CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID285
Family Name Sigma non-opioid intracellular receptor 1 Ligand Dimemorfan Family
No. of Seeds 5 No. of Other Members 15
Family Centroid CFAMM00186397 Functional Category Investigative Drug
Superfamily Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor Binder Superfamily
Class Class 585

Cousin Family NamesSeedsMembers
5-hydroxytryptamine 2 receptor Ligand tricyclic antidepressant... 29 680
Voltage-dependent T-type calcium channel subunit alpha-1H liga... 10 397
Extracellular calcium-sensing receptor ligand Cinacalcet Family 2 30
Histamine H1 receptor ligand piperazine derivative Cyclizine F... 16 140
Amine oxidase [flavin-containing] B Inhibitor Selegiline Family 6 26
Squalene monooxygenase Inhibitor Naftifine Family 8 32
Noradrenergic re-uptake Inhibitor Protriptyline Family 3 25
Dopamine receptor ligand norcamphene derivative Fencamfamine F... 3 41
Muscarinic acetylcholine receptor M3 Ligand Diphemanil Methyls... 22 45
Noradrenergic re-uptake Inhibitor Maprotiline Family 6 33
Serotonin re-uptake Inhibitor Dexfenfluramine Family 6 31
Dermatan family 1 11
Glutamate receptor AMPA subtype and Noradrenaline uptake Ligan... 9 17
Zicronapine family 43 62
D(2) dopamine receptor and D(3) dopamine receptor Ligand (-)-3... 15 19
Adenosine receptor A3 and Glutamate receptor ionotropic, NMDA ... 4 30
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 8 32
Sodium-dependent noradrenaline transporter and Sodium-dependen... 3 10
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 7 19
Histamine H3 receptor Ligand 1-[2-(2,4,6-trimethyl-phenyl)-eth... 9 15
Amine oxidase [flavin-containing] A Inhibitor 1-(2-naphthyl)-2... 4 4
Sodium-dependent serotonin transporter Inhibitor 1-(2-(naphtha... 5 2
Sodium-dependent dopamine transporter and Sodium-dependent nor... 28 71
Sodium-dependent serotonin transporter Inhibitor Tefludazine F... 8 9
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 1
Amine oxidase [flavin-containing] B Inhibitor Methyl-(1,2,3,4-... 2 0
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 17 9
Melatonin receptor type 1A Ligand N-(2,3-dihydro-1h-phenalen-2... 8 13
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 4 1
Sodium-dependent dopamine transporter and Sodium-dependent ser... 8 2
Sigma non-opioid intracellular receptor 1 ligand CHEMBL101300 ... 2 1
Sodium-dependent noradrenaline transporter and Sodium-dependen... 4 2
Sodium-dependent serotonin transporter and Sodium-dependent no... 12 0
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 1 2
5-hydroxytryptamine receptor 7 and Sodium-dependent serotonin ... 5 1
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 3 3
Transporter and Sodium-dependent serotonin transporter inhibit... 4 8
5-hydroxytryptamine receptor 7 ligand 5-methyl-6-(6-methyl-5,6... 2 0
Sigma non-opioid intracellular receptor 1 ligand 1-[2-[4-[1-ad... 1 0
Sodium-dependent noradrenaline transporter and Sodium-dependen... 2 12
Histamine H3 receptor ligand SureCN1641166 family 3 0
5-hydroxytryptamine receptor 1A ligand SureCN8901985 family 1 0
Histamine H3 receptor ligand 2-benzyl-4-[4-(2-pyrrolidin-1-yle... 8 4
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 6 7
Sodium-dependent serotonin transporter and Transporter inhibit... 7 2
Sodium-dependent serotonin transporter and Transporter inhibit... 7 2
C-C chemokine receptor type 5 ligand 1-[[(3S,4S)-1-(cyclohexyl... 1 0
Sodium-dependent serotonin transporter and Sodium-dependent do... 2 0
Histamine H3 receptor ligand 1-[4-[4-(pyrrolidin-1-ylmethyl)ph... 4 2
Sodium-dependent dopamine transporter and Sodium-dependent nor... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00186403 CHEMBL48157 Bioactive CHEMBL48157
CFAMM00186397 DNC000565 Investigative Drug Dimemorfan

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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