CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2781
Family Name Poly [ADP-ribose] polymerase 1 Inhibitor N-(4-phenylthiazol-2-yl)isonicotinamide Family
No. of Seeds 6 No. of Other Members 150
Family Centroid CFAMM00276159 Functional Category Investigative Drug with Natural Product
Superfamily Cyclin-dependent kinase 5 and Poly [ADP-ribose] polymerase 1 Binder Superfamily
Class Class 1600

Cousin Family NamesSeedsMembers
Abelson tyrosine-protein kinase 2 inhibitor thiazole derivativ... 19 50
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Omega 1 Benzodiazepine receptor Ligand Indiplon Family 4 25
Aurora kinase B and Aurora kinase C Inhibitor SNS-314 Family 2 75
Aurora kinase B and Aurora kinase A Inhibitor CYC116 Family 16 135
Cytochrome P450 26A1 Inhibitor Rambazole Family 7 77
mRNA of Glucagon receptor Ligand Isis 325568 Family 1 3
Serine/threonine-protein kinase B-raf Inhibitor GSK2118436 Family 5 19
Aurora kinase A Inhibitor ABT-348 Family 20 49
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing... 3 16
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 37 57
DNA primase Inhibitor Bay 57-1293 Family 1 2
5-hydroxytryptamine receptor Ligand Sl65.0472 Family 2 16
Cyclin-dependent kinase 2 Inhibitor 4-(2,4-dimethyl-thiazol-5-... 2 14
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 4 22
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor 7-me... 2 45
TGF-beta receptor type-1 Ligand 4-pyridin-2-yl-5-quinolin-4-yl... 4 23
Cathepsin B and Cathepsin K Inhibitor L-006235-1 Family 19 75
Mitogen-activated protein kinase 14 Inhibitor 4-(2-ethyl-4-m-t... 14 41
Metabotropic glutamate receptor 5 Ligand N-[4-(3-pyridylethyny... 2 10
Inhibitor of nuclear factor kappa-B kinase subunit beta Inhibi... 6 64
C-C chemokine receptor type 4 Ligand N-(naphthalen-1-yl)-4-neo... 5 78
C-C chemokine receptor type 4 Ligand N-(4-tert-butylthiazol-2-... 3 9
Arachidonate 5-lipoxygenase Inhibitor N-(thiazol-2-yl)benzamid... 3 53
Arachidonate 5-lipoxygenase Inhibitor 2-phenyl-n-(thiazol-2-yl... 3 27
Vascular endothelial growth factor receptor 2 Ligand 3-(4-amin... 2 5
Cyclin-dependent kinase 5 Inhibitor 1-phenyl-3-(2-(pyridin-4-y... 3 53
Mitogen-activated protein kinase 11 and Mitogen-activated prot... 10 31
Glycogen synthase kinase-3 beta and Mitogen-activated protein ... 4 23
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(2... 2 20
Adenosine receptor A1 Ligand N-(4-phenyl-thiazol-2-yl)-benzami... 5 2
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-264... 6 32
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(5-b... 3 9
Amine oxidase [flavin-containing] B Inhibitor 2-(2-cyclohexyli... 6 44
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 4 22
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 55
Adenosine receptor A1 Ligand 4-nitro-n-(4-phenyl-thiazol-2-yl)... 2 38
Reverse transcriptase/RNaseH inhibitor AC1LAJTF family 6 5
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 2 13
Adenosine receptor A2b and Adenosine receptor A2a ligand SureC... 1 26
RAC-alpha serine/threonine-protein kinase and Cyclin-dependent... 2 7
Substance-K receptor ligand 6-methyl-N-[1-[[(2S)-1-phenyl-5-(4... 3 9
Potassium voltage-gated channel subfamily H member 2 and Neuro... 2 3
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 2-[3-(4-acet... 4 12
Insulin receptor and Tyrosine-protein kinase Lck ligand AGN-PC... 1 1
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 2 1
Tyrosine-protein kinase JAK2 and Potassium voltage-gated chann... 1 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 2
Receptor tyrosine-protein kinase erbB-2 ligand AGN-PC-07ZDR2 f... 7 33
Histone deacetylase 1 and Histone deacetylase 2 inhibitor AGN-... 2 5
Mitogen-activated protein kinase 14 inhibitor 4-[4-(4-fluoroph... 2 0
Neuropeptide Y receptor type 5 ligand N-[[(1S,5R)-3-(1-phenyle... 5 1
Neuropeptide Y receptor type 5 ligand 2-phenyl-1-[(1R,5S)-6-[[... 9 11
Neuropeptide Y receptor type 5 and Potassium voltage-gated cha... 2 0
Mitogen-activated protein kinase 14 inhibitor AGN-PC-07ZXHN fa... 2 4
Serine/threonine-protein kinase Chk1 inhibitor SureCN13010134 ... 7 29
Cyclin-dependent kinase 5 and Cyclin-dependent kinase 1 inhibi... 2 0
Vascular endothelial growth factor receptor 2 and Mast/stem ce... 10 27
Mitogen-activated protein kinase 14 inhibitor AGN-PC-09M88D fa... 2 1
Mitogen-activated protein kinase 14 and LIM domain kinase 1 in... 4 19
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 8 12
Serine/threonine-protein kinase Chk1 inhibitor SureCN3070314 f... 16 32
Serine/threonine-protein kinase Chk1 inhibitor 2-(1-methylindo... 3 4
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 8 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 8
Prelamin-A/C and Niemann-Pick C1 protein inhibitor CHEMBL13592... 1 16
Thyroid hormone receptor beta and Ferritin light chain ligand ... 3 10
Cellular tumor antigen p53 inhibitor CHEMBL1395891 family 1 6
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 1
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 9 1
Inosine-5'-monophosphate dehydrogenase and Nuclear receptor RO... 2 9
Coagulation factor X inhibitor AGN-PC-078Y4E family 4 6
Amine oxidase [flavin-containing] B inhibitor 4-(4-fluoropheny... 3 4
Coagulation factor X and Prothrombin inhibitor (2S)-2-(benzyls... 4 4
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 13 2
Platelet-activating factor receptor ligand Foropafant family 2 0
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 5 27
Fatty-acid amide hydrolase 1 inhibitor AGN-PC-0A9RCZ family 7 7
Calcitonin gene-related peptide type 1 receptor ligand SureCN1... 2 0
Metabotropic glutamate receptor 1 and Metabotropic glutamate r... 13 37
Metabotropic glutamate receptor 4 and Potassium voltage-gated ... 2 15
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 7 21
Neuropeptide Y receptor type 5 ligand N-[5-[(4-thiophen-3-yl-1... 1 4
Neuropeptide Y receptor type 5 ligand 2-fluoro-N-[5-[(4-pyridi... 2 2
Hepatocyte growth factor receptor ligand 5-[[6-(1-methylpyrazo... 4 0
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 9 16
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 2 2
Mitogen-activated protein kinase 14 inhibitor N-[4-[2-ETHYL-4-... 4 5
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 0
Vascular endothelial growth factor receptor 2 and Platelet-der... 3 3
Adenosine receptor A2b and Adenosine receptor A3 ligand 3-[5-(... 4 2
Vascular endothelial growth factor receptor 1 and Receptor-typ... 1 0
Protein kinase C zeta type and Inhibitor of nuclear factor kap... 1 6
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 15 8
Serine/threonine-protein kinase Chk1 inhibitor 3-[5-[2-[(4-mor... 2 3
Serine/threonine-protein kinase Chk1 inhibitor 5-[5-(1-methylp... 3 2
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 2 8
Orexin receptor type 2 and Orexin receptor type 1 ligand (2-me... 3 1
Cell division cycle 7-related protein kinase and Protein DBF4 ... 2 1
Glycogen synthase kinase-3 beta inhibitor N-[2-[4-(ethylsulfon... 2 2
Dipeptidyl peptidase 4 inhibitor [(2S,4S)-4-[4-(4-phenyl-1,3-t... 3 4
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 3
TGF-beta receptor type-1 and Mitogen-activated protein kinase ... 6 4
Melanin-concentrating hormone receptor 1 and Muscarinic acetyl... 8 2
D(3) dopamine receptor and D(2) dopamine receptor ligand [4-[2... 6 5
Metabotropic glutamate receptor 5 ligand 5-methyl-N-(4-methyl-... 1 2
Cholinesterase and Acetylcholinesterase inhibitor 3-[ethyl-[3-... 6 9
Eukaryotic translation initiation factor 2-alpha kinase 3 and ... 5 0
Eukaryotic translation initiation factor 2-alpha kinase 3 inhi... 2 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 1 0
Vascular endothelial growth factor receptor 2 ligand AC1NS6KN ... 4 5
P2X purinoceptor 7 inhibitor SureCN110930 family 2 0
Vascular endothelial growth factor receptor 2 ligand N-(1,3-Th... 4 4
C-C chemokine receptor type 2 ligand N-[[3,5-bis(trifluorometh... 22 16
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor CDK Inhibito... 8 3
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 2-[3-(1,4-di... 3 3
Protein-cysteine N-palmitoyltransferase porcupine inhibitor 2-... 5 2
NAD-dependent protein deacetylase sirtuin-2 and NAD-dependent ... 8 12
Cyclin-dependent kinase 5 and Cyclin-dependent kinase 5 activa... 4 4
Serine/threonine-protein kinase Chk1 inhibitor 2-(1,3-dihydroi... 2 5
Serine/threonine-protein kinase Chk1 inhibitor 2-indazol-1-yl-... 4 5
Orexin receptor type 2 and Orexin receptor type 1 ligand 6-ami... 3 1
Glucocorticoid receptor ligand 3-[1-(4-fluorophenyl)imidazo[1,... 5 3
Glucocorticoid receptor ligand 3-(1H-indol-5-yl)-2,2-dimethyl-... 2 7
Glucocorticoid receptor ligand (3R)-3-[1-(4-fluorophenyl)indaz... 4 2
MAP kinase-activated protein kinase 2 inhibitor 2-[(4,4-dimeth... 11 11
Thrombopoietin receptor ligand N-[4-[2-fluoro-3-(trifluorometh... 2 14
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 2 1
Transient receptor potential cation channel subfamily V member... 1 0
High affinity nerve growth factor receptor and Hepatocyte grow... 6 8
Intercellular adhesion molecule 1 and E-selectin inhibitor Sur... 1 0
Tyrosine-protein kinase Lck inhibitor benzothiazole analog 11 ... 7 13
Neuropeptide Y receptor type 5 ligand 1-[4-[[(9-fluoro-5,6-dih... 11 0
Epidermal growth factor receptor and Vascular endothelial grow... 7 0
Tyrosine-protein kinase Lck inhibitor AGN-PC-074MSE family 18 2
Tyrosine-protein kinase Lck inhibitor AGN-PC-074MPV family 4 0
Mitogen-activated protein kinase 14 inhibitor 303163-37-3 family 1 2
Vascular endothelial growth factor receptor 2 ligand Thienopyr... 2 2
Tyrosine-protein kinase Lck inhibitor AGN-PC-03HL8Q family 4 0
Tyrosine-protein kinase Lck inhibitor AGN-PC-03HLHQ family 2 0
RAC-alpha serine/threonine-protein kinase and RAC-gamma serine... 20 7
Histone deacetylase 1 and Potassium voltage-gated channel subf... 3 2
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 2 2
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-00A4QJ family 12 6
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 4 1
Transient receptor potential cation channel subfamily V member... 1 0
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-04XL74 family 1 0
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 2 4
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor AGN-P... 1 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 5 1
Metabotropic glutamate receptor 1 and Metabotropic glutamate r... 5 0
Neuropeptide Y receptor type 5 ligand SureCN6213316 family 3 1
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 2 1
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 1
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 2
Integrin beta-3 and Integrin alpha-IIb inhibitor 4-[[4-(4-carb... 4 2
Thrombopoietin receptor ligand (4R)-1-[3-chloro-5-[[4-[2-fluor... 3 8
Proto-oncogene tyrosine-protein kinase LCK and Tyrosine-protei... 3 9
Vascular endothelial growth factor receptor 2 and Insulin rece... 2 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 3
Methionine aminopeptidase and Methionine aminopeptidase 1 inhi... 8 13
Methionine aminopeptidase and Methionine aminopeptidase 1 inhi... 3 7
Methionine aminopeptidase and Methionine aminopeptidase 1 inhi... 11 2
Methionine aminopeptidase and Methionine aminopeptidase 1 inhi... 3 0
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-03LEDF family 3 4
Probable G-protein coupled receptor 142 ligand (2S)-3-phenyl-N... 2 2
Ephrin type-B receptor 4 ligand SureCN4473188 family 3 1
Histone deacetylase 1 inhibitor SureCN1066177 family 1 1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 5 1
Mitogen-activated protein kinase kinase kinase 8 inhibitor AGN... 2 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 2
Glucokinase inhibitor AGN-PC-078XNA family 2 9
Tyrosine-protein kinase ABL1 inhibitor F0344-0933 family 2 1
Tyrosyl-DNA phosphodiesterase 1 and ATP-dependent molecular ch... 1 0
Methionine aminopeptidase 1 inhibitor N-[5-[2-oxo-2-[4-(2-pyri... 1 0
Histamine H3 receptor ligand 3-[2-[2-(1H-imidazol-5-yl)ethylsu... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00276158 CHEMBL2181976 Bioactive N-[4-(3,5-dimethylphenyl)-5-pyridin-4-yl-1,3-thiazol-2-yl]pyridine-3-carboxamide
CFAMM00276262 CHEMBL199160 Bioactive N-[4-[2-ETHYL-4-(3-METHYLPHENYL)-1,3-THIAZOL-5-YL]-2-PYRIDYL]PROPIONAMIDE
CFAMM00276301 CHEMBL1209051 Bioactive CHEMBL1209050
CFAMM00276244 CHEMBL363648 Bioactive 303162-79-0
CFAMM00276241 CHEMBL572135 Bioactive AGN-PC-0144PE
CFAMM00276159 DNC009389 Investigative Drug N-(4-Phenylthiazol-2-yl)isonicotinamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

24347 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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