CFam Chemical Families Database
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CFam Family Information

CFAM Family ID CFFID2837
Family Name 5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-yl)-1h-indole-3-carboxamide Family
No. of Seeds 9 No. of Other Members 69
Family Centroid CFAMM00277527 Functional Category Investigative Drug with Natural Product
Superfamily 5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin transporter Ligand Vilazodone Superfamily
Class Class 656

Cousin Family NamesSeedsMembers
Serine/threonine-protein kinase B-raf inhibitor diaryl urea an... 12 93
Cysteinyl leukotriene receptor 1 Ligand Zafirlukast Family 48 78
DNA Binder Primaquine Family 3 245
5-hydroxytryptamine receptor 3A Ligand Dolasetron Family 12 171
Melatonin receptor type 1A Ligand Melatonin Family 20 988
Sodium channel protein type 5 subunit alpha Ligand Dibucaine F... 2 136
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Cyclooxygenase Inhibitor Indomethacin Family 6 271
Phospholipase A2 Inhibitor Quinacrine Family 13 95
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Somatostatin receptor type 2 ligand octapeptide Lanreotide Family 93 156
ostatin receptor 5 Ligand Pasireotide Diaspartate Family 11 151
DNA Binder Elliptinium Acetate Family 11 116
Gamma-secretase subunit APH-1B Inhibitor E2012 Family 3 67
Multidrug resistance protein Inhibitor Tariquidar Family 3 60
Mast/stem cell growth factor receptor Kit and Vascular endothe... 1 4
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor GSK2... 15 18
Coagulation factor X Inhibitor Apixaban Family 34 52
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
Vascular endothelial growth factor receptor 2 Ligand E 7080 Fa... 7 17
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 11 49
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 12 197
Smoothened homolog Inhibitor LDE225 Family 3 76
Apricoxib family 8 77
Indeglitazar family 3 39
Nicotinic acetylcholine receptor alpha2 / alpha3 Ligand Ibogai... 3 21
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine recept... 11 41
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
5-hydroxytryptamine receptor 1A Ligand Sun N4057 Family 2 86
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 13 22
Substance-K receptor and Substance-P receptor Ligand L-732138 ... 8 147
Aromatase Inhibitor 2-phenyl-3-pyridin-4-ylmethylene-chroman-4... 3 30
Platelet-derived growth factor receptor alpha and Platelet-der... 2 17
Cathepsin B and Cathepsin K Inhibitor Z-arg-leu-val-agly-ile-v... 3 19
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 2-benzyl-6-... 9 80
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 18
Adenosine receptor A1 and Adenosine receptor A3 Ligand 4-metho... 1 16
Integrin beta-3 Inhibitor L-756568 Family 8 59
Oestrogen receptor and Estrogen receptor beta Ligand Pipendoxi... 11 48
Alpha-1A adrenergic receptor Ligand RS-17053 Family 9 6
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
Alpha-1A adrenergic receptor Ligand A-131701 Family 16 17
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand WIN-5... 12 52
Vascular endothelial growth factor receptor 1 Ligand Lycogarub... 6 292
D(2) dopamine receptor Ligand SLV-314 Family 19 69
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Serine/threonine-protein kinase Chk1 Inhibitor A-432411 Family 4 70
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(furan-3-... 3 44
Platelet-derived growth factor receptor alpha and Platelet-der... 4 54
Platelet-derived growth factor receptor alpha and Platelet-der... 2 13
Proto-oncogene tyrosine-protein kinase Src Inhibitor BAS-48443... 1 0
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 14 214
RAF proto-oncogene serine/threonine-protein kinase Inhibitor 5... 3 7
Acetylcholinesterase and Cholinesterase Inhibitor 6-hydroxy-1,... 4 2
Neuromedin-K receptor Ligand 3-methoxy-n',2-diphenylquinoline-... 14 33
C-X-C chemokine receptor type 3 Ligand AMG-487 Family 28 73
Mu-type opioid receptor Ligand 6-(4-(2-(benzylamino)ethyl)phen... 3 27
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 8 57
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(4-methoxyphenyl)qu... 2 11
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
Adenosine receptor A1 and Adenosine receptor A2a Ligand SB-298... 53 320
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-366... 5 75
Bifunctional epoxide hydrolase 2 Inhibitor N-benzyl-6-(3,3,3-t... 21 62
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2-(... 21 108
Kinesin-like protein KIF11 Inhibitor Methyl 7-tert-butyl-9h-ca... 2 9
5-hydroxytryptamine receptor 2A and Alpha-2A adrenergic recept... 4 29
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 24 64
Renin Inhibitor CP-305202 Family 9 30
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Prostaglandin G/H synthase 2 Inhibitor L-761000 Family 8 44
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 2 31
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Beta-ketoacyl-acyl carrier protein synthase III Inhibitor 2-[3... 1 2
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Fatty-acid amide hydrolase 1 Inhibitor 3-(benzo[d]oxazol-2-yl)... 1 6
Acetylcholinesterase Inhibitor Lysicamine Family 2 8
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 16
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 7 44
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 17 69
Tyrosine-protein kinase SYK and Low affinity immunoglobulin ep... 1 0
Disintegrin and metalloproteinase domain-containing protein 17... 14 9
Glycogen synthase kinase-3 beta and Protein kinase C alpha typ... 2 30
Vasopressin V1a receptor and Vasopressin V2 receptor ligand [4... 1 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 14
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
Disintegrin and metalloproteinase domain-containing protein 17... 2 8
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 11
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 7 1
Cathepsin K and Cathepsin S inhibitor dipeptidyl nitrile, 16f ... 3 18
Glycogen synthase kinase-3 beta and Protein kinase C alpha typ... 1 18
Serine/threonine-protein kinase PLK1 and Serine/threonine-prot... 14 42
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 4 20
Hepatocyte growth factor receptor and Receptor-type tyrosine-p... 12 26
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 3 28
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 6
Sodium-dependent serotonin transporter and D(2) dopamine recep... 13 2
Vascular endothelial growth factor receptor 2 ligand indolyl q... 4 3
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 3 5
Receptor-type tyrosine-protein kinase FLT3 and Vascular endoth... 4 4
Lysine--tRNA ligase and Dual specificity protein kinase CLK4 i... 4 27
cAMP-dependent protein kinase type II-alpha regulatory subunit... 2 4
Muscarinic acetylcholine receptor M2 and Acetylcholinesterase ... 4 24
Acetylcholinesterase and Muscarinic acetylcholine receptor M2 ... 2 7
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 8 32
Somatostatin receptor type 5 ligand AGN-PC-080TDB family 10 14
Neuronal acetylcholine receptor subunit alpha-7 ligand 2-[3-cy... 2 5
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 8 21
Somatostatin receptor type 5 and Somatostatin receptor type 1 ... 2 8
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 5
Vascular endothelial growth factor receptor 2 and Aurora kinas... 3 3
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 4 14
Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-00... 18 32
Bifunctional epoxide hydrolase 2 inhibitor SureCN3216677 family 4 9
Potassium voltage-gated channel subfamily H member 2 and Kappa... 5 33
Histamine H3 receptor ligand AGN-PC-00BG7Z family 11 49
Histamine H3 receptor ligand (4S)-7-bromo-4-methyl-8-(1-propan... 2 0
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 6
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 2 21
MAP kinase-activated protein kinase 2 and Mitogen-activated pr... 5 2
Renin inhibitor AGN-PC-09M9MJ family 2 23
Sodium channel protein type 10 subunit alpha and Sodium channe... 3 22
Disintegrin and metalloproteinase domain-containing protein 17... 4 1
Melanin-concentrating hormone receptor 1 and Cytochrome P450 3... 8 2
Prelamin-A/C inhibitor 1-[(3,4-dimethoxyphenethyl)amino]-3-(1H... 1 2
Cellular tumor antigen p53 and DNA polymerase beta inhibitor C... 1 15
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 2 15
Disintegrin and metalloproteinase domain-containing protein 17... 2 1
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 3 3
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(1,3-... 2 9
B2 bradykinin receptor ligand SureCN6640854 family 7 4
D(2) dopamine receptor and D(4) dopamine receptor ligand N-[3-... 6 22
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 1
5-hydroxytryptamine receptor 2C and Cytochrome P450 1A2 ligand... 6 4
Poly [ADP-ribose] polymerase 1 inhibitor SureCN5002485 family 2 11
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 16
D(4) dopamine receptor and D(2) dopamine receptor ligand 1-(2-... 3 3
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-3-... 8 3
Thyroid hormone receptor beta and Cruzipain ligand CHEMBL14730... 1 12
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 19 40
Cathepsin S and Cathepsin K inhibitor N-[(2S)-3-(1-methylcyclo... 2 0
Translocator protein inhibitor N-(4-methoxyphenyl)-N,3-dimethy... 2 2
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 15
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 11
Cannabinoid receptor 2 ligand [(4R,4aS,8aR)-4-hydroxy-4-phenyl... 2 41
Histamine H3 receptor ligand SureCN2784306 family 5 3
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
Melanocortin receptor 4 ligand AGN-PC-076AML family 3 24
MAP kinase-activated protein kinase 2 and Mitogen-activated pr... 4 0
D(3) dopamine receptor ligand N-[4-[4-(2,3-dichlorophenyl)pipe... 3 15
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 2 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 21
Acetylcholinesterase inhibitor CHEMBL1651140 family 4 4
Prostaglandin D2 receptor 2 ligand SureCN137822 family 3 0
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 2 6
Gonadotropin-releasing hormone receptor and Cytochrome P450 3A... 3 0
Matrix metalloproteinase-9 and Interstitial collagenase inhibi... 2 3
Cannabinoid receptor 1 ligand 5-cyano-N-(3-hydroxy-2,2-dimethy... 17 4
Cytochrome P450 11B2, mitochondrial and Cytochrome P450 11B1, ... 9 7
Coagulation factor X and Prothrombin inhibitor 6-[4-[2-[[(3R)-... 15 2
Serine/threonine-protein kinase PLK1 inhibitor AGN-PC-0A9RFQ f... 2 1
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-09ODY0 ... 2 5
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9RSG ... 6 5
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 5
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 19
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor dihydro-benz... 1 7
Histone deacetylase 3 and Histone deacetylase 9 inhibitor (3S,... 1 16
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1801290 ... 3 0
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 2 ... 1 14
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 2 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Histone deacetylase 1 and Potassium voltage-gated channel subf... 1 0
Renin inhibitor [2-(3-fluoro-2,6-dimethylphenoxy)-1-phenylpyrr... 5 12
Retinoic acid receptor RXR-alpha ligand (E)-3-[3-(3,5-ditert-b... 5 5
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 4 11
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand [5-(o... 4 4
Mitogen-activated protein kinase 14 inhibitor 3-fluoro-N-[4-me... 2 5
Sodium-dependent serotonin transporter inhibitor SureCN7536104... 6 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 2
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 3 0
Mu-type opioid receptor ligand AGN-PC-075GBK family 4 4
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 2 3
NS5B protein inhibitor AC1O5AET family 3 1
Renin and Potassium voltage-gated channel subfamily H member 2... 4 0
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 19 10
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 12 13
Rho-associated protein kinase 2 and Rho-associated protein kin... 2 6
Mitogen-activated protein kinase 8 and Mitogen-activated prote... 1 13
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 10
D(2) dopamine receptor and D(3) dopamine receptor ligand N-[3-... 7 3
C-C chemokine receptor type 5 ligand N-[(3R)-3-[4-[4-methoxy-N... 13 1
MAP kinase-activated protein kinase 2 inhibitor N-[4-(4-oxospi... 3 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 2
Glycogen synthase kinase-3 beta inhibitor CHEMBL1940990 family 3 3
Cathepsin S and Cathepsin L1 inhibitor arylaminoethyl amide, 1... 1 0
Translocator protein inhibitor (4S)-N,N-diethyl-9-(2-fluoranyl... 9 10
RAC-alpha serine/threonine-protein kinase and cAMP-dependent p... 3 0
5-hydroxytryptamine receptor 1A and Alpha-1D adrenergic recept... 3 0
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 14 2
Serine/threonine-protein kinase pim-2 and cGMP-dependent prote... 8 1
Rho-associated protein kinase 1 and cAMP-dependent protein kin... 1 11
D(3) dopamine receptor ligand AGN-PC-075Z0O family 2 3
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 2 8
Vascular endothelial growth factor receptor 2 and Vascular end... 2 52
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Cholinesterase and Acetylcholinesterase inhibitor 4-oxo-N-[9-(... 11 13
Prostaglandin D2 receptor 2 ligand 2-[1-[4-[(4-methoxybenzoyl)... 2 2
Substance-P receptor ligand (3R)-4-[3,5-bis(trifluoromethyl)be... 2 3
Arachidonate 5-lipoxygenase-activating protein inhibitor 2-[(1... 2 0
Histamine H3 receptor ligand 2-[4-(1-methylpyrrole-2-carbonyl)... 3 4
Cytosolic phospholipase A2 inhibitor AGN-PC-00BH8R family 6 13
Disintegrin and metalloproteinase domain-containing protein 17... 13 3
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Substance-P receptor ligand 1-[4-(2-methoxyphenyl)piperazin-1-... 11 12
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 3 0
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 12 0
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 7 11
Disintegrin and metalloproteinase domain-containing protein 17... 16 2
Plasmepsin-2 and Cathepsin D inhibitor 4-[4-[[(2S,3S)-1-[[(3S,... 3 0
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-(1-... 3 2
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 2 0
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 3 1
Growth hormone secretagogue receptor type 1 ligand SureCN36800... 14 42
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 159
Cathepsin K inhibitor (1R,2R)-N-(1-cyanocyclopropyl)-2-(6-meth... 3 0
Mu-type opioid receptor and Mu-type opioid receptor ligand (3S... 6 2
Fatty-acid amide hydrolase 1 inhibitor [3-(3-carbamoylpyrrol-1... 4 6
Substance-P receptor ligand AGN-PC-01VLKE family 9 11
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
Casein kinase I isoform gamma-2 and Casein kinase I isoform de... 5 2
C-C chemokine receptor type 3 and Histamine H1 receptor ligand... 2 2
Acetylcholinesterase and Cholinesterase inhibitor N-[5-[(6-chl... 4 2
RAC-beta serine/threonine-protein kinase and 3-phosphoinositid... 1 1
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4461871 f... 2 2
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand N-(cy... 3 2
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 1 1
Beta-2 adrenergic receptor ligand SureCN4598646 family 7 7
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
Acetylcholinesterase and Cholinesterase inhibitor CHEMBL237591... 1 1
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 4 3
Seprase and Prolyl endopeptidase inhibitor N-[2-[(2S)-2-cyanop... 1 3
Estrogen receptor and Estrogen receptor beta ligand N-[(2R)-4-... 7 11
Proto-oncogene tyrosine-protein kinase receptor Ret and Vascul... 5 14
Leucine-rich repeat serine/threonine-protein kinase 2 and Vasc... 1 1
Growth hormone secretagogue receptor type 1 ligand N-[(1R)-2-(... 3 2
Serine/threonine-protein kinase PLK4 inhibitor (3E)-5-methoxy-... 4 0
Serine/threonine-protein kinase PLK4 inhibitor (3E)-3-[[3-[(E)... 1 1
Disintegrin and metalloproteinase domain-containing protein 17... 5 4
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 5
Bifunctional epoxide hydrolase 2 inhibitor 8-(quinoline-5-carb... 1 0
Potassium voltage-gated channel subfamily KQT member 2 ligand ... 3 4
D(2) dopamine receptor and D(4) dopamine receptor ligand AGN-P... 1 0
Glutamate receptor ionotropic, NMDA 2B ligand SureCN5532501 fa... 1 0
C-C chemokine receptor type 2 ligand (E)-3-(3,4-dichlorophenyl... 1 3
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 4 1
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 1 0
Neutrophil collagenase and Stromelysin-3 inhibitor [3-[[1-amin... 3 2
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 1 1
Gonadotropin-releasing hormone receptor ligand SureCN7905635 f... 2 2
Platelet-activating factor receptor ligand N,N-dimethyl-6-phen... 12 18
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 1
Histone deacetylase 3 and Histone deacetylase 9 inhibitor AGN-... 4 20
Mu-type opioid receptor ligand MITRAGYNINE family 2 8
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 2 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2,6-... 3 15
Substance-P receptor ligand (4R)-N-[(2R)-1-[benzyl(methyl)amin... 1 4
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
Substance-P receptor ligand SureCN2139814 family 7 7
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 6 8
Vasopressin V1a receptor and Vasopressin V2 receptor ligand AG... 2 2
Matrix metalloproteinase-9 and Neutrophil collagenase inhibito... 3 7
Vasopressin V2 receptor and Vasopressin V1a receptor ligand Su... 2 2
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 2
Interstitial collagenase and Matrilysin inhibitor (3S,6R,7S)-N... 2 4
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 1 8
Gonadotropin-releasing hormone receptor ligand methyl 4-[2-[[(... 2 1
Vasopressin V2 receptor ligand SureCN4400636 family 1 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 1
Gonadotropin-releasing hormone receptor ligand 2-[2-(4-methoxy... 1 1
Gastrin/cholecystokinin type B receptor and Tyrosyl-DNA phosph... 2 10
RAC-alpha serine/threonine-protein kinase inhibitor Isoquinoli... 1 0
Poly [ADP-ribose] polymerase 1 inhibitor 1-(4-methoxyphenyl)-3... 1 0
KiSS-1 receptor ligand [2-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[[(2S... 1 1
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-(3-me... 2 10
Adenosine receptor A3 and Adenosine receptor A1 ligand N-[2-(4... 3 2
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 9
Cannabinoid receptor 2 ligand AGN-PC-03LKW5 family 24 5
RAF proto-oncogene serine/threonine-protein kinase inhibitor a... 8 6
Neuromedin-B receptor and Gastrin-releasing peptide receptor l... 4 1
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 0
Substance-P receptor ligand AGN-PC-00FIT5 family 3 11
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
CGMP-dependent protein kinase inhibitor AGN-PC-075IHL family 2 8
Melanocortin receptor 4 and Melanocyte-stimulating hormone rec... 1 0
Cell division cycle 7-related protein kinase inhibitor Pyrrolo... 2 6
Macrophage colony-stimulating factor 1 receptor ligand 4-(2,3-... 12 7
Hepatocyte growth factor receptor ligand 4-pyridone analogue, ... 8 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL4... 6 2
Insulin-like growth factor 1 receptor ligand AGN-PC-050GPS family 7 0
Oxysterols receptor LXR-beta and Oxysterols receptor LXR-alpha... 4 3
Macrophage colony-stimulating factor 1 receptor ligand AGN-PC-... 1 3
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 6 0
Protein kinase C theta type and Protein kinase C delta type in... 10 7
72 kDa type IV collagenase and Aminopeptidase N inhibitor ly52... 1 0
Adenosine receptor A3 and Adenosine receptor A1 ligand CHEMBL4... 2 3
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 0
Cyclin-dependent kinase 4 and Cyclin-dependent kinase 2 inhibi... 1 12
Cysteinyl leukotriene receptor 2 and Cysteinyl leukotriene rec... 1 6
Macrophage colony-stimulating factor 1 receptor ligand AGN-PC-... 1 0
Acyl-CoA desaturase inhibitor SureCN1182719 family 1 0
B2 bradykinin receptor ligand 1-N,3-N-dimethyl-4-[methyl-[2-[[... 4 1
Serine/threonine-protein kinase Chk1 inhibitor 9-(1-methylpyrr... 1 1
Melanin-concentrating hormone receptor 1 and Potassium voltage... 2 0
5-hydroxytryptamine receptor 4 ligand 4-amino-5-chloro-N-[1-[8... 2 2
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 0
C-C chemokine receptor type 8 and Potassium voltage-gated chan... 5 1
Protein kinase C theta type and Protein kinase C delta type in... 5 4
Protein kinase C theta type and Protein kinase C delta type in... 13 0
Mitogen-activated protein kinase 1 and Aurora kinase A inhibit... 1 0
Bombesin receptor subtype-3 ligand 2-[[(E)-furan-2-ylmethylide... 2 4
Sodium-dependent serotonin transporter inhibitor SureCN5477150... 4 1
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 2 3
Mitogen-activated protein kinase 14 inhibitor SureCN4508019 fa... 1 0
Survival motor neuron protein and Arachidonate 15-lipoxygenase... 1 2
Growth factor receptor-bound protein 2 ligand [4-[(2S)-2-aceta... 2 1
Signal transducer and activator of transcription 1-alpha/beta ... 1 36
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 1
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 3
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
Microtubule-associated protein tau and Glycogen synthase kinas... 9 15
Mitogen-activated protein kinase 14 inhibitor AGN-PC-08866Z fa... 2 0
Gamma-aminobutyric acid receptor subunit pi and Gamma-aminobut... 2 10
Gamma-aminobutyric acid receptor subunit pi and Gamma-aminobut... 1 1
P2Y purinoceptor 1 inhibitor N-[2-(2-tert-butylphenoxy)pyridin... 1 0
Tyrosine-protein kinase JAK3 and Activated CDC42 kinase 1 inhi... 4 1
Cyclin-dependent kinase 2 inhibitor N-[(4-chlorophenyl)carbamo... 3 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 3
Glycogen synthase kinase-3 beta and G2/mitotic-specific cyclin... 4 13
Macrophage colony-stimulating factor 1 receptor ligand 4-[3-ch... 1 0
5-hydroxytryptamine receptor 2C ligand SureCN4230099 family 1 1
Thromboxane-A synthase and Platelet-activating factor receptor... 1 6
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 1 1
Bile acid receptor ligand SureCN1243717 family 1 4
Fatty-acid amide hydrolase 1 and Monoglyceride lipase inhibito... 1 3
Aurora kinase A inhibitor SureCN3802792 family 2 3
Platelet-derived growth factor receptor beta and Vascular endo... 1 3
ATP-binding cassette sub-family G member 2 inhibitor 5-[(4-bro... 1 1
Oxysterols receptor LXR-beta ligand indole derivative, 39 family 2 0
Potassium-transporting ATPase subunit beta and Potassium-trans... 2 3
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 1 0
Pol polyprotein inhibitor Phenprocoumon IndolEtCONH deriv. family 2 0
Indoleamine 2,3-dioxygenase 1 inhibitor CHEMBL576950 family 1 0
NP N-(1h-indol-6-yl)-3-(4-methoxy-1h-indol-1-yl)propanamide Fa... 2 0
NP N-(2-(3,4-dimethoxyphenyl)-4-oxo-4h-chromen-6-yl)nicotinami... 6 1
NP N-(2-(2-methoxyphenyl)-4-oxo-4h-chromen-6-yl)nicotinamide F... 9 0
NP N1-(5-bromo-1-ethyl-2-oxoindolin-3-yl)-N2-(2-(5-methoxy-1H-... 2 0
(9-oxo-2,3-dihydro-1H-pyrrolo[2,1-b]quinazolin-7-yl) (2S)-3-(1... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00277577 CHEMBL516452 Bioactive AGN-PC-04TF8B
CFAMM00277552 CHEMBL480127 Bioactive SureCN4229232
CFAMM00277587 CHEMBL479952 Bioactive AGN-PC-073UJB
CFAMM00277611 CHEMBL479763 Bioactive SureCN4233556
CFAMM00277602 CHEMBL451486 Bioactive SureCN4236768
CFAMM00277607 CHEMBL519103 Bioactive SureCN4230540
CFAMM00277527 DNC009567 Investigative Drug N-(6-phenoxypyridin-3-yl)-1H-indole-3-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

22920 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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