CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2842
Family Name Potassium voltage-gated channel subfamily H member 2 Ligand AZD-5438 Family
No. of Seeds 21 No. of Other Members 42
Family Centroid CFAMM00277716 Functional Category Investigative Drug with Natural Product
Superfamily Potassium voltage-gated channel subfamily H member 2 Ligand AZD-5438 Superfamily
Class Class 829

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 2C ligand Tetracyclic antidepress... 14 498
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
5-hydroxytryptamine receptor 1D Ligand Rizatriptan Family 7 460
Alpha-2 adrenergic receptor Ligand Dexmedetomidine Family 32 639
Benzodiazepine receptor Ligand Midazolam Family 5 160
Omega 1 Benzodiazepine receptor Ligand Zaleplon Family 6 589
Toll-like receptor 7 Ligand Imiquimod Family 3 237
Alpha-2A adrenergic receptor Ligand Brimonidine Family 3 6
Amiloride-sensitive sodium channel subunit alpha Ligand Triamt... 8 98
Histamine H1 receptor Ligand Emedastine Family 5 115
Dihydropterin pyrophosphokinase-dihydropteroate synthase inhib... 5 60
Dihydropterin pyrophosphokinase-dihydropteroate synthase inhib... 4 14
Histamine H1 receptor Ligand Mizolastine Family 14 603
Mast/stem cell growth factor receptor Kit and Vascular endothe... 6 34
Aurora kinase B and Aurora kinase A Inhibitor CYC116 Family 16 135
Metabotropic glutamate receptor 5 Ligand ADX-48621 Family 15 444
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Transient receptor potential cation channel subfamily V member... 15 457
Vascular endothelial growth factor Inhibitor PTC299 Family 6 145
Transient receptor potential cation channel subfamily V member... 6 66
Cyclin-dependent kinase 2 Inhibitor Seliciclib Family 29 292
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Fibroblast growth factor receptor 2 and Fibroblast growth fact... 11 86
Cyclin-dependent kinase 4 Inhibitor PD-332991 Family 13 155
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
Reverse transcriptase Inhibitor Dapivirine Family 5 72
Translocator protein Inhibitor Emapunil Family 7 89
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Adenosine receptor A1 Ligand SLV320 Family 6 79
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
HCV NS4B protein Inhibitor Clemizole Family 2 43
Serine/threonine-protein kinase B-raf Inhibitor GSK2118436 Family 5 19
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 13 55
GDC-0349 family 44 77
C-Jun N-terminal kinase Inhibitor CC-930 Family 2 9
PF-4217903 family 14 65
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 8 55
Corticotropin-releasing factor receptor 1 Ligand CP-154526 Family 9 29
Tryptase Inhibitor Babim Family 12 90
Reverse transcriptase Inhibitor Benzothiadiazines Family 4 21
D(4) dopamine receptor Ligand L-745,870 Family 30 205
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Olprin... 2 7
Glucan synthesis regulatory protein Inhibitor Pyridobenzimidaz... 2 12
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Prostaglandin G/H synthase 2 Inhibitor RWJ-67657 Family 3 33
Interleukin-1 receptor type 1 and Mitogen-activated protein ki... 7 151
Adenosine receptor A1 and Adenosine receptor A2a Ligand N6-met... 7 72
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2,6-di... 13 14
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Vascular endothelial growth factor receptor 1 and Vascular end... 6 23
Thromboxane-A synthase Inhibitor CGS-13080 Family 3 19
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-cyanobenzyl... 14 13
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Adenosine receptor A2a and Adenosine receptor A3 Ligand 5-buty... 3 18
Cyclin-dependent kinase 4 Inhibitor 1-pyridin-2-yl-3-quinolin-... 2 5
Arachidonate 5-lipoxygenase Inhibitor 2,4,5-triarylimidazole A... 3 16
Methionine aminopeptidase 2 Inhibitor 2-(pyridin-2-yl)-1h-benz... 6 19
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 5 7
Scytalone dehydratase Inhibitor Isoquinolin-1-yl-(3-phenyl-pro... 4 9
Epidermal growth factor receptor Ligand Benzo[g]quinazolin-4-y... 5 3
Aromatase and Thromboxane-A synthase Inhibitor 6-(1h-imidazol-... 3 8
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
Adenosine receptor A1 Ligand Phenyl-(9-phenyl-9h-purin-6-yl)-a... 7 12
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 1 9
Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... 8 5
Alpha-1A adrenergic receptor Ligand A-315456 Family 7 17
RAC-gamma serine/threonine-protein kinase and Rho-associated p... 16 46
Adenosine receptor A3 and Dual specificity mitogen-activated p... 5 27
Metabotropic glutamate receptor 5 Ligand 2-m-tolyl-1,8-naphthy... 7 11
Adenosine receptor A3 Ligand 2-(5-chloro-1h-benzo[d]imidazol-2... 7 51
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-(4-e... 2 5
Adenosine receptor A3 Ligand 2-(4-nitro-1h-benzo[d]imidazol-2-... 2 12
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 45
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-phen... 8 11
Dipeptidyl peptidase 4 Inhibitor (5-phenyl-3h-benzo[d]imidazol... 5 13
Mitogen-activated protein kinase kinase kinase 8 and Stromelys... 6 53
Fatty-acid amide hydrolase 1 Inhibitor JNJ-1661010 Family 3 14
Indoleamine 2,3-dioxygenase 1 Inhibitor 3-(4h-imidazol-4-yl)be... 6 3
Aromatase Inhibitor NSC-356781 Family 3 10
Macrophage migration inhibitory factor Inhibitor 4-iodo-6-phen... 5 4
Histamine H4 receptor Ligand A-943931 Family 14 11
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Farnesyl pyrophosphate synthase Inhibitor [2-(benzoimidazol-1-... 2 16
Glycogen synthase kinase-3 beta Inhibitor CHIR-98023 Family 5 6
Glycogen synthase kinase-3 beta Inhibitor 4-(5-bromo-1h-indol-... 7 18
Hepatocyte growth factor receptor Ligand 3-(phenylsulfonyl)-1h... 17 59
Hepatocyte growth factor receptor Ligand 1-benzyl-1h-pyrrolo[3... 2 16
Prostaglandin G/H synthase 2 Inhibitor GW-637185X Family 27 48
Aurora kinase B and Tyrosine-protein kinase Lck Inhibitor CGP-... 2 29
Macrophage metalloelastase Inhibitor Ageladine A Family 1 0
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-bromobenzyl... 3 0
Histamine H3 receptor Ligand 4-(2-(phenylamino)ethyl)-1h-imida... 5 16
Type-2 angiotensin II receptor Ligand L-158282 Family 24 58
Type-2 angiotensin II receptor Ligand L-158809 Family 22 136
Proto-oncogene tyrosine-protein kinase Src Inhibitor CGP-62464... 3 10
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 4 22
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 55
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Protein farnesyltransferase subunit beta Inhibitor BMS-316810 ... 11 18
Farnesyltransferase beta subunit, putative and Protein farnesy... 12 4
Acetylcholinesterase Inhibitor N-benzyl-2-morpholinopyrimidin-... 6 16
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 1 4
RAC-gamma serine/threonine-protein kinase Inhibitor BMS-754807... 20 90
Adenosine receptor A3 and Adenosine receptor A2a ligand 5-buty... 3 13
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 14 4
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-07ZB89 family 6 13
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 2 3
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 7 3
Inhibitor of nuclear factor kappa-B kinase subunit beta inhibi... 1 7
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 9
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 3 12
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 4
Mitogen-activated protein kinase 8 and Mitogen-activated prote... 2 5
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 34 11
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN5... 6 24
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 7 7
Histamine H3 receptor ligand SureCN7853275 family 2 5
Thromboxane-A synthase inhibitor AGN-PC-00N7V2 family 3 6
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 6 60
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 1 7
Platelet-activating factor receptor ligand AGN-PC-0750SP family 4 0
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 7 4
Transient receptor potential cation channel subfamily V member... 1 0
Polycystin-2 and Serine/threonine-protein kinase D1 inhibitor ... 4 12
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 7 10
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 27
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor AGN-PC... 1 0
Aurora kinase A and Aurora kinase B inhibitor AGN-PC-09M82N fa... 13 0
Aurora kinase A and Aurora kinase B inhibitor AGN-PC-09M46L fa... 2 7
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 3 11
Vascular endothelial growth factor receptor 2 and Mitogen-acti... 2 2
Type-1B angiotensin II receptor ligand SureCN683399 family 3 0
Beta-3 adrenergic receptor and Beta-2 adrenergic receptor liga... 4 1
Sorbitol dehydrogenase inhibitor SureCN6335187 family 2 6
Mitogen-activated protein kinase 14 inhibitor AGN-PC-03XQYG fa... 7 1
D(4) dopamine receptor and D(2) dopamine receptor ligand 4-met... 13 8
Nociceptin receptor and Kappa-type opioid receptor ligand 1-[1... 4 4
Prelamin-A/C inhibitor CHEMBL1472945 family 1 32
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 3 10
Metabotropic glutamate receptor 1 and Metabotropic glutamate r... 2 2
Nuclear receptor ROR-gamma and Mitogen-activated protein kinas... 1 10
Growth hormone secretagogue receptor type 1 and Dihydrofolate ... 3 6
Coagulation factor X and Trypsin-1 inhibitor 1-(3-carbamimidoy... 4 1
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 5 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 5 0
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 3 7
Insulin-like growth factor 1 receptor ligand AGN-PC-09QIDN family 1 3
Corticotropin-releasing factor receptor 1 ligand 9-(2-bromo-4-... 15 3
Glycogen synthase kinase-3 beta and Dual specificity protein k... 4 5
Corticotropin-releasing factor receptor 1 ligand SureCN6301726... 4 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 1 2
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 1 1
Signal transducer and activator of transcription 6 inhibitor A... 3 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 1
Prostaglandin E2 receptor EP3 subtype ligand (E)-N-(3,4-difluo... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 5
Fatty-acid amide hydrolase 1 inhibitor 5-[5-(4-chlorophenyl)su... 2 4
Fatty-acid amide hydrolase 1 inhibitor [5-(4-chlorophenyl)tria... 2 2
Tyrosine-protein kinase JAK2 inhibitor N-tert-butyl-3-[2-[3-fl... 4 14
Aurora kinase A and Cyclin-dependent kinase 1 inhibitor N-[4-[... 12 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 11
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 0
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 1
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 0
Adenosine deaminase inhibitor AGN-PC-00FYYU family 4 5
Vascular endothelial growth factor receptor 2 ligand urea deri... 3 9
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 4 ... 2 1
Ribosomal protein S6 kinase alpha-5 inhibitor AGN-PC-075HAD fa... 2 0
Histamine H4 receptor and Histamine H3 receptor ligand (E)-[(3... 4 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Mitogen-activated protein kinase 14 inhibitor 4-(2-chloropheny... 4 0
Tyrosine-protein kinase JAK2 and ALK tyrosine kinase receptor ... 5 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family 10 11
Tyrosine-protein kinase JAK2 and Focal adhesion kinase 1 inhib... 11 3
Cyclin-dependent kinase 1 inhibitor 4-[[4-(3H-benzimidazol-5-y... 1 0
Serine/threonine-protein kinase mTOR inhibitor 5-(2-amino-3H-b... 3 1
Aurora kinase A and Aurora kinase B inhibitor 2-[[5-chloro-2-[... 3 7
Cannabinoid receptor 2 ligand 2-tert-butyl-1-(oxan-4-ylmethyl)... 8 2
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 2 2
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 1 0
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 10 6
Aurora kinase B and Vascular endothelial growth factor recepto... 1 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 11 3
Protein-tyrosine kinase 2-beta and Focal adhesion kinase 1 inh... 1 4
Tyrosine-protein kinase Mer and Tyrosine-protein kinase recept... 5 3
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 3 0
TGF-beta receptor type-1 and TGF-beta receptor type-2 ligand S... 2 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 7 15
Cannabinoid receptor 2 ligand 8-(2-chlorophenyl)-9-cyclopropyl... 4 5
Neuropeptide Y receptor type 5 and Cytochrome P450 1A2 ligand ... 8 19
D(4) dopamine receptor and Alpha-1D adrenergic receptor ligand... 3 3
D(4) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 2 0
Protein farnesyltransferase alpha subunit and Protein farnesyl... 5 0
Mitogen-activated protein kinase 14 inhibitor imidazole 81 family 2 1
Dipeptidyl peptidase 4 inhibitor [(2S,4S)-4-[4-(1-phenylimidaz... 2 1
Aurora kinase A and Cyclin-dependent kinase 4 inhibitor 7-cycl... 1 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2152412 family 8 0
High affinity nerve growth factor receptor ligand N-[3-amino-5... 4 10
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2152398 family 16 1
Serine/threonine-protein kinase SMG1 and Serine/threonine-prot... 10 0
Neuropeptide Y receptor type 5 ligand 2-(3-phenylpiperidin-1-y... 6 2
Serine/threonine-protein kinase SMG1 and Cyclin-dependent kina... 3 1
Tyrosine-protein kinase JAK1 and Non-receptor tyrosine-protein... 7 0
C-C chemokine receptor type 3 ligand 5-fluoro-1-[1-[3-(4-fluor... 1 2
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 3 4
Bombesin receptor subtype-3 and Nuclear receptor subfamily 1 g... 3 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 5 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand N-[1-... 5 3
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206058 family 5 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206614 family 2 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 7 4
CGMP-dependent protein kinase inhibitor 1-[2-(4-fluorophenyl)-... 1 4
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 7 10
Adenosine receptor A1 ligand N-butyl-5-phenyl-3-[[2-(trifluoro... 7 2
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 6 3
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor CDK Inhibito... 8 3
Tyrosine-protein kinase JAK1 and Aurora kinase A inhibitor CHE... 2 0
Serine/threonine-protein kinase ATR and Serine/threonine-prote... 8 10
Protein kinase C theta type and Protein kinase C delta type in... 9 0
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Cholinesterase inhibitor 4-[4,5-diphenyl-1-[7-(1,2,3,4-tetrahy... 2 1
Dipeptidyl peptidase 4 and Seprase inhibitor (1S,5S)-5-[3-(tri... 1 0
Motilin receptor ligand SureCN2004322 family 2 1
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 16 0
Nicotinamide phosphoribosyltransferase and Cytochrome P450 2C9... 4 5
Mitogen-activated protein kinase 8 and Mitogen-activated prote... 4 5
Mitogen-activated protein kinase 8 and Mitogen-activated prote... 2 1
Nicotinamide phosphoribosyltransferase inhibitor N-[[4-(3,5-di... 4 8
Serine/threonine-protein kinase mTOR inhibitor 1-ethyl-3-[4-[6... 4 1
Nicotinamide phosphoribosyltransferase inhibitor N-[[4-(3,5-di... 2 0
Nicotinamide phosphoribosyltransferase inhibitor N-[[4-(6-morp... 2 0
Nicotinamide phosphoribosyltransferase inhibitor N-[[4-(benzen... 4 0
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 1
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor AG... 3 1
Cathepsin K inhibitor SureCN4141224 family 3 0
Cyclin-dependent kinase 1 and Proto-oncogene tyrosine-protein ... 5 13
Cathepsin K and Cathepsin S inhibitor SureCN4138353 family 3 0
Mitogen-activated protein kinase 10 inhibitor CYCLOPROPYL-{4-[... 2 1
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 3 0
Cannabinoid receptor 2 ligand 4-[[2-tert-butyl-1-(cyclohexylme... 2 0
Nociceptin receptor and Potassium voltage-gated channel subfam... 5 2
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 3 0
LIM domain kinase 2 inhibitor (2S)-N-cyano-N'-(3-cyanophenyl)-... 4 0
Prostaglandin G/H synthase 2 inhibitor 4-N,4-N-diethyl-2-(4-me... 5 1
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 10 0
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 2
Adenosine receptor A1 and Adenosine receptor A2b ligand SureCN... 2 3
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 1 0
D(4) dopamine receptor and D(3) dopamine receptor ligand SureC... 1 0
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 1 0
Vascular endothelial growth factor receptor 2 and Vascular end... 1 1
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 4 1
Histamine H3 receptor ligand AGN-PC-074FK2 family 4 1
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 3 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 4
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
5-hydroxytryptamine receptor 6 ligand 8-(1-pyrrolidin-3-ylpyrr... 1 0
Gamma-aminobutyric acid receptor subunit pi and Gamma-aminobut... 4 0
Cyclin-dependent kinase 2 inhibitor Imidazo[1,2-a]pyridine der... 4 0
Alpha-1A adrenergic receptor and Alpha-2A adrenergic receptor ... 3 0
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Proto-oncogene tyrosine-protein kinase Src and Tyrosine-protei... 3 0
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 0
Nuclear receptor subfamily 1 group I member 2 ligand AGN-PC-07... 2 13
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 2 3
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 4 0
Metabotropic glutamate receptor 1 ligand AGN-PC-00FV3S family 2 0
Cyclin-dependent kinase 2 inhibitor SureCN3549598 family 3 1
Nociceptin receptor and Mu-type opioid receptor ligand 2-(3-ch... 2 0
Cyclin-dependent kinase 2 inhibitor Imidazo[1,2-b]pyridazine d... 2 1
Focal adhesion kinase 1 and Protein-tyrosine kinase 2-beta inh... 1 1
Ribosomal protein S6 kinase beta-1 and Aurora kinase B inhibit... 1 5
Neuropeptide Y receptor type 5 ligand 1-methylsulfonyl-N-(2-ph... 4 0
5-hydroxytryptamine receptor 3A ligand AGN-PC-077D8K family 3 1
Carbonic anhydrase 2 and Carbonic anhydrase 9 inhibitor ZINC00... 1 0
5-hydroxytryptamine receptor 2B ligand SureCN1299053 family 1 1
Nociceptin receptor and Potassium voltage-gated channel subfam... 1 0
Cannabinoid receptor 2 ligand AGN-PC-07C4UJ family 2 0
Tyrosine-protein kinase Lck inhibitor (3S)-3-[(1S)-1-[[4-(benz... 14 0
LIM domain kinase 1 and LIM domain kinase 2 inhibitor (2S)-N'-... 9 0
LIM domain kinase 2 inhibitor (2S)-N-cyano-N'-[3-(2-hydroxyeth... 2 1
Neuropeptide Y receptor type 5 ligand AGN-PC-01NS1A family 7 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
Histamine H3 receptor ligand AGN-PC-074FFM family 1 2
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 5
Adenosine receptor A1 ligand AGN-PC-075Q3Q family 1 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 0
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor (2S)-2-[[9-p... 4 5
Tyrosine-protein kinase Lck inhibitor N-(2-bromophenyl)imidazo... 1 0
Transient receptor potential cation channel subfamily V member... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00277720 CHEMBL520187 Bioactive AGN-PC-03N6KB
CFAMM00277732 CHEMBL484555 Bioactive AGN-PC-077RBL
CFAMM00277697 CHEMBL70824 Bioactive sulfonamide deriv. 3f
CFAMM00277725 CHEMBL71044 Bioactive sulfonamide deriv. 3e
CFAMM00277689 CHEMBL478407 Bioactive AGN-PC-077L3J
CFAMM00277718 CHEMBL72510 Bioactive Imidazo[1,2-a]pyridine deriv. 7
CFAMM00277731 CHEMBL308853 Bioactive sulfonamide deriv. 3a
CFAMM00277724 CHEMBL477785 Bioactive SureCN3556094
CFAMM00277738 CHEMBL477567 Bioactive SureCN3555947
CFAMM00277755 CHEMBL73214 Bioactive Imidazo[1,2-a]pyridine deriv. 4f
CFAMM00277688 CHEMBL514384 Bioactive SureCN3558929
CFAMM00277709 CHEMBL485425 Bioactive AGN-PC-03N6KH
CFAMM00277745 CHEMBL485618 Bioactive SureCN5092316
CFAMM00277693 CHEMBL73243 Bioactive sulfonamide deriv. 3c
CFAMM00277699 CHEMBL485240 Bioactive AGN-PC-077RC4
CFAMM00277714 CHEMBL520353 Bioactive AGN-PC-077RCR
CFAMM00277727 CHEMBL73303 Bioactive 4-[(4-IMIDAZO[1,2-A]PYRIDIN-3-YLPYRIMIDIN-2-YL)AMINO]BENZENESULFONAMIDE
CFAMM00277742 CHEMBL2391585 Bioactive 1-[4-(benzenesulfonyl)phenyl]-3-(imidazo[1,2-a]pyridin-6-ylmethyl)urea
CFAMM00277716 DNC009585 Investigative Drug AZD-5438

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27409 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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