CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2840
Family Name Leukotriene A-4 hydrolase Inhibitor (r/s)-2-((4-phenoxyphenoxy)methyl)piperidine Family
No. of Seeds 7 No. of Other Members 18
Family Centroid CFAMM00277638 Functional Category Investigative Drug
Superfamily Tyrosinase and Histamine H3 receptor Binder Superfamily
Class Class 282

Cousin Family NamesSeedsMembers
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 61 433
Beta adrenergic receptor ligand naphthol derivative Propranolo... 11 218
Oestrogen receptor Ligand triphenyl ethylene stilbene derivati... 22 420
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Beta-1 adrenergic receptor Ligand Metoprolol Family 29 90
Alpha adrenergic receptor Ligand Phenoxybenzamine Family 4 63
Beta-1 adrenergic receptor Ligand Oxprenolol Family 3 27
Sodium channel protein type 5 subunit alpha Ligand Mexiletine ... 7 74
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Tyrosinase Inhibitor Monobenzone Family 6 197
Alpha adrenergic receptor Ligand Bevantolol Family 4 48
Beta-1 adrenergic receptor Ligand Nebivolol Family 5 22
Oestrogen receptor Ligand Lasofoxifene Family 19 152
Leukotriene A-4 hydrolase Inhibitor DG051 Family 2 8
Serine/threonine-protein kinase PLK1 Inhibitor On 019190.na Fa... 16 138
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 6 33
Alpha-2 adrenergic receptor Ligand Idazoxan Family 6 26
5-hydroxytryptamine receptor 1A Ligand MN-305 Family 12 26
Dapoxetine family 3 40
5-hydroxytryptamine receptor 2A and Sodium-dependent serotonin... 2 5
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
M-phase inducer phosphatase 1 Inhibitor Naphthoquinone Analogs... 11 56
Beta-3 adrenergic receptor Ligand ZD7114 Family 1 4
Histamine H3 receptor Ligand A-331440 Family 6 7
Histamine H3 receptor Ligand UCL-2138 Family 23 172
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 11
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 25 50
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
Leukotriene A-4 hydrolase Inhibitor 1-butoxy-4-phenoxybenzene ... 3 85
Histamine H3 receptor Ligand 4-isopropyl-2-(phenoxymethyl)morp... 4 10
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 11
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 2
Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 4-meth... 4 12
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 13
5-hydroxytryptamine receptor 7 Ligand (r)-8-phenyl-n,n-dipropy... 9 14
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 10 15
Renin Inhibitor Ro-65-7219 Family 10 8
5-hydroxytryptamine receptor 2A Ligand C-(9h-xanthen-9-yl)-met... 3 5
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 2 3
Tyrosinase Inhibitor 1-(3-phenoxypropyl)-4-(piperidin-1-yl)pip... 2 13
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 2 2
5-hydroxytryptamine receptor 1A and Alpha-1D adrenergic recept... 2 2
Leukotriene A-4 hydrolase inhibitor SureCN13809114 family 2 7
Sigma non-opioid intracellular receptor 1 and 3-beta-hydroxyst... 15 11
D(4) dopamine receptor and D(3) dopamine receptor ligand N-[2-... 6 15
Survival motor neuron protein and Lysine-specific demethylase ... 1 16
5-hydroxytryptamine receptor 1A and Sodium-dependent noradrena... 5 4
5-hydroxytryptamine receptor 1A and Sodium-dependent noradrena... 2 0
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 1 0
5-hydroxytryptamine receptor 1A ligand oxalic acid;(1R,5S)-5-[... 2 0
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 7 1
Histamine H3 receptor and Sodium-dependent serotonin transport... 3 6
Neuronal acetylcholine receptor subunit alpha-10 ligand (2S)-2... 1 0
Squalene synthase inhibitor [4-[3-(propan-2-ylamino)propoxy]ph... 1 3
Scytalone dehydratase inhibitor 2-cyano-N-[(1S,2R)-1-(2-cyanop... 5 0
Sigma non-opioid intracellular receptor 1 ligand SureCN7450653... 1 0
Muscleblind-like protein 1 and Ferritin light chain inhibitor ... 1 1
Sodium-dependent noradrenaline transporter and Sodium-dependen... 4 2
Sodium-dependent noradrenaline transporter and Sodium-dependen... 1 1
Amine oxidase [flavin-containing] B and Membrane primary amine... 1 1
Membrane primary amine oxidase and Amine oxidase [flavin-conta... 1 1
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 2 3
Leukotriene A-4 hydrolase inhibitor SureCN2106446 family 1 1
Beta-lactamase inhibitor CHEMBL1566697 family 1 5


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00277644 CHEMBL22892 Bioactive 4-[2-(3-phenoxypropylamino)ethoxy]phenol
CFAMM00277638 DNC010852 Investigative Drug (R/S)-2-((4-phenoxyphenoxy)methyl)piperidine
CFAMM00277643 DNC009583 Investigative Drug 2-(4-phenoxyphenoxy)ethanamine
CFAMM00277640 DNC010855 Investigative Drug (S)-2-((4-phenoxyphenoxy)methyl)piperidine
CFAMM00277639 DNC010854 Investigative Drug (R)-2-((4-phenoxyphenoxy)methyl)piperidine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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