CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2841
Family Name 5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-containing] A Ligand 8-methoxy-4,9-dihydro-3h-beta-carboline Family
No. of Seeds 4 No. of Other Members 32
Family Centroid CFAMM00277664 Functional Category Investigative Drug with Human Metabolite & Natural Product
Superfamily Melatonin receptor type 1A Ligand Melatonin Superfamily
Class Class 24

Cousin Family NamesSeedsMembers
Beta adrenergic receptor ligand monosubstituted indole derivat... 14 475
DNA Binder Primaquine Family 3 245
Melatonin receptor type 1A Ligand Melatonin Family 20 988
Calcium-activated potassium channel subunit alpha-1 Ligand Qui... 3 46
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Phospholipase A2 Inhibitor Quinacrine Family 13 95
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
DNA Binder Elliptinium Acetate Family 11 116
Amyloid beta A4 protein Inhibitor Florbetapir F-18 Family 8 265
Arachidonate 5-lipoxygenase-activating protein Inhibitor DG031... 3 206
Hepatocyte growth factor receptor and Vascular endothelial gro... 28 178
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
Nicotinic acetylcholine receptor Ligand AZD0328 Family 11 97
Neuronal acetylcholine receptor subunit alpha-4 Ligand Isproni... 49 172
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 11 49
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 12 197
Apricoxib family 8 77
Indeglitazar family 3 39
Grt 6005/06 family 4 22
PF-02545920 family 16 140
Nicotinic acetylcholine receptor alpha2 / alpha3 Ligand Ibogai... 3 21
Nicotinic acetylcholine receptor Ligand Dianicline Family 6 13
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine recept... 11 41
Tyrosine kinase Inhibitor PKI166 Family 17 198
Tissue-type plasminogen activator Inhibitor N-(7-benzyloxy-iso... 4 37
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 13 22
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Estradiol 17-beta-dehydrogenase 1 Inhibitor 4'-(6-methoxypyrid... 5 34
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
D(2) dopamine receptor and D(3) dopamine receptor Ligand [2-(1... 17 100
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
Platelet-derived growth factor receptor alpha and Platelet-der... 2 14
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 2-benzyl-6-... 9 80
D(2) dopamine receptor and D(3) dopamine receptor Ligand L-741... 9 73
5-hydroxytryptamine receptor 2A Ligand [2-(6-methoxy-indol-1-y... 2 10
Oestrogen receptor and Estrogen receptor beta Ligand Pipendoxi... 11 48
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 2 0
Alpha-1A adrenergic receptor Ligand RS-17053 Family 9 6
Melanin-concentrating hormone receptor 1 Ligand 8-sec-butoxy-q... 30 39
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand WIN-5... 12 52
Adenosine receptor A3 Ligand 4-methoxy-2-phenyl-2h-pyrazolo[4,... 9 49
Vascular endothelial growth factor receptor 1 Ligand Lycogarub... 6 292
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 6
D(2) dopamine receptor Ligand SLV-314 Family 19 69
Metabotropic glutamate receptor 5 Ligand (3-ethoxy-pyridin-2-y... 3 12
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 11 12
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Oestrogen receptor and Estrogen receptor beta Ligand 4-(3-phen... 5 14
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(furan-3-... 3 44
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Acetylcholinesterase and Cholinesterase Inhibitor 6-hydroxy-1,... 4 2
Glycogen synthase kinase-3 beta Inhibitor 9-n-ethyl-8-ethoxy-m... 3 0
Cytochrome P450 11B1, mitochondrial Inhibitor 5-(6-methoxynaph... 7 4
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Indoleamine 2,3-dioxygenase 1 Inhibitor 5-aminoquinolin-8-ol F... 3 16
Fatty-acid amide hydrolase 1 Inhibitor Pyridin-3-yl 4-butoxybe... 10 5
Progesterone receptor Ligand PF-02367982 Family 2 8
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 4-(2-m... 2 12
5-hydroxytryptamine receptor 2A and Alpha-2A adrenergic recept... 4 29
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 18 17
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Metabotropic glutamate receptor 5 Ligand 7-(3,5-dimethoxypheny... 2 7
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
Prostaglandin G/H synthase 2 Inhibitor 5-methoxy-2-(4-(methyls... 3 12
Neuronal acetylcholine receptor subunit beta-2 Ligand ABT-594 ... 4 5
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 16
Sigma non-opioid intracellular receptor 1 and Kappa-type opioi... 3 12
Progesterone receptor and Glucocorticoid receptor ligand (5Z)-... 5 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 17 69
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 4
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 7 1
3-phosphoinositide-dependent protein kinase 1 and Ribosomal pr... 10 4
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 6
Translocator protein inhibitor SureCN13502542 family 20 2
5-hydroxytryptamine receptor 6 ligand N-[3-[[(2R)-1-methylpyrr... 6 0
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 2 10
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Vascular endothelial growth factor receptor 2 ligand indolyl q... 2 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 8 32
5-hydroxytryptamine receptor 2A and Alpha-1A adrenergic recept... 4 1
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 8 21
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 3 1
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 5
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 5 40
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 2 0
Glucocorticoid receptor and Progesterone receptor ligand AGN-P... 3 3
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 8 12
Proto-oncogene tyrosine-protein kinase Src inhibitor SureCN525... 8 8
Prelamin-A/C inhibitor 1-[(3,4-dimethoxyphenethyl)amino]-3-(1H... 1 2
Cellular tumor antigen p53 and DNA polymerase beta inhibitor C... 1 15
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 1 1
Hypoxia-inducible factor 1-alpha and Lethal factor inhibitor C... 1 1
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 15
Melatonin receptor type 1A ligand N-[2-(5-methoxy-2-phenyl-1H-... 1 2
5-hydroxytryptamine receptor 2C and Cytochrome P450 1A2 ligand... 6 4
D(4) dopamine receptor and D(2) dopamine receptor ligand 1-(2-... 3 3
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 1 1
Glucagon receptor and Mitogen-activated protein kinase 14 liga... 6 5
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 8 8
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 11 4
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL15681... 1 5
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 4
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
MAP kinase-activated protein kinase 2 and Mitogen-activated pr... 4 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 2 13
5-hydroxytryptamine receptor 6 ligand 1-[9-(benzenesulfonyl)-6... 11 2
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 2 0
Somatostatin receptor type 2 ligand SureCN4313450 family 2 25
5-hydroxytryptamine receptor 6 ligand SureCN5498885 family 5 4
Beta-2 adrenergic receptor and Beta-3 adrenergic receptor liga... 9 22
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Translocator protein inhibitor 2-fluoro-N-[(2-methoxyphenyl)me... 8 27
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075FPC ... 6 1
Histone deacetylase 1 and Potassium voltage-gated channel subf... 1 0
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 2 0
Melanin-concentrating hormone receptor 1 ligand N-[3-(2-aminoq... 4 1
Retinoic acid receptor RXR-alpha ligand (E)-3-[3-(3,5-ditert-b... 5 5
Thyroid hormone receptor alpha and Thyroid hormone receptor be... 2 11
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 16 19
Muscarinic acetylcholine receptor M3 ligand 3-fluoro-2-(3-pipe... 3 1
Beta-3 adrenergic receptor and Beta-2 adrenergic receptor liga... 16 2
Sodium-dependent serotonin transporter inhibitor SureCN7536104... 6 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 2
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 3 0
Sodium-dependent serotonin transporter inhibitor SureCN6575591... 2 0
Sodium-dependent serotonin transporter inhibitor AGN-PC-075G9A... 3 2
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 2 3
Integrin alpha-V and Integrin beta-5 inhibitor SureCN2489170 f... 8 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 0
Sodium-dependent serotonin transporter and D(2) dopamine recep... 3 0
CGMP-dependent protein kinase inhibitor AGN-PC-075XJ0 family 9 1
Serine/threonine-protein kinase B-raf inhibitor pyrrole-based ... 2 0
RAC-alpha serine/threonine-protein kinase inhibitor N-[(2S)-1-... 2 1
RAC-alpha serine/threonine-protein kinase and cAMP-dependent p... 3 0
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 14 2
Serine/threonine-protein kinase pim-2 and cGMP-dependent prote... 8 1
Neuronal acetylcholine receptor subunit alpha-2 and Neuronal a... 6 1
Substance-P receptor ligand 1-[4-(2-methoxyphenyl)piperazin-1-... 11 12
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
Translocator protein inhibitor N-methyl-2-(2-oxo-5-pyridin-4-y... 8 15
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 2 0
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 3 1
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 5
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 0
Neuronal acetylcholine receptor subunit alpha-7 ligand 5-[6-[[... 1 0
Beta-secretase 1 inhibitor (5S)-3'-(3,4-difluorophenyl)-7'-(2-... 4 0
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 5 0
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 5 14
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 6 4
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 4 4
Sodium-dependent noradrenaline transporter and Sodium-dependen... 2 7
5-hydroxytryptamine receptor 6 ligand 2-methyl-5-(2-nitropheno... 1 6
Histamine H3 receptor and Sodium-dependent serotonin transport... 3 2
D(3) dopamine receptor and D(2) dopamine receptor ligand 4-[1-... 1 0
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 5 1
Potassium voltage-gated channel subfamily KQT member 2 ligand ... 3 4
D(2) dopamine receptor and D(4) dopamine receptor ligand AGN-P... 1 0
Serine/threonine-protein kinase Chk1 and Aurora kinase B inhib... 14 0
Transient receptor potential cation channel subfamily V member... 6 1
Melanin-concentrating hormone receptor 1 ligand (1S,3S)-3-N-(7... 2 2
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 1 2
Arachidonate 5-lipoxygenase-activating protein inhibitor 2-[[2... 4 4
Beta-3 adrenergic receptor ligand 3-[2-[[(2R)-2-(3-chloropheny... 1 1
C-C chemokine receptor type 2 ligand (E)-1-[4-[2-hydroxy-1-[4-... 2 2
Renin inhibitor SureCN6043852 family 2 0
Renin inhibitor SureCN6042213 family 2 3
Substance-P receptor ligand N-[(2R)-1-[acetyl-[(2-chlorophenyl... 2 2
D(2) dopamine receptor ligand SureCN10575660 family 1 1
Sigma non-opioid intracellular receptor 1 ligand 1'-[4-[1-(4-f... 2 0
Glucagon receptor ligand SureCN2647807 family 3 7
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 2
D(1A) dopamine receptor and D(3) dopamine receptor ligand RU-2... 3 4
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 0
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 1 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(2,3-... 2 0
RAC-alpha serine/threonine-protein kinase inhibitor Isoquinoli... 1 0
RAC-alpha serine/threonine-protein kinase and cAMP-dependent p... 2 0
Substance-P receptor ligand AGN-PC-00FIT5 family 3 11
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 23 5
Protein kinase C theta type and Protein kinase C delta type in... 10 7
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 18 0
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-04UHB... 4 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 2
Bifunctional epoxide hydrolase 2 and Voltage-dependent L-type ... 2 1
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 1
Lanosterol synthase inhibitor AGN-PC-07BZTX family 2 0
B2 bradykinin receptor ligand SureCN13145573 family 7 6
B2 bradykinin receptor and Cytochrome P450 3A4 ligand SureCN15... 4 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 0
Sodium-dependent serotonin transporter and D(2) dopamine recep... 4 0
Protein kinase C theta type and Protein kinase C delta type in... 5 4
TGF-beta receptor type-1 ligand SureCN373216 family 3 14
Nischarin inhibitor SureCN7810370 family 1 0
RAC-alpha serine/threonine-protein kinase and Rho-associated p... 1 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 6 0
Signal transducer and activator of transcription 1-alpha/beta ... 1 36
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 1
Sodium/hydrogen exchanger 1 inhibitor 2-[(E)-[7-(2-chloropheny... 2 0
Coagulation factor VII and Tissue factor inhibitor 5-azaindole... 4 3
Corticotropin-releasing factor receptor 1 ligand 2-[2,6-dimeth... 9 0
DNA gyrase subunit B and DNA gyrase subunit A inhibitor (1S,2R... 4 6
5-hydroxytryptamine receptor 7 and 5-hydroxytryptamine recepto... 1 1
Acyl-CoA:cholesterol acyltransferase inhibitor SureCN8919280 f... 23 18
Nitric oxide synthase, brain and Nitric oxide synthase, induci... 1 8
Acetylcholinesterase and Cholinesterase inhibitor P10358 family 2 0
Gamma-aminobutyric acid receptor subunit beta-3 and Gamma-amin... 2 0
Indoles Metabolite Mukeic acid Family 1 1
NP N-(1h-indol-6-yl)-3-(4-methoxy-1h-indol-1-yl)propanamide Fa... 2 0
NP (2r,3r,4s,5r)-2-(acetoxymethyl)-6-(quinolin-8-yloxy)tetrahy... 2 1
5-methoxy-1,3,3-trimethylspiro[indole-2,3'-pyrido[3,2-f][1,4]b... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00277665 DNC009584 Investigative Drug 2-(7-(benzyloxy)-1H-indol-3-yl)ethanamine
CFAMM00277664 DNC011684 Investigative Drug 8-Methoxy-4,9-dihydro-3H-beta-carboline
CFAMM00277656 DNC011694 Investigative Drug 8-Methoxy-2,3,4,9-tetrahydro-1H-beta-carboline

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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