CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2760
Family Name Beta-2 adrenergic receptor Ligand Gnf-pf-1694 Family
No. of Seeds 4 No. of Other Members 70
Family Centroid CFAMM00275823 Functional Category Investigative Drug with Natural Product
Superfamily adrenergic receptor Ligand Befunolol Hci Superfamily
Class Class 769

Cousin Family NamesSeedsMembers
Alpha-1 adrenergic receptor ligand arylethanolamine derivative... 4 37
Beta adrenergic receptor Ligand Levobunolol Family 6 133
Beta-1 adrenergic receptor Ligand Esmolol Family 5 39
Beta-1 adrenergic receptor Ligand Metoprolol Family 29 90
Heat shock protein 90, putative Inhibitor Cromoglicate Family 14 2827
DNA Binder Methoxsalen Family 10 1638
Muscarinic acetylcholine receptor Ligand Flavoxate Family 9 350
D-alanyl-D-alanine carboxypeptidase Inhibitor B-lactams Family 59 1364
Beta-2 adrenergic receptor Ligand Salmeterol Xinafoate Family 9 51
Hidrosmin family 14 61
Ipriflavone family 62 2480
adrenergic receptor Ligand Befunolol Hci Family 1 1
Rotenone family 16 107
Agrimophol family 10 22
Cyclin-dependent kinase 2 Inhibitor Flavopiridol Family 4 124
Leukotriene B4 receptor 1 Ligand LY293111 Family 24 79
C-C chemokine receptor type 5 Ligand GW873140 Family 6 78
Cytochrome P450 2D6 and Delta-type opioid receptor Ligand 4-(s... 17 381
Tyrosine-protein phosphatase non-receptor type 1 Ligand PNU177... 1 5
Plasmepsin-2 Inhibitor PS-662477 Family 7 55
Leukotriene B4 receptor 1 Ligand SC-51146 Family 6 315
DNA-dependent protein kinase catalytic subunit Inhibitor 7-pro... 5 49
Acetylcholinesterase and Cholinesterase Inhibitor 3-[7-(benzyl... 22 303
Oestrogen receptor and Estrogen receptor beta Ligand 3,8-dihyd... 20 57
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor Ellagi... 1 11
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Epidermal growth factor receptor Ligand 3-(3-chloro-phenyl)-5,... 10 64
Protein farnesyltransferase subunit beta Inhibitor Cylindrol A... 3 43
Prostaglandin G/H synthase 2 Inhibitor 3,4-dibenzyloxy-2'-hydr... 7 40
Liver carboxylesterase 1 Inhibitor 2-methoxy-3,4-methylenediox... 4 26
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 4 10
Beta-2 adrenergic receptor and Beta-1 adrenergic receptor liga... 2 18
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 3 2
Multidrug resistance protein 1 inhibitor 1-[2-[(2R)-3-[4-(2,3-... 2 41
Hypoxia-inducible factor 1-alpha and Cytochrome P450 2D6 inhib... 1 2
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2,6-... 16 23
Peroxisome proliferator-activated receptor gamma ligand (9aS)-... 4 44
Melanin-concentrating hormone receptor 1 and Potassium voltage... 12 53
C-C chemokine receptor type 1 and Chemokine (C-C motif) recept... 1 16
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 14 1
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 5
Beta-2 adrenergic receptor and Beta-1 adrenergic receptor liga... 1 3
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase and Prelamin... 1 0
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 2 3
Cyclin-dependent kinase 5 and Cyclin-dependent kinase 5 activa... 2 110
Cathepsin D inhibitor (E)-N-butyl-4-[1-(3,4,5-trimethoxybenzoy... 1 3
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 7
Estrogen receptor ligand AGN-PC-073KIM family 1 0
Calpain-1 catalytic subunit inhibitor (3S)-3-[[4-[2-(methoxyme... 2 4
Putative NP ZINC08790414 Family 23 0
NP 2-(5,7-dihydroxy-4-methyl-2-oxo-2h-chromen-3-yl)-n-(3-(fura... 6 0
NP (z)-2-(4-isopropylbenzylidene)-3-oxo-2,3-dihydrobenzofuran-... 16 0
Putative NP ZINC08790868 Family 10 0
Putative NP ZINC02124510 Family 1 0
2-amino-3-methylpentanoate NP 2-((3-(4-fluorophenoxy)-4-oxo-4h... 13 2
NP 2-((5-hydroxy-2,2-dimethyl-4-oxochroman-7-yl)oxy)-n-(3-meth... 18 0
Putative NP ZINC08878071 Family 9 2
NP Molport-006-318-109 Family 13 0
Putative NP ZINC04085259 Family 3 0
4-(7-((2-amino-3-phenylpropanoyl)oxy)-5-hydroxy-4-oxo-4H-chrom... 3 0
NP 1-(2-((1-hydroxy-7-methoxy-9-oxo-9h-xanthen-3-yl)oxy)acetyl... 2 0
NP 2-((1'-acetyl-4-oxospiro[chroman-2,4'-piperidin]-7-yl)oxy)-... 5 0
2-[4-(6-methoxy-2-oxochromen-3-yl)phenoxy]acetamide NP (s)-n-(... 7 0
NP 5-hydroxy-4-oxo-2-phenyl-4h-chromen-7-yl 2-((tert-butoxycar... 19 0
NP 7-(2-((4as,8as)-4a-hydroxyoctahydroisoquinolin-2(1h)-yl)-2-... 3 0
hydroxyspiro[3H-chromene-2,4'-piperidine]-4-one NP 1'-acetyl-7... 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00275895 CHEMBL57185 Bioactive FLAVODILOL
CFAMM00275876 CHEMBL1233771 Bioactive ethyl 4-[(2S)-2-hydroxy-3-(propan-2-ylamino)propoxy]-3-methyl-1-benzofuran-2-carboxylate
CFAMM00275847 CHEMBL51667 Bioactive Ethyl 4-{3-[(tert-butyl)amino]-2-hydroxypropoxy}-3-methylbenzo[d]furan-2-carboxylate
CFAMM00275823 DNC009289 Investigative Drug GNF-PF-1694

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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