alpha Ligand A-803467 F... 2 81
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Histamine H3 receptor Ligand A-317920 Family 9 240
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 3 89
Plasmepsin-2 Inhibitor PS-662477 Family 7 55
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
Histamine H3 receptor Ligand A-349821 Family 49 228
Kappa-type opioid receptor Ligand ICI-204448 Family 7 26
Interstitial collagenase Inhibitor N-hydroxycarbamoylmethyl-4-... 5 24
Histamine H1 receptor Ligand MDL-105212 Family 16 56
Mitogen-activated protein kinase 14 Inhibitor N-(4-(trifluorom... 8 39
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Fatty-acid amide hydrolase 1 Inhibitor 3'-carbamoylbiphenyl-3-... 8 50
Sodium channel protein type 10 subunit alpha and Sodium channe... 2 13
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
Arachidonate 5-lipoxygenase Inhibitor 2-(4-butoxy-phenyl)-n-hy... 3 9
D(2) dopamine receptor Ligand Epidepride Family 31 66
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 5 17
Acetylcholinesterase Inhibitor 6-methyl-4-(4-benzoylpiperazin-... 2 6
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 24 73
Glycine receptor subunit beta Ligand ORG-25543 Family 10 153
Vasopressin V1a receptor and Vasopressin V2 receptor ligand [4... 4 7
Substance-K receptor ligand 5-chloro-N-[1-[[(2S)-5-[4-(oxan-4-... 2 4
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 8 12
Neutrophil elastase inhibitor (2S)-N-[(3S)-6-benzamido-5,5-dif... 6 10
Substance-P receptor ligand AGN-PC-075NP5 family 4 8
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[4-... 7 9
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[4-... 6 16
Prelamin-A/C and Beta-lactamase inhibitor CHEMBL1589265 family 1 0
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 11 6
Substance-K receptor and Substance-P receptor ligand AGN-PC-07... 1 0
Growth hormone secretagogue receptor type 1 ligand 2-(2-acetyl... 2 0
Vasopressin V1a receptor ligand 1-(4-chlorophenyl)-N-[(2R)-1-[... 2 8
Melanin-concentrating hormone receptor 1 ligand N-[1-[3-(4-chl... 1 1
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 3
Cytochrome P450 1A2 and Cytochrome P450 3A4 inhibitor 4-[4-[2-... 2 3
Bifunctional epoxide hydrolase 2 inhibitor 1-(1-adamantyl)-3-[... 2 0
Potassium voltage-gated channel subfamily H member 2 and Melan... 5 4
Kinesin-like protein KIF11 and Potassium voltage-gated channel... 1 0
P2X purinoceptor 7 inhibitor N-(1-adamantylmethyl)-2-chloro-5-... 3 0
C-C chemokine receptor type 1 and Chemokine (C-C motif) recept... 11 15
C-C chemokine receptor type 1 ligand 2-[(2S)-3-(5-chlorospiro[... 2 3
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 0
C-C chemokine receptor type 5 ligand 4-[4-[[4-[(5R)-3-cyclohex... 4 2
Melanocortin receptor 4 ligand [(3R,4S)-4-(4-chlorophenyl)-1-p... 5 8
Histamine H3 receptor and Sodium-dependent serotonin transport... 4 2
Histamine H3 receptor and Sodium-dependent serotonin transport... 14 3
Histamine H3 receptor and Sodium-dependent serotonin transport... 8 0
Melanocortin receptor 4 and Melanocortin receptor 3 ligand N-[... 1 0
Cannabinoid receptor 1 ligand AGN-PC-03RV6L family 10 3
Potassium voltage-gated channel subfamily H member 2 and C-C c... 2 1
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 11
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 15
Substance-P receptor ligand 1-[3-(3,4-dichlorophenyl)-3-[2-(1'... 5 4
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 0
Kappa-type opioid receptor ligand 2-(3,4-dichlorophenyl)-1-[(4... 7 1
Substance-K receptor ligand AGN-PC-074GE0 family 1 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 6 2
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 3
Melanocortin receptor 4 and Melanocortin receptor 5 ligand 3-a... 2 2
Substance-P receptor ligand AGN-PC-073LX9 family 1 0
Sodium-dependent serotonin transporter and Sodium-dependent no... 3 0
Renin inhibitor (1R,5S)-N-[(2-chlorophenyl)methyl]-7-[4-[3-[(2... 9 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 1 0
C-C chemokine receptor type 5 ligand (4-chlorophenyl) N-[1-[(4... 2 2
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 7 0
Dipeptidyl peptidase 4 inhibitor SureCN5777647 family 1 0
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-07R5XZ family 2 2
D(3) dopamine receptor ligand S33084 family 1 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(2-chlo... 2 4
Survival motor neuron protein and Muscleblind-like protein 1 i... 1 10
Sodium- and chloride-dependent glycine transporter 1 inhibitor... 1 1
Melanin-concentrating hormone receptor 1 ligand AGN-PC-00AWDS ... 1 0
Urotensin-2 receptor ligand SureCN6580253 family 1 1
Potassium voltage-gated channel subfamily H member 2 ligand me... 3 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00275647 CHEMBL482259 Bioactive SureCN6950604
CFAMM00275640 CHEMBL479994 Bioactive SureCN6947844
CFAMM00275629 CHEMBL272503 Bioactive [4-(3,4-dichlorophenoxy)-3-(methylaminomethyl)phenyl]-(4-propan-2-yl-1,4-diazepan-1-yl)methanone
CFAMM00275674 CHEMBL495075 Bioactive SureCN6944299
CFAMM00275673 CHEMBL139569 Bioactive SureCN7989837
CFAMM00275672 DNC009268 Investigative Drug SB-436811

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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