CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2818
Family Name Cytochrome P450 3A4 Inhibitor (-)-cubebininolide Family
No. of Seeds 4 No. of Other Members 28
Family Centroid CFAMM00277167 Functional Category Investigative Drug with Human Metabolite & Natural Product
Superfamily Oxi4503 Superfamily
Class Class 1241

Cousin Family NamesSeedsMembers
Retinoic acid receptor Ligand naphthoic acid derivative Adapal... 2 264
Histamine H1 receptor Ligand Doxepin Family 8 89
Cannabinoid receptor 1 Ligand Marinol Family 32 454
Cyclooxygenase Inhibitor Fenoprofen Family 4 1077
DNA topoisomerase 2-beta Inhibitor Etoposide Family 3 29
Prostaglandin G/H synthase 2 Inhibitor Nabumetone Family 4 267
Signal transducer and activator of transcription 3 Inhibitor A... 5 249
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor Mycophenola... 4 353
Heat shock protein 90, putative Inhibitor Cromoglicate Family 14 2827
Oestrogen receptor ligand Dienestrol Family 35 440
DNA Binder Methoxsalen Family 10 1638
Vitamin K-dependent gamma-carboxylase Inhibitor Anisindione Fa... 3 243
D-alanyl-D-alanine carboxypeptidase Inhibitor B-lactams Family 59 1364
Aldehyde oxidase Inhibitor Isovanillin Family 6 429
Hidrosmin family 14 61
Ipriflavone family 62 2480
Rotenone family 16 107
taste receptor Ligand Cynarin Family 6 124
Agrimophol family 10 22
Leukotriene B4 receptor 1 Ligand LY293111 Family 24 79
Sphingosine kinase 2 Inhibitor Phenoxodiol Family 24 682
NAD-dependent protein deacetylase sirtuin-1 Inhibitor SRT501 F... 19 88
Steryl-sulfatase Inhibitor Stx 64 Family 7 160
DNA topoisomerase 2-beta Inhibitor TOP-53 Family 2 12
Muscarinic acetylcholine receptor M1 Ligand GSK1034702 Family 7 148
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 9 123
Translocator protein Inhibitor Dextofisopam Family 3 250
Transient receptor potential cation channel subfamily V member... 29 18
Multidrug resistance protein Inhibitor Curcumin I Family 19 278
Oxi4503 family 4 27
Free fatty acid receptor 1 Ligand TAK-875 Family 2 54
TS-071 family 8 36
Arachidonate 5-lipoxygenase Inhibitor Caffeic Acid Family 3 32
Integrase Inhibitor L-708,906 Family 1 8
Endothelin-1 receptor Ligand PD156707 Family 41 211
Macrophage migration inhibitory factor and Prothrombin Inhibit... 2 49
Phospholipase A2 Inhibitor P-anisic Acid Family 2 178
Peroxisome proliferator-activated receptor gamma Ligand (2s)-2... 10 126
Arachidonate 15-lipoxygenase Inhibitor Isoscopoletin Family 5 98
Platelet-activating factor receptor Ligand L-652731 Family 5 116
Cytosolic phospholipase A2 Inhibitor 1,1,1-trifluoro-6-(4-hexy... 9 86
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 Ligand... 4 26
Steryl-sulfatase Inhibitor Sulfamic Acid 4-(3-methoxy-benzoyl)... 5 24
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 2,5-... 2 96
Endothelin B receptor and Endothelin-1 receptor Ligand PD-1631... 9 13
Epidermal growth factor receptor Ligand AG-538 Family 5 11
Phospholipase A2 Inhibitor 3,9-dihydroxy-2,10-diprenylpterocap... 9 25
Abelson tyrosine-protein kinase 2 Inhibitor 3'',5''-dimethoxy-... 3 9
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 5 13
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 2 56
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 9 81
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 4 127
Oestrogen receptor and Estrogen receptor beta Ligand 3,8-dihyd... 20 57
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor Ellagi... 1 11
Tubulin beta chain Inhibitor Combretastatin Family 3 5
Arachidonate 15-lipoxygenase and Arachidonate 5-lipoxygenase I... 3 18
Sodium/glucose cotransporter 2 Inhibitor Maackiain Family 1 5
Carbonic anhydrase 9 and Carbonic anhydrase 12 Inhibitor Ethox... 12 80
Thyroid hormone receptor beta Ligand 2-hexylphenyl Acrylate Fa... 4 83
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 4 37
Protein kinase C alpha type and Protein kinase C beta type Inh... 2 1
Protein kinase C alpha type Inhibitor Acetoside Family 5 39
MO15-related protein kinase Pfmrk Inhibitor WR-289012 Family 2 17
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 3-ben... 4 74
Cannabinoid receptor 2 Ligand 2-(2-methoxybenzyl)-3h-benzo[f]c... 6 32
Squalene monooxygenase Inhibitor Octyl_gallate Family 5 5
Arachidonate 12-lipoxygenase, 12S-type and Arachidonate 15-lip... 2 1
Cytochrome P450 3A4 Inhibitor (8r,8'r,9's)-5-methoxyclusin Family 6 20
Cytochrome P450 3A4 Inhibitor Hinokinin Family 2 10
NAD(P)H dehydrogenase [quinone] 1 Inhibitor Ethyl Bis(4-hydrox... 5 7
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 6-meth... 2 36
Tyrosine-protein phosphatase non-receptor type 1 and Neuramini... 10 2
Aromatase Inhibitor 3,4-bis(3,4-dimethoxyphenyl)furan-2(5h)-on... 4 86
NF-kappa-B Inhibitor Rocaglamide Family 8 8
Beta-secretase 1 Inhibitor Eckol Family 6 40
Heat shock cognate 71 kDa protein Inhibitor NSC-119913 Family 2 1
Epidermal growth factor receptor Ligand 3-(3-chloro-phenyl)-5,... 10 64
Protein farnesyltransferase subunit beta Inhibitor Cylindrol A... 3 43
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 3 0
Prostaglandin G/H synthase 2 Inhibitor 3,4-dibenzyloxy-2'-hydr... 7 40
Androgen receptor Ligand Palodesangren E Family 12 43
Sodium-dependent dopamine transporter Inhibitor Secocularidine... 3 9
CGMP-dependent protein kinase Inhibitor Tenellone A Family 1 7
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 3 27
Amine oxidase [flavin-containing] B Inhibitor Methyl Piperate ... 1 19
72 kDa type IV collagenase Inhibitor Lithospermic Acid Family 1 0
Liver carboxylesterase 1 Inhibitor 2-methoxy-3,4-methylenediox... 4 26
Aromatase inhibitor (3R,4R)-4-benzyl-3-[(3-hydroxyphenyl)methy... 1 10
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 6 6
Sodium/glucose cotransporter 2 and Sodium/glucose cotransporte... 3 19
Peroxisome proliferator-activated receptor alpha and Peroxisom... 2 7
Squalene synthase inhibitor (6R,7R)-1-[(4S,5R)-4-acetyloxy-5-m... 8 5
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 4
Acetylcholinesterase inhibitor AGN-PC-003A5N family 3 9
Endothelin-1 receptor ligand (2S)-2-(1,3-benzodioxol-5-yl)-4-m... 17 0
Arachidonate 5-lipoxygenase inhibitor 7-[[3-fluoro-5-[(1S,3S,5... 2 0
Endothelin-1 receptor ligand SureCN8117947 family 1 3
Peroxisome proliferator-activated receptor delta and Peroxisom... 4 2
Eukaryotic initiation factor 4A-I inhibitor methyl (1R,2R,3S,3... 12 1
Peroxisome proliferator-activated receptor delta ligand SureCN... 1 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 14
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 7 13
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 7
Androgen receptor and Estrogen receptor ligand estradiol benzo... 1 29
Endothelin-1 receptor and Endothelin B receptor ligand SureCN7... 2 2
Peroxisome proliferator-activated receptor delta and Peroxisom... 2 2
Endothelin B receptor and Endothelin-1 receptor ligand AGN-PC-... 2 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 1 1
Platelet-activating factor receptor ligand (2S,3R,3aS)-2-(3,4-... 2 7
Free fatty acid receptor 1 ligand 2-[(8S)-3-(3-bromophenyl)-2,... 2 3
Free fatty acid receptor 1 ligand 2-[(3R,8S)-3-(3-chlorophenyl... 2 2
Free fatty acid receptor 1 ligand 2-[(8S)-3-[5-[2-chloro-4-(3-... 3 3
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 1 1
Multidrug resistance protein 1 inhibitor CHEMBL1 family 2 0
Estradiol 17-beta-dehydrogenase 1 inhibitor SureCN4589665 family 2 4
Putative fructose-1,6-bisphosphate aldolase and Retinal dehydr... 1 0
Epidermal growth factor receptor and Receptor tyrosine-protein... 1 3
G2/mitotic-specific cyclin-B1 and Cyclin-dependent kinase 1 in... 2 8
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 4
Carbonic anhydrase 9 and Carbonic anhydrase 12 inhibitor 5,10-... 1 0
Arachidonate 5-lipoxygenase inhibitor AGN-PC-00PO2W family 1 1
Arachidonate 5-lipoxygenase inhibitor 5-(1,3-benzodioxol-5-yl)... 2 2
Cholesteryl ester transfer protein inhibitor [8-[(1S)-1-hydrox... 1 0
Receptor-type tyrosine-protein phosphatase C and Tyrosine-prot... 1 0
Sugar Acids and Derivatives Metabolite 3-Methoxy-4-hydroxyphen... 1 6
Steroids and Steroid Derivatives Metabolite 2-Methoxyestrone 3... 1 3
Prenol Lipids Metabolite 13-Hydroxydihydromelleolide Family 3 0
Phenols and Derivatives Metabolite 2-Ethoxy-4-(4-methyl-1,3-di... 1 0
Phenylacetic Acid Derivatives Metabolite Guaicyl phenylacetate... 1 3
Phenols and Derivatives Metabolite 6-Gingesulfonic acid Family 1 2
2-(2-methoxyphenyl)-5-oxooxolane-3-carboxylate NP ZINC00132596... 4 2
NP 4-(2,3,4-trimethoxyphenyl)-3,4-dihydro-2h-benzo[g]chromene-... 2 1
2-[(3,4-dimethoxyphenyl)methyl]propanedioate NP 4aji Family 1 0
NP 4-(3,4-dimethoxyphenyl)-4-oxo-2-(3,4,5-trimethoxyphenyl)but... 2 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00277189 CHEMBL97543 Bioactive beta-Peltatin A
CFAMM00277090 CHEMBL435734 Bioactive Arctigenin
CFAMM00277167 DNC009496 Investigative Drug (-)-cubebininolide
CFAMM00277102 DNC009502 Investigative Drug (-)-thujaplicatintrimethyl ether

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

46042 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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