CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2799
Family Name 5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine transporter Ligand 1-(2-(phenoxymethyl)phenyl)piperazine Family
No. of Seeds 9 No. of Other Members 79
Family Centroid CFAMM00276695 Functional Category Investigative Drug with Natural Product
Superfamily 5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine transporter Binder Superfamily 2
Class Class 490

Cousin Family NamesSeedsMembers
D(2) dopamine receptor ligand phenylpiperazine derivative Arip... 3 53
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Beta-2 adrenergic receptor Ligand Formoterol Family 16 63
Alpha adrenergic receptor Ligand Phenoxybenzamine Family 4 63
Potassium voltage-gated channel subfamily H member 2 Ligand Do... 5 30
Sodium channel protein type 5 subunit alpha Ligand Encainide F... 4 248
Acetylcholinesterase Inhibitor Edrophonium Family 7 40
Acetylcholinesterase Inhibitor Neostigmine Family 4 76
Sodium channel protein type 10 subunit alpha and Sodium channe... 1 7
Beta-1 adrenergic receptor Ligand Practolol Family 2 82
Squalene monooxygenase Inhibitor Tolnaftate Family 1 4
Acyl-CoA desaturase Inhibitor Isoxyl Family 5 62
Serine/threonine-protein kinase PLK1 Inhibitor On 019190.na Fa... 16 138
Cholesteryl ester transfer protein Inhibitor CP-800569 Family 5 81
D(2) dopamine receptor Ligand Aplindore Fumarate Family 2 30
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 3 27
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 3 67
Substance-P receptor Ligand Ezlopitant Family 10 207
D(4) dopamine receptor Ligand PD-165167 Family 2 96
Tumor necrosis factor Inhibitor Tgaac-94 Family 6 107
Dihydroorotate dehydrogenase and Interleukin-17A Inhibitor Vid... 4 74
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Muscarinic acetylcholine receptor M1 Ligand AC-260584 Family 4 36
Alpha-2C adrenergic receptor Ligand ARC239 Family 15 23
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
Alpha-1 adrenergic receptor Ligand DC-015 Family 8 25
Glucose-6-phosphate 1-dehydrogenase Inhibitor Metazamide Family 9 69
5-hydroxytryptamine receptor 1A Ligand NAN-190 Family 14 28
Extracellular calcium-sensing receptor Ligand Nps 568 Family 5 54
5-hydroxytryptamine receptor 6 Ligand Sb 258585 Family 11 121
Histamine H3 receptor Ligand UCL-2138 Family 23 172
Multidrug resistance protein Inhibitor MM36 Family 1 1
Peptidyl-prolyl cis-trans isomerase A Inhibitor 7-amino-4-meth... 4 59
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 7 49
Leukotriene A-4 hydrolase Inhibitor N-benzyl-4-[(2r)-pyrrolidi... 6 40
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 11
Mineralocorticoid receptor and Androgen receptor Ligand AL-43 ... 79 235
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 11 20
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 18 12
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor Liga... 40 90
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 6 23
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 131
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 7 22
Substance-K receptor Ligand MEN-14933 Family 13 154
Coagulation factor VII and Coagulation factor X Inhibitor 4-(4... 2 12
Alpha-1A adrenergic receptor Ligand Upidosin Family 8 46
Alpha-1A adrenergic receptor Ligand Naftopidil Family 15 119
Cannabinoid receptor 1 Ligand N-(4-methoxyphenyl)oleamide Family 4 23
Adenosine receptor A3 and Muscarinic acetylcholine receptor M2... 4 31
Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16
Alpha-1A adrenergic receptor and D(2) dopamine receptor Ligand... 5 49
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 41
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 11 13
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Macrophage migration inhibitory factor Inhibitor 3-benzyl-5-me... 10 42
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 11
Amine oxidase [flavin-containing] B Inhibitor N-methyl-n-pheny... 6 25
Bifunctional epoxide hydrolase 2 Inhibitor 1-adamantan-1-yl-3-... 12 44
Sodium-dependent serotonin transporter Inhibitor 4-(2-((dimeth... 3 1
Cholesteryl ester transfer protein Inhibitor Tetrahydroquinoli... 3 8
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
Renin Inhibitor Ro-66-1168 Family 10 30
Bifunctional epoxide hydrolase 2 Inhibitor 1-(3-(3-morpholinop... 24 102
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 8 41
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-237... 21 56
Indoleamine 2,3-dioxygenase 1 Inhibitor 4-aminonaphthalen-1-ol... 2 34
Indoleamine 2,3-dioxygenase 1 Inhibitor 4-(ethylamino)naphthal... 10 13
Leukotriene A-4 hydrolase Inhibitor 1-[4-(4-iodophenoxy)phenyl... 5 18
Urotensin-2 receptor Ligand JNJ-28318706 Family 4 227
Fatty-acid amide hydrolase 1 Inhibitor 3-(trifluoromethyl)phen... 3 0
Fatty-acid amide hydrolase 1 Inhibitor Benzaldehyde O-4-ethoxy... 21 4
Fatty-acid amide hydrolase 1 Inhibitor Phenylcarbamic Acid Bip... 3 7
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
Fatty-acid amide hydrolase 1 Inhibitor Phenmedipham Family 2 5
Aromatase Inhibitor 2,3-dimethoxy-4'-amino-trans-stilbene Family 5 12
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 28
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 21 13
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 9
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 2 3
Tyrosinase Inhibitor 1-(4-(benzyloxy)phenyl)-3-hydroxyurea Family 9 23
Fatty-acid amide hydrolase 1 Inhibitor 4-nitrophenyl 4-benzylp... 5 35
Liver carboxylesterase 1 Inhibitor SCH-48375 Family 2 28
Estrogen receptor and Estrogen receptor beta ligand AGN-PC-00G... 16 4
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 2 6
D(4) dopamine receptor ligand AGN-PC-004XJQ family 2 1
D(4) dopamine receptor and D(2) dopamine receptor ligand 2-[4-... 2 6
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 1
Substance-P receptor ligand N-[1-[acetyl-[(2-methoxyphenyl)met... 3 9
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 10
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
Cathepsin K inhibitor N-[(2S)-1-(4-methoxyanilino)propan-2-yl]... 11 10
D(2) dopamine receptor ligand 7-[4-[4-(2-ethoxyphenyl)piperazi... 12 14
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 14 12
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 5 13
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 5
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 8 4
D(4) dopamine receptor and D(2) dopamine receptor ligand 1-(4-... 3 5
Beta-2 adrenergic receptor and Beta-1 adrenergic receptor liga... 3 6
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 6 2
Alpha-2A adrenergic receptor and 5-hydroxytryptamine receptor ... 7 10
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 4 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 3 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 49 8
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 4
D(3) dopamine receptor and D(2) dopamine receptor ligand (E)-N... 2 2
Estrogen receptor and Estrogen receptor beta ligand SureCN5681... 7 3
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 3
Transient receptor potential cation channel subfamily V member... 3 15
Survival motor neuron protein and DNA-(apurinic or apyrimidini... 1 5
Acetylcholinesterase inhibitor trimethyl-(2-methyl-3-propanoyl... 3 2
Acetylcholinesterase inhibitor AGN-PC-075N8G family 2 9
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 3 1
D(4) dopamine receptor and D(2) dopamine receptor ligand SureC... 4 3
D(4) dopamine receptor and D(3) dopamine receptor ligand SureC... 5 0
Sodium-dependent serotonin transporter inhibitor SureCN3890472... 2 0
Substance-P receptor ligand (2S,4S)-1-N-(3-chlorophenyl)-2-N-[... 5 2
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[4-... 6 16
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 2 9
Gastrin/cholecystokinin type B receptor ligand 1-[3-[[2-(3-met... 2 12
Potassium voltage-gated channel subfamily H member 2 and Melan... 9 4
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 11 2
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 11 4
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 2 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 2
Gonadotropin-releasing hormone receptor ligand SureCN5756131 f... 5 7
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 4 1
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 6 1
Androgen receptor ligand (2R)-2-ethyl-1-(2,2,2-trifluoroethyl)... 32 6
Substance-P receptor ligand 1-[(5-amino-2-methoxyphenyl)methyl... 3 5
Neuropeptide Y receptor type 5 ligand N-[[4-[2-[7-(trifluorome... 1 1
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 2 4
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 5
Histamine H3 receptor ligand 5-[4-[3-[(2R)-2-methylpyrrolidin-... 2 3
D(4) dopamine receptor and 5-hydroxytryptamine receptor 2A lig... 2 3
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 2 0
Cathepsin K and Cathepsin L1 inhibitor 4-ethyl-N-[(2S)-1-[2-(4... 7 10
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 4 19
Sodium-dependent serotonin transporter inhibitor 2-[2-[(dimeth... 3 3
Carbonic anhydrase 1 and Carbonic anhydrase 2 inhibitor [4-(2,... 2 11
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial ... 3 3
Translocator protein inhibitor [11C]DAA1106 family 15 2
Histamine H3 receptor ligand SureCN6109532 family 1 0
5-hydroxytryptamine receptor 7 and 5-hydroxytryptamine recepto... 1 3
Fatty-acid amide hydrolase 1 inhibitor 4-[[3-(4-chlorophenoxy)... 1 0
Cathepsin K inhibitor (1R,2R)-N-(cyanomethyl)-2-[4-(3-methoxyp... 2 1
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2A lig... 1 0
Bifunctional epoxide hydrolase 2 inhibitor SureCN3178516 family 3 1
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 1
Histamine H3 receptor and Histamine receptor H3 ligand 1-(3,5-... 1 0
5-hydroxytryptamine receptor 7 ligand 1-(2-methoxyphenyl)-4-[2... 6 2
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 1
Coagulation factor X and Cationic trypsin inhibitor 3-[(E)-3-[... 3 2
Glutamate receptor ionotropic, NMDA 2B and Potassium voltage-g... 2 1
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 20 23
Mitogen-activated protein kinase 14 inhibitor (2R)-2-amino-N-[... 9 0
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 2 11
5-hydroxytryptamine receptor 1A ligand AGN-PC-0034EG family 5 2
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 4 7
Hormone-sensitive lipase inhibitor SureCN7553414 family 1 1
5-hydroxytryptamine receptor 1A ligand (1R,2R)-2-[4-(2,3-dihyd... 2 3
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 2
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
Neuropeptide Y receptor type 5 ligand 3-[4-(4-fluorophenoxy)ph... 4 0
Neuropeptide Y receptor type 5 ligand 1-[1-(4-fluorophenyl)pro... 2 8
Neuropeptide Y receptor type 5 ligand AGN-PC-01NRZ6 family 3 6
Substance-P receptor ligand CP 141938 family 1 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 1 2
Sigma non-opioid intracellular receptor 1 ligand (5S)-5-[(4-hy... 1 5
D(3) dopamine receptor ligand rac S 33138 family 1 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand Desac... 2 3
Melanin-concentrating hormone receptor 1 ligand SureCN6779516 ... 1 0
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 1 0
D(4) dopamine receptor ligand 1-Piperidineacetamide, 4-(3-hydr... 1 0
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-00RZQT family 3 4
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 5 5
5-hydroxytryptamine receptor 7 and 5-hydroxytryptamine recepto... 1 0
Histamine H3 receptor ligand SureCN3057839 family 1 0
Amyloid beta A4 protein inhibitor 2-(fluoranylmethyl)-3-[4-[(E... 1 3
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 1
D(4) dopamine receptor and 5-hydroxytryptamine receptor 2C lig... 1 7
Sodium-dependent noradrenaline transporter and Sodium-dependen... 3 0
Poly [ADP-ribose] polymerase 1 inhibitor SureCN8058778 family 13 4
Histamine H3 receptor ligand AGN-PC-07ZCFA family 1 0
C-C chemokine receptor type 3 ligand SureCN6700764 family 2 2
Prelamin-A/C and Nonstructural protein 1 inhibitor CHEMBL14536... 1 2
Histone deacetylase 8 and Histone deacetylase 6 inhibitor (3S)... 4 16
Protein-S-isoprenylcysteine O-methyltransferase inhibitor N-[2... 1 2
Transient receptor potential cation channel subfamily V member... 2 7
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 2 8
Arachidonate 5-lipoxygenase inhibitor ethyl (E)-3-(10H-phenoxa... 1 1
Protein-S-isoprenylcysteine O-methyltransferase inhibitor 3-me... 1 0
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075HBO ... 2 44


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00276613 CHEMBL2164328 Bioactive 1-[3-(2-methoxyphenyl)phenyl]piperazine
CFAMM00276659 CHEMBL98125 Bioactive (2S,3S)-N-[[5-(dimethylamino)-2-methoxyphenyl]methyl]-2-phenylpiperidin-3-amine
CFAMM00276671 CHEMBL483358 Bioactive tolylpiperazine, 5b
CFAMM00276684 CHEMBL194548 Bioactive N-[[4-(1-propan-2-ylpiperidin-4-yl)oxyphenyl]methyl]aniline
CFAMM00276639 CHEMBL483560 Bioactive tolylpiperazine, 5e
CFAMM00276616 DNC009433 Investigative Drug 1-(3-(benzyloxy)-2-methylphenyl)piperazine
CFAMM00276608 DNC010042 Investigative Drug 1-(2-((3-fluorophenoxy)methyl)phenyl)piperazine
CFAMM00276695 DNC010055 Investigative Drug 1-(2-(phenoxymethyl)phenyl)piperazine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27291 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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