CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2778
Family Name Poly [ADP-ribose] polymerase 1 Inhibitor 2-(4-methoxyphenyl)quinoline-8-carboxamide Family
No. of Seeds 2 No. of Other Members 11
Family Centroid CFAMM00276098 Functional Category Investigative Drug with Natural Product
Superfamily Poly [ADP-ribose] polymerase 1 and Metabotropic glutamate receptor 1 Binder Superfamily
Class Class 656

Cousin Family NamesSeedsMembers
DNA Binder Primaquine Family 3 245
Sodium channel protein type 5 subunit alpha Ligand Dibucaine F... 2 136
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Arachidonate 5-lipoxygenase-activating protein Inhibitor DG031... 3 206
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor GSK2... 15 18
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
Platelet-derived growth factor receptor alpha and Platelet-der... 2 17
Adenosine receptor A1 and Adenosine receptor A3 Ligand 4-metho... 1 16
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Platelet-derived growth factor receptor alpha and Platelet-der... 2 13
Neuromedin-K receptor Ligand 3-methoxy-n',2-diphenylquinoline-... 14 33
Mu-type opioid receptor Ligand 6-(4-(2-(benzylamino)ethyl)phen... 3 27
Metabotropic glutamate receptor 1 Ligand JNJ-16259685 Family 3 20
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 2 31
Acetylcholinesterase Inhibitor Lysicamine Family 2 8
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Disintegrin and metalloproteinase domain-containing protein 17... 2 8
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 11
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 10 4
Plasmepsin-2 inhibitor N-[(2S)-1-[[(2S)-6-amino-1-[4-[(6-metho... 5 12
Vascular endothelial growth factor receptor 2 and Aurora kinas... 3 3
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 6
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 2 21
Vascular endothelial growth factor receptor 2 ligand AGN-PC-05... 2 2
Sodium channel protein type 10 subunit alpha and Sodium channe... 1 1
Sodium channel protein type 10 subunit alpha and Sodium channe... 3 22
Cysteinyl leukotriene receptor 1 ligand AGN-PC-075KCE family 5 33
Poly [ADP-ribose] polymerase 1 inhibitor SureCN5002485 family 2 11
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 16
Translocator protein inhibitor N-(4-methoxyphenyl)-N,3-dimethy... 2 2
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 15
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 11
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 21
Cysteinyl leukotriene receptor 2 and Cysteinyl leukotriene rec... 16 5
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 5
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 19
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1801290 ... 3 0
Cysteinyl leukotriene receptor 1 and Peripheral myelin protein... 1 1
Mitogen-activated protein kinase 14 inhibitor 3-fluoro-N-[4-me... 2 5
NS5B protein inhibitor AC1O5AET family 3 1
C-C chemokine receptor type 5 ligand N-[(3R)-3-[4-[4-methoxy-N... 13 1
Translocator protein inhibitor (4S)-N,N-diethyl-9-(2-fluoranyl... 9 10
D(3) dopamine receptor ligand AGN-PC-075Z0O family 2 3
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Arachidonate 5-lipoxygenase-activating protein inhibitor methy... 12 3
Disintegrin and metalloproteinase domain-containing protein 17... 13 3
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 12 0
Disintegrin and metalloproteinase domain-containing protein 17... 16 2
Acetylcholinesterase and Butyrylcholinesterase inhibitor (E)-3... 4 5
Casein kinase I isoform gamma-2 and Casein kinase I isoform de... 5 2
Cannabinoid receptor 1 ligand AGN-PC-0766FR family 4 3
Prostaglandin E synthase inhibitor 3-[4-(3-cyanopropoxy)-3-met... 2 4
Estrogen receptor and Estrogen receptor beta ligand N-[(2R)-4-... 7 11
Serine/threonine-protein kinase Chk1 inhibitor SureCN4854955 f... 2 0
Platelet-activating factor receptor ligand N,N-dimethyl-6-phen... 12 18
Prothrombin and Trypsin-1 inhibitor AGN-PC-074I4I family 3 1
Interstitial collagenase and Matrilysin inhibitor (3S,6R,7S)-N... 2 4
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-(3-me... 2 10
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-077PI... 4 0
Macrophage colony-stimulating factor 1 receptor ligand 4-(2,3-... 12 7
Macrophage colony-stimulating factor 1 receptor ligand 4-(3-ch... 5 4
Ras guanyl-releasing protein 3 and Protein kinase C alpha type... 2 6
Inositol monophosphatase 1 and Prelamin-A/C inhibitor GNF-Pf-3... 1 5
Serine/threonine-protein kinase Chk1 inhibitor 9-(1-methylpyrr... 1 1
DNA polymerase beta and Microtubule-associated protein tau inh... 1 1
Potassium-transporting ATPase alpha chain 1 and Potassium-tran... 1 3
2-en-1-one NP (e)-3-(benzo[d][1,3]dioxol-5-yl)-1-(6-bromo-2-me... 3 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00276098 DNC009373 Investigative Drug 2-(4-methoxyphenyl)quinoline-8-carboxamide
CFAMM00276105 DNC009390 Investigative Drug 3-(4-methoxyphenyl)quinoxaline-5-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26830 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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