CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2771
Family Name Estradiol 17-beta-dehydrogenase 1 Inhibitor 3,3'-pyrazine-2,5-diyldiphenol Family
No. of Seeds 2 No. of Other Members 14
Family Centroid CFAMM00275960 Functional Category Investigative Drug
Superfamily Estradiol 17-beta-dehydrogenase 1 and DNA topoisomerase 1 Binder Superfamily
Class Class 1991

Cousin Family NamesSeedsMembers
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
DNA Binder Elliptinium Acetate Family 11 116
Citric Acid family 2 58
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
Reverse transcriptase Inhibitor 3'thiacytidine Family 4 29
5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine recept... 11 41
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Estradiol 17-beta-dehydrogenase 1 Inhibitor 4'-(6-methoxypyrid... 5 34
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 12 3
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 13 26
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 6
Oestrogen receptor and Estrogen receptor beta Ligand 4-(3-phen... 5 14
Glycogen synthase kinase-3 beta and Mitogen-activated protein ... 8 8
Oestrogen receptor and Estrogen receptor beta Ligand Estrogen ... 7 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
Acetylcholinesterase and Cholinesterase Inhibitor 6-hydroxy-1,... 4 2
Glycogen synthase kinase-3 beta Inhibitor 6-hydroxymanzamine A... 3 0
Cytochrome P450 11B1, mitochondrial Inhibitor 5-(6-methoxynaph... 7 4
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-366... 5 75
Indoleamine 2,3-dioxygenase 1 Inhibitor 5-aminoquinolin-8-ol F... 3 16
Potassium voltage-gated channel subfamily A member 5 Ligand 2-... 5 69
DNA topoisomerase 1 Inhibitor 3-(4-phenyl-2,4'-bipyridin-6-yl)... 4 13
Cytochrome P450 11B1, mitochondrial Inhibitor Metyrapol Family 3 41
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 38 35
Metabotropic glutamate receptor 5 Ligand 7-(3,5-dimethoxypheny... 2 7
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 4
Serine/threonine-protein kinase B-raf inhibitor AGN-PC-00CFYH ... 2 1
Sodium-dependent serotonin transporter inhibitor SureCN7536104... 6 2
D(4) dopamine receptor ligand AGN-PC-00SXAZ family 2 4
D(1A) dopamine receptor and D(2) dopamine receptor ligand (6aR... 3 6
Mitogen-activated protein kinase 14 inhibitor (4E)-4-[3-amino-... 1 4
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 3 2
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 2
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 7 1
D(1A) dopamine receptor and D(2) dopamine receptor ligand (6aS... 2 1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 2 4
Nuclear receptor ROR-gamma and Induced myeloid leukemia cell d... 1 1
Poly [ADP-ribose] polymerase 1 inhibitor N-(6-oxo-5H-benzo[c][... 1 3
Estrogen receptor and Estrogen receptor beta ligand AGN-PC-074... 1 0
(E)-3-(2-hydroxyphenyl)-1-pyridin-4-ylprop-2-en-1-one NP (e)-3... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00275959 CHEMBL1254773 Bioactive AGN-PC-09M5OD
CFAMM00275960 DNC009349 Investigative Drug 3,3'-pyrazine-2,5-diyldiphenol

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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