CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2794
Family Name Potassium voltage-gated channel subfamily H member 2 Ligand Betrixaban Family
No. of Seeds 22 No. of Other Members 56
Family Centroid CFAMM00276498 Functional Category Investigative Drug with Natural Product
Superfamily Potassium voltage-gated channel subfamily H member 2 Ligand Betrixaban Superfamily
Class Class 974

Cousin Family NamesSeedsMembers
Serine/threonine-protein kinase PLK1 Inhibitor Bi 6727 Family 15 81
Gamma-secretase subunit APH-1B Inhibitor E2012 Family 3 67
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
Sodium-dependent noradrenaline transporter Inhibitor Neri Iv F... 6 58
Smoothened homolog Inhibitor LDE225 Family 3 76
AP26113 family 16 90
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 11 10
MK-6096 family 3 69
Glucokinase Inhibitor GKA1 Family 2 67
Proto-oncogene tyrosine-protein kinase Src Inhibitor PD166285 ... 6 70
Bacterial outer membrane Inhibitor HKI-9924129 Family 19 85
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
5-hydroxytryptamine receptor 1A Ligand Sun N4057 Family 2 86
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
Mitogen-activated protein kinase 8 Inhibitor 2-(2-phenoxypyrim... 12 30
C-X-C chemokine receptor type 3 Ligand AMG-487 Family 28 73
Coagulation factor X and Neutrophil elastase Inhibitor ZK-8140... 51 17
Hepatocyte growth factor receptor Ligand BMS-777607 Family 10 1
Bifunctional epoxide hydrolase 2 Inhibitor N-benzyl-6-(3,3,3-t... 21 62
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2-(... 21 108
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 2 3
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Metabotropic glutamate receptor 5 Ligand 3-methoxy-n-(6-methyl... 3 15
Liver carboxylesterase 1 Inhibitor SM-32504 Family 3 28
Reverse transcriptase/RNaseH inhibitor AC1LALKM family 2 19
Disintegrin and metalloproteinase domain-containing protein 17... 14 9
Mitogen-activated protein kinase 14 inhibitor N-(4-aminobutyl)... 1 28
Hepatocyte growth factor receptor and Receptor-type tyrosine-p... 12 26
Hepatocyte growth factor receptor ligand SureCN4492034 family 2 2
Muscarinic acetylcholine receptor M2 and Muscarinic receptor 3... 4 3
Bifunctional epoxide hydrolase 2 inhibitor SureCN3216677 family 4 9
Potassium voltage-gated channel subfamily H member 2 and Kappa... 5 33
Reverse transcriptase/RNaseH inhibitor 1-(5-cyanopyridin-2-yl)... 5 0
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
ALK tyrosine kinase receptor and Insulin receptor ligand SureC... 7 1
Prostaglandin D2 receptor ligand 1-[3-[2-methoxy-6-[2-(4-metho... 6 16
Metabotropic glutamate receptor 5 ligand AGN-PC-09QLD2 family 1 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 2
Calcium/calmodulin-dependent protein kinase kinase 2 and Focal... 3 17
Melanin-concentrating hormone receptor 1 ligand N-[3-(2-aminoq... 4 1
Reverse transcriptase/RNaseH and Cytochrome P450 2C19 inhibito... 7 2
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 2 0
Mitogen-activated protein kinase 8 and Mitogen-activated prote... 1 13
MAP kinase-activated protein kinase 2 inhibitor N-[4-(4-oxospi... 3 0
Melanin-concentrating hormone receptor 1 ligand N-[1-(1,3-benz... 2 5
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075X2X ... 2 0
Insulin-like growth factor 1 receptor ligand GSK1220512A family 20 15
Rho-associated protein kinase 1 and cAMP-dependent protein kin... 1 11
ALK tyrosine kinase receptor and Ribosomal protein S6 kinase a... 6 2
ALK tyrosine kinase receptor and Insulin receptor ligand 7-[[5... 4 1
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Melanin-concentrating hormone receptor 1 ligand 3-[6-[3-(dimet... 14 6
Melanocortin receptor 4 ligand N-[(2R)-3-(2,4-dichlorophenyl)-... 2 2
Fatty-acid amide hydrolase 1 inhibitor 4-[[3-(4-chlorophenoxy)... 2 7
Nitric oxide synthase, inducible inhibitor 2-[1-(2-imidazol-1-... 4 3
Fatty-acid amide hydrolase 1 inhibitor 4-[[3-(4-chlorophenoxy)... 4 2
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 6
Fatty-acid amide hydrolase 1 inhibitor 4-[[3-(4-chlorophenoxy)... 1 0
Fatty-acid amide hydrolase 1 inhibitor 4-[[3-(4-chlorophenoxy)... 1 1
Motilin receptor ligand SureCN2765637 family 1 1
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
Non-receptor tyrosine-protein kinase TYK2 ligand AGN-PC-0D0Z0U... 2 0
Focal adhesion kinase 1 inhibitor 2-[[2-(2-methoxy-4-morpholin... 2 1
Metabotropic glutamate receptor 5 and Cytochrome P450 3A4 liga... 3 7
Angiopoietin-1 receptor and Vascular endothelial growth factor... 5 0
Mast/stem cell growth factor receptor Kit and Serine/threonine... 11 29
Ephrin type-A receptor 3 and Tyrosine-protein kinase Fgr ligan... 1 3
Coagulation factor X inhibitor 5-chloro-N-(5-chloropyridin-2-y... 1 0
Vascular endothelial growth factor receptor 2 ligand N-(4-chlo... 4 4
Reverse transcriptase/RNaseH inhibitor 1-(5-chloropyridin-2-yl... 3 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 1
Vasopressin V1a receptor and Vasopressin V2 receptor ligand AG... 2 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 3 5
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075X2R ... 1 3
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 15 1
Hepatocyte growth factor receptor ligand 4-pyridone analogue, ... 8 0
Insulin-like growth factor 1 receptor ligand AGN-PC-050GPS family 7 0
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 6 0
Adenosine receptor A3 and Adenosine receptor A1 ligand CHEMBL4... 2 3
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
Adenosine receptor A1 and Adenosine receptor A2a ligand AGN-PC... 2 25
Metabotropic glutamate receptor 5 ligand AGN-PC-09QJ1Q family 1 0
Hepatocyte growth factor receptor ligand [4-[6-amino-5-[1-(2,6... 5 1
Proto-oncogene tyrosine-protein kinase Src and Fibroblast grow... 2 0
Thromboxane-A synthase and Platelet-activating factor receptor... 1 6
Thromboxane-A synthase and Platelet-activating factor receptor... 1 0
Metabotropic glutamate receptor 5 ligand 2-oxo-N-pyridin-2-yl-... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00276422 CHEMBL260085 Bioactive SureCN1998460
CFAMM00276435 CHEMBL515919 Bioactive SureCN1286409
CFAMM00276501 CHEMBL470734 Bioactive AGN-PC-078Y3T
CFAMM00276493 CHEMBL218315 Bioactive 1-[2-[[2-[(5-chloropyridin-2-yl)carbamoyl]-4-methoxyphenyl]carbamoyl]-5-(N,N-dimethylcarbamimidoyl)phenyl]piperidine-4-carboxylic acid
CFAMM00276456 CHEMBL472778 Bioactive N-[4-chloro-2-[(5-chloropyridin-2-yl)carbamoyl]phenyl]-4-(N,N-dimethylcarbamimidoyl)-2-methoxybenzamide
CFAMM00276476 CHEMBL221231 Bioactive AGN-PC-020GUE
CFAMM00276427 CHEMBL402980 Bioactive 5-chloro-N-(5-chloropyridin-2-yl)-3-methoxy-2-[[4-(2-oxopyridin-1-yl)benzoyl]amino]benzamide
CFAMM00276475 CHEMBL475551 Bioactive 5-chloro-N-(5-chloropyridin-2-yl)-2-[[4-(N,N-dimethylcarbamimidoyl)benzoyl]amino]-3-propan-2-yloxybenzamide
CFAMM00276439 CHEMBL472779 Bioactive N-[4-chloro-2-[(5-chloropyridin-2-yl)carbamoyl]phenyl]-4-(N,N-dimethylcarbamimidoyl)-2-(2-methoxyethoxy)benzamide
CFAMM00276453 CHEMBL515545 Bioactive SureCN12132355
CFAMM00276419 CHEMBL260369 Bioactive N-[4-chloro-2-[(5-chloropyridin-2-yl)carbamoyl]-6-methoxyphenyl]-6-(2-oxopyridin-1-yl)pyridine-3-carboxamide
CFAMM00276432 CHEMBL260160 Bioactive 5-chloro-N-(5-chloropyridin-2-yl)-2-[[2-fluoro-4-(2-oxopyridin-1-yl)benzoyl]amino]-3-methoxybenzamide
CFAMM00276445 CHEMBL472974 Bioactive AGN-PC-078Y0W
CFAMM00276438 CHEMBL219106 Bioactive N-[2-[(5-chloropyridin-2-yl)carbamoyl]-4-methoxyphenyl]-4-(N,N-dimethylcarbamimidoyl)-2-piperidin-1-ylbenzamide
CFAMM00276467 CHEMBL261536 Bioactive 5-chloro-N-(5-chloropyridin-2-yl)-3-[2-(dimethylamino)ethoxy]-2-[[4-(2-oxopiperidin-1-yl)benzoyl]amino]benzamide
CFAMM00276481 CHEMBL257399 Bioactive N-(5-chloropyridin-2-yl)-3-methoxy-2-[[4-(2-oxopyridin-1-yl)benzoyl]amino]benzamide
CFAMM00276418 CHEMBL475370 Bioactive AGN-PC-078Y4H
CFAMM00276497 CHEMBL195511 Bioactive AGN-PC-075X2N
CFAMM00276489 CHEMBL1923217 Bioactive 2-[[5-chloro-2-(4-methoxyphenoxy)pyrimidin-4-yl]amino]benzamide
CFAMM00276430 CHEMBL472610 Bioactive SureCN12134484
CFAMM00276498 DNC009421 Investigative Drug BETRIXABAN

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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